Analysis of Ki-ras codon 12 mutations in the duodenal juice of patients with pancreatic cancer.

abstract：BACKGROUND & AIMS:Colorectal cancers (CRC) associated with the hereditary nonpolyposis colorectal cancer (HNPCC) syndrome display high-level microsatellite instability (MSI-H) as a consequence of mismatch repair deficiency. HNPCC-associated CRC frequently show features of a pronounced immune response, most likely resul...

journal_title：Gastroenterology

authors： Schwitalle Y,Kloor M,Eiermann S,Linnebacher M,Kienle P,Knaebel HP,Tariverdian M,Benner A,von Knebel Doeberitz M

更新日期：2008-04-01 00:00:00

abstract：:Serum amino acid levels were determined in 29 patients with severe chronic active liver disease before, during, and after administration of prednisone or placebo and in 22 healthy controls. The pretreatment molar ratio of amino acids was less in patients than in controls (p less than 0.001) and was lower in those with...

journal_title：Gastroenterology

authors： McCullough AJ,Czaja AJ,Jones JD,Go VL

更新日期：1981-10-01 00:00:00

abstract：BACKGROUND & AIMS:Patients with chronic hepatitis C and persistently normal alanine aminotransferase (ALT) levels have been routinely excluded from large randomized treatment trials; consequently, the efficacy and safety of antiviral therapy in this population are unknown. METHODS:Patients with at least 3 normal ALT v...

journal_title：Gastroenterology

authors： Zeuzem S,Diago M,Gane E,Reddy KR,Pockros P,Prati D,Shiffman M,Farci P,Gitlin N,O'Brien CB,Lamour F,Lardelli P,PEGASYS Study NR16071 Investigator Group.

更新日期：2004-12-01 00:00:00

abstract：BACKGROUND & AIMS:The sarcomatoid change in cholangiocarcinoma (CC) contributes to more aggressive intrahepatic spread and widespread metastasis. Therefore, the aim of this study was to identify the molecular mechanisms of CC metastasis during tumor progression and sarcomatoid change. METHODS:Using the subtraction sup...

journal_title：Gastroenterology

authors： Lee MJ,Yu GR,Yoo HJ,Kim JH,Yoon BI,Choi YK,Kim DG

更新日期：2009-09-01 00:00:00

abstract：BACKGROUND & AIMS:This study aimed to determine if hiatal hernia influences vulnerability to reflux and transient lower esophageal sphincter relaxation (tLESR) during gastric distention in patients with gastroesophageal reflux disease (GERD). METHODS:Eight normal subjects and 15 patients with GERD were studied. A meta...

journal_title：Gastroenterology

authors： Kahrilas PJ,Shi G,Manka M,Joehl RJ

更新日期：2000-04-01 00:00:00

abstract：BACKGROUND & AIMS:Linaclotide is a minimally absorbed agonist of guanylate cyclase-C (GUCY2C or GC-C) that reduces symptoms associated with irritable bowel syndrome with constipation (IBS-C). Little is known about the mechanism by which linaclotide reduces abdominal pain in patients with IBS-C. METHODS:We determined t...

journal_title：Gastroenterology

authors： Castro J,Harrington AM,Hughes PA,Martin CM,Ge P,Shea CM,Jin H,Jacobson S,Hannig G,Mann E,Cohen MB,MacDougall JE,Lavins BJ,Kurtz CB,Silos-Santiago I,Johnston JM,Currie MG,Blackshaw LA,Brierley SM

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND & AIMS:Previous studies have suggested that dietary folic acid (FA) can protect against certain types of cancers. However, the findings have varied, and the mechanisms by which FA exerts chemopreventive effects remain to be clarified. We examined the effects of FA supplementation on DNA methylation, gene exp...

journal_title：Gastroenterology

authors： Gonda TA,Kim YI,Salas MC,Gamble MV,Shibata W,Muthupalani S,Sohn KJ,Abrams JA,Fox JG,Wang TC,Tycko B

更新日期：2012-04-01 00:00:00

abstract：BACKGROUND/AIMS:Little is known about the evolution of morphological changes in pelvic ileal-pouch mucosa. This study evaluates prospectively the sequence of early morphological, histochemical, and phenotypic features in pouch mucosal biopsy specimens. METHODS:Twenty-two patients with pelvic ileal pouches constructed ...

journal_title：Gastroenterology

authors： Apel R,Cohen Z,Andrews CW Jr,McLeod R,Steinhart H,Odze RD

更新日期：1994-08-01 00:00:00

abstract：:This report defines criteria and reviews the epidemiology, pathophysiology, and management of common anorectal disorders: fecal incontinence (FI), functional anorectal pain and functional defecation disorders. FI is defined as the recurrent uncontrolled passage of fecal material for at least 3 months. The clinical fea...

journal_title：Gastroenterology

authors： Rao SS,Bharucha AE,Chiarioni G,Felt-Bersma R,Knowles C,Malcolm A,Wald A

更新日期：2016-03-25 00:00:00

abstract：:The aim of this study was to test in vivo (a) whether the sphincter of Oddi acts as a resistor or also as a pump, (b) the effect of an IV infusion of cholecystokinin (CCK) on choledochoduodenal flow, and (c) the ability of the choledochoduodenal junction to prevent duodenobiliary reflux in two animal species, opossums...

journal_title：Gastroenterology

authors： Calabuig R,Weems WA,Moody FG

更新日期：1990-12-01 00:00:00

abstract：:We investigated whether intrapancreatic coagulation, with deposition of the fibrinogen-γ dimer (Fib-γD) and hypoxia, affect the severity of acute pancreatitis (AP) in mice. Pancreata of mice with AP induced by administration of cerulein or by L-arginine, or from patients with pancreatitis, had increased deposition of ...

journal_title：Gastroenterology

authors： Park MJ,Iyer S,Xue X,Bragazzi Cunha J,Gu S,Moons D,Pipe SW,Williams JA,Simeone DM,Shah YM,Omary MB

更新日期：2018-05-01 00:00:00

abstract：BACKGROUND & AIMS:Modulation of the host innate immune response is an attractive means of inhibiting hepatitis C virus (HCV) replication. Having previously determined that expression of the interferon-sensitive gene (ISG)15 protease USP18 is increased in the liver biopsy specimens of patients who do not respond to inte...

journal_title：Gastroenterology

authors： Randall G,Chen L,Panis M,Fischer AK,Lindenbach BD,Sun J,Heathcote J,Rice CM,Edwards AM,McGilvray ID

更新日期：2006-11-01 00:00:00

abstract：:In this review, we compared the outcome of 25 studies of experimentally induced pancreatitis in animals with 13 studies of human acute pancreatitis in which the same therapeutic agents were used (aprotinin, glucagon, 5-fluorouracil, somatostatin, peritoneal lavage). Whereas 81% of the animal studies had a positive out...

journal_title：Gastroenterology

authors： Steinberg WM,Schlesselman SE

更新日期：1987-12-01 00:00:00

abstract：BACKGROUND & AIMS:We have few population-level data on the performance of endoscopic retrograde cholangiopancreatography (ERCP) in the United States. We investigated the numbers of unplanned hospital encounters (UHEs), patient and facility factors associated with UHEs, and variation in quality and outcomes in the perfo...

journal_title：Gastroenterology

authors： Huang RJ,Barakat MT,Girotra M,Lee JS,Banerjee S

更新日期：2019-01-01 00:00:00

abstract：:To look for possible HLA linkage in familial Crohn's disease, HLA haplotype segregation patterns were determined in 70 members of five kindreds, each having 2 or more patients with Crohn's disease (total number: 13 with Crohn's disease, 1 with ulcerative colitis). Concordant segregation of HLA haplotypes and disease w...

journal_title：Gastroenterology

authors： Eade OE,Moulton C,MacPherson BR,Andre-Ukena SS,Albertini RJ,Beeken WL

更新日期：1980-08-01 00:00:00

abstract：BACKGROUND & AIMS:It is uncertain whether peptide YY (PYY) inhibits human intestinal secretion directly through enterocyte receptors or via indirect neural mechanisms. Thus, the effect of PYY on prostaglandin E2 (PGE2)-induced jejunal secretion in normal volunteers was measured, and it was determined whether a dopamine...

journal_title：Gastroenterology

authors： Rozé C,Molis C,Xiaomei FC,Ropert A,Genève J,Galmiche JP

更新日期：1997-05-01 00:00:00

abstract：:Serum group I pepsinogen (PG I) levels, basal acid output, and peak acid output (PAO) have been determined in 120 patients, 54 with duodenal ulcer, 14 with prepyloric ulcer, 12 with gastric ulcer, and 40 without ulcer. The correlation between serum PG I and PAO was statistically significant (r = 0.736, P less than 0.0...

journal_title：Gastroenterology

authors： Samloff IM,Secrist DM,Passaro E Jr

更新日期：1975-12-01 00:00:00

abstract：BACKGROUND & AIMS:Hepatic encephalopathy (HE) is associated with typical changes of cerebral metabolite pattern observed by proton magnetic resonance (MR) spectroscopy consisting of a depletion of myo-inositol and an increase of glutamine. The aim of this study was to determine whether abnormalities in brain metabolism...

journal_title：Gastroenterology

authors： Laubenberger J,Häussinger D,Bayer S,Gufler H,Hennig J,Langer M

更新日期：1997-05-01 00:00:00

abstract：:Hepatitis C virus (HCV) is the agent responsible for posttransfusion hepatitis. The incidence, timing, and clinical course of HCV positive hepatitis in liver transplant recipients are unknown. Three hundred and seventeen donor-recipient liver transplant pairs were grouped on the basis of their pretransplant HCV antibo...

journal_title：Gastroenterology

authors： Shah G,Demetris AJ,Gavaler JS,Lewis JH,Todo S,Starzl TE,Van Thiel DH

更新日期：1992-07-01 00:00:00

abstract：:The bioavailability of parenteral cimetidine was tested in 12 volunteers in a balanced three-way crossover study. Blood levels and urinary excretion were compared after intramuscular and intravenous injection and oral administration of 300 mg of cinetidine. The results indicated that the intramuscular and intravenous ...

journal_title：Gastroenterology

authors： Walkenstein SS,Dubb JW,Randolph WC,Westlake WJ,Stote RM,Intoccia AP

更新日期：1978-02-01 00:00:00

abstract：BACKGROUND & AIMS:We have shown previously that cure of Helicobacter pylori infection leads to the disappearance of acid-neutralizing substances. Also, patients with ulcer after cure may gain weight. The aim of this study was to investigate whether cure of the infection increases the risk of reflux esophagitis. METHOD...

journal_title：Gastroenterology

authors： Labenz J,Blum AL,Bayerdörffer E,Meining A,Stolte M,Börsch G

更新日期：1997-05-01 00:00:00

abstract：BACKGROUND & AIMS:Pancreatitis is the most important risk factor for pancreatic ductal adenocarcinoma (PDAC). Pancreatitis predisposes to PDAC because it induces a process of acinar cell reprogramming known as acinar-to-ductal metaplasia (ADM)-a precursor of pancreatic intraepithelial neoplasia lesions that can progres...

journal_title：Gastroenterology

authors： Gruber R,Panayiotou R,Nye E,Spencer-Dene B,Stamp G,Behrens A

更新日期：2016-09-01 00:00:00

abstract：:We investigated the ability of isolated human colonic epithelial cells to express the common acute lymphoblastic leukemia antigen (CALLA), the transferrin receptor, and the 4F2 antigen in response to different types of stimuli. The expression of these markers was assessed by immunofluorescence using monoclonal antibod...

journal_title：Gastroenterology

authors： Fais S,Pallone F

更新日期：1989-12-01 00:00:00

abstract：BACKGROUND & AIMS:The effects of leukotriene (LT) D(4) on intestinal epithelial cells govern events that are involved in cell survival and colon cancer, notably increased expression of cyclooxygenase (COX)-2 and enhanced production of prostaglandin E(2). We investigated possible correlations between distribution of the...

journal_title：Gastroenterology

authors： Ohd JF,Nielsen CK,Campbell J,Landberg G,Löfberg H,Sjölander A

更新日期：2003-01-01 00:00:00

abstract：:A case of a 29-year-old woman who has had two episodes both clinically and biochemically consistent with acute fatty liver of pregnancy is described. These episodes occurred in two successive pregnancies, and liver biopsy confirmed the diagnosis in the second pregnancy. Both pregnancies were managed by prompt fetal de...

journal_title：Gastroenterology

authors： Schoeman MN,Batey RG,Wilcken B

更新日期：1991-02-01 00:00:00

abstract：:It is possible to estimate hepatic triglyceride content by calculating the proton density fat fraction (PDFF), using proton magnetic resonance spectroscopy (1H-MRS), instead of collecting and analyzing liver biopsy specimens to detect steatosis. However, the current PDFF cut-off value (5%) used to define steatosis by ...

journal_title：Gastroenterology

authors： Nasr P,Forsgren MF,Ignatova S,Dahlström N,Cedersund G,Leinhard OD,Norén B,Ekstedt M,Lundberg P,Kechagias S

更新日期：2017-07-01 00:00:00

abstract：:In spite of the widespread use of the Garren-Edwards gastric bubble as an adjuvant device in weight reduction, its efficacy has not been established. Therefore, our purpose was to conduct a randomized, double-blind, crossover study of this device in the management of exogenous obesity. The study group consisted of 23 ...

journal_title：Gastroenterology

authors： Meshkinpour H,Hsu D,Farivar S

更新日期：1988-09-01 00:00:00

abstract：BACKGROUND/AIMS:Heat-shock protein (Hsp) 60 is an immunodominant antigen of mycobacteria and other microorganisms that is highly homologous to its human counterpart. Hsp60 may provide a link between immunity to invading microorganisms and autoimmune diseases. METHODS:Expression of Hsp60 was studied by immunohistochemi...

journal_title：Gastroenterology

authors： Peetermans WE,D'Haens GR,Ceuppens JL,Rutgeerts P,Geboes K

更新日期：1995-01-01 00:00:00

abstract：BACKGROUND & AIMS:Narrow-band imaging (NBI) allows real-time histologic classification of colorectal polyps. We investigated whether endoscopists without prior training in NBI can achieve the following thresholds recommended by the American Society for Gastrointestinal Endoscopy: for diminutive colorectal polyps charac...

journal_title：Gastroenterology

authors： Patel SG,Schoenfeld P,Kim HM,Ward EK,Bansal A,Kim Y,Hosford L,Myers A,Foster S,Craft J,Shopinski S,Wilson RH,Ahnen DJ,Rastogi A,Wani S

更新日期：2016-02-01 00:00:00

abstract：BACKGROUND & AIMS:JC virus (JCV), a human polyomavirus, has been found in a limited number of normal human tissues and cancers. The oncogenic potential of this virus is mediated by a transforming protein, the T antigen (TAg). We have previously demonstrated the presence of JCV-TAg in colorectal cancers, in adjacent nor...

journal_title：Gastroenterology

authors： Ricciardiello L,Laghi L,Ramamirtham P,Chang CL,Chang DK,Randolph AE,Boland CR

更新日期：2000-11-01 00:00:00