Abstract:
:The bioavailability of parenteral cimetidine was tested in 12 volunteers in a balanced three-way crossover study. Blood levels and urinary excretion were compared after intramuscular and intravenous injection and oral administration of 300 mg of cinetidine. The results indicated that the intramuscular and intravenous routes are virtually interchangeable for parenteral cimetidine, and that the oral liquid, although exhibiting a reduced area under the blood level curve as compared with the parenteral doses, nevertheless demonstrated equivalence with respect to the time the blood level remained above 0.5 microgram per ml. The 300-mg cimetidine tablet formulation was found in another group of 12 volunteers to be bioequivalent to a 300-mg dose of oral liquid.
journal_name
Gastroenterologyjournal_title
Gastroenterologyauthors
Walkenstein SS,Dubb JW,Randolph WC,Westlake WJ,Stote RM,Intoccia APsubject
Has Abstractpub_date
1978-02-01 00:00:00pages
360-5issue
2 Pt 2eissn
0016-5085issn
1528-0012pii
S0016508578000451journal_volume
74pub_type
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