Intrahepatic bile duct loss in biliary atresia despite portoenterostomy: a consequence of ongoing obstruction?

abstract：:Chlorpromazine (CPZ) is a long recognized cause of jaundice, but the mechanism by which this agent produces icteric liver disease is not well defined. This study examined some effects of CPZ administration on bilirubin metabolism and biliary secretion in the rat. Acute CPZ treatment (25 mg per kg intravenously) produc...

journal_title：Gastroenterology

authors： Knodell RG

更新日期：1975-10-01 00:00:00

abstract：BACKGROUND & AIMS:Cirrhotic liver diseases are associated with abnormalities in cardiac geometry and function in adults (cirrhotic cardiomyopathy) but rarely explored in cirrhotic infants or children. We proposed that features of cirrhotic cardiomyopathy are present in infants with cirrhosis due to biliary atresia (BA)...

journal_title：Gastroenterology

authors： Desai MS,Zainuer S,Kennedy C,Kearney D,Goss J,Karpen SJ

更新日期：2011-10-01 00:00:00

abstract：BACKGROUND & AIMS:Crohn's disease (CD) is an inflammatory bowel disease characterized by uncontrolled immune responses to bacterial flora, with excessive activation of T lymphocytes. MICA is a stress-induced major histocompatibility complex-related molecule expressed on normal intestinal epithelial cells (IECs) and rec...

journal_title：Gastroenterology

authors： Allez M,Tieng V,Nakazawa A,Treton X,Pacault V,Dulphy N,Caillat-Zucman S,Paul P,Gornet JM,Douay C,Ravet S,Tamouza R,Charron D,Lémann M,Mayer L,Toubert A

更新日期：2007-06-01 00:00:00

abstract：BACKGROUND & AIMS:Cost-effectiveness of colorectal cancer screening will be maximized by selecting the widest screening intervals that effectively prevent cancer mortality. However, data on the incidence of neoplasia in persons with no abnormal findings on initial examination are limited. The aim of this study was to d...

journal_title：Gastroenterology

authors： Rex DK,Cummings OW,Helper DJ,Nowak TV,McGill JM,Chiao GZ,Kwo PY,Gottlieb KT,Ikenberry SO,Gress FG,Lehman GA,Born LJ

更新日期：1996-11-01 00:00:00

abstract：:A new model of an acute bleeding gastric ulcer with a single bleeding artery in its base has been developed. A suction ulcer defect is created over a large, submucosal artery. Small bleeding marginal vessels are electrocoagulated with a fine-tipped bipolar forceps. The artery in the base of the ulcer is dissected free...

journal_title：Gastroenterology

authors： Dennis MB,Silverstein FE,Gilbert DA,Peoples JE

更新日期：1981-06-01 00:00:00

abstract：:We have recently demonstrated that release of oxygen-derived free radicals by activated hepatic macrophages may be involved in the pathogenesis of a rat model of liver injury induced by Corynebacterium parvum and endotoxin. In the present study we have compared the respiratory burst activity of isolated normal rat Kup...

journal_title：Gastroenterology

authors： Arthur MJ,Kowalski-Saunders P,Wright R

更新日期：1986-07-01 00:00:00

abstract：BACKGROUND & AIMS:Few studies, even those with cohort designs, test the mediating effects of infant gut microbes and metabolites on the onset of disease. We undertook such a study. METHODS:Using structural equation modeling path analysis, we tested directional relationships between first pregnancy, birth mode, prolong...

journal_title：Gastroenterology

authors： Vu K,Lou W,Tun HM,Konya TB,Morales-Lizcano N,Chari RS,Field CJ,Guttman DS,Mandal R,Wishart DS,Azad MB,Becker AB,Mandhane PJ,Moraes TJ,Lefebvre DL,Sears MR,Turvey SE,Subbarao P,Scott JA,Kozyrskyj AL

更新日期：2021-01-01 00:00:00

abstract：:The effect of magnesium on calcium- and pentagastrin-induced gastric acid secretion and on calcium-induced gastrin secretion were studied in healthy volunteers. Intravenous infusion of calcium gluconate increased serum gastrin concentration as well as gastric volume secretion, acidity, and acid output. Addition of mag...

journal_title：Gastroenterology

authors： Christiansen J,Rehfeld JF,Stadil F

更新日期：1975-05-01 00:00:00

abstract：:A 17-yr-old boy developed acute proctosigmoiditis after the institution of isotretinoin for the treatment of cystic acne vulgaris. Painless diarrhea, accompanied by mucus and eventually blood, began within days of commencing treatment and persisted while the drug was administered. At sigmoidoscopy patchy mucosal infla...

journal_title：Gastroenterology

authors： Martin P,Manley PN,Depew WT,Blakeman JM

更新日期：1987-09-01 00:00:00

abstract：BACKGROUND & AIMS:Omeprazole is metabolized by cytochrome P450 (CYP2C19). The activity of this enzyme is polymorphic, with incidences of poor metabolizers (PMs), heterozygous extensive metabolizers (EMs), and homozygous EMs in white populations of 3%, 30%, and 67%, respectively. The importance of the CYP2C19 polymorphi...

journal_title：Gastroenterology

authors： Sagar M,Tybring G,Dahl ML,Bertilsson L,Seensalu R

更新日期：2000-09-01 00:00:00

abstract：:Three cases of Stevens-Johnson syndrome with intestinal involvement are described. Two patients had esophageal involvement, the severity of which paralleled skin lesions and, in 1 case, probably contributed to death. Dysphagia and bleeding were manifestations. The third patient was unique and had gastric, small and la...

journal_title：Gastroenterology

authors： Zweiban B,Cohen H,Chandrasoma P

更新日期：1986-08-01 00:00:00

abstract：BACKGROUND & AIMS:Endoscopic and Histologic remission are important goals in the treatment of ulcerative colitis (UC). We investigated the correlation of the recently developed Paddington International Virtual ChromoendoScopy ScOre( PICaSSO) and other established endoscopic scores against multiple histological indices ...

journal_title：Gastroenterology

authors： Iacucci M,Smith SC,Bazarova A,Shivaji UN,Bhandari P,Cannatelli R,Daperno M,Ferraz J,Goetz M,Gui X,Hayee B,De Hertogh G,Lazarev M,Li J,Nardone OM,Parra-Blanco A,Pastorelli L,Panaccione R,Occhipinti V,Rath T,Tontini

更新日期：2020-12-18 00:00:00

abstract：:The influence of endogenous prostaglandins on secretin-mediated inhibition of gastric acid secretion was examined in 6 mongrel dogs with Thomas gastric and Herrera pancreatic cannulas. The dogs were given intravenous pentagastrin (1 microgram/kg.h) during the 180-min experiment, and graded doses of secretin (0.3-1.5 m...

journal_title：Gastroenterology

authors： MacLellan DG,Upp JR Jr,Thompson JC

更新日期：1988-09-01 00:00:00

abstract：BACKGROUND & AIMS:Manganese (Mn) deposition could be responsible for the T(1)-weighted magnetic resonance signal hyperintensities observed in cirrhotic patients. These experiments were designed to assess the regional specificity of the Mn increases as well as their relationship to portal-systemic shunting or hepatobili...

journal_title：Gastroenterology

authors： Rose C,Butterworth RF,Zayed J,Normandin L,Todd K,Michalak A,Spahr L,Huet PM,Pomier-Layrargues G

更新日期：1999-09-01 00:00:00

abstract：:Pancreatic ductal adenocarcinoma is a devastating disease, and patient outcomes have not improved in decades. Treatments that target tumor cells have largely failed. This could be because research has focused on cancer cells and the influence of the stroma on tumor progression has been largely ignored. The focus of pa...

journal_title：Gastroenterology

authors： Apte MV,Wilson JS,Lugea A,Pandol SJ

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND & AIMS:Hepatitis B virus (HBV) covalently closed circular DNA (cccDNA) is a unique episomal replicative intermediate responsible for persistent infection of hepatocytes. Technical constraints have hampered the direct study of cccDNA maintenance and clearance mechanisms in patients. The aim of this study was ...

journal_title：Gastroenterology

authors： Werle-Lapostolle B,Bowden S,Locarnini S,Wursthorn K,Petersen J,Lau G,Trepo C,Marcellin P,Goodman Z,Delaney WE 4th,Xiong S,Brosgart CL,Chen SS,Gibbs CS,Zoulim F

更新日期：2004-06-01 00:00:00

abstract：:There are apparent similarities in the mechanisms of the intestinal phase of exocrine and pancreatic polypeptide (PP) secretion by the pancreas. To characterize this relationship, we measured incremental responses of protein, bicarbonate, and PP to graded doses of intravenous secretin, caerulein, CCK8, CCK33, bethanec...

journal_title：Gastroenterology

authors： Beglinger C,Taylor IL,Grossman MI,Solomon TE

更新日期：1984-09-01 00:00:00

abstract：BACKGROUND & AIMS:Depletion of interstitial cells of Cajal (ICCs) is common in diabetic gastroparesis. However, in approximately 20% of patients with diabetes, gastric emptying (GE) is accelerated. GE also occurs faster in obese individuals, and is associated with increased blood levels of glucose in patients with type...

journal_title：Gastroenterology

authors： Hayashi Y,Toyomasu Y,Saravanaperumal SA,Bardsley MR,Smestad JA,Lorincz A,Eisenman ST,Cipriani G,Nelson Holte MH,Al Khazal FJ,Syed SA,Gajdos GB,Choi KM,Stoltz GJ,Miller KE,Kendrick ML,Rubin BP,Gibbons SJ,Bharucha AE,

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND:Liver injury in many patients with chronic hepatitis B is sporadic and is often characterized by acute exacerbations alternating with relatively normal liver function. The aim of this study was to perform detailed serological and biochemical analysis during periods of active liver disease to better understan...

journal_title：Gastroenterology

authors： Maruyama T,Iino S,Koike K,Yasuda K,Milich DR

更新日期：1993-10-01 00:00:00

abstract：:Increasing evidence has emerged that supports an important intersection between 3 fundamental cell biologic pathways in the pathogenesis of inflammatory bowel disease. These include the intersection between autophagy, as revealed by the original identification of ATG16L1 and IRGM as major genetic risk factors for Croh...

journal_title：Gastroenterology

authors： Kaser A,Blumberg RS

更新日期：2011-05-01 00:00:00

abstract：BACKGROUND:The mucosal response to intestinal resection has been extensively studied; little is known of the motor response. Our aim was to evaluate motility in the intestinal remnant following distal resection. METHODS:Motor activity, duodenocecal transit, nutrition, and absorption were studied over a 3-month period ...

journal_title：Gastroenterology

authors： Quigley EM,Thompson JS

更新日期：1993-09-01 00:00:00

abstract：:Jejunal absorption of acetate, propionate, and butyrate--the three predominant short chain fatty acids (SCFA's) in small and large intestinal contents--was studied in 5 volunteer subjects. A triple-lumen perfusion technique was employed; the test solutions were isotonic and contained 0, 5, 10, 25, 40, or 50 mM of a SC...

journal_title：Gastroenterology

authors： Schmitt MG Jr,Soergel KH,Wood CM

更新日期：1976-02-01 00:00:00

abstract：BACKGROUND & AIMS:Congenital tufting enteropathy (CTE) is a rare autosomal recessive diarrheal disorder presenting in the neonatal period. CTE is characterized by intestinal epithelial cell dysplasia leading to severe malabsorption and significant morbidity and mortality. The pathogenesis and genetics of this disorder ...

journal_title：Gastroenterology

authors： Sivagnanam M,Mueller JL,Lee H,Chen Z,Nelson SF,Turner D,Zlotkin SH,Pencharz PB,Ngan BY,Libiger O,Schork NJ,Lavine JE,Taylor S,Newbury RO,Kolodner RD,Hoffman HM

更新日期：2008-08-01 00:00:00

abstract：BACKGROUND & AIMS:Induction of heat-shock protein 72 is associated with enhanced tolerance to subsequent nonthermal stresses. This study evaluated whether induction of heat-shock protein 72 protects against intestinal ischemia/reperfusion injury. METHODS:Groups of nonheated and heated rats underwent sham operation, 30...

journal_title：Gastroenterology

authors： Stojadinovic A,Kiang J,Smallridge R,Galloway R,Shea-Donohue T

更新日期：1995-08-01 00:00:00

abstract：BACKGROUND & AIMS:We have previously shown that patients with irritable bowel syndrome (IBS) have impaired transit of intestinal gas loads. Because abnormal gas retention can be experimentally reproduced in healthy subjects by pharmacological inhibition of gut motility, we hypothesized that impaired gas transit and ret...

journal_title：Gastroenterology

authors： Caldarella MP,Serra J,Azpiroz F,Malagelada JR

更新日期：2002-06-01 00:00:00

abstract：:Sixty chronically alcoholic men who were impotent and known to have abstained from alcohol were followed prospectively to determine (a) the frequency of spontaneous recovery of normal sexual functioning, (b) indicators of spontaneous recovery, and (c) the response of those who did not achieve a spontaneous recovery to...

journal_title：Gastroenterology

authors： Van Thiel DH,Gavaler JS,Sanghvi A

更新日期：1983-04-01 00:00:00

abstract：BACKGROUND & AIMS:An increased duodenal expression of the iron transporters, divalent-metal-transporter-1, and ferroportin is observed in patients with iron deficiency or hereditary hemochromatosis. Two oxidoreductases, termed duodenal cytochrome b and hephaestin, are proposed to co-operate with divalent-metal-transpor...

journal_title：Gastroenterology

authors： Zoller H,Theurl I,Koch RO,McKie AT,Vogel W,Weiss G

更新日期：2003-09-01 00:00:00

abstract：BACKGROUND & AIMS:Mechanisms of diarrhea in ulcerative colitis (UC) are still unknown. Functional and structural characterization of epithelial barrier and transport properties in ulcerative colitis (UC) was performed. METHODS:Inflamed sigmoid colon epithelium from UC patients was studied by alternating current impeda...

journal_title：Gastroenterology

authors： Schmitz H,Barmeyer C,Fromm M,Runkel N,Foss HD,Bentzel CJ,Riecken EO,Schulzke JD

更新日期：1999-02-01 00:00:00

abstract：BACKGROUND & AIMS:Infection with Tropheryma whipplei has a range of effects-some patients can be chronic carriers without developing any symptoms, whereas others can develop systemic Whipple disease, characterized by a lack a protective inflammatory immune response. Alterations in HLA-G function have been associated wi...

journal_title：Gastroenterology

authors： Ben Azzouz E,Boumaza A,Mezouar S,Bardou M,Carlini F,Picard C,Raoult D,Mège JL,Desnues B

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND & AIMS:Previous studies indicated that the peptide neurotensin (NT) stimulates Cl(-) secretion in animal small intestinal mucosa in vitro. In this study, we investigated whether NT causes Cl(-) secretion in human colonic mucosa and examined the mechanism of this response. METHODS:Human mucosal preparations ...

journal_title：Gastroenterology

authors： Riegler M,Castagliuolo I,Wang C,Wlk M,Sogukoglu T,Wenzl E,Matthews JB,Pothoulakis C

更新日期：2000-08-01 00:00:00