Abstract：
:Pancreatic ductal adenocarcinoma is a devastating disease, and patient outcomes have not improved in decades. Treatments that target tumor cells have largely failed. This could be because research has focused on cancer cells and the influence of the stroma on tumor progression has been largely ignored. The focus of pancreatic cancer research began to change with the identification of pancreatic stellate cells, which produce the pancreatic tumor stroma. There is compelling in vitro and in vivo evidence for the influence of pancreatic stellate cells on pancreatic cancer development; several recent preclinical studies have reported encouraging results with approaches designed to target pancreatic stellate cells and the stroma. We review the background and recent advances in these areas, along with important areas of future research that could improve therapy.
journal_name
Gastroenterologyjournal_title
Gastroenterologyauthors
Apte MV,Wilson JS,Lugea A,Pandol SJdoi
10.1053/j.gastro.2012.11.037subject
Has Abstractpub_date
2013-06-01 00:00:00pages
1210-9issue
6eissn
0016-5085issn
1528-0012pii
S0016-5085(13)00196-0journal_volume
144pub_type
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