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Lactose enemas plus placebo tablets vs. neomycin tablets plus starch enemas in acute portal systemic encephalopathy. A double-blind randomized controlled study.

Abstract：

:A randomized, double-blind comparison of lactose enemas plus placebo tablets vs. starch enemas plus neomycin tablets was performed on 18 patients with acute portal systemic encephalopathy. Ten patients received starch enemas (10%; 1000 ml t.i.d.) plus neomycin tablets and 8 patients received lactose enemas (20%; 1000 ml t.i.d.) plus placebo tablets. A significant mental state improvement was demonstrated in the group of patients treated with starch enemas-neomycin tablets (p less than 0.05) and in the group of patients treated with lactose enemas-placebo tablets (p less than 0.025). Both treatments significantly improved the frequency of asterixis, ammonia blood levels, and electroencephalograms. In addition, patients treated with lactose enemas showed significant improvement in number-connection test times (p less than 0.02), and their stools showed a more acid pH (p less than 0.05). No side effects were evident with either treatment. Lactose enemas are a safe and effective treatment for acute portal systemic encephalopathy.

journal_name

Gastroenterology

journal_title

Gastroenterology

authors

Uribe M,Berthier JM,Lewis H,Mata JM,Sierra JG,García-Ramos G,Ramírez Acosta J,Dehesa M

subject

Has Abstract

pub_date

1981-07-01 00:00:00

pages

101-6

issue

1

eissn

0016-5085

issn

1528-0012

pii

S0016508581001480

journal_volume

81

pub_type

临床试验,杂志文章,随机对照试验

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