A new cause of Zollinger-Ellison syndrome: non-small cell lung cancer.

abstract：:Microsatellite instability (MSI) caused by mismatch repair deficiency (dMMR) is detected in a small proportion of pancreatic ductal adenocarcinomas (PDACs). dMMR and MSI have been associated with responses of metastatic tumors, including PDACs, to immune checkpoint inhibitor therapy. We performed immunohistochemical a...

journal_title：Gastroenterology

authors： Lupinacci RM,Goloudina A,Buhard O,Bachet JB,Maréchal R,Demetter P,Cros J,Bardier-Dupas A,Collura A,Cervera P,Scriva A,Dumont S,Hammel P,Sauvanet A,Louvet C,Delpéro JR,Paye F,Vaillant JC,André T,Closset J,Emile JF

更新日期：2018-03-01 00:00:00

abstract：:Skin tests and measurement of serum levels of immunoglobulin E do not accurately identify foods for elimination from the diets of patients with eosinophilic esophagitis (EoE). We investigated whether an esophageal prick test, in which the esophageal mucosa is challenged by local injection of allergen extracts, could i...

journal_title：Gastroenterology

authors： Warners MJ,Terreehorst I,van den Wijngaard RM,Akkerdaas J,van Esch BCAM,van Ree R,Versteeg SA,Smout AJPM,Bredenoord AJ

更新日期：2018-01-01 00:00:00

abstract：:An animal model for giardiasis was developed using Giardia muris in Swiss albino mice. Intraesophageal inoculation of G. muris cysts caused a reproducible pattern of infection, with trophozoite and cyst counts reaching a maximum on days 5 to 14 after cyst inoculation and thereafter showing a progressive decline. Spont...

journal_title：Gastroenterology

authors： Roberts-Thomson IC,Stevens DP,Mahmoud AA,Warren KS

更新日期：1976-07-01 00:00:00

abstract：BACKGROUND & AIMS:The host immune response during the chronic phase of hepatitis C virus infection varies among individuals; some patients have a no interferon (IFN) response in the liver, whereas others have full activation of IFN-stimulated genes (ISGs). Preactivation of this endogenous IFN system is associated with ...

journal_title：Gastroenterology

authors： Dill MT,Duong FH,Vogt JE,Bibert S,Bochud PY,Terracciano L,Papassotiropoulos A,Roth V,Heim MH

更新日期：2011-03-01 00:00:00

abstract：:A variety of noninvasive molecular approaches to colorectal cancer screening are emerging with potential to improve screening effectiveness and user-friendliness. These approaches are based on the sensitive assay of molecular markers in stool, blood, and urine samples. New methods, especially next generation stool-bas...

journal_title：Gastroenterology

authors： Ahlquist DA

更新日期：2010-06-01 00:00:00

abstract：:Ethanol (10 or 15% in the drinking water) was found to increase the amount of collagen in the livers of rats receiving a cirrhogenic diet. This effect of ethanol was most striking in the animals receiving 10% ethanol. Ethanol lowered the amount of labeled proline incorporated into hydroxyproline and, therefore, into c...

journal_title：Gastroenterology

authors： Henley KS,Laughrey EG,Appelman HD,Flecker K

更新日期：1977-03-01 00:00:00

abstract：:A 36-year-old man with brittle diabetes mellitus developed hepatic infarction immediately after an episode of ketoacidosis. The infarction was documented by angiogram 99mTc sulfur colloid scan, and biopsy. Except for the association with ketoacidosis, no other possible cause of hepatic infarction was found. ...

journal_title：Gastroenterology

authors： Ng RC,Sigmund CJ Jr,Lagos JA,Chernin M

更新日期：1977-10-01 00:00:00

abstract：:The short-term effects of rat pancreatic duct obstruction were evaluated and compared with those recently reported to follow obstruction of the rabbit pancreatic duct. In both species pancreatic edema and hyperamylasemia are noted, and the lysosomal hydrolase cathepsin B is redistributed from the lysosome-enriched to ...

journal_title：Gastroenterology

authors： Ohshio G,Saluja A,Steer ML

更新日期：1991-01-01 00:00:00

abstract：:To understand mechanisms of viral diarrhea further, we studied ileal ion transport in vitro in relation to mucosal changes and epithelial differentiation in transmissible gastroenteritis in piglets, an invasive viral enteritis thought to involve mainly proximal intestine. In infected pigs, at the height of diarrhea, s...

journal_title：Gastroenterology

authors： Shepherd RW,Gall DG,Butler DG,Hamilton JR

更新日期：1979-01-01 00:00:00

abstract：:Polyethylene glycol (PEG) is commonly used as a nonabsorbable volume marker in intestinal perfusion and flow studies. It has been assumed that PEG does not affect water and electrolyte movement, but this has not been extensively investigated. Using triple-lumen tube perfusion technique, we examined the effect of vario...

journal_title：Gastroenterology

authors： Davis GR,Santa Ana CA,Morawski SG,Fordtran JS

更新日期：1980-07-01 00:00:00

abstract：:Many women report that bowel symptoms are associated with menstruation, but neither the prevalence of these complaints nor their physiological basis is known. This study aimed to estimate prevalence, to determine whether patients with irritable bowel syndrome are more likely to make such complaints, and to determine w...

journal_title：Gastroenterology

authors： Whitehead WE,Cheskin LJ,Heller BR,Robinson JC,Crowell MD,Benjamin C,Schuster MM

更新日期：1990-06-01 00:00:00

abstract：:Biofeedback has been advocated as first-line therapy for patients whose symptoms of mild to moderate fecal incontinence have not responded to simple dietary advice or medication. Three main modalities have been described: (1) use of an intra-anal electromyographic sensor, a probe to measure intra-anal pressure, or per...

journal_title：Gastroenterology

authors： Norton C

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND & AIMS:Interstitial cells of Cajal (ICC) serve as pacemaker cells and mediators of neurotransmission from the enteric nervous system to gastrointestinal muscles. ICC develop from mesenchymal cells that express c-Kit, and signaling via Kit receptors is necessary for normal development of ICC. We studied the f...

journal_title：Gastroenterology

authors： Torihashi S,Nishi K,Tokutomi Y,Nishi T,Ward S,Sanders KM

更新日期：1999-07-01 00:00:00

abstract：:Evidence-based medicine combines clinical expertise and the best available evidence from systematic research to aid decision making in patient care. Levels of evidence can be graded from I to V, with level I, the strongest, coming from large randomized controlled trials (RCTs). When a definitive RCT has not been perfo...

journal_title：Gastroenterology

authors： Howden CW

更新日期：1997-12-01 00:00:00

abstract：:Primary sclerosing cholangitis is a chronic cholestatic liver disease that is commonly associated with chronic ulcerative colitis. We observed the development of varices in the abdominal wall surrounding the ileostomy stoma of patients with primary sclerosing cholangitis who underwent proctocolectomy and ileostomy for...

journal_title：Gastroenterology

authors： Wiesner RH,LaRusso NF,Dozois RR,Beaver SJ

更新日期：1986-02-01 00:00:00

abstract：BACKGROUND & AIMS:Therapy with interferon alfa (IFN-alpha) leads to remission of disease in one third of patients with chronic hepatitis B. The aim of this study was to better define the long-term prognosis of this outcome. METHODS:One hundred three patients with chronic hepatitis B who underwent IFN-alpha therapy in ...

journal_title：Gastroenterology

authors： Lau DT,Everhart J,Kleiner DE,Park Y,Vergalla J,Schmid P,Hoofnagle JH

更新日期：1997-11-01 00:00:00

abstract：:We investigated the possibility that monocyte suppressor cells play a role in the peripheral lymphocyte hyporesponsiveness of chronic liver disease by utilizing assays of monocyte-mediated suppressor activity in 46 patients with chronic liver disease and 46 controls. The percent change achieved by the addition of indo...

journal_title：Gastroenterology

authors： Holdstock G,Chastenay BF,Krawitt EL

更新日期：1982-02-01 00:00:00

abstract：:Uptake of inorganic sulfate into brush-border membrane vesicles isolated by a calcium precipitation method from rat small intestine was investigated using a rapid filtration technique and 35Sulfur acid as tracer. Sulfate uptake by membrane vesicles was osmotically sensitive, suggesting transport into an intravesicular...

journal_title：Gastroenterology

authors： Lücke H,Stange G,Murer H

更新日期：1981-01-01 00:00:00

abstract：BACKGROUND & AIMS:Abnormal processing of visceral sensation at the level of the central nervous system is believed to be involved in functional dyspepsia. However, compared with studies of stimulation-related changes in brain activity, few studies have focused on resting brain activity, which also is important in patho...

journal_title：Gastroenterology

authors： Zeng F,Qin W,Liang F,Liu J,Tang Y,Liu X,Yuan K,Yu S,Song W,Liu M,Lan L,Gao X,Liu Y,Tian J

更新日期：2011-08-01 00:00:00

abstract：BACKGROUND & AIMS:Current therapy for primary sclerosing cholangitis is of limited efficacy. Multidrug resistance gene 2 knockout mice (Mdr2(-/-)) represent a well-characterized model for sclerosing cholangitis. Experiments were performed to test in such mice the therapeutic effects of 24-norUrsodeoxycholic acid, a C(2...

journal_title：Gastroenterology

authors： Fickert P,Wagner M,Marschall HU,Fuchsbichler A,Zollner G,Tsybrovskyy O,Zatloukal K,Liu J,Waalkes MP,Cover C,Denk H,Hofmann AF,Jaeschke H,Trauner M

更新日期：2006-02-01 00:00:00

abstract：BACKGROUND & AIMS:Serotonin transporter (SERT) plays a critical role in regulating serotonin (5-hydroxytryptamine [5-HT]) availability in the gut. Elevated 5-HT levels are associated with diarrheal conditions such as irritable bowel syndrome and enteric infections. Whether alteration in SERT activity contributes to the...

journal_title：Gastroenterology

authors： Esmaili A,Nazir SF,Borthakur A,Yu D,Turner JR,Saksena S,Singla A,Hecht GA,Alrefai WA,Gill RK

更新日期：2009-12-01 00:00:00

abstract：BACKGROUND & AIMS:Intercellular communication through gap junctions has been proposed to be an important mechanism for the maintenance of tissue homeostasis. However, few studies have considered the role of gap junctions in gastric mucosa. The purpose of this study was to evaluate the distribution of gap junction-speci...

journal_title：Gastroenterology

authors： Uchida Y,Matsuda K,Sasahara K,Kawabata H,Nishioka M

更新日期：1995-11-01 00:00:00

abstract：BACKGROUND & AIMS:Oral linaclotide, a novel agonist of guanylate cylase-C, stimulates intestinal fluid secretion and transit, and decreases visceral hypersensitivity in animal studies. In healthy volunteers, linaclotide was safe, well tolerated, increased stool frequency, and decreased stool consistency and time to fir...

journal_title：Gastroenterology

authors： Andresen V,Camilleri M,Busciglio IA,Grudell A,Burton D,McKinzie S,Foxx-Orenstein A,Kurtz CB,Sharma V,Johnston JM,Currie MG,Zinsmeister AR

更新日期：2007-09-01 00:00:00

abstract：:We examined whether patients with irritable bowel syndrome have increased airway responsiveness by measuring forced expiratory volumes in 1 second (FEV1) after inhalation of increasing concentrations of methacholine. Responses obtained in 11 IBS patients were compared with those obtained in 11 normal subjects and in 1...

journal_title：Gastroenterology

authors： White AM,Stevens WH,Upton AR,O'Byrne PM,Collins SM

更新日期：1991-01-01 00:00:00

abstract：BACKGROUND & AIMS:Capillarization of the sinusoids in cirrhosis is proposed to reduce oxygen availability to the hepatocyte, resulting in the patterns of altered drug metabolism observed in cirrhosis. If this were true, drug metabolism in cirrhotic livers would be expected to be more sensitive to reduced oxygen deliver...

journal_title：Gastroenterology

authors： Hickey PL,McLean AJ,Angus PW,Choo EF,Morgan DJ

更新日期：1996-10-01 00:00:00

abstract：:Previous investigations demonstrated that S-adenosyl-L-methionine suppresses the cholestatic effect of ethynylestradiol and reduces the irreversible binding of the estrogen to rat liver microsomes, probably favoring ethynylestradiol transformation into its methyl-derivatives. Since it is not known whether SAMe also pr...

journal_title：Gastroenterology

authors： Stramentinoli G,Di Padova C,Gualano M,Rovagnati P,Galli-Kienle M

更新日期：1981-01-01 00:00:00

abstract：:The effects of pancreatic duct ligation on the digestion and absorption of a randomly 14C-labeled protein meal has been investigated in the rat. Although there was a significant reduction in luminal digestion and absorption of the protein meal in the pancreatic duct-ligated animals compared with controls, 37% of admin...

journal_title：Gastroenterology

authors： Curtis KJ,Gaines HD,Kim YS

更新日期：1978-06-01 00:00:00

abstract：:The effect of substance P (SP) on the release of gastric somatostatinlike immunoreactivity (SLI) was studied. Substance P inhibited both basal SLI release and SLI release stimulated by gastric inhibitory polypeptide or 1-isoproterenol. This inhibitory action of SP was not blocked by atropine or hexamethonium, suggesti...

journal_title：Gastroenterology

authors： Kwok YN,McIntosh CH,Pederson RA,Brown JC

更新日期：1985-01-01 00:00:00

abstract：BACKGROUND & AIMS:The effects of leukotriene (LT) D(4) on intestinal epithelial cells govern events that are involved in cell survival and colon cancer, notably increased expression of cyclooxygenase (COX)-2 and enhanced production of prostaglandin E(2). We investigated possible correlations between distribution of the...

journal_title：Gastroenterology

authors： Ohd JF,Nielsen CK,Campbell J,Landberg G,Löfberg H,Sjölander A

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND & AIMS:Long-term data on the risk of colorectal cancer according to dose, duration, and consistency of aspirin therapy are limited. METHODS:We conducted a prospective study of 47,363 male health professionals who were ages 40-75 years at enrollment in 1986. Biennially, we collected data on aspirin use, othe...

journal_title：Gastroenterology

authors： Chan AT,Giovannucci EL,Meyerhardt JA,Schernhammer ES,Wu K,Fuchs CS

更新日期：2008-01-01 00:00:00