Systemic sclerosis (scleroderma) and esophageal adenocarcinoma: Is increased patient screening necessary?

abstract：:The effect of neuropeptide Y on the motor activity of the circular and longitudinal muscle of the guinea pig small intestine was investigated. Neuropeptide Y (0.3-30 nM) inhibited, in a concentration-dependent manner, the ascending enteric reflex contraction of the circular muscle; both the cholinergic and noncholiner...

journal_title：Gastroenterology

authors： Holzer P,Lippe IT,Barthó L,Saria A

更新日期：1987-06-01 00:00:00

abstract：BACKGROUND & AIMS:The US Medicare indications for intestinal transplantation are based on failure of home parenteral nutrition. The American Society of Transplantation also includes patients at high risk of death from their primary disease or with high morbidity intestinal failure. A 3-year prospective study evaluated ...

journal_title：Gastroenterology

authors： Pironi L,Forbes A,Joly F,Colomb V,Lyszkowska M,Van Gossum A,Baxter J,Thul P,Hébuterne X,Gambarara M,Gottrand F,Moreno Villares JM,Messing B,Goulet O,Staun M,Home Artificial Nutrition Working Group of the European Society fo

更新日期：2008-07-01 00:00:00

abstract：:A case of acute bacterial endocarditis is presented in which gallbladder infarction and areas of hepatic infarction were documented. Selective angiography showed findings consistent with emboli to the gallbladder and hepatic circulations. ...

journal_title：Gastroenterology

authors： Henrich WL,Huehnegarth RJ,Rösch J,Melnyk CS

更新日期：1975-06-01 00:00:00

abstract：BACKGROUND/AIMS:In vivo hepatic 31P magnetic resonance spectroscopy (MRS) can provide information on hepatic energy metabolism, phospholipid substrates, and hepatocyte lipid bilayers. The aim of this study was to ascertain the effects of alcohol ingestion on hepatic 31P spectral variables. METHODS:Twenty-six chronic a...

journal_title：Gastroenterology

authors： Menon DK,Harris M,Sargentoni J,Taylor-Robinson SD,Cox IJ,Morgan MY

更新日期：1995-03-01 00:00:00

abstract：BACKGROUND AND AIMS:Although cholesterol is the most abundant sterol in animal tissues, oxidized products of cholesterol (oxysterols) also occur in mammalian organs and blood and are cytotoxic, atherogenic, and carcinogenic. However, the presence of oxysterols in bile or gallstones has never been reported. METHODS:Fre...

journal_title：Gastroenterology

authors： Haigh WG,Lee SP

更新日期：2001-07-01 00:00:00

abstract：:We describe 2 siblings with multiple gastrointestinal stromal tumors (GISTs) and cutaneous hyperpigmentation. Both had a point mutation of the c-kit gene. The patients were sisters who had exhibited cutaneous hyperpigmentation since their late teens, but the diagnosis of multiple gastrointestinal submucosal tumors was...

journal_title：Gastroenterology

authors： Maeyama H,Hidaka E,Ota H,Minami S,Kajiyama M,Kuraishi A,Mori H,Matsuda Y,Wada S,Sodeyama H,Nakata S,Kawamura N,Hata S,Watanabe M,Iijima Y,Katsuyama T

更新日期：2001-01-01 00:00:00

abstract：:Basolateral, brush-border, and Golgi-enriched subcellular membrane fractions, prepared from homogenates of rat small intestinal mucosa obtained by scraping, had unusually high concentrations of nonesterified fatty acids. These fatty acids appear to be responsible for the large amount of calcium binding, an effect that...

journal_title：Gastroenterology

authors： Walters JR,Horvath PJ,Weiser MM

更新日期：1986-07-01 00:00:00

abstract：BACKGROUND & AIMS:It is not clear whether H2-receptor antagonists (H2RAs) reduce the risk of gastrointestinal (GI) bleeding in aspirin users at high risk. We performed a double-blind randomized trial to compare the effects of a proton pump inhibitor (PPI) vs a H2RA antagonist in preventing recurrent upper GI bleeding a...

journal_title：Gastroenterology

authors： Chan FK,Kyaw M,Tanigawa T,Higuchi K,Fujimoto K,Cheong PK,Lee V,Kinoshita Y,Naito Y,Watanabe T,Ching JY,Lam K,Lo A,Chan H,Lui R,Tang RS,Sakata Y,Tse YK,Takeuchi T,Handa O,Nebiki H,Wu JC,Abe T,Mishiro T,Ng S

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND & AIMS:A variety of gastrointestinal motility disorders have been attributed to alterations of interstitial cells of Cajal and malformations of the enteric nervous system. This study evaluates both the distribution of interstitial cells of Cajal and the pathohistology of the enteric nervous system in 2 sever...

journal_title：Gastroenterology

authors： Wedel T,Spiegler J,Soellner S,Roblick UJ,Schiedeck TH,Bruch HP,Krammer HJ

更新日期：2002-11-01 00:00:00

abstract：:In rats, hypergastrinemia due to achlorhydria produced by antisecretory drugs or resection of the gastric fundus leads to enterochromaffinlike (ECL) cell hyperplasia and gastric carcinoids. In humans, achlorhydria due to pernicious anemia may also lead to ECL cell hyperplasia and multicentric gastric carcinoids in as ...

journal_title：Gastroenterology

authors： Hirschowitz BI,Griffith J,Pellegrin D,Cummings OW

更新日期：1992-04-01 00:00:00

abstract：BACKGROUND & AIMS:In experimental animals, the indigenous microbiota modulates mucosal immunity. In humans, such direct evidence is scarce. The aim of this study was to examine the effect of intestinal bacteria on the local immunoglobulin (Ig) response. METHODS:The numbers of IgA-, IgM-, and IgG-producing immunocytes ...

journal_title：Gastroenterology

authors： Kett K,Baklien K,Bakken A,Kral JG,Fausa O,Brandtzaeg P

更新日期：1995-09-01 00:00:00

abstract：BACKGROUND & AIMS:A random biopsy is recommended for surveillance of ulcerative colitis (UC)-associated colorectal cancer. However, a targeted biopsy might be more effective. We conducted a randomized controlled trial to compare rates of neoplasia detection by targeted vs random biopsies in patients with UC. METHODS:W...

journal_title：Gastroenterology

authors： Watanabe T,Ajioka Y,Mitsuyama K,Watanabe K,Hanai H,Nakase H,Kunisaki R,Matsuda K,Iwakiri R,Hida N,Tanaka S,Takeuchi Y,Ohtsuka K,Murakami K,Kobayashi K,Iwao Y,Nagahori M,Iizuka B,Hata K,Igarashi M,Hirata I,Kudo S

更新日期：2016-12-01 00:00:00

abstract：:Detailed porphyrin analysis and additional ultrastructural abnormalities of liver cells are described in a patient with features of Rotor's syndrome. Normal values of porphyrin precursors, delta-aminolevulinic acid and porphobilinogen, and porphyrins were found in plasma, urine, and erythrocytes. However, fecal porphy...

journal_title：Gastroenterology

authors： Evans J,Lefkowitch J,Lim CK,Billing B

更新日期：1981-12-01 00:00:00

abstract：:We report a patient with severe peptic ulcer disease and a right ovarian mass that was found to be a gastrin-producing cystadenocarcinoma. Gastrin production by the tumor was stimulated by secretin and inhibited by the long-acting somatostatin analogue SMS 201-995. Following resection of the tumor, serum gastrin level...

journal_title：Gastroenterology

authors： Heyd J,Livni N,Herbet D,Mor-Yosef S,Glaser B

更新日期：1989-08-01 00:00:00

abstract：BACKGROUND & AIMS:Crohn's disease (CD) and ulcerative colitis (UC) are associated with chronic tissue damage and continuous tissue repair. A central, but not well-characterized, event during this process is the migration of activated fibroblasts to the wound. METHODS:Human colonic lamina propria fibroblasts (CLPF) wer...

journal_title：Gastroenterology

authors： Leeb SN,Vogl D,Gunckel M,Kiessling S,Falk W,Göke M,Schölmerich J,Gelbmann CM,Rogler G

更新日期：2003-11-01 00:00:00

abstract：BACKGROUND AND AIMS:Serrated polyp (SPs) are precursors to 20% to 30% of cases of colorectal tumors, but patients' long-term risk after removal of SPs is poorly understood. We investigated the risk of colorectal cancer (CRC) in individuals with a history of SPs. METHODS:We performed a retrospective cohort study of Kai...

journal_title：Gastroenterology

authors： Li D,Liu L,Fevrier HB,Alexeeff SE,Doherty AR,Raju M,Amsden LB,Lee JK,Levin TR,Corley DA,Herrinton LJ

更新日期：2020-08-01 00:00:00

abstract：BACKGROUND & AIMS:The sarcomatoid change in cholangiocarcinoma (CC) contributes to more aggressive intrahepatic spread and widespread metastasis. Therefore, the aim of this study was to identify the molecular mechanisms of CC metastasis during tumor progression and sarcomatoid change. METHODS:Using the subtraction sup...

journal_title：Gastroenterology

authors： Lee MJ,Yu GR,Yoo HJ,Kim JH,Yoon BI,Choi YK,Kim DG

更新日期：2009-09-01 00:00:00

abstract：:Previous studies suggested that the food-containing canine stomach retains large, nondigestible spheres until all food has emptied; but it is not known whether there is a threshold size or a gradation of sizes that will empty along with food. Further, nothing is known of the effects of such parameters as density, shap...

journal_title：Gastroenterology

authors： Meyer JH,Dressman J,Fink A,Amidon G

更新日期：1985-10-01 00:00:00

abstract：:A prospective screening program was undertaken at the Royal Free Hospital, London, to ascertain the incidence of alpha-1-antitrypsin (AAT) deficiency in patients with liver disease. Quantitative determinations of serum alpha-1-antitrypsin were performed on 469 patients with hepatobiliary disease and 98 subjects with n...

journal_title：Gastroenterology

authors： Fisher RL,Taylor L,Sherlock S

更新日期：1976-10-01 00:00:00

abstract：:This study examines restitution of the gastric surface epithelium at luminal pH 1 after damage to the gastric mucosa by instillation of 2 M NaCl for 10 min. After mucosal damage, potential difference decreased to zero and H+ back-diffusion increased. Gastric blood flow increased after exposure to 2 M NaCl, irrespectiv...

journal_title：Gastroenterology

authors： Grönbech JE,Grong K,Varhaug JE,Lekven J,Svanes K

更新日期：1987-10-01 00:00:00

abstract：BACKGROUND/AIMS:Previous studies have shown that psychological factors play a role in symptom perception among patients with gastroesophageal reflux disease. This report describes the first controlled study showing the effects of relaxation training on symptom reports and esophageal acid exposure in patients with reflu...

journal_title：Gastroenterology

authors： McDonald-Haile J,Bradley LA,Bailey MA,Schan CA,Richter JE

更新日期：1994-07-01 00:00:00

abstract：BACKGROUND & AIMS:The goal of the study was to facilitate fat balance measurements with an appropriate intestinal marker for the transit of dietary fat and thereby eliminate the need for complete diet and fecal collections. METHODS:Dietary fat containing 5% sucrose polybehenate was fed in a semisynthetic diet to rats ...

journal_title：Gastroenterology

authors： Jandacek RJ,Heubi JE,Tso P

更新日期：2004-07-01 00:00:00

abstract：BACKGROUND & AIMS:The mechanisms by which mutations in the familial intrahepatic cholestasis-1 gene cause Byler's disease (progressive familial intrahepatic cholestasis type 1) are unknown. METHODS:Interactions among the apical sodium-dependent bile acid transporter, the farnesoid X receptor (FXR), and familial intrah...

journal_title：Gastroenterology

authors： Chen F,Ananthanarayanan M,Emre S,Neimark E,Bull LN,Knisely AS,Strautnieks SS,Thompson RJ,Magid MS,Gordon R,Balasubramanian N,Suchy FJ,Shneider BL

更新日期：2004-03-01 00:00:00

abstract：BACKGROUND & AIMS:The majority of patients with Helicobacter pylori infection have autoantibodies cross-reacting with gastric antigens. In this study, the relation between autoantibody status, histopathology of body mucosa, and antigenic profile of H. pylori was investigated. METHODS:One hundred patients were examined...

journal_title：Gastroenterology

authors： Negrini R,Savio A,Poiesi C,Appelmelk BJ,Buffoli F,Paterlini A,Cesari P,Graffeo M,Vaira D,Franzin G

更新日期：1996-09-01 00:00:00

abstract：BACKGROUND & AIMS:Alterations in the gastrointestinal microbiota have been associated with metabolic diseases. However, little is known about host factors that induce changes in gastrointestinal bacterial populations. We investigated the role of bile acids in this process because of their strong antimicrobial activitie...

journal_title：Gastroenterology

authors： Islam KB,Fukiya S,Hagio M,Fujii N,Ishizuka S,Ooka T,Ogura Y,Hayashi T,Yokota A

更新日期：2011-11-01 00:00:00

abstract：BACKGROUND/AIMS:Conventional flow-cytometric analysis of colorectal tumor DNA content includes both tumor and stromal cell DNA. To improve the method, we evaluated the DNA content of purified epithelial cells using the crypt-isolation technique. METHODS:Normal and neoplastic crypts were isolated from fresh resected co...

journal_title：Gastroenterology

authors： Nakamura S,Goto J,Kitayama M,Kino I

更新日期：1994-01-01 00:00:00

abstract：:Phospholipases are enzymes that hydrolyze specific portions of phospholipid molecules. Their role in the digestion of exogenous phospholipids and as the active principle in snake and bee venoms has long been appreciated. Interest has increased in phospholipases recently because of new data implicating them in the infl...

journal_title：Gastroenterology

authors： Mansbach CM 2nd

更新日期：1990-05-01 00:00:00

abstract：:Of 550 patients admitted with acute upper gastrointestinal hemorrhage, 143 with peptic ulcers containing stigmata of recent hemorrhage accessible to endoscopic therapy were included in a randomized comparison of neodymium yttrium aluminum garnet laser, heater probe, and no endoscopic therapy. The rebleeding rate in la...

journal_title：Gastroenterology

authors： Matthewson K,Swain CP,Bland M,Kirkham JS,Bown SG,Northfield TC

更新日期：1990-05-01 00:00:00

abstract：BACKGROUND & AIMS:Hypoxic inflammation (decreased oxygen tension at sites of inflammation) is a feature of inflammatory bowel disease (IBD). The hypoxia response is mediated by the transcription factors hypoxia-inducible factor (HIF) 1α and endothelial PAS domain protein 1 (EPAS1 or HIF2α), which are induced in intesti...

journal_title：Gastroenterology

authors： Xue X,Ramakrishnan S,Anderson E,Taylor M,Zimmermann EM,Spence JR,Huang S,Greenson JK,Shah YM

更新日期：2013-10-01 00:00:00

abstract：BACKGROUND & AIMS:Type 2 diabetes mellitus (DM) is associated with an increased risk of colorectal cancer (CRC); it is not clear if this association varies by sex or other factors. Insulin use might also be associated with CRC risk. We investigated associations of type 2 DM and insulin use with CRC risk. METHODS:The C...

journal_title：Gastroenterology

authors： Campbell PT,Deka A,Jacobs EJ,Newton CC,Hildebrand JS,McCullough ML,Limburg PJ,Gapstur SM

更新日期：2010-10-01 00:00:00