当前位置： SCI文献检索 > GASTROENTEROLOGY期刊下所有文献 > Ontogeny of the receptor for polymeric immunoglobulins in rat hepatocytes.

Ontogeny of the receptor for polymeric immunoglobulins in rat hepatocytes.

Abstract：

:Based on in vitro experiments measuring daily secretion rates in the culture media of rat hepatocytes and in vivo experiments using pulse labeling of intracellular precursors, the present study examines the ontogenic expression of the polymeric immunoglobulin receptor and secretory component by hepatocytes during growth. Our data indicate that hepatocytes from infant and suckling rats (day 5, 15) cultured in serum-free and hormone-free conditions only secreted trace amounts of secretory component. Beginning on day 20, basal secretion rate showed a marked upsurge with a 10-fold increase by day 35. The addition of dexamethasone (10(-7) mol/L) to the culture media enhanced by 2.5-fold the basal secretion of secretory component by hepatocytes from 20-, 25-, and 35-day-old rats, while addition of insulin to the media had no effect. The response to dexamethasone was dose-dependent (10(-5), 10(-6), 10(-7) mol/L) and specific. In vivo pulse labeling of receptor precursors in hepatocytes from 40-day-old rats allowed the identification of three intracellular forms: a 105-kilodalton peptide and a 116-120-kilodalton mature doublet. In 13-day-old rats, three immature precursors were detected: a 105-kilodalton peptide and a high molecular weight doublet of 185-190 kilodaltons. Sucklings (13 days) treated with corticosterone showed a pattern of precursors similar to controls. These findings support the following conclusions: (a) hepatocytes from infant and suckling rats synthesize and process immature receptor precursors whose expression is unaffected by corticosterone treatment, and (b) active secretion of secretory component is initiated at weaning independently from humoral and hormonal factors while the magnitude of its production by the liver is under the control of glucocorticoids.

journal_name

Gastroenterology

journal_title

Gastroenterology

authors

Buts JP,Vaerman JP,Lescoat G

doi

10.1016/0016-5085(92)90181-w

keywords:

subject

Has Abstract

pub_date

1992-03-01 00:00:00

pages

949-55

issue

3

eissn

0016-5085

issn

1528-0012

pii

0016-5085(92)90181-W

journal_volume

102

pub_type

杂志文章

相关文献

GASTROENTEROLOGY文献大全
  • Efficacy of linaclotide for patients with chronic constipation.

    abstract：BACKGROUND & AIMS:Linaclotide is a minimally absorbed peptide agonist of the guanylate cyclase-C receptor that stimulates intestinal fluid secretion and transit and reduces pain in animal models. We assessed the safety and efficacy of a range of linaclotide doses in patients with chronic constipation. METHODS:We perfo...

    journal_title：Gastroenterology

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1053/j.gastro.2009.12.050

    authors： Lembo AJ,Kurtz CB,Macdougall JE,Lavins BJ,Currie MG,Fitch DA,Jeglinski BI,Johnston JM

    更新日期：2010-03-01 00:00:00

  • Isolation and characterization of Crohn's disease tissue-specific glycoproteins.

    abstract：:Two Crohn's disease tissue-specific proteins are identified and purified several thousand-fold from crude tissue extracts by different chromatographic procedures. The two proteins migrate in sodium dodecyl sulfate-polyacrylamide gel electrophoresis as 200-210-kilodalton and 150-160-kilodalton species. They are glycopr...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/0016-5085(86)90564-0

    authors： Bagchi S,Baral B,Das KM

    更新日期：1986-08-01 00:00:00

  • Cytomegalovirus DNA level on biopsy specimens during treatment of cytomegalovirus gastrointestinal disease.

    abstract：BACKGROUND & AIMS:There is no clear and point for the response to treatment of gastrointestinal human cytomegalovirus (HCMV) disease. HCMV-DNA quantitation on gastrointestinal biopsy specimens has proven its value for the diagnosis of gastrointestinal HCMV disease in patients with acquired immunodeficiency syndrome (AI...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/gast.1996.v111.pm8690210

    authors： Cotte L,Drouet E,Bailly F,Vitozzi S,Denoyel G,Trepo C

    更新日期：1996-08-01 00:00:00

  • Long-term efficacy and safety of endoscopic resection for patients with mucosal adenocarcinoma of the esophagus.

    abstract：BACKGROUND & AIMS:Barrett's esophagus-associated high-grade dysplasia is commonly treated by endoscopy. However, most guidelines offer no recommendations for endoscopic treatment of mucosal adenocarcinoma of the esophagus (mAC). We investigated the efficacy and safety of endoscopic resection in a large series of patien...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2013.11.006

    authors： Pech O,May A,Manner H,Behrens A,Pohl J,Weferling M,Hartmann U,Manner N,Huijsmans J,Gossner L,Rabenstein T,Vieth M,Stolte M,Ell C

    更新日期：2014-03-01 00:00:00

  • Long Noncoding RNA uc.173 Promotes Renewal of the Intestinal Mucosa by Inducing Degradation of MicroRNA 195.

    abstract：BACKGROUND AND AIMS:The mammalian intestinal epithelium self-renews rapidly and homeostasis is preserved via tightly controlled mechanisms. Long noncoding RNAs transcribed from ultraconserved regions (T-UCRs) control different cell functions, but little is known about their role in maintaining the integrity of the inte...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2017.10.009

    authors： Xiao L,Wu J,Wang JY,Chung HK,Kalakonda S,Rao JN,Gorospe M,Wang JY

    更新日期：2018-02-01 00:00:00

  • Binding of secretin to plastic surfaces.

    abstract：:Five carboxyl-terminal fragments of secretin ranging in size from 6 to 21 amino acid residues were tested for pancreatic secretory activity in the rat. None of the fragments displayed activity when given alone but each displayed significant activity when given after secretin. This apparent activity was shown to be the...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：

    authors： Bitar KN,Zfass AM,Makhlouf GM

    更新日期：1978-12-01 00:00:00

  • Effect of age on the etiologic role of the hepatitis B virus in hepatocellular carcinoma in blacks.

    abstract：:Hepatocellular carcinoma often affects blacks at an early age. The purpose of this study was to ascertain if the association between chronic hepatitis B virus infection and hepatocellular carcinoma is the same in young and older black patients. Serum markers of hepatitis B infection were measured by radioimmunoassay i...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/0016-5085(88)90434-9

    authors： Kew MC,Macerollo P

    更新日期：1988-02-01 00:00:00

  • Development and validation of a symptom-based activity index for adults with eosinophilic esophagitis.

    abstract：BACKGROUND & AIMS:Standardized instruments are needed to assess the activity of eosinophilic esophagitis (EoE) and to provide end points for clinical trials and observational studies. We aimed to develop and validate a patient-reported outcome (PRO) instrument and score, based on items that could account for variations...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2014.08.028

    authors： Schoepfer AM,Straumann A,Panczak R,Coslovsky M,Kuehni CE,Maurer E,Haas NA,Romero Y,Hirano I,Alexander JA,Gonsalves N,Furuta GT,Dellon ES,Leung J,Collins MH,Bussmann C,Netzer P,Gupta SK,Aceves SS,Chehade M,Moawad F

    更新日期：2014-12-01 00:00:00

  • Cholecystokinin is a negative regulator of gastric acid secretion and postprandial release of gastrin in humans.

    abstract：BACKGROUND/AIMS:The role of cholecystokinin (CCK) in the regulation of gastric acid secretion is still controversial. This study examined the effect of the CCK-A receptor antagonist loxiglumide (lox) on gastrin- or CCK-induced gastric acid secretion and meal-stimulated plasma gastrin levels in a placebo-controlled stud...

    journal_title：Gastroenterology

    pub_type： 临床试验,杂志文章

    doi：10.1016/0016-5085(94)90799-4

    authors： Schmidt WE,Schenk S,Nustede R,Holst JJ,Fölsch UR,Creutzfeldt W

    更新日期：1994-12-01 00:00:00

  • Increased lipogenesis, induced by AKT-mTORC1-RPS6 signaling, promotes development of human hepatocellular carcinoma.

    abstract：BACKGROUND & AIMS:De novo lipogenesis is believed to be involved in oncogenesis. We investigated the role of aberrant lipid biosynthesis in the pathogenesis of human hepatocellular carcinoma (HCC). METHODS:We evaluated expression of enzymes that regulate lipogenesis in human normal liver tissues and HCC and surroundin...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2010.12.006

    authors： Calvisi DF,Wang C,Ho C,Ladu S,Lee SA,Mattu S,Destefanis G,Delogu S,Zimmermann A,Ericsson J,Brozzetti S,Staniscia T,Chen X,Dombrowski F,Evert M

    更新日期：2011-03-01 00:00:00

  • The relation of iron status and hemochromatosis gene mutations in patients with chronic hepatitis C.

    abstract：BACKGROUND & AIMS:Elevated hepatic iron concentration may affect the response to antiviral therapy in chronic hepatitis C. This study explored the contribution of genetic hemochromatosis to iron accumulation in chronic hepatitis C. METHODS:HFE mutations (C282Y and H63D) were assessed in 184 patients with chronic hepat...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/s0016-5085(99)70236-2

    authors： Kazemi-Shirazi L,Datz C,Maier-Dobersberger T,Kaserer K,Hackl F,Polli C,Steindl PE,Penner E,Ferenci P

    更新日期：1999-01-01 00:00:00

  • Glycine cytoprotection during lethal hepatocellular injury from adenosine triphosphate depletion.

    abstract：:Glycine protects renal tubule cells from cell death during adenosine triphosphate (ATP) depletion. Although the liver plays a key role in glycine metabolism, information is lacking regarding the effects of glycine on lethal hepatocellular injury. Thus, the aim of this study was to determine the potential cytoprotectiv...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/0016-5085(92)90338-y

    authors： Dickson RC,Bronk SF,Gores GJ

    更新日期：1992-06-01 00:00:00

  • Role of Cannabis and Its Derivatives in Gastrointestinal and Hepatic Disease.

    abstract：:Medical and recreational cannabis use has increased dramatically over the last decade, resulting from mainstream cultural acceptance and legalization in several countries worldwide. Cannabis and its derivatives affect many gastrointestinal processes via the endocannabinoid system (ECS). The ECS influences gastrointest...

    journal_title：Gastroenterology

    pub_type： 杂志文章,评审

    doi：10.1053/j.gastro.2020.03.087

    authors： Gotfried J,Naftali T,Schey R

    更新日期：2020-07-01 00:00:00

  • Irbit mediates synergy between ca(2+) and cAMP signaling pathways during epithelial transport in mice.

    abstract：BACKGROUND & AIMS:The cyclic adenosine monophosphate (cAMP) and Ca(2+) signaling pathways synergize to regulate many physiological functions. However, little is known about the mechanisms by which these pathways interact. We investigated the synergy between these signaling pathways in mouse pancreatic and salivary glan...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2013.03.047

    authors： Park S,Shcheynikov N,Hong JH,Zheng C,Suh SH,Kawaai K,Ando H,Mizutani A,Abe T,Kiyonari H,Seki G,Yule D,Mikoshiba K,Muallem S

    更新日期：2013-07-01 00:00:00

  • Nonsteroidal anti-inflammatory drugs and statins have chemopreventative effects in patients with Barrett's esophagus.

    abstract：BACKGROUND & AIMS:The incidence of Barrett's esophagus and esophageal adenocarcinoma has increased despite surveillance of patients with Barrett's esophagus. Limited data indicate that nonsteroidal anti-inflammatory drug (NSAID) and statin use reduce the risk for esophageal adenocarcinoma. We investigated whether NSAID...

    journal_title：Gastroenterology

    pub_type： 杂志文章,多中心研究

    doi：10.1053/j.gastro.2011.08.036

    authors： Kastelein F,Spaander MC,Biermann K,Steyerberg EW,Kuipers EJ,Bruno MJ,Probar-study Group.

    更新日期：2011-12-01 00:00:00

  • Pathology features in Bethesda guidelines predict colorectal cancer microsatellite instability: a population-based study.

    abstract：BACKGROUND & AIMS:The revised Bethesda guidelines for Lynch syndrome recommend microsatellite instability (MSI) testing all colorectal cancers in patients diagnosed before age 50 years and colorectal cancers diagnosed in patients between ages 50 and 59 years with particular pathology features. Our aim was to identify p...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2007.04.044

    authors： Jenkins MA,Hayashi S,O'Shea AM,Burgart LJ,Smyrk TC,Shimizu D,Waring PM,Ruszkiewicz AR,Pollett AF,Redston M,Barker MA,Baron JA,Casey GR,Dowty JG,Giles GG,Limburg P,Newcomb P,Young JP,Walsh MD,Thibodeau SN,Lindor NM

    更新日期：2007-07-01 00:00:00

  • REG Ialpha protein may function as a trophic and/or anti-apoptotic factor in the development of gastric cancer.

    abstract：BACKGROUND & AIMS:Although a significant amount of regenerating gene (REG) Ialpha protein is present not only in normal gastric mucosa but also in gastric cancer tissues, its pathophysiologic role in gastric cancer development remains unclear. We investigated REG Ialpha protein expression in early gastric cancers, and ...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2004.12.045

    authors： Sekikawa A,Fukui H,Fujii S,Takeda J,Nanakin A,Hisatsune H,Seno H,Takasawa S,Okamoto H,Fujimori T,Chiba T

    更新日期：2005-03-01 00:00:00

  • Antroduodenal resistance to flow in the control of duodenogastric bile reflux during fasting.

    abstract：:Our objectives in this study were (a) to determine the role of antroduodenal resistance in the control of fasting duodenogastric bile reflux in the dog and (b) to elucidate the contribution of the pylorus both to resistance and to reflux. Thus, we measured simultaneously throughout the interdigestive motor cycle (a) a...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/0016-5085(87)90566-x

    authors： Mearin F,Azpiroz F,Malagelada JR,Zinsmeister AR

    更新日期：1987-11-01 00:00:00

  • Hepatocyte tight-junctional permeability is increased in rat experimental colitis.

    abstract：BACKGROUND & AIMS:Hepatobiliary complications occur in inflammatory bowel disease and may be caused by the translocation of intestinal toxins from portal blood into bile through leaky hepatocyte tight junctions. The role of tight junctions in the pathogenesis of hepatobiliary complications in experimental inflammatory ...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/gast.1997.v113.pm9322530

    authors： Lora L,Mazzon E,Martines D,Fries W,Muraca M,Martin A,d'Odorico A,Naccarato R,Citi S

    更新日期：1997-10-01 00:00:00

  • Steatosis and liver cancer in transgenic mice expressing the structural and nonstructural proteins of hepatitis C virus.

    abstract：BACKGROUND & AIMS:The aim of this study was to determine whether expression of hepatitis C virus proteins alters hepatic morphology or function in the absence of inflammation. METHODS:Transgenic C57BL/6 mice with liver-specific expression of RNA encoding the complete viral polyprotein (FL-N transgene) or viral structu...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/gast.2002.31001

    authors： Lerat H,Honda M,Beard MR,Loesch K,Sun J,Yang Y,Okuda M,Gosert R,Xiao SY,Weinman SA,Lemon SM

    更新日期：2002-02-01 00:00:00

  • Much of the genetic risk of colorectal cancer is likely to be mediated through susceptibility to adenomas.

    abstract：:Several single-nucleotide polymorphisms (SNPs) have been associated with colorectal cancer (CRC) susceptibility. Most CRCs arise from adenomas, and SNPs therefore might affect predisposition to CRC by increasing adenoma risk. We found that 8 of 18 known CRC-associated SNPs (rs10936599, rs6983267, rs10795668, rs3802842...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2012.09.016

    authors： Carvajal-Carmona LG,Zauber AG,Jones AM,Howarth K,Wang J,Cheng T,APC Trial Collaborators.,APPROVe Trial Collaborators.,CORGI Study Collaborators.,Colon Cancer Family Registry Collaborators.,CGEMS Collaborators.,Riddell R,Lanas A,

    更新日期：2013-01-01 00:00:00

  • Ethynylestradiol-induced impairment of bile secretion in the rat: protective effects of S-adenosyl-L-methionine and its implication in estrogen metabolism.

    abstract：:Previous investigations demonstrated that S-adenosyl-L-methionine suppresses the cholestatic effect of ethynylestradiol and reduces the irreversible binding of the estrogen to rat liver microsomes, probably favoring ethynylestradiol transformation into its methyl-derivatives. Since it is not known whether SAMe also pr...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：

    authors： Stramentinoli G,Di Padova C,Gualano M,Rovagnati P,Galli-Kienle M

    更新日期：1981-01-01 00:00:00

  • Vitamin E reduces oxidant injury to mitochondria and the hepatotoxicity of taurochenodeoxycholic acid in the rat.

    abstract：BACKGROUND & AIMS:Hydrophobic bile acids have been implicated in the pathogenesis of cholestatic liver injury. The hypothesis that hydrophobic bile acid toxicity is mediated by oxidant stress in an in vivo rat model was tested in this study. METHODS:A dose-response study of bolus intravenous (i.v.) taurochenodeoxychol...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/s0016-5085(98)70644-4

    authors： Sokol RJ,McKim JM Jr,Goff MC,Ruyle SZ,Devereaux MW,Han D,Packer L,Everson G

    更新日期：1998-01-01 00:00:00

  • Sustained remission after corticosteroid therapy of severe hepatitis B surface antigen-negative chronic active hepatitis.

    abstract：:To determine the frequency of a sustained remission and to assess the long-term prognosis of relapse and retreatment, 66 patients with severe hepatitis B surface antigen-negative chronic active hepatitis and prolonged follow-up after initial corticosteroid withdrawal (mean, 10 +/- 0.4 yr) were evaluated. Selection of ...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/0016-5085(87)90862-6

    authors： Czaja AJ,Beaver SJ,Shiels MT

    更新日期：1987-01-01 00:00:00

  • Circulating levels of endothelin in cirrhosis.

    abstract：BACKGROUND:Current information concerning endothelin in cirrhosis is conflicting. Plasma endothelin concentration has been found to be increased in some studies and normal or reduced in others. The present study was aimed to investigate the plasma levels of endothelin in cirrhosis and to assess whether it is involved i...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/0016-5085(93)90360-o

    authors： Asbert M,Ginès A,Ginès P,Jiménez W,Clària J,Saló J,Arroyo V,Rivera F,Rodés J

    更新日期：1993-05-01 00:00:00

  • Smad4-mediated signaling inhibits intestinal neoplasia by inhibiting expression of β-catenin.

    abstract：BACKGROUND & AIMS:Mutational inactivation of adenomatous polyposis coli (APC) is an early event in colorectal cancer (CRC) progression that affects the stability and increases the activity of β-catenin, a mediator of Wnt signaling. Progression of CRC also involves inactivation of signaling via transforming growth facto...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2011.11.026

    authors： Freeman TJ,Smith JJ,Chen X,Washington MK,Roland JT,Means AL,Eschrich SA,Yeatman TJ,Deane NG,Beauchamp RD

    更新日期：2012-03-01 00:00:00

  • Urocortin reduces food intake and gastric emptying in lean and ob/ob obese mice.

    abstract：BACKGROUND & AIMS:Gastric emptying plays an important role in regulating food intake. This study was designed to investigate whether intraperitoneally injected urocortin reduces gastric emptying, feeding, and body weight in lean and ob/ob obese mice. METHODS:Food intake and body weight were measured after intraperiton...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/s0016-5085(99)70491-9

    authors： Asakawa A,Inui A,Ueno N,Makino S,Fujino MA,Kasuga M

    更新日期：1999-06-01 00:00:00

  • Use of selective mesenteric vasodilator peptides in experimental nonocclusive mesenteric ischemia in the dog.

    abstract：:Three structurally related peptides, ovine corticotropin-releasing factor, sauvagine, and urotensin I are selective mesenteric vasodilators in dogs. To assess the possible benefit of these peptides in nonocclusive mesenteric ischemia, they were compared with a nonselective vasodilator, sodium nitroprusside, in the ane...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/0016-5085(86)91122-4

    authors： MacCannell KL,Newton CA,Lederis K,Rivier J,Tiffany M

    更新日期：1986-03-01 00:00:00

  • HCCR-1-interacting molecule "deleted in polyposis 1" plays a tumor-suppressor role in colon carcinogenesis.

    abstract：BACKGROUND & AIMS:Human cervical cancer oncogene (HCCR-1) has appeared to act as a negative regulator of p53 and contributes to tumorigenesis of various organs including the colon. We identified the HCCR-1 binding protein deleted in polyposis 1 (DP1) and accessed the role of HCCR-1 and DP1 in colon tumorigenesis. METH...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2006.03.055

    authors： Shin SM,Chung YJ,Oh ST,Jeon HM,Hwang LJ,Namkoong H,Kim HK,Cho GW,Hur SY,Kim TE,Lee YS,Park YG,Ko J,Kim JW

    更新日期：2006-06-01 00:00:00

  • MicroRNA 375 mediates palmitate-induced enteric neuronal damage and high-fat diet-induced delayed intestinal transit in mice.

    abstract：BACKGROUND & AIMS:A high-fat diet (HFD) can cause serious health problems, including alteration of gastrointestinal transit, the exact mechanism of which is not clear. Several microRNAs (miRNAs) are involved in energy homeostasis, lipid metabolism, and HFD-induced weight gain. We investigated the role of miRNAs in HFD-...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2013.10.053

    authors： Nezami BG,Mwangi SM,Lee JE,Jeppsson S,Anitha M,Yarandi SS,Farris AB 3rd,Srinivasan S

    更新日期：2014-02-01 00:00:00