The relation of iron status and hemochromatosis gene mutations in patients with chronic hepatitis C.

abstract：:Thirty-five 1-day-old Pekin-Aylesbury ducks were inoculated intravenously or intraperitoneally with duck hepatitis B virus, and the time-course of infection was examined by Southern-blot, dot-blot, and in situ hybridization and by immunohistochemistry. Randomly scattered single infected hepatocytes were first seen on ...

journal_title：Gastroenterology

authors： Jilbert AR,Freiman JS,Burrell CJ,Holmes M,Gowans EJ,Rowland R,Hall P,Cossart YE

更新日期：1988-11-01 00:00:00

abstract：BACKGROUND & AIMS:The physiologic significance of the M(3) muscarinic receptor is unclear due to an absence of specific ligand. In the present study, M(3) receptor knockout (KO) mice were used to elucidate the role of M(3) receptors in gastric acid secretion and gastric mucosal integrity. METHODS:M(3) KO versus wild-t...

journal_title：Gastroenterology

authors： Aihara T,Fujishita T,Kanatani K,Furutani K,Nakamura E,Taketo MM,Matsui M,Chen D,Okabe S

更新日期：2003-12-01 00:00:00

abstract：:A 76-yr-old male presented with Guillain-Barré syndrome after acute hepatitis B virus infection. Main immunologic features were: (a) high levels of circulating hepatitis B surface antigen-containing immune complexes in serum and cerebrospinal fluid during the acute neurologic syndrome, and (b) clearance of immune-comp...

journal_title：Gastroenterology

authors： Penner E,Maida E,Mamoli B,Gangl A

更新日期：1982-03-01 00:00:00

abstract：:Vascular casts of human oxyntic mucosa, examined by scanning electron microscopy, revealed that (a) arterial breakup occurs only at the submucosal aspect of the mucosa, there being no arterial vessels further into the mucosa and (b) mucosal capillaries drain into the infrequent mucosal venules only in the most luminal...

journal_title：Gastroenterology

authors： Gannon B,Browning J,O'Brien P,Rogers P

更新日期：1984-05-01 00:00:00

abstract：:A patient with a lifelong history of asthma and hay fever was investigated because of symptoms of esophageal spasm. Esophageal biopsies revealed elongated papillae and basal zone hyperplasia of the epithelial layer with eosinophilic infiltration of the lamina propria and muscularis mucosae. There was no evidence of re...

journal_title：Gastroenterology

authors： Dobbins JW,Sheahan DG,Behar J

更新日期：1977-06-01 00:00:00

abstract：BACKGROUND/AIMS:Cytokines are thought to be important in mediating tissue damage in inflammatory bowel disease (IBD). Many of the in vivo activities of tumor necrosis factor alpha (TNF-alpha) match the changes found in IBD, but its importance is controversial. METHODS:A sensitive, reverse hemolytic plaque assay was us...

journal_title：Gastroenterology

authors： Breese EJ,Michie CA,Nicholls SW,Murch SH,Williams CB,Domizio P,Walker-Smith JA,MacDonald TT

更新日期：1994-06-01 00:00:00

abstract：BACKGROUND & AIMS:We followed patients with ongoing hepatitis C virus (HCV) exposure following control of an initial HCV infection to determine whether primary control conferred protection against future persistent infections. METHODS:Twenty-two active injection drug users (IDU) who had cleared a primary hepatitis C v...

journal_title：Gastroenterology

authors： Osburn WO,Fisher BE,Dowd KA,Urban G,Liu L,Ray SC,Thomas DL,Cox AL

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND & AIMS:Methylation of specific microRNAs (miRNAs) often occurs in an age-dependent manner, as a field defect in some instances, and may be an early event in colitis-associated carcinogenesis. We aimed to determine whether specific mRNA signature patterns (MIR1, MIR9, MIR124, MIR137, MIR34B/C) could be used t...

journal_title：Gastroenterology

authors： Toiyama Y,Okugawa Y,Tanaka K,Araki T,Uchida K,Hishida A,Uchino M,Ikeuchi H,Hirota S,Kusunoki M,Boland CR,Goel A

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND & AIMS:Liver X receptors (LXRs) are transcriptional regulators of cholesterol metabolism, controlling cholesterol flow into cells, catabolism, and efflux. Cholesterol controls cell proliferation; disruptions in cholesterol metabolism have been associated with the development of colon cancer. We investigated ...

journal_title：Gastroenterology

authors： Lo Sasso G,Bovenga F,Murzilli S,Salvatore L,Di Tullio G,Martelli N,D'Orazio A,Rainaldi S,Vacca M,Mangia A,Palasciano G,Moschetta A

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND & AIMS:Hepcidin is an antimicrobial peptide thought to be involved in the regulation of intestinal iron absorption. To further investigate its role in this process, we examined hepatic and duodenal gene expression in rats after the switch from a control diet to an iron-deficient diet. METHODS:Adult rats on ...

journal_title：Gastroenterology

authors： Frazer DM,Wilkins SJ,Becker EM,Vulpe CD,McKie AT,Trinder D,Anderson GJ

更新日期：2002-09-01 00:00:00

abstract：:The effects of calcium channel blockers on water transport in the rat ileum and distal colon were studied in vivo using the single-pass perfusion technique. Parenteral but not intraluminal verapamil, and parenteral nifedipine increased ileal water absorption, with effects lasting at least 60 min. In contrast, i.p. ver...

journal_title：Gastroenterology

authors： Donowitz M,Levin S,Powers G,Elta G,Cohen P,Cheng H

更新日期：1985-10-01 00:00:00

abstract：:A 20-yr-old man developed recurrent respiratory symptoms and left lower lobe pneumonia 14 yr after long-segment colonic interposition for corrosive esophageal injury. A fistula, from a redundant supradiaphragmatic pouch of colon to a subsegmental bronchus of the lower lobe of the left lung, was discovered and treated ...

journal_title：Gastroenterology

authors： Perlmutter DH,Tapper D,Teele RL,Winter HS

更新日期：1984-06-01 00:00:00

abstract：:By correlating morphological observations with quantitative measurements of net water transport, we determined whether bile salts altered colonic absorptive cells. Epithelial alteration was equivocal and water absorption was uninhibited during infusions of 1 mM deoxycholate or of concentrations of taurocholate less th...

journal_title：Gastroenterology

authors： Saunders DR,Hedges JR,Sillery J,Esther L,Matsumura K,Rubin CE

更新日期：1975-05-01 00:00:00

abstract：BACKGROUND AND AIMS:We set out to test the hypothesis that irritable bowel syndrome (IBS) is characterized by an augmented cellular immune response with enhanced production of proinflammatory cytokines. We further aimed to explore whether symptoms and psychiatric comorbidity in IBS are linked to the release of proinfla...

journal_title：Gastroenterology

authors： Liebregts T,Adam B,Bredack C,Röth A,Heinzel S,Lester S,Downie-Doyle S,Smith E,Drew P,Talley NJ,Holtmann G

更新日期：2007-03-01 00:00:00

abstract：:The cause of Ménétrier's disease is unknown, although allergic, autoimmune, and infectious, particularly viral, causes have been postulated. This case report describes a 3-year-old child with Ménétrier's disease in whom evidence of acute cytomegalovirus (CMV) infection was found. To our knowledge, this is the first ca...

journal_title：Gastroenterology

authors： Eisenstat DD,Griffiths AM,Cutz E,Petric M,Drumm B

更新日期：1995-08-01 00:00:00

abstract：:Helicobacter pylori infection has been associated with gastritis, duodenal ulcer, gastric ulcer, and the epidemic form of gastric carcinoma. Eradication of H. pylori infection has proven to be difficult. Recently, combinations of antimicrobial drugs have been shown to eradicate greater than 50% of infections; however,...

journal_title：Gastroenterology

authors： Graham DY,Lew GM,Malaty HM,Evans DG,Evans DJ Jr,Klein PD,Alpert LC,Genta RM

更新日期：1992-02-01 00:00:00

abstract：BACKGROUND & AIMS:Previous research has yielded conflicting data as to whether the natural history of inflammatory bowel disease follows a seasonal pattern. The purpose of this study was to determine whether relapse of inflammatory bowel disease follows a seasonal pattern either across a cohort of patients or within in...

journal_title：Gastroenterology

authors： Lewis JD,Aberra FN,Lichtenstein GR,Bilker WB,Brensinger C,Strom BL

更新日期：2004-03-01 00:00:00

abstract：BACKGROUND & AIMS:We aimed to identify long noncoding RNAs (lncRNAs) that are up-regulated in gastric cancer tissues from patients and study their function in gastric tumor metastasis. METHODS:We collected gastric tumor and nontumor tissues from patients in China and analyzed levels of lncRNAs by microarray analysis, ...

journal_title：Gastroenterology

authors： Zhuo W,Liu Y,Li S,Guo D,Sun Q,Jin J,Rao X,Li M,Sun M,Jiang M,Xu Y,Teng L,Jin Y,Si J,Liu W,Kang Y,Zhou T

更新日期：2019-02-01 00:00:00

abstract：BACKGROUND & AIMS:Osteoporosis is common in patients with Crohn's disease, but less is known about their risk of actual fractures. METHODS:The medical records of all 238 Olmsted County, Minnesota, residents diagnosed with Crohn's disease between 1940 and 1993 were reviewed for evidence of subsequent fractures compared...

journal_title：Gastroenterology

authors： Loftus EV Jr,Crowson CS,Sandborn WJ,Tremaine WJ,O'Fallon WM,Melton LJ 3rd

更新日期：2002-08-01 00:00:00

abstract：BACKGROUND & AIMS:Hepatic bile salt secretion is an essential function of vertebrate liver. Rat and mouse bile salt export pump (Bsep) are adenosine triphosphate (ATP)-dependent bile salt transporters. Mutations in human BSEP were identified as the cause of progressive familial intrahepatic cholestasis type 2. BSEP pro...

journal_title：Gastroenterology

authors： Noé J,Stieger B,Meier PJ

更新日期：2002-11-01 00:00:00

abstract：BACKGROUND & AIMS:A random biopsy is recommended for surveillance of ulcerative colitis (UC)-associated colorectal cancer. However, a targeted biopsy might be more effective. We conducted a randomized controlled trial to compare rates of neoplasia detection by targeted vs random biopsies in patients with UC. METHODS:W...

journal_title：Gastroenterology

authors： Watanabe T,Ajioka Y,Mitsuyama K,Watanabe K,Hanai H,Nakase H,Kunisaki R,Matsuda K,Iwakiri R,Hida N,Tanaka S,Takeuchi Y,Ohtsuka K,Murakami K,Kobayashi K,Iwao Y,Nagahori M,Iizuka B,Hata K,Igarashi M,Hirata I,Kudo S

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND & AIMS:Changes in the properties of visceral sensory neurons contribute to the development of gastrointestinal pain. However, little is known about the molecules involved in mechanosensation from the gastrointestinal tract. We investigated the phosphorylation of extracellular signal-regulated kinase 1/2 (ERK...

journal_title：Gastroenterology

authors： Sakurai J,Obata K,Ozaki N,Tokunaga A,Kobayashi K,Yamanaka H,Dai Y,Kondo T,Miyoshi K,Sugiura Y,Matsumoto T,Miwa H,Noguchi K

更新日期：2008-04-01 00:00:00

abstract：BACKGROUND & AIMS:Molecules that regulate T-cell adhesion to hepatic endothelium and thereby recirculation of T cells to the liver are poorly understood. Because the adhesion molecule vascular adhesion protein-1 (VAP-1), which mediates lymphocyte binding to lymph node endothelium, is expressed on hepatic endothelium, i...

journal_title：Gastroenterology

authors： McNab G,Reeves JL,Salmi M,Hubscher S,Jalkanen S,Adams DH

更新日期：1996-02-01 00:00:00

abstract：BACKGROUND & AIMS:Polymorphisms in the region of the interleukin (IL)-28B gene on chromosome 19 have been associated with peginterferon-alfa-induced clearance of genotype 1 hepatitis C virus (HCV); there are no data for patients with genotype 2 or 3 HCV. We evaluated the effects of IL-28B polymorphisms on response to t...

journal_title：Gastroenterology

authors： Mangia A,Thompson AJ,Santoro R,Piazzolla V,Tillmann HL,Patel K,Shianna KV,Mottola L,Petruzzellis D,Bacca D,Carretta V,Minerva N,Goldstein DB,McHutchison JG

更新日期：2010-09-01 00:00:00

abstract：BACKGROUND & AIMS:Transplantation of wild-type (H-2k) bone marrow into tg epsilon26 mice (BM-->tg epsilon26) induces colitis, characterized by T-helper cell type 1 activation in the lamina propria. Here we determined whether pathogenic T-cell clones could be derived by serial adoptive transfers into healthy tg epsilon2...

journal_title：Gastroenterology

authors： Abadía-Molina AC,Mizoguchi A,Faubion WA,De Jong YP,Rietdijk ST,Comiskey M,Clarke K,Bhan AK,Terhorst C

更新日期：2005-05-01 00:00:00

abstract：BACKGROUND & AIMS:Knowledge of the placebo outcomes and understanding specific study features that influence these outcomes is important for designing future clinical trials evaluating therapy of ulcerative colitis (UC). The aims of this study were to estimate the placebo rates of remission and response in placebo-cont...

journal_title：Gastroenterology

authors： Su C,Lewis JD,Goldberg B,Brensinger C,Lichtenstein GR

更新日期：2007-02-01 00:00:00

abstract：BACKGROUND & AIMS:Treatment of hepatitis C virus (HCV) infection with boceprevir, peginterferon, and ribavirin can lead to anemia, which has been managed by reducing ribavirin dose and/or erythropoietin therapy. We assessed the effects of these anemia management strategies on rates of sustained virologic response (SVR)...

journal_title：Gastroenterology

authors： Poordad F,Lawitz E,Reddy KR,Afdhal NH,Hézode C,Zeuzem S,Lee SS,Calleja JL,Brown RS Jr,Craxi A,Wedemeyer H,Nyberg L,Nelson DR,Rossaro L,Balart L,Morgan TR,Bacon BR,Flamm SL,Kowdley KV,Deng W,Koury KJ,Pedicone LD

更新日期：2013-11-01 00:00:00

abstract：:The incidence of celiac disease is increasing, partly because of improved recognition of, and testing for, the disease. The rise in incidence is also due to a real increase of this immune-based disorder, independent of disease detection. The reasons for this true rise in recent decades are unknown but may be related t...

journal_title：Gastroenterology

authors： Lebwohl B,Rubio-Tapia A

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND & AIMS:Alterations in the gastrointestinal microbiota have been associated with metabolic diseases. However, little is known about host factors that induce changes in gastrointestinal bacterial populations. We investigated the role of bile acids in this process because of their strong antimicrobial activitie...

journal_title：Gastroenterology

authors： Islam KB,Fukiya S,Hagio M,Fujii N,Ishizuka S,Ooka T,Ogura Y,Hayashi T,Yokota A

更新日期：2011-11-01 00:00:00

abstract：BACKGROUND & AIMS:Ground-glass (GG) inclusions within hepatocytes are an important histopathologic marker of chronic hepatitis B virus (HBV) infection but may also be seen in Lafora's disease (myoclonus epilepsy), cyanamide alcohol aversion therapy, and type IV glycogenosis. We have noted a recent increased incidence o...

journal_title：Gastroenterology

authors： Lefkowitch JH,Lobritto SJ,Brown RS Jr,Emond JC,Schilsky ML,Rosenthal LA,George DM,Cairo MS

更新日期：2006-09-01 00:00:00