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Efficacy of re-treatment with TMC435 as combination therapy in hepatitis C virus-infected patients following TMC435 monotherapy.

Abstract：

:In the TMC435-C101 study, 6 patients infected with hepatitis C virus genotype 1 were treated with the protease inhibitor TMC435 (200 mg once daily) as monotherapy for 5 days. Approximately 1.5 years later, 5 of these patients were re-treated with TMC435 (200 mg once daily) plus pegylated interferon alfa-2a and ribavirin (PegIFNα-2a and RBV) for 4 weeks, followed by PegIFNα-2a and RBV until week 48 (in the Optimal Protease inhibitor Enhancement of Response to therApy [OPERA-1] study). TMC435-resistant variants, which emerged in all 5 patients during the TMC435-C101 study, were no longer detected at the beginning of the OPERA-1 study based on virus population sequencing. During the OPERA-1 study, 3 patients had a sustained virologic response; deep sequencing indicated low-level persistence of resistant variants in the remaining 2 patients, which might have affected their response to re-treatment.

journal_name

Gastroenterology

journal_title

Gastroenterology

authors

Lenz O,de Bruijne J,Vijgen L,Verbinnen T,Weegink C,Van Marck H,Vandenbroucke I,Peeters M,Simmen K,Fanning G,Verloes R,Picchio G,Reesink H

doi

10.1053/j.gastro.2012.07.117

subject

Has Abstract

pub_date

2012-11-01 00:00:00

pages

1176-1178.e6

issue

5

eissn

0016-5085

issn

1528-0012

pii

S0016-5085(12)01160-2

journal_volume

143

pub_type

临床试验,杂志文章

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