Differential role of selectins in experimental colitis.

abstract：BACKGROUND & AIMS:Although protein kinase C (PKC) alterations may play a role in the abnormal reactivity of cirrhotic rat aortas, its isoforms and cellular distribution are unknown. We therefore studied the protein expression and cellular distribution of PKC isoforms and their activation in cirrhotic rat aortas. METHO...

journal_title：Gastroenterology

authors： Tazi KA,Moreau R,Heller J,Poirel O,Lebrec D

更新日期：2000-07-01 00:00:00

abstract：BACKGROUND & AIMS:Body weight (BW) loss and reduction of blood ghrelin level are commonly observed after total gastrectomy (TG). A prospective study was designed to elucidate whether exogenous ghrelin administration prevents postoperative BW loss by improving appetite and oral food intake in patients with gastric cance...

journal_title：Gastroenterology

authors： Adachi S,Takiguchi S,Okada K,Yamamoto K,Yamasaki M,Miyata H,Nakajima K,Fujiwara Y,Hosoda H,Kangawa K,Mori M,Doki Y

更新日期：2010-04-01 00:00:00

abstract：BACKGROUND/AIMS:A double-blind, placebo-controlled trial of ursodeoxycholic acid (UDCA) was conducted in 180 patients with primary biliary cirrhosis (PBC) to define the efficacy and safety of UDCA. Efficacy was assessed by time to treatment failure defined as death; liver transplantation; histological progression; deve...

journal_title：Gastroenterology

authors： Lindor KD,Dickson ER,Baldus WP,Jorgensen RA,Ludwig J,Murtaugh PA,Harrison JM,Wiesner RH,Anderson ML,Lange SM

更新日期：1994-05-01 00:00:00

abstract：:Vascular casts of human oxyntic mucosa, examined by scanning electron microscopy, revealed that (a) arterial breakup occurs only at the submucosal aspect of the mucosa, there being no arterial vessels further into the mucosa and (b) mucosal capillaries drain into the infrequent mucosal venules only in the most luminal...

journal_title：Gastroenterology

authors： Gannon B,Browning J,O'Brien P,Rogers P

更新日期：1984-05-01 00:00:00

abstract：BACKGROUND & AIMS:We aimed to identify the incidence and predictors of de novo gastroesophageal variceal formation and progression in a large cohort of patients with chronic hepatitis C and advanced fibrosis. METHODS:All participants in the Hepatitis C Antiviral Long-Term Treatment against Cirrhosis Trial were offered...

journal_title：Gastroenterology

authors： Fontana RJ,Sanyal AJ,Ghany MG,Lee WM,Reid AE,Naishadham D,Everson GT,Kahn JA,Di Bisceglie AM,Szabo G,Morgan TR,Everhart JE,HALT-C Trial Group.

更新日期：2010-06-01 00:00:00

abstract：:Of 550 patients admitted with acute upper gastrointestinal hemorrhage, 143 with peptic ulcers containing stigmata of recent hemorrhage accessible to endoscopic therapy were included in a randomized comparison of neodymium yttrium aluminum garnet laser, heater probe, and no endoscopic therapy. The rebleeding rate in la...

journal_title：Gastroenterology

authors： Matthewson K,Swain CP,Bland M,Kirkham JS,Bown SG,Northfield TC

更新日期：1990-05-01 00:00:00

abstract：BACKGROUND & AIMS:We assessed the association of body mass and gastric volumes (fasting and postprandial) with satiation and postprandial symptoms. METHODS:Healthy obese and nonobese subjects underwent measurement of caloric intake at maximum satiation; postprandial symptoms were measured with visual analogue scales 3...

journal_title：Gastroenterology

authors： Delgado-Aros S,Cremonini F,Castillo JE,Chial HJ,Burton DD,Ferber I,Camilleri M

更新日期：2004-02-01 00:00:00

abstract：BACKGROUND/AIMS:Heat-shock protein (Hsp) 60 is an immunodominant antigen of mycobacteria and other microorganisms that is highly homologous to its human counterpart. Hsp60 may provide a link between immunity to invading microorganisms and autoimmune diseases. METHODS:Expression of Hsp60 was studied by immunohistochemi...

journal_title：Gastroenterology

authors： Peetermans WE,D'Haens GR,Ceuppens JL,Rutgeerts P,Geboes K

更新日期：1995-01-01 00:00:00

abstract：BACKGROUND & AIMS:Activation of Fas or tumor necrosis factor receptor 1 (TNF-R1) on hepatocytes leads to apoptosis, which requires mitochondria activation. The pro-death Bcl-2 family protein, Bid, mediates this pathway by inducing mitochondrial releases of cytochrome c and other apoptotic factors. How Bid activates mit...

journal_title：Gastroenterology

authors： Zhao Y,Ding WX,Qian T,Watkins S,Lemasters JJ,Yin XM

更新日期：2003-09-01 00:00:00

abstract：BACKGROUND & AIMS:Prucalopride is a selective, high-affinity agonist of the 5-hydroxytryptamine (serotonin) receptor 4 that enhances motility in the gastrointestinal tract. We performed a multicenter, randomized, placebo-controlled, double-blind, phase 3 trial to evaluate the efficacy and safety of prucalopride in chil...

journal_title：Gastroenterology

authors： Mugie SM,Korczowski B,Bodi P,Green A,Kerstens R,Ausma J,Ruth M,Levine A,Benninga MA

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND & AIMS:To elucidate the survival of the patients with unresectable hepatocellular carcinoma (HCC) who underwent transcatheter arterial lipiodol chemoembolization (TACE) and to analyze the factors affecting the survivals. METHODS:During the last 8 years, a nationwide prospective cohort study was performed in...

journal_title：Gastroenterology

authors： Takayasu K,Arii S,Ikai I,Omata M,Okita K,Ichida T,Matsuyama Y,Nakanuma Y,Kojiro M,Makuuchi M,Yamaoka Y,Liver Cancer Study Group of Japan.

更新日期：2006-08-01 00:00:00

abstract：BACKGROUND AND AIMS:Antibodies directed against oligomannose sequences alpha-1,3 Man (alpha-1,2 Man alpha-1,2 Man)(n) (n = 1 or 2), termed anti-Saccharomyces cerevisiae antibodies (ASCAs) are markers of Crohn's disease (CD). S. cerevisiae mannan, which expresses these haptens, is used to detect ASCA, but the exact immu...

journal_title：Gastroenterology

authors： Standaert-Vitse A,Jouault T,Vandewalle P,Mille C,Seddik M,Sendid B,Mallet JM,Colombel JF,Poulain D

更新日期：2006-05-01 00:00:00

abstract：BACKGROUND & AIMS:Hepatitis E virus (HEV) infection can cause chronic hepatitis in recipients of solid organ transplants. However, the factors that contribute to chronic infection and the outcomes of these patients are incompletely understood. We performed a retrospective analysis of data from 17 centers from Europe an...

journal_title：Gastroenterology

authors： Kamar N,Garrouste C,Haagsma EB,Garrigue V,Pischke S,Chauvet C,Dumortier J,Cannesson A,Cassuto-Viguier E,Thervet E,Conti F,Lebray P,Dalton HR,Santella R,Kanaan N,Essig M,Mousson C,Radenne S,Roque-Afonso AM,Izopet J,

更新日期：2011-05-01 00:00:00

abstract：:Random fecal alpha 1-antitrypsin levels were determined in 34 patients, 24 with Crohn's disease, and 10 "controls" having diarrheal illnesses not associated with intestinal protein loss, in an effort to evaluate its usefulness as a measure of Crohn's disease intestinal activity. In the control group, all alpha 1-antit...

journal_title：Gastroenterology

authors： Meyers S,Wolke A,Field SP,Feuer EJ,Johnson JW,Janowitz HD

更新日期：1985-07-01 00:00:00

abstract：:A prospective and randomized study was performed comparing pneumatic forceful dilatation and surgical esophagomyotomy as primary treatment of patients with achalasia of the esophagus. Eighteen dilated and 20 operated patients were studied before and after treatment with 1 patient lost. Clinical, radiologic, and manome...

journal_title：Gastroenterology

authors： Csendes A,Velasco N,Braghetto I,Henriquez A

更新日期：1981-04-01 00:00:00

abstract：:We performed 92 computed tomography-guided percutaneous needle aspirations of pancreatic inflammatory masses in 60 patients suspected of harboring pancreatic infection. Thirty-six patients (60%) were found by Gram stain and culture to have a total of 41 separate episodes of pancreatic infection. Among 42 aspirates jud...

journal_title：Gastroenterology

authors： Gerzof SG,Banks PA,Robbins AH,Johnson WC,Spechler SJ,Wetzner SM,Snider JM,Langevin RE,Jay ME

更新日期：1987-12-01 00:00:00

abstract：:A case of a 41-year-old man with diarrhea, hypoalbuminemia, and cryptogenic cirrhosis with features of portal hypertension is described. Protein-losing enteropathy was confirmed by analysis of whole-gut lavage fluid, and intestinal inflammation and infection were excluded. Distal duodenal biopsy specimens showed evide...

journal_title：Gastroenterology

authors： Stanley AJ,Gilmour HM,Ghosh S,Ferguson A,McGilchrist AJ

更新日期：1996-12-01 00:00:00

abstract：BACKGROUND & AIMS:Empirical therapy has been proposed for initial management of dyspepsia. The aim of this study was to evaluate initial endoscopy, empirical therapy, and testing for Helicobacter pylori in the management of patients with a new onset of dyspepsia. METHODS:Decision analysis was used to compare the direc...

journal_title：Gastroenterology

authors： Silverstein MD,Petterson T,Talley NJ

更新日期：1996-01-01 00:00:00

abstract：BACKGROUND & AIMS:In patients with achalasia esophagus, swallows induce simultaneous pressure waves known as esophageal pressurization. We studied the mechanism of esophageal pressurization and bolus flow patterns in patients with type 2 or type 3 achalasia. METHODS:We recorded high-resolution manometry with impedance...

journal_title：Gastroenterology

authors： Park S,Zifan A,Kumar D,Mittal RK

更新日期：2018-08-01 00:00:00

abstract：:Using flowing isotonic NaCl or flowing molar KCl electrodes, the magnitude of liquid junction potentials between the electrode tip and gastric juice was measured directly, and calculated from electrolyte concentrations in gastric juice according to standard formulas. Gastric transepithelial potential difference was ob...

journal_title：Gastroenterology

authors： Read NW,Fordtran JS

更新日期：1979-05-01 00:00:00

abstract：:In dogs provided with Heidenhain pouch and gastric fistula, we studied the effect of near-total excision of the fundic mucosa of the main stomach on acid secretion and gastrin release. Fundic mucosal excision abolished the mean response of the gastric fistula and reduced its maximal response to pentagastrin and to his...

journal_title：Gastroenterology

authors： Soon-Shiong P,Debas HT

更新日期：1980-11-01 00:00:00

abstract：:This study was undertaken to determine the pathogenesis of muscle atrophy that frequently accompanies liver disease. Hepatic injury was induced in rats by giving weekly intragastric doses of carbon tetrachloride (CCl4) in combination with phenobarbital in the drinking water. Muscle protein catabolism was assessed duri...

journal_title：Gastroenterology

authors： Weber FL Jr,Macechko PT,Kelson SR,Karajiannis E,Hassan MO

更新日期：1992-05-01 00:00:00

abstract：BACKGROUND & AIMS:In colorectal adenoma and carcinoma, glutathione S-transferase-pi (GSTP1-1) is highly expressed. K-ras mutation is also known to occur frequently in colorectal adenoma and carcinoma, as well as in the putative precursor of adenoma, aberrant crypt foci (ACF). Further, forced expression of v-H-ras in ra...

journal_title：Gastroenterology

authors： Miyanishi K,Takayama T,Ohi M,Hayashi T,Nobuoka A,Nakajima T,Takimoto R,Kogawa K,Kato J,Sakamaki S,Niitsu Y

更新日期：2001-10-01 00:00:00

abstract：BACKGROUND & AIMS:Pancreatic acinar cells are used to study regulated exocytosis. We investigated the role of interferon regulatory factor-2 (IRF2) in exocytosis in pancreatic acinar cells. METHODS:Pancreas tissues from Irf2⁺/⁺, Irf2⁺/⁻), and Irf2⁻/⁻ mice were examined by microscopy, immunohistochemical, and immunoblo...

journal_title：Gastroenterology

authors： Mashima H,Sato T,Horie Y,Nakagawa Y,Kojima I,Ohteki T,Ohnishi H

更新日期：2011-09-01 00:00:00

abstract：:Ornithine decarboxylase activity is known to be increased in certain premalignant conditions. We determined the activity of this enzyme in mucosal biopsy specimens from 15 patients with Barrett's esophagus. Ornithine decarboxylase was greater in Barrett's mucosa than in squamous esophageal or gastric mucosa. In Barret...

journal_title：Gastroenterology

authors： Garewal HS,Sampliner R,Gerner E,Steinbronn K,Alberts D,Kendall D

更新日期：1988-03-01 00:00:00

abstract：BACKGROUND & AIMS:This longitudinal study investigated the interactions and roles of hepatitis B virus (HBV) genotypes, pre-S deletions, and core promoter and precore mutations on the progression of liver disease in hepatitis B e antigen (HBeAg)-negative patients. METHODS:A total of 141 HBeAg-negative patients without...

journal_title：Gastroenterology

authors： Chen CH,Hung CH,Lee CM,Hu TH,Wang JH,Wang JC,Lu SN,Changchien CS

更新日期：2007-11-01 00:00:00

abstract：BACKGROUND & AIMS:The peroxisome proliferator-activated receptor delta (PPARD) regulates cell metabolism, proliferation, and inflammation and has been associated with gastric and other cancers. Villin-positive epithelial cells are a small population of quiescent gastric progenitor cells. We expressed PPARD from a villi...

journal_title：Gastroenterology

authors： Zuo X,Deguchi Y,Xu W,Liu Y,Li HS,Wei D,Tian R,Chen W,Xu M,Yang Y,Gao S,Jaoude JC,Liu F,Chrieki SP,Moussalli MJ,Gagea M,Sebastian MM,Zheng X,Tan D,Broaddus R,Wang J,Ajami NJ,Swennes AG,Watowich SS,Shureiqi

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND & AIMS:Coffee is one of the most widely consumed beverages worldwide. Epidemiologic data indicate that coffee consumption protects against the progression of chronic liver disease and development of hepatocellular carcinoma and diabetes, but the mechanisms are not clear. UDP glucuronosyltransferases (UGT1A) ...

journal_title：Gastroenterology

authors： Kalthoff S,Ehmer U,Freiberg N,Manns MP,Strassburg CP

更新日期：2010-11-01 00:00:00

abstract：:The management of colon polyps has been completely revolutionized since the introduction of colonoscopic polypectomy. The reductions in patient time, cost, morbidity, and mortality are major advantages. Reported complications include primarily hemorrhage (1.7%) and frank clinical perforation (0.32%). This report descr...

journal_title：Gastroenterology

authors： Overholt BF,Hargrove RL,Farris RK,Wilson BM

更新日期：1976-01-01 00:00:00

abstract：BACKGROUND & AIMS:Patients with inflammatory bowel disease who are in remission and those who developed irritable bowel syndrome after enteric infection continue to have symptoms of diarrhea or constipation in the absence of overt inflammation, indicating motility dysfunction. We investigated whether oxidative stress d...

journal_title：Gastroenterology

authors： Choi K,Chen J,Mitra S,Sarna SK

更新日期：2011-10-01 00:00:00