Abstract:
BACKGROUND & AIMS:Prucalopride is a selective, high-affinity agonist of the 5-hydroxytryptamine (serotonin) receptor 4 that enhances motility in the gastrointestinal tract. We performed a multicenter, randomized, placebo-controlled, double-blind, phase 3 trial to evaluate the efficacy and safety of prucalopride in children (6 months to 18 years old) with functional constipation. METHODS:Children with functional constipation, based on the Rome III criteria, were given prucalopride (children ≤ 50 kg were given a 0.04 mg/kg oral solution; children >50 kg were given a 2-mg tablet) or placebo once daily for 8 weeks. The primary efficacy end point was the proportion of children with toileting skills who had a mean of ≥ 3 spontaneous bowel movements/week and ≤ 1 episode of fecal incontinence/2 weeks, from study weeks 5-8 (responders). Adverse events, clinical laboratory values, and electrocardiograms were monitored. RESULTS:Efficacy and safety were assessed in 213 children (106 prucalopride, 107 placebo). Twenty-five percent were younger than 4 years old, 50% were 4-11 years old, and 25% were 12-18 years old; 55.4% were girls. At screening, 62.3% of patients in the prucalopride group and 55.1% in the placebo group had a history of fecal incontinence; 60.4% and 55.1% in the prucalopride and placebo groups, respectively, had a mean of ≤ 1 spontaneous bowel movements/week. The proportion of responders was similar between groups (prucalopride, 17.0% and placebo, 17.8%). There were no statistically significant differences in the primary efficacy end point when patients were stratified by sex, age group, or country. The incidence of treatment-emergent adverse events was similar in the prucalopride (69.8%) and placebo (60.7%) groups. CONCLUSIONS:Prucalopride, although generally well tolerated, was not more effective than placebo in children with functional constipation. ClinicalTrials.gov Number: NCT01330381.
journal_name
Gastroenterologyjournal_title
Gastroenterologyauthors
Mugie SM,Korczowski B,Bodi P,Green A,Kerstens R,Ausma J,Ruth M,Levine A,Benninga MAdoi
10.1053/j.gastro.2014.09.005subject
Has Abstractpub_date
2014-12-01 00:00:00pages
1285-95.e1issue
6eissn
0016-5085issn
1528-0012pii
S0016-5085(14)01127-5journal_volume
147pub_type
杂志文章,多中心研究,随机对照试验相关文献
GASTROENTEROLOGY文献大全abstract::Chlorpromazine (CPZ) is a long recognized cause of jaundice, but the mechanism by which this agent produces icteric liver disease is not well defined. This study examined some effects of CPZ administration on bilirubin metabolism and biliary secretion in the rat. Acute CPZ treatment (25 mg per kg intravenously) produc...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1975-10-01 00:00:00
abstract::The cause of Ménétrier's disease is unknown, although allergic, autoimmune, and infectious, particularly viral, causes have been postulated. This case report describes a 3-year-old child with Ménétrier's disease in whom evidence of acute cytomegalovirus (CMV) infection was found. To our knowledge, this is the first ca...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(95)90349-6
更新日期:1995-08-01 00:00:00
abstract::We describe 2 siblings with multiple gastrointestinal stromal tumors (GISTs) and cutaneous hyperpigmentation. Both had a point mutation of the c-kit gene. The patients were sisters who had exhibited cutaneous hyperpigmentation since their late teens, but the diagnosis of multiple gastrointestinal submucosal tumors was...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/gast.2001.20880
更新日期:2001-01-01 00:00:00
abstract:BACKGROUND/AIMS:We have identified several clones specifically expressed during malignant cell proliferation by screening a complementary DNA library constructed from a human primary liver cancer with subtractive probes. One clone was identified as the glutamine synthetase (GS) transcript. Its expression is tightly reg...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(94)90024-8
更新日期:1994-05-01 00:00:00
abstract:BACKGROUND & AIMS:The pregnane X receptor (PXR) regulates an array of genes involved in the response to xenobiotics. Evidence from several studies suggests that xenobiotic metabolism may play a role in inflammatory bowel disease (IBD) and that low levels of PXR may be associated with disease expression. The aim of this...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2005.12.008
更新日期:2006-02-01 00:00:00
abstract:BACKGROUND & AIMS:Oral administration of ursodeoxycholic acid (UDCA) and cholesterol causes bile salt malabsorption; the former by competition for and the latter by down-regulation of ileal bile acid transporters. Because ileectomy in rats induces enterohepatic cycling of bilirubin, the hypothesis that dietary steroids...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/s0016-5085(98)70152-0
更新日期:1998-09-01 00:00:00
abstract:BACKGROUND & AIMS:Weight loss in response to sibutramine is highly variable. We assessed the association of specific markers of polymorphisms of candidate alpha2A adrenoreceptor, 5-HT transporter, and GNbeta3 genes and weight loss with sibutramine. METHODS:We conducted a randomized, double-blind, pharmacogenetic study...
journal_title:Gastroenterology
pub_type: 杂志文章,随机对照试验
doi:10.1053/j.gastro.2008.07.009
更新日期:2008-10-01 00:00:00
abstract::Enriched populations of human intestinal and colonic intraepithelial lymphocytes were isolated separate from lamina propria lymphocytes. These populations, and peripheral blood mononuclear cells, were characterized for membrane features, lymphocyte subsets, and proliferative potential to the nonspecific mitogenic lect...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1983-11-01 00:00:00
abstract:BACKGROUND & AIMS:Adenomatous polyps are by definition dysplastic and pathologically indistinguishable from the dysplasia-associated lesion or mass (DALM) described in 1981. Yet, adenomatous polyps in noncolitic colons are usually removed definitively endoscopically, whereas DALMs are regarded as harbingers of colon ca...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/s0016-5085(99)70279-9
更新日期:1999-12-01 00:00:00
abstract::A combination of approaches has begun to elucidate the mechanisms of gastrointestinal development. This review describes progress over the last 20 years in understanding human gastrointestinal development, including data from both human and experimental animal studies that address molecular mechanisms. Rapid progress ...
journal_title:Gastroenterology
pub_type: 杂志文章,评审
doi:10.1016/s0016-5085(99)70193-9
更新日期:1999-03-01 00:00:00
abstract:BACKGROUND & AIMS:Gastroesophageal reflux is common among patients with postnasal drainage. We investigated whether proton pump inhibitor therapy improved symptoms in patients with postnasal drainage without sinusitis or allergies. METHODS:In a parallel-group, double-blind, multi-specialty trial, we randomly assigned ...
journal_title:Gastroenterology
pub_type: 杂志文章,随机对照试验
doi:10.1053/j.gastro.2010.08.039
更新日期:2010-12-01 00:00:00
abstract:BACKGROUND & AIMS:IKBL gene lies telomeric of the tumor necrosis factor cluster in the central major histocompatibility complex and carries a structural polymorphism at position +738. In the Spanish white population, we found the IKBL+738(C) allele in haplotypes carrying either HLA-DRB1(*)1501 or -DRB1(*)0103. Because ...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/gast.2000.20258
更新日期:2000-12-01 00:00:00
abstract:BACKGROUND & AIMS:Induction of heat-shock protein 72 is associated with enhanced tolerance to subsequent nonthermal stresses. This study evaluated whether induction of heat-shock protein 72 protects against intestinal ischemia/reperfusion injury. METHODS:Groups of nonheated and heated rats underwent sham operation, 30...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(95)90339-9
更新日期:1995-08-01 00:00:00
abstract::Circulating precursors of mucosal immunoglobulin A plasma cells and T-cell immunoblasts migrate selectively into mucosal sites from the blood, but the mechanisms controlling this selective trafficking have not been determined. One possibility is that the site-specific extravasation of circulating effector cell populat...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(88)90226-0
更新日期:1988-03-01 00:00:00
abstract::The intestinal epithelium is a repetitive sheet of crypt and villus units with stem cells at the bottom of the crypts. During postnatal development, crypts multiply via fission, generating 2 daughter crypts from 1 parental crypt. In the adult intestine, crypt fission is observed at a low frequency. Using intravital mi...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2017.05.019
更新日期:2017-09-01 00:00:00
abstract:BACKGROUND & AIMS:A Western-style diet, which is high in fat and sugar, can cause significant dyslipidemia and nonalcoholic fatty liver disease; the diet has an especially strong effect in women, regardless of total calorie intake. Dietary supplementation with beneficial microbes might reduce the detrimental effects of...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2020.03.010
更新日期:2020-08-01 00:00:00
abstract::A 36-year-old woman was admitted to hospital with a first attack of acute intermittent porphyria. At the same time increased serum levels of amylase and lipase as well as an increased amylase clearance to creatinine clearance ratio were observed, permitting the diagnosis of acute pancreatitis. The etiology of the latt...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1976-09-01 00:00:00
abstract::The purpose of this American Gastroenterological Association (AGA) Institute Clinical Practice Update was to rapidly review the emerging evidence and provide timely expert recommendations regarding the management of patients with inflammatory bowel disease during the coronavirus disease 2019 pandemic. This expert comm...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2020.04.012
更新日期:2020-07-01 00:00:00
abstract:BACKGROUND & AIMS:Barrier functions across epithelia and endothelia are essential for homeostatic tissue regulation. Astroglia interact with cerebral endothelia to maintain the blood-brain barrier. Whether similar interactions between astrocyte-like enteric glia and epithelia regulate intestinal barrier function is not...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2007.01.051
更新日期:2007-04-01 00:00:00
abstract:BACKGROUND & AIMS:The morphology of acid damage to esophageal epithelium is characterized by marked cell (swelling) edema. This observation suggests that, in the process of acid damage, an increase in osmotic forces develops within the cell that accounts for the increase in cell water. The aim of this study was to docu...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(95)90328-3
更新日期:1995-08-01 00:00:00
abstract::A case of primary undifferentiated sarcoma of the liver in a 66-year-old woman is reported. The similarity of the presenting symptoms to those of a hepatic abscess is emphasized. The patient's response to palliative treatment by means of hepatic artery ligation and chemotherapy was excellent. We believe that this is t...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1978-01-01 00:00:00
abstract::The role of central (supraspinal and spinal) and peripheral alpha-adrenoceptors in the regulation of gastrointestinal propulsion in the mouse was studied using clonidine, an alpha 2-adrenoceptor agonist. Clonidine produced a dose-dependent inhibition of propulsion when given intracerebroventricularly, intrathecally, o...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(88)90360-5
更新日期:1988-11-01 00:00:00
abstract:BACKGROUND & AIMS:Epithelial stem cells in the stomach are responsible for constant renewal of the epithelium through generation of multiple gastric cell lineages that populate the gastric glands. However, gastric stem or progenitor cells have not been well-characterized because of the lack of specific markers that per...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2007.09.031
更新日期:2007-12-01 00:00:00
abstract::In addition to the previously described molecular forms of gastrin, a new component has been found in high concentrations in the serum of 6 patients with Zollinger-Ellison syndrome. Serum was fractionated by gel filtration, and ion exchange chromatography, and the new component was identified in eluates by radioimmuno...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1975-02-01 00:00:00
abstract::Most studies show that oral ingestion of iron does not cause a positive stool guaiac reaction. However, all in vitro studies show that iron does cause a positive guaiac reaction and some in vivo studies have shown a positive stool guaiac reaction in response to oral iron. This study examines this unresolved question. ...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(89)90766-x
更新日期:1989-01-01 00:00:00
abstract::To examine the premise that exercise reduces the gastrointestinal transit time, we evaluated the effect of walking 4.5 km in an hour on mouth-to-cecum transit time. Twenty-three healthy volunteers, 9 men and 14 women, with an age range of 19-28 yr, were studied. After an overnight fast, the subjects ingested 10 g of l...
journal_title:Gastroenterology
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1989-03-01 00:00:00
abstract::Seven patients with persistent hyponatremia but normal or elevated serum arginine vasopressin levels and refractory ascites undergoing peritoneovenous shunting were studied in a Metabolic Unit on a 20 mEq sodium 1200 ml fluid-restricted diet to elucidate the mechanism of this response. The intravascular volume expansi...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1983-04-01 00:00:00
abstract:BACKGROUND & AIMS:The course of hereditary hemochromatosis may depend on the degree of iron overload and the time of therapeutic intervention. This analysis evaluates the impact of early diagnosis and iron removal on survival and complications in hereditary hemochromatosis. METHODS:A Cohort of 251 patients with hemoch...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/gast.1996.v110.pm8613000
更新日期:1996-04-01 00:00:00
abstract:BACKGROUND & AIMS:People infected with human immunodeficiency virus (HIV) have an increased risk of some malignancies, but little is known about the effects of infection on risk of cancers of the upper gastrointestinal tract. We evaluated the risks of different histologic and anatomic subtypes of carcinomas and non-Hod...
journal_title:Gastroenterology
pub_type: 杂志文章,收录出版
doi:10.1053/j.gastro.2012.07.013
更新日期:2012-10-01 00:00:00
abstract::We have examined the possibility that the 33- and 39-amino acid forms of cholecystokinin (CCK) are cleaved to produce CCK-octapeptide (CCK-8) during circulation in humans. When a mixture of the 33- and 39-amino acid forms of porcine CCK was infused at 0.1-2.5 pmol/kg.min into normal subjects, material indistinguishabl...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(88)90303-4
更新日期:1988-07-01 00:00:00