AGA Clinical Practice Update on Management of Inflammatory Bowel Disease During the COVID-19 Pandemic: Expert Commentary.

abstract：:Several single-nucleotide polymorphisms (SNPs) have been associated with colorectal cancer (CRC) susceptibility. Most CRCs arise from adenomas, and SNPs therefore might affect predisposition to CRC by increasing adenoma risk. We found that 8 of 18 known CRC-associated SNPs (rs10936599, rs6983267, rs10795668, rs3802842...

journal_title：Gastroenterology

authors： Carvajal-Carmona LG,Zauber AG,Jones AM,Howarth K,Wang J,Cheng T,APC Trial Collaborators.,APPROVe Trial Collaborators.,CORGI Study Collaborators.,Colon Cancer Family Registry Collaborators.,CGEMS Collaborators.,Riddell R,Lanas A,

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND & AIMS:Standardized instruments are needed to assess the activity of eosinophilic esophagitis (EoE) and to provide end points for clinical trials and observational studies. We aimed to develop and validate a patient-reported outcome (PRO) instrument and score, based on items that could account for variations...

journal_title：Gastroenterology

authors： Schoepfer AM,Straumann A,Panczak R,Coslovsky M,Kuehni CE,Maurer E,Haas NA,Romero Y,Hirano I,Alexander JA,Gonsalves N,Furuta GT,Dellon ES,Leung J,Collins MH,Bussmann C,Netzer P,Gupta SK,Aceves SS,Chehade M,Moawad F

更新日期：2014-12-01 00:00:00

abstract：:The effects of hypothalamic microinfusions of cholecystokinin octapeptide and its antagonist L364,718 on cecocolonic myoelectrical activity were evaluated by electromyography in fasted and fed rats. The rats were chronically fitted with electrodes implanted on the cecum and proximal colon and cannulas placed bilateral...

journal_title：Gastroenterology

authors： Liberge M,Arruebo MP,Bueno L

更新日期：1991-02-01 00:00:00

abstract：:The efficacy of cimetidine (1.6 g per day) was evaluated using a double blind placebo-controlled trial in 24 patients with moderate or severe peptic reflux esophagitis. The results show that cimetidine is superior to placebo when using endoscopic and histological criteria. Improved patient symptomatology and lower ant...

journal_title：Gastroenterology

authors： Wesdorp E,Bartelsman J,Pape K,Dekker W,Tytgat GN

更新日期：1978-05-01 00:00:00

abstract：BACKGROUND/AIMS:The neuropeptide somatostatin exerts multiple functions in the gastrointestinal tract and may also play a regulatory role in inflammatory bowel disease, as several other neuropeptides do, e.g., substance P or calcitonin gene-related peptide. Therefore, the expression of somatostatin receptors was evalua...

journal_title：Gastroenterology

authors： Reubi JC,Mazzucchelli L,Laissue JA

更新日期：1994-04-01 00:00:00

abstract：BACKGROUND & AIMS:Polymorphisms in the region of the interleukin (IL)-28B gene on chromosome 19 have been associated with peginterferon-alfa-induced clearance of genotype 1 hepatitis C virus (HCV); there are no data for patients with genotype 2 or 3 HCV. We evaluated the effects of IL-28B polymorphisms on response to t...

journal_title：Gastroenterology

authors： Mangia A,Thompson AJ,Santoro R,Piazzolla V,Tillmann HL,Patel K,Shianna KV,Mottola L,Petruzzellis D,Bacca D,Carretta V,Minerva N,Goldstein DB,McHutchison JG

更新日期：2010-09-01 00:00:00

abstract：BACKGROUND & AIMS:Prior thermal stress induces heat shock protein 70 (HSP70) expression in the pancreas and protects against secretagogue-induced pancreatitis, but it is not clear that this thermal stress-induced protection is actually mediated by HSP70 since thermal stress may have other, non-HSP related, effects. ME...

journal_title：Gastroenterology

authors： Bhagat L,Singh VP,Song AM,van Acker GJ,Agrawal S,Steer ML,Saluja AK

更新日期：2002-01-01 00:00:00

abstract：:A 14-yr-old girl presented with long-standing symptoms of partial gastric outlet obstruction due to an antral mucosal diaphragm that had a central aperture of 4-5 mm. The literature of this congenital malformation is reviewed with respect to diagnostic criteria and feasibility of endoscopic transection. The procedure ...

journal_title：Gastroenterology

authors： Berr F,Rienmueller R,Sauerbruch T

更新日期：1985-11-01 00:00:00

abstract：BACKGROUND AND AIMS:Although cholesterol is the most abundant sterol in animal tissues, oxidized products of cholesterol (oxysterols) also occur in mammalian organs and blood and are cytotoxic, atherogenic, and carcinogenic. However, the presence of oxysterols in bile or gallstones has never been reported. METHODS:Fre...

journal_title：Gastroenterology

authors： Haigh WG,Lee SP

更新日期：2001-07-01 00:00:00

abstract：BACKGROUND AND AIMS:Serrated polyp (SPs) are precursors to 20% to 30% of cases of colorectal tumors, but patients' long-term risk after removal of SPs is poorly understood. We investigated the risk of colorectal cancer (CRC) in individuals with a history of SPs. METHODS:We performed a retrospective cohort study of Kai...

journal_title：Gastroenterology

authors： Li D,Liu L,Fevrier HB,Alexeeff SE,Doherty AR,Raju M,Amsden LB,Lee JK,Levin TR,Corley DA,Herrinton LJ

更新日期：2020-08-01 00:00:00

abstract：BACKGROUND/AIMS:Cytokines are thought to be important in mediating tissue damage in inflammatory bowel disease (IBD). Many of the in vivo activities of tumor necrosis factor alpha (TNF-alpha) match the changes found in IBD, but its importance is controversial. METHODS:A sensitive, reverse hemolytic plaque assay was us...

journal_title：Gastroenterology

authors： Breese EJ,Michie CA,Nicholls SW,Murch SH,Williams CB,Domizio P,Walker-Smith JA,MacDonald TT

更新日期：1994-06-01 00:00:00

abstract：:We have used measurements of intestinal epithelial cell kinetics and counts of intraepithelial lymphocytes and mucosal mast cells to measure small intestinal mucosal changes during the proliferative and recovery phases of graft-vs.-host reaction in neonatal mice. Unirradiated (CBA x BALB/c)F1 mice were injected with p...

journal_title：Gastroenterology

authors： Mowat AM,Ferguson A

更新日期：1982-08-01 00:00:00

abstract：BACKGROUND & AIMS:Practice guidelines recommend that endoscopists spend at least 7 minutes examining the colonic mucosa during colonoscopy withdrawal to optimize polyp yield. The aim of this study was to determine if the implementation of an institution-wide policy of colonoscopy withdrawal time > or = 7 minutes was as...

journal_title：Gastroenterology

authors： Sawhney MS,Cury MS,Neeman N,Ngo LH,Lewis JM,Chuttani R,Pleskow DK,Aronson MD

更新日期：2008-12-01 00:00:00

abstract：:Weight gain and obesity are major risk factors for conditions and diseases ranging from insulin resistance and type 2 diabetes mellitus to atherosclerosis and the sequelae of nonalcoholic fatty liver disease. A chronic, subacute state of inflammation often accompanies the accumulation of excess lipid in adipose tissue...

journal_title：Gastroenterology

authors： Shoelson SE,Herrero L,Naaz A

更新日期：2007-05-01 00:00:00

abstract：:A method of measuring gastric secretions and emptying rates after ingestion of an ordinary (solid-liquid) meal has been developed and validated. The technique quantifies movements of volume across the pylorus using constant duodenal perfusion with a nonabsorbable marker, polyethylene glycol (PEG), which, in turn, quan...

journal_title：Gastroenterology

authors： Malagelada JR,Longstreth GF,Summerskill WH,Go VL

更新日期：1976-02-01 00:00:00

abstract：BACKGROUND AND AIMS:The peptidyl prolyl isomerase Pin1 frequently is overexpressed in hepatocellular carcinoma (HCC). Hepatitis B virus (HBV) is the most common etiologic agent in HCC, and its encoded X-protein (HBx) is oncogenic and possesses a serine-proline motif that may bind Pin1. The role of Pin1 in hepatocarcino...

journal_title：Gastroenterology

authors： Pang R,Lee TK,Poon RT,Fan ST,Wong KB,Kwong YL,Tse E

更新日期：2007-03-01 00:00:00

abstract：:The effect of experimental bypass on the intestinal epithelium of the rat was investigated from 2 to 360 days after creating a Thiry-Vella fistula. Within 7 to 14 days the number of cells per villus column and, to a lesser degree, the number of cells per crypt column decreased and subsequently these values remained co...

journal_title：Gastroenterology

authors： Rijke RP,Plaisier HM,de Ruiter H,Galjaard H

更新日期：1977-05-01 00:00:00

abstract：:A patient is described with Campylobacter enteritis complicated by massive lower gastrointestinal bleeding from multiple mucosal ulcers in the terminal ileum and at the ileocecal valve. Repeated stool cultures and antibiotic therapy may be indicated in certain patients to diminish the morbidity arising from what may s...

journal_title：Gastroenterology

authors： Michalak DM,Perrault J,Gilchrist MJ,Dozois RR,Carney JA,Sheedy PF 2nd

更新日期：1980-10-01 00:00:00

abstract：BACKGROUND & AIMS:Corticotropin-releasing factor (CRF) signaling pathways play a key role in the stress response through the activation of CRF(1) and CRF(2) receptors. We investigated the CRF receptor subtypes involved in gastric postoperative ileus. METHODS:Adult male mice (C57BL/6, CRF(1)-deficient, and wild-type), ...

journal_title：Gastroenterology

authors： Luckey A,Wang L,Jamieson PM,Basa NR,Million M,Czimmer J,Vale W,Taché Y

更新日期：2003-09-01 00:00:00

abstract：BACKGROUND & AIMS:Most previous population-based studies of mortality in inflammatory bowel disease (IBD) did not account for medication use. We evaluated mortality by IBD medication use among members of the Kaiser Permanente Northern California IBD Registry. METHODS:The retrospective, population-based cohort study in...

journal_title：Gastroenterology

authors： Hutfless SM,Weng X,Liu L,Allison J,Herrinton LJ

更新日期：2007-12-01 00:00:00

abstract：BACKGROUND:The role of cytotoxicity mediated by peripheral blood mononuclear cells for colonic epithelial cells in inflammatory bowel disease (IBD) is still controversial. To clarify it, we studied major histocompatibility antigen (MHC)-restricted T cell-mediated cytotoxicity (CTL). METHODS:Cytotoxicity was measured b...

journal_title：Gastroenterology

authors： Okazaki K,Morita M,Nishimori I,Sano S,Toyonaga M,Nakazawa Y,Yamamoto Y,Yamamoto Y

更新日期：1993-02-01 00:00:00

abstract：:Plasma amino acid abnormalities are common in alcoholics, but the respective role of alcoholism, nutrition, and liver injury in producing these abnormalities is unknown. To elucidate this question, amino acids were measured in 56 alcoholics and 32 nonalcoholics with liver disease, and in an experimental model of alcoh...

journal_title：Gastroenterology

authors： Shaw S,Lieber CS

更新日期：1978-04-01 00:00:00

abstract：BACKGROUND & AIMS:Intestinal lactase activity is high in all healthy human babies, but in adults a genetic polymorphism, which acts in cis to the lactase gene, determines high or low messenger RNA (mRNA) expression and activity (lactase persistence and nonpersistence, respectively). Our aim was to investigate the onset...

journal_title：Gastroenterology

authors： Wang Y,Harvey CB,Hollox EJ,Phillips AD,Poulter M,Clay P,Walker-Smith JA,Swallow DM

更新日期：1998-06-01 00:00:00

abstract：:A human colon cancer cell line, HCT-8, is shown to be an appropriate target cell for study of natural killer (NK) activity in man. In parallel experiments, effector cell characteristics for NK and antibody-dependent cellular cytotoxicity (ADCC) were found to be vested in a single lymphocyte subpopulation, which bore r...

journal_title：Gastroenterology

authors： Helms RA,Bull DM

更新日期：1980-04-01 00:00:00

abstract：BACKGROUND & AIMS:Molecules that regulate T-cell adhesion to hepatic endothelium and thereby recirculation of T cells to the liver are poorly understood. Because the adhesion molecule vascular adhesion protein-1 (VAP-1), which mediates lymphocyte binding to lymph node endothelium, is expressed on hepatic endothelium, i...

journal_title：Gastroenterology

authors： McNab G,Reeves JL,Salmi M,Hubscher S,Jalkanen S,Adams DH

更新日期：1996-02-01 00:00:00

abstract：BACKGROUND & AIMS:Coffee is one of the most widely consumed beverages worldwide. Epidemiologic data indicate that coffee consumption protects against the progression of chronic liver disease and development of hepatocellular carcinoma and diabetes, but the mechanisms are not clear. UDP glucuronosyltransferases (UGT1A) ...

journal_title：Gastroenterology

authors： Kalthoff S,Ehmer U,Freiberg N,Manns MP,Strassburg CP

更新日期：2010-11-01 00:00:00

abstract：:Wilson's disease may present with severe acute hepatocellular failure. The only effective treatment for fulminant Wilson's disease is liver transplantation, which may lead to reversal of the underlying disease. Some patients with cirrhosis who are too ill to undergo orthotopic liver transplantation have been treated w...

journal_title：Gastroenterology

authors： Stampfl DA,Muñoz SJ,Moritz MJ,Rubin R,Armenti VT,Jarrell BE,Maddrey WC

更新日期：1990-12-01 00:00:00

abstract：BACKGROUND & AIMS:The vagus nerve negatively regulates macrophage cytokine production via the release of acetylcholine (ACh) and activation of nicotinic acetylcholine receptors (nAChR). In various models of intestinal inflammation, vagus nerve efferent stimulation ameliorates disease. Given the actively constrained cyt...

journal_title：Gastroenterology

authors： van der Zanden EP,Snoek SA,Heinsbroek SE,Stanisor OI,Verseijden C,Boeckxstaens GE,Peppelenbosch MP,Greaves DR,Gordon S,De Jonge WJ

更新日期：2009-09-01 00:00:00

abstract：:This report defines criteria and reviews the epidemiology, pathophysiology, and management of common anorectal disorders: fecal incontinence (FI), functional anorectal pain and functional defecation disorders. FI is defined as the recurrent uncontrolled passage of fecal material for at least 3 months. The clinical fea...

journal_title：Gastroenterology

authors： Rao SS,Bharucha AE,Chiarioni G,Felt-Bersma R,Knowles C,Malcolm A,Wald A

更新日期：2016-03-25 00:00:00

abstract：:To gain further insight on the mosaic expression of specific functional intestinal markers (such as sucrase-isomaltase) in postconfluent Caco-2 cells, a human colon cancer cell line unique in its property to differentiate in vitro into a mature enterocyte-like cell type, a comparative study was undertaken to examine t...

journal_title：Gastroenterology

authors： Vachon PH,Beaulieu JF

更新日期：1992-08-01 00:00:00