当前位置： SCI文献检索 > GASTROENTEROLOGY期刊下所有文献 > Mortality by medication use among patients with inflammatory bowel disease, 1996-2003.

Mortality by medication use among patients with inflammatory bowel disease, 1996-2003.

Abstract：

BACKGROUND & AIMS:Most previous population-based studies of mortality in inflammatory bowel disease (IBD) did not account for medication use. We evaluated mortality by IBD medication use among members of the Kaiser Permanente Northern California IBD Registry. METHODS:The retrospective, population-based cohort study included 9032 persons who received at least one inpatient or 2 outpatient diagnoses of IBD during 1996-2002. Age and sex standardized mortality ratios measured the associations between IBD and all-cause and cause-specific mortality. Age, sex, and smoking adjusted odds ratios measured the association of mortality by IBD medication use. RESULTS:Compared with health plan members without IBD, mortality was increased in patients with Crohn's disease (CD) (1.4; 95% confidence interval, 1.2-1.6) but not ulcerative colitis (UC) (1.0; 95% CI, 0.9-1.2). CD was associated with increased mortality from infectious and parasitic diseases (4.1; 95% CI, 1.7-8.5), septicemia (6.8; 95% CI, 2.2-15.8), small intestinal cancer (48.1; 95% CI, 5.8-17.4), respiratory diseases (1.9; 95% CI, 1.3-2.7), digestive diseases other than IBD (2.4; 95% CI, 1.0-4.8), and liver diseases (2.6; 95% CI, 1.0-5.3). UC was associated with increased mortality from digestive diseases other than IBD (3.9; 95% CI, 2.4-6.0). The relationship with CD mortality was 0.7 for aminosalicylates (95% CI, 0.5-1.1), 1.3 (95% CI, 0.9-1.9) for immunomodulators, and 1.0 (95% CI, 0.7-1.4) for corticosteroids. Among patients with UC, these odds ratios were 0.8 (95% CI, 0.5-1.1) for aminosalicylates, 0.5 (95% CI, 0.3-0.9) for immunomodulators, and 0.8 (95% CI, 0.6-1.1) for corticosteroids. CONCLUSIONS:Mortality is increased in CD. Infections, respiratory diseases, and digestive diseases are important specific causes of death. IBD medication use has varying associations with mortality.

journal_name

Gastroenterology

journal_title

Gastroenterology

authors

Hutfless SM,Weng X,Liu L,Allison J,Herrinton LJ

doi

10.1053/j.gastro.2007.09.022

subject

Has Abstract

pub_date

2007-12-01 00:00:00

pages

1779-86

issue

eissn

0016-5085

issn

1528-0012

pii

S0016-5085(07)01691-5

journal_volume

133

pub_type

杂志文章

在线工具

Mortality by medication use among patients with inflammatory bowel disease, 1996-2003.