Ablation of Foxl1-Cre-labeled hepatic progenitor cells and their descendants impairs recovery of mice from liver injury.

abstract：BACKGROUND & AIMS:The Forkhead box gene, group O (FoxO) family of Forkhead transcription factors is phopsphorylated and inactivated by the phosphatidylinositol 3-kinase (PI3K)/AKT pathway and regulates a variety of cellular functions. Hepatic stellate cells (HSCs) play a crucial role in liver fibrosis. A fibrotic stimu...

journal_title：Gastroenterology

authors： Adachi M,Osawa Y,Uchinami H,Kitamura T,Accili D,Brenner DA

更新日期：2007-04-01 00:00:00

abstract：BACKGROUND & AIMS:The evaluation of patients with chronic watery diarrhea represents a diagnostic challenge for clinicians because organic causes, including inflammatory bowel disease, microscopic colitis, and chronic infection, must be differentiated from functional diarrhea and diarrhea-predominant irritable bowel sy...

journal_title：Gastroenterology

authors： Carrasco-Labra A,Lytvyn L,Falck-Ytter Y,Surawicz CM,Chey WD

更新日期：2019-09-01 00:00:00

abstract：BACKGROUND & AIMS:Nonalcoholic fatty liver disease (NAFLD) is a consequence of defects in diverse metabolic pathways that involve hepatic accumulation of triglycerides. Features of these aberrations might determine whether NAFLD progresses to nonalcoholic steatohepatitis (NASH). We investigated whether the diverse defe...

journal_title：Gastroenterology

authors： Alonso C,Fernández-Ramos D,Varela-Rey M,Martínez-Arranz I,Navasa N,Van Liempd SM,Lavín Trueba JL,Mayo R,Ilisso CP,de Juan VG,Iruarrizaga-Lejarreta M,delaCruz-Villar L,Mincholé I,Robinson A,Crespo J,Martín-Duce A,Romero-Gó

更新日期：2017-05-01 00:00:00

abstract：:The role of cholinergic mechanisms in the control of gallbladder emptying has not been defined. In this report a scintigraphic technique using 2,6-dimethylphenylcarbamoylmethyl iminodiacetic acid labeled with technetium 99m to visualize the gallbladder and its emptying and diethylenetriamine pentaacetic acid labeled w...

journal_title：Gastroenterology

authors： Fisher RS,Rock E,Malmud LS

更新日期：1985-10-01 00:00:00

abstract：:A case of primary liver cell carcinoma is presented in which tumor emboli to the pulmonary microvasculature resulted in pulmonary hypertension, documented by clinical, radiologic, electrocardiographic, and cardiac catheter studies. Emboli arose from tumor invading the portal vein and passed via a patent splenorenal sh...

journal_title：Gastroenterology

authors： Willett IR,Sutherland RC,O'Rourke MF,Dudley FJ

更新日期：1984-11-01 00:00:00

abstract：:Phlebotomy constitutes the established treatment for HFE-related hemochromatosis. Retrospective studies have suggested proton pump inhibitors (PPIs) reduce the need for phlebotomy in this population. We conducted a randomized controlled trial to prove this. Thirty p.C282Y homozygous patients were randomly allocated to...

journal_title：Gastroenterology

authors： Vanclooster A,van Deursen C,Jaspers R,Cassiman D,Koek G

更新日期：2017-09-01 00:00:00

abstract：:A 76-yr-old male presented with Guillain-Barré syndrome after acute hepatitis B virus infection. Main immunologic features were: (a) high levels of circulating hepatitis B surface antigen-containing immune complexes in serum and cerebrospinal fluid during the acute neurologic syndrome, and (b) clearance of immune-comp...

journal_title：Gastroenterology

authors： Penner E,Maida E,Mamoli B,Gangl A

更新日期：1982-03-01 00:00:00

abstract：BACKGROUND & AIMS:The accurate identification of inactive (serum HBV-DNA persistently

journal_title：Gastroenterology

authors： Brunetto MR,Oliveri F,Colombatto P,Moriconi F,Ciccorossi P,Coco B,Romagnoli V,Cherubini B,Moscato G,Maina AM,Cavallone D,Bonino F

更新日期：2010-08-01 00:00:00

abstract：BACKGROUND & AIMS:Tumor necrosis factor alpha (TNF-alpha) release plays a pivotal role in the pathogenesis of liver injury induced by lipopolysaccharide (LPS) administration in D-galactosamine (GalN)-sensitized mice. Interleukin (IL) 10 is an anti-inflammatory cytokine that inhibits TNF-alpha synthesis and release both...

journal_title：Gastroenterology

authors： Santucci L,Fiorucci S,Chiorean M,Brunori PM,Di Matteo FM,Sidoni A,Migliorati G,Morelli A

更新日期：1996-09-01 00:00:00

abstract：BACKGROUND & AIMS:The majority of patients with Helicobacter pylori infection have autoantibodies cross-reacting with gastric antigens. In this study, the relation between autoantibody status, histopathology of body mucosa, and antigenic profile of H. pylori was investigated. METHODS:One hundred patients were examined...

journal_title：Gastroenterology

authors： Negrini R,Savio A,Poiesi C,Appelmelk BJ,Buffoli F,Paterlini A,Cesari P,Graffeo M,Vaira D,Franzin G

更新日期：1996-09-01 00:00:00

abstract：BACKGROUND & AIMS:The lipocalin superfamily, including the mouse and human homologues 24p3/lcn2 and neutrophil gelatinase-associated lipocalin, show great functional diversity including roles in olfaction, transportation, and prostaglandin synthesis in mammals. Their potential role in maintaining gastrointestinal mucos...

journal_title：Gastroenterology

authors： Playford RJ,Belo A,Poulsom R,Fitzgerald AJ,Harris K,Pawluczyk I,Ryon J,Darby T,Nilsen-Hamilton M,Ghosh S,Marchbank T

更新日期：2006-09-01 00:00:00

abstract：:Serum amino acid levels were determined in 29 patients with severe chronic active liver disease before, during, and after administration of prednisone or placebo and in 22 healthy controls. The pretreatment molar ratio of amino acids was less in patients than in controls (p less than 0.001) and was lower in those with...

journal_title：Gastroenterology

authors： McCullough AJ,Czaja AJ,Jones JD,Go VL

更新日期：1981-10-01 00:00:00

abstract：BACKGROUND & AIMS:Sjögren's syndrome and autoimmune pancreatitis are disorders with decreased function of salivary, lacrimal glands, and the exocrine pancreas. Nonobese diabetic/ShiLTJ mice and mice transduced with the cytokine BMP6 develop Sjögren's syndrome and chronic pancreatitis and MRL/Mp mice are models of autoi...

journal_title：Gastroenterology

authors： Zeng M,Szymczak M,Ahuja M,Zheng C,Yin H,Swaim W,Chiorini JA,Bridges RJ,Muallem S

更新日期：2017-10-01 00:00:00

abstract：:A patient with a lifelong history of asthma and hay fever was investigated because of symptoms of esophageal spasm. Esophageal biopsies revealed elongated papillae and basal zone hyperplasia of the epithelial layer with eosinophilic infiltration of the lamina propria and muscularis mucosae. There was no evidence of re...

journal_title：Gastroenterology

authors： Dobbins JW,Sheahan DG,Behar J

更新日期：1977-06-01 00:00:00

abstract：BACKGROUND & AIMS:The activation of Wnt/beta-catenin signaling causes the development of gastric and colon cancers. Sox17 represses Wnt/beta-catenin signaling and is down-regulated in colon cancer. This study was designed to elucidate the role of Sox17 during the course of gastrointestinal tumorigenesis. METHODS:Sox17...

journal_title：Gastroenterology

authors： Du YC,Oshima H,Oguma K,Kitamura T,Itadani H,Fujimura T,Piao YS,Yoshimoto T,Minamoto T,Kotani H,Taketo MM,Oshima M

更新日期：2009-10-01 00:00:00

abstract：:Among the components of dietary fiber, the soluble polysaccharides, primarily guaran and pectin, have been found to impair intestinal absorption. Little is known, however, about the mechanism of this effect. The direct action of guaran on small intestinal absorption was evaluated by a single-pass perfusion technique. ...

journal_title：Gastroenterology

authors： Elsenhans B,Zenker D,Caspary WF

更新日期：1984-04-01 00:00:00

abstract：BACKGROUND & AIMS:We have reported that contrast echocardiography is a sensitive screening test for the hepatopulmonary syndrome (HPS). However, contrast echocardiography lacks specificity because many cirrhotic patients have positive study results with normal arterial blood gases and therefore do not fulfill criteria ...

journal_title：Gastroenterology

authors： Abrams GA,Nanda NC,Dubovsky EV,Krowka MJ,Fallon MB

更新日期：1998-02-01 00:00:00

abstract：BACKGROUND & AIMS:Corticofugal pathways to the human esophagus have been recently identified in humans using transcranial magnetic stimulation. The aim of this study was to determine the topographic representation of the esophagus on the cerebral cortex. METHODS:Focal magnetic stimulation of 1-cm areas was performed o...

journal_title：Gastroenterology

authors： Aziz Q,Rothwell JC,Hamdy S,Barlow J,Thompson DG

更新日期：1996-10-01 00:00:00

abstract：BACKGROUND AND AIMS:Hepatic lymphocytes are composed mainly of natural killer (NK) cells and NKT cells, which play key roles in innate immune responses against pathogens and tumors in the liver. This report analyzes the effects of activation of innate immunity by viral infection or the toll-like receptor 3 (TLR3) ligan...

journal_title：Gastroenterology

authors： Sun R,Gao B

更新日期：2004-11-01 00:00:00

abstract：:Intragastric titration, introduced in 1973, has become more popular than in the past and is being applied to the study of gastric secretion under a variety of conditions using NaHCO3 and NaOH as titrant. Physical chemical and technical considerations point to limitations on the conditions under which quantitative resu...

journal_title：Gastroenterology

authors： Spenney JG

更新日期：1979-05-01 00:00:00

abstract：:The importance of various factors for dietary fiber effects on pancreatic enzyme activities was studied in vitro. Pectin of high methylic esterification and guar gum, which reduced enzyme activities, particularly lipase activity, increased the viscosity of duodenal juice. Increasing duodenal juice viscosity by polyeth...

journal_title：Gastroenterology

authors： Isaksson G,Lundquist I,Ihse I

更新日期：1982-05-01 00:00:00

abstract：:Cholinergic innervation in the aganglionic bowel of the piebald lethal mouse model of Hirschsprung's disease was investigated by analysis of muscarinic acetylcholine receptors before and after administration of hexamethonium. After hexamethonium administration in the normal rectum, the maximum specific binding (Bmax) ...

journal_title：Gastroenterology

authors： Ueki S,Okamoto E,Kuwata K,Toyosaka A,Nagai K

更新日期：1985-06-01 00:00:00

abstract：:Identification of physiologic factors that predict response to fecal incontinence therapy would be helpful in choosing the optimal treatment and advising patients on the likelihood of a successful outcome. However, few physiologic parameters have been consistently identified as important in predicting response to eith...

journal_title：Gastroenterology

authors： Prather CM

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND & AIMS:Host cell lipid rafts form a scaffold required for replication of hepatitis C virus (HCV). Serine palmitoyltransferases (SPTs) produce sphingolipids, which are essential components of the lipid rafts that associate with HCV nonstructural proteins. Prevention of the de novo synthesis of sphingolipids b...

journal_title：Gastroenterology

authors： Katsume A,Tokunaga Y,Hirata Y,Munakata T,Saito M,Hayashi H,Okamoto K,Ohmori Y,Kusanagi I,Fujiwara S,Tsukuda T,Aoki Y,Klumpp K,Tsukiyama-Kohara K,El-Gohary A,Sudoh M,Kohara M

更新日期：2013-10-01 00:00:00

abstract：:This study was performed to ascertain whether testosterone metabolism is altered in male rats with portal bypass, and whether such changes could contribute to the reduction in serum testosterone concentration and raised serum estrogen levels that are observed in this situation. The metabolic clearance rate of testoste...

journal_title：Gastroenterology

authors： Farrell G,Koltai A

更新日期：1988-08-01 00:00:00

abstract：:We studied the influence of morphine on intestinal secretion induced by three different secretogogues in an attempt to elucidate the mechanism for its antisecretory activity. In rabbit ileal mucosa in vitro morphine (10(-4) M) did not influence the electrical response to the subsequent administration of prostaglandin ...

journal_title：Gastroenterology

authors： McKay JS,Linaker BD,Higgs NB,Turnberg LA

更新日期：1982-02-01 00:00:00

abstract：BACKGROUND & AIMS:In cirrhosis, increased amounts of circulating hormones such as angiotensin II may induce vascular tone changes and alter vascular smooth muscle cell (VSMC) function and growth. The aim of this study was to investigate the growth of aortic VSMCs from cirrhotic rats with or without the addition of angi...

journal_title：Gastroenterology

authors： Tazi KA,Moreau R,Cailmail S,Gadano A,Trombino C,Lebrec D

更新日期：1997-06-01 00:00:00

abstract：BACKGROUND/AIMS:Butyrate and factor XIII may improve ulcerative colitis; they also affect tissue and serum transglutaminase levels. We investigated the therapeutic potential of sodium butyrate and factor XIII and the role of transglutaminase during mucosal repair in experimental colitis. METHODS:Rats with induced coli...

journal_title：Gastroenterology

authors： D'Argenio G,Cosenza V,Sorrentini I,De Ritis F,Gatto A,Delle Cave M,D'Armiento FP,Mazzacca G

更新日期：1994-02-01 00:00:00

abstract：BACKGROUND & AIMS:Hepatic iron toxicity may be mediated by free radical species and lipid peroxidation of biological membranes. The antioxidant property of silybin, a main constituent of natural flavonoids, was investigated in vivo during experimental iron overload. METHODS:Rats were fed a 2.5% carbonyl-iron diet and ...

journal_title：Gastroenterology

authors： Pietrangelo A,Borella F,Casalgrandi G,Montosi G,Ceccarelli D,Gallesi D,Giovannini F,Gasparetto A,Masini A

更新日期：1995-12-01 00:00:00

abstract：:Encephalopathy in liver disease may be unresponsive to protein restriction, lactulose, and neomycin. Zinc supplements have been reported to improve psychometric performance in liver cirrhosis, but the importance of zinc deficiency in overt hepatic encephalopathy has not yet been clearly established. A patient with sev...

journal_title：Gastroenterology

authors： Van der Rijt CC,Schalm SW,Schat H,Foeken K,De Jong G

更新日期：1991-04-01 00:00:00