Abstract：
:Encephalopathy in liver disease may be unresponsive to protein restriction, lactulose, and neomycin. Zinc supplements have been reported to improve psychometric performance in liver cirrhosis, but the importance of zinc deficiency in overt hepatic encephalopathy has not yet been clearly established. A patient with severe recurrent hepatic encephalopathy was studied to determine the relation between her signs of encephalopathy and zinc deficiency. The study included a period in which zinc deficiency was artificially induced by oral histidine. An episode of overt encephalopathy occurred that was identical to earlier episodes and responded to oral zinc. The study showed an association between encephalopathy and zinc deficiency by successive zinc depletion and supplementation regimens. Long-term zinc supplementation improved severe recurrent hepatic encephalopathy and therefore the quality of life.
journal_name
Gastroenterologyjournal_title
Gastroenterologyauthors
Van der Rijt CC,Schalm SW,Schat H,Foeken K,De Jong Gdoi
10.1016/0016-5085(91)90290-2subject
Has Abstractpub_date
1991-04-01 00:00:00pages
1114-8issue
4eissn
0016-5085issn
1528-0012pii
0016-5085(91)90290-2journal_volume
100pub_type
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