Role of extrinsic and intrinsic nerves in the relationship between intestinal motility and transmural potential difference in the anesthetized ferret.

abstract：:The purpose of these experiments was to determine the contribution of gastrin to the acid secretory response to eating in healthy human subjects. To simulate the gastric and intestinal phases of eating, a meal was homogenized and then infused into the stomach through a nasogastric tube. At the same time, the cephalic ...

journal_title：Gastroenterology

authors： Blair AJ 3rd,Richardson CT,Walsh JH,Feldman M

更新日期：1987-04-01 00:00:00

abstract：BACKGROUND & AIMS:IKBL gene lies telomeric of the tumor necrosis factor cluster in the central major histocompatibility complex and carries a structural polymorphism at position +738. In the Spanish white population, we found the IKBL+738(C) allele in haplotypes carrying either HLA-DRB1(*)1501 or -DRB1(*)0103. Because ...

journal_title：Gastroenterology

authors： de la Concha EG,Fernandez-Arquero M,Lopez-Nava G,Martin E,Allcock RJ,Conejero L,Paredes JG,Diaz-Rubio M

更新日期：2000-12-01 00:00:00

abstract：BACKGROUND:Active transport of conjugated bile acids by ileal enterocytes is a key mechanism for conservation of the bile acid pool. Experiments were performed to determine whether such transport is regulated by substrate load. METHODS:Using anesthetized biliary fistula guinea pigs or rats, the ileum was perfused with...

journal_title：Gastroenterology

authors： Lillienau J,Crombie DL,Munoz J,Longmire-Cook SJ,Hagey LR,Hofmann AF

更新日期：1993-01-01 00:00:00

abstract：BACKGROUND & AIMS:Liver disease has been associated with cardiovascular disorders, but little is known about the relationship between serum levels of alanine aminotransferase (ALT) and markers of atherogenesis. We investigated the relationship between low-normal and high-normal levels of ALT and an extended panel of ca...

journal_title：Gastroenterology

authors： Siddiqui MS,Sterling RK,Luketic VA,Puri P,Stravitz RT,Bouneva I,Boyett S,Fuchs M,Sargeant C,Warnick GR,Grami S,Sanyal AJ

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND:Nitric oxide acts as a neurotransmitter of nonadrenergic, noncholinergic pathways. The present study examined the role of the L-arginine/NO pathway on sphincter of Oddi motility. METHODS:In anesthetized guinea pigs and rabbits, intracholedochal pressure was recorded by a perfused catheter whose open tip was...

journal_title：Gastroenterology

authors： Mourelle M,Guarner F,Moncada S,Malagelada JR

更新日期：1993-11-01 00:00:00

abstract：:In dogs with gastric fistulas, intragastric pressure was measured with a flaccid ballon containing 500 ml of water. Graded doses of dopamine caused graded decreases in intragastric pressure. The effect was blocked by pimozide or by metoclopramide but was not significantly affected by phenoxybenzamine, propranolol, gua...

journal_title：Gastroenterology

authors： Valenzuela JE

更新日期：1976-12-01 00:00:00

abstract：:The effects of hypothalamic microinfusions of cholecystokinin octapeptide and its antagonist L364,718 on cecocolonic myoelectrical activity were evaluated by electromyography in fasted and fed rats. The rats were chronically fitted with electrodes implanted on the cecum and proximal colon and cannulas placed bilateral...

journal_title：Gastroenterology

authors： Liberge M,Arruebo MP,Bueno L

更新日期：1991-02-01 00:00:00

abstract：:The purpose of this American Gastroenterological Association (AGA) Institute Clinical Practice Update was to rapidly review the emerging evidence and provide timely expert recommendations regarding the management of patients with inflammatory bowel disease during the coronavirus disease 2019 pandemic. This expert comm...

journal_title：Gastroenterology

authors： Rubin DT,Feuerstein JD,Wang AY,Cohen RD

更新日期：2020-07-01 00:00:00

abstract：BACKGROUND & AIMS:Adenomatous polyps are by definition dysplastic and pathologically indistinguishable from the dysplasia-associated lesion or mass (DALM) described in 1981. Yet, adenomatous polyps in noncolitic colons are usually removed definitively endoscopically, whereas DALMs are regarded as harbingers of colon ca...

journal_title：Gastroenterology

authors： Rubin PH,Friedman S,Harpaz N,Goldstein E,Weiser J,Schiller J,Waye JD,Present DH

更新日期：1999-12-01 00:00:00

abstract：:A technique for the direct measurement of portal vein pressure in fully conscious patients is described. This uses a percutaneous transhepatic approach with a thin Chiba needle and is shown to be simple and safe. The technique has been applied to 123 patients with a variety of liver disorders and the pressure measurem...

journal_title：Gastroenterology

authors： Boyer TD,Triger DR,Horisawa M,Redeker AG,Reynolds TB

更新日期：1977-04-01 00:00:00

abstract：:Twenty-seven carriers of the hepatitis B surface antigen who underwent liver transplantation in Italy and Belgium for terminal Hepatitis delta virus (HDV) cirrhosis were investigated. In 22 of the patients, HDV infection recurred. Two patients died of coexisting HDV and hepatitis B virus (HBV) reactivation. Four patie...

journal_title：Gastroenterology

authors： Ottobrelli A,Marzano A,Smedile A,Recchia S,Salizzoni M,Cornu C,Lamy ME,Otte JB,De Hemptinne B,Geubel A

更新日期：1991-12-01 00:00:00

abstract：:Fluorescent periodic acid-Schiff reaction (FPR) was used in the study of the normal rabbit ileal epithelium and its changes after injection of living cultures or enterotoxins of enterotoxigenic Escherichia coli. This reaction, with the use of auramine OO-SO2 complex as a Schiff-type reagent, demonstrates gut epitheliu...

journal_title：Gastroenterology

authors： Khavkin TN,Kudryavtseva MV,Dragunskaya EM,Polotsky YE,Kudryavtsev BN

更新日期：1980-04-01 00:00:00

abstract：:Female monozygotic triplets all developed Crohn's disease within a period of 11 mo. The monozygosity was demonstrated by analysis of 24 genetic markers of different chromosomal localization. Crohn's disease was diagnosed using clinical, radiologic, and endoscopic findings. Histologic evaluation of bowel tissue was con...

journal_title：Gastroenterology

authors： Purrmann J,Bertrams J,Borchard F,Miller B,Cleveland S,Stolze T,Strohmeyer G

更新日期：1986-12-01 00:00:00

abstract：:In order to study the natural history of fundic gland polyposis, 23 patients with familial adenomatosis coli/Gardner's syndrome were examined over a follow-up period ranging from 17 mo to 13 yr (average 6 yr). Examinations included gastric radiography and endoscopy with biopsy. Fundic gland polyps were found in 10 ind...

journal_title：Gastroenterology

authors： Iida M,Yao T,Itoh H,Watanabe H,Kohrogi N,Shigematsu A,Iwashita A,Fujishima M

更新日期：1985-11-01 00:00:00

abstract：BACKGROUND & AIMS:Elevated hepatic iron concentration may affect the response to antiviral therapy in chronic hepatitis C. This study explored the contribution of genetic hemochromatosis to iron accumulation in chronic hepatitis C. METHODS:HFE mutations (C282Y and H63D) were assessed in 184 patients with chronic hepat...

journal_title：Gastroenterology

authors： Kazemi-Shirazi L,Datz C,Maier-Dobersberger T,Kaserer K,Hackl F,Polli C,Steindl PE,Penner E,Ferenci P

更新日期：1999-01-01 00:00:00

abstract：BACKGROUND & AIMS:Ground-glass (GG) inclusions within hepatocytes are an important histopathologic marker of chronic hepatitis B virus (HBV) infection but may also be seen in Lafora's disease (myoclonus epilepsy), cyanamide alcohol aversion therapy, and type IV glycogenosis. We have noted a recent increased incidence o...

journal_title：Gastroenterology

authors： Lefkowitch JH,Lobritto SJ,Brown RS Jr,Emond JC,Schilsky ML,Rosenthal LA,George DM,Cairo MS

更新日期：2006-09-01 00:00:00

abstract：BACKGROUND/AIMS:Familial adenomatous polyposis is caused by germline mutation of the adenomatous polyposis coli (APC) gene. Affected individuals develop hundreds of colorectal adenomas at young age and can have extracolonic lesions. METHODS:This study evaluated the phenotype of 74 patients with familial adenomatous po...

journal_title：Gastroenterology

authors： Giardiello FM,Krush AJ,Petersen GM,Booker SV,Kerr M,Tong LL,Hamilton SR

更新日期：1994-06-01 00:00:00

abstract：BACKGROUND AND AIMS:The peptidyl prolyl isomerase Pin1 frequently is overexpressed in hepatocellular carcinoma (HCC). Hepatitis B virus (HBV) is the most common etiologic agent in HCC, and its encoded X-protein (HBx) is oncogenic and possesses a serine-proline motif that may bind Pin1. The role of Pin1 in hepatocarcino...

journal_title：Gastroenterology

authors： Pang R,Lee TK,Poon RT,Fan ST,Wong KB,Kwong YL,Tse E

更新日期：2007-03-01 00:00:00

abstract：BACKGROUND & AIMS:The effects of trypsin on pancreatic ductal epithelial cells (PDECs) vary among species and depend on the localization of proteinase-activated receptor 2 (PAR-2). We compared PAR-2 localization in human and guinea-pig PDECs, and used isolated guinea pig ducts to study the effects of trypsin and a PAR-...

journal_title：Gastroenterology

authors： Pallagi P,Venglovecz V,Rakonczay Z Jr,Borka K,Korompay A,Ozsvári B,Judák L,Sahin-Tóth M,Geisz A,Schnúr A,Maléth J,Takács T,Gray MA,Argent BE,Mayerle J,Lerch MM,Wittmann T,Hegyi P

更新日期：2011-12-01 00:00:00

abstract：:The normal surface anatomy of rat hepatocytes, sinusoids, and bile canaliculi was examined by scanning electron microscopy following finger fracture of tissues that were perfused via the portal vein and fixed with 2.5% glutaraldehyde. These normal findings were contrasted with several models of cholestasis, including ...

journal_title：Gastroenterology

authors： Layden TJ,Schwarz,Boyer JL

更新日期：1975-09-01 00:00:00

abstract：BACKGROUND & AIMS:Gain-of-function mutations in the KIT receptor tyrosine kinase gene and rare mutations in the platelet-derived growth factor receptor alpha (PDGFRA) gene are important events in gastrointestinal stromal tumor (GIST) development. Different mutations are reportedly associated with distinctive phenotypes...

journal_title：Gastroenterology

authors： Andersson J,Bümming P,Meis-Kindblom JM,Sihto H,Nupponen N,Joensuu H,Odén A,Gustavsson B,Kindblom LG,Nilsson B

更新日期：2006-05-01 00:00:00

abstract：BACKGROUND & AIMS:Conflicting results have been published concerning the effects of different opioid-receptor agonists against visceral noxious stimulation. The introduction of colorectal distention facilitates research in this field. The aim of this study was to examine intrathecally administered opioid agonists again...

journal_title：Gastroenterology

authors： Borgbjerg FM,Frigast C,Madsen JB,Mikkelsen LF

更新日期：1996-01-01 00:00:00

abstract：BACKGROUND & AIMS:Iron overload may cause or contribute to hepatic injury and fibrosis. Mutations in the HFE gene may influence development or progression of chronic liver disease by increasing iron stores or modulating immune responses. The aim of this work was to assess the influence of HFE mutations and serum and he...

journal_title：Gastroenterology

authors： Bonkovsky HL,Naishadham D,Lambrecht RW,Chung RT,Hoefs JC,Nash SR,Rogers TE,Banner BF,Sterling RK,Donovan JA,Fontana RJ,Di Bisceglie AM,Ghany MG,Morishima C,HALT-C Trial Group.

更新日期：2006-11-01 00:00:00

abstract：BACKGROUND & AIMS:Both androgenic and estrogenic steroids have been implicated in the development and course of several liver diseases, including hepatocellular carcinoma. The aim of this study was to investigate temporal changes in hepatic estrogen and androgen receptors and hormone metabolism in a rat model of liver ...

journal_title：Gastroenterology

authors： Eagon PK,Elm MS,Epley MJ,Shinozuka H,Rao KN

更新日期：1996-04-01 00:00:00

abstract：BACKGROUND & AIMS:The cytokine macrophage migration inhibitory factor (MIF) is expressed throughout the human gastrointestinal tract. Recently, protumorigenic activity of MIF has been described in several cancer models. Therefore, we investigated the expression and function of MIF during the early stages of intestinal ...

journal_title：Gastroenterology

authors： Wilson JM,Coletta PL,Cuthbert RJ,Scott N,MacLennan K,Hawcroft G,Leng L,Lubetsky JB,Jin KK,Lolis E,Medina F,Brieva JA,Poulsom R,Markham AF,Bucala R,Hull MA

更新日期：2005-11-01 00:00:00

abstract：:Short-chain (C2-C5) fatty acids account for 60%-70% of the anions in the colon. Acetate (C2) is nontoxic in contrast to C(3)4-C5 fatty acids (propionate, butyrate, isobutyrate, valerate, and isovalerate), which induce coma in animals and may be important in the pathogenesis of hepatic coma in humans. An in-vitro fecal...

journal_title：Gastroenterology

authors： Mortensen PB,Holtug K,Bonnén H,Clausen MR

更新日期：1990-02-01 00:00:00

abstract：:Frequent occurrence of post-transfusion hepatitis continues despite screening for Australia antigen in blood before transfusion and elimination of commercial donor sources. The majority of these cases appears unrelated to hepatitis B virus. Preoperative, acute, and convalescent serra were screened for evidence of hepa...

journal_title：Gastroenterology

authors： Knodell RG,Conrad ME,Dienstag JL,Bell CJ

更新日期：1975-12-01 00:00:00

abstract：BACKGROUND & AIMS:Human primary liver cancer is classified into biologically distinct subgroups based on cellular origin. Liver cancer stem cells (CSCs) have been recently described. We investigated the ability of distinct lineages of hepatic cells to become liver CSCs and the phenotypic and genetic heterogeneity of pr...

journal_title：Gastroenterology

authors： Holczbauer Á,Factor VM,Andersen JB,Marquardt JU,Kleiner DE,Raggi C,Kitade M,Seo D,Akita H,Durkin ME,Thorgeirsson SS

更新日期：2013-07-01 00:00:00

abstract：:The anatomical extent of fiberoptic sigmoidoscopy was determined by placing a clip on the colonic mucosa and subsequently locating the clip on barium enema. A 60 cm exam viewed the entire sigmoid colon in 81% of patients. Exams of 50-55 cm, 40-45 cm, and 30-35 cm extent viewed the entire sigmoid colon in 68%, 27%, and...

journal_title：Gastroenterology

authors： Lehman GA,Buchner DM,Lappas JC

更新日期：1983-04-01 00:00:00

abstract：BACKGROUND & AIMS:Genetic and epigenetic alterations contribute to the pathogenesis of colorectal cancer (CRC). There is considerable molecular heterogeneity among colorectal tumors, which appears to arise as polyps progress to cancer. This heterogeneity results in different pathways to tumorigenesis. Although epigenet...

journal_title：Gastroenterology

authors： Luo Y,Wong CJ,Kaz AM,Dzieciatkowski S,Carter KT,Morris SM,Wang J,Willis JE,Makar KW,Ulrich CM,Lutterbaugh JD,Shrubsole MJ,Zheng W,Markowitz SD,Grady WM

更新日期：2014-08-01 00:00:00