Monozygotic triplets with Crohn's disease of the colon.

Abstract:

:Female monozygotic triplets all developed Crohn's disease within a period of 11 mo. The monozygosity was demonstrated by analysis of 24 genetic markers of different chromosomal localization. Crohn's disease was diagnosed using clinical, radiologic, and endoscopic findings. Histologic evaluation of bowel tissue was consistent with Crohn's disease. All 3 patients had colon involvement; the terminal ileum appeared normal. The patient in whom Crohn's disease was first diagnosed had the severest course. Our observations support the role of a genetic influence in the manifestation of Crohn's disease. Nevertheless, environmental factors or microorganisms, or both, have to be taken into account, perhaps as factors promoting the outbreak of Crohn's disease.

journal_name

Gastroenterology

journal_title

Gastroenterology

authors

Purrmann J,Bertrams J,Borchard F,Miller B,Cleveland S,Stolze T,Strohmeyer G

doi

10.1016/0016-5085(86)90215-5

subject

Has Abstract

pub_date

1986-12-01 00:00:00

pages

1553-9

issue

6

eissn

0016-5085

issn

1528-0012

pii

0016-5085(86)90215-5

journal_volume

91

pub_type

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