Abstract:
:Female monozygotic triplets all developed Crohn's disease within a period of 11 mo. The monozygosity was demonstrated by analysis of 24 genetic markers of different chromosomal localization. Crohn's disease was diagnosed using clinical, radiologic, and endoscopic findings. Histologic evaluation of bowel tissue was consistent with Crohn's disease. All 3 patients had colon involvement; the terminal ileum appeared normal. The patient in whom Crohn's disease was first diagnosed had the severest course. Our observations support the role of a genetic influence in the manifestation of Crohn's disease. Nevertheless, environmental factors or microorganisms, or both, have to be taken into account, perhaps as factors promoting the outbreak of Crohn's disease.
journal_name
Gastroenterologyjournal_title
Gastroenterologyauthors
Purrmann J,Bertrams J,Borchard F,Miller B,Cleveland S,Stolze T,Strohmeyer Gdoi
10.1016/0016-5085(86)90215-5subject
Has Abstractpub_date
1986-12-01 00:00:00pages
1553-9issue
6eissn
0016-5085issn
1528-0012pii
0016-5085(86)90215-5journal_volume
91pub_type
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