Trypsin reduces pancreatic ductal bicarbonate secretion by inhibiting CFTR Cl⁻ channels and luminal anion exchangers.

abstract：BACKGROUND & AIMS:Pancreatic cancers contain exclusively tumorigenic cancer stem cells (CSCs), which are highly resistant to chemotherapy, resulting in a relative increase in CSC numbers during gemcitabine treatment. Signaling through sonic hedgehog and mammalian target of rapamycin (mTOR), respectively, may be essenti...

journal_title：Gastroenterology

authors： Mueller MT,Hermann PC,Witthauer J,Rubio-Viqueira B,Leicht SF,Huber S,Ellwart JW,Mustafa M,Bartenstein P,D'Haese JG,Schoenberg MH,Berger F,Jauch KW,Hidalgo M,Heeschen C

更新日期：2009-09-01 00:00:00

abstract：BACKGROUND & AIMS:Patients with sphincter of Oddi dysfunction are at high risk of developing pancreatitis after endoscopic biliary sphincterotomy. Impaired pancreatic drainage caused by pancreatic sphincter hypertension is the likely explanation for this increased risk. A prospective, randomized controlled trial was co...

journal_title：Gastroenterology

authors： Tarnasky PR,Palesch YY,Cunningham JT,Mauldin PD,Cotton PB,Hawes RH

更新日期：1998-12-01 00:00:00

abstract：:Pancreatic blood flow and its relationship to pancreatic interstitial pressure were investigated in a model of chronic pancreatitis in cats using a hydrogen gas-clearance technique with an intraductal electrode. The intraductal technique correlated well with blood flow measurements made using gamma-labeled microsphere...

journal_title：Gastroenterology

authors： Reber HA,Karanjia ND,Alvarez C,Widdison AL,Leung FW,Ashley SW,Lutrin FJ

更新日期：1992-08-01 00:00:00

abstract：BACKGROUND & AIMS:Methylation of specific microRNAs (miRNAs) often occurs in an age-dependent manner, as a field defect in some instances, and may be an early event in colitis-associated carcinogenesis. We aimed to determine whether specific mRNA signature patterns (MIR1, MIR9, MIR124, MIR137, MIR34B/C) could be used t...

journal_title：Gastroenterology

authors： Toiyama Y,Okugawa Y,Tanaka K,Araki T,Uchida K,Hishida A,Uchino M,Ikeuchi H,Hirota S,Kusunoki M,Boland CR,Goel A

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND & AIMS:We performed a prospective, randomized, controlled study to compare the combination of esomeprazole and clopidogrel vs clopidogrel alone in preventing recurrent peptic ulcers in patients with atherosclerosis and a history of peptic ulcers. We also investigated the effects of esomeprazole on the antipl...

journal_title：Gastroenterology

authors： Hsu PI,Lai KH,Liu CP

更新日期：2011-03-01 00:00:00

abstract：BACKGROUND & AIMS:Beta-blockers are extensively used to prevent variceal bleeding in patients with large esophageal varices. It is not established if beta-blockers delay the growth of small varices. METHODS:A total of 161 patients with cirrhosis and small esophageal varices (F1 according to the classification of Beppu...

journal_title：Gastroenterology

authors： Merkel C,Marin R,Angeli P,Zanella P,Felder M,Bernardinello E,Cavallarin G,Bolognesi M,Donada C,Bellini B,Torboli P,Gatta A,Gruppo Triveneto per l'Ipertensione Portale.

更新日期：2004-08-01 00:00:00

abstract：:It has recently been shown that repeated large-volume paracentesis associated with intravenous albumin infusion is a rapid, effective, and safe therapy of ascites in cirrhosis. To investigate whether intravenous albumin infusion is necessary in the treatment of cirrhotics with large-volume paracentesis, 105 patients w...

journal_title：Gastroenterology

authors： Ginès P,Titó L,Arroyo V,Planas R,Panés J,Viver J,Torres M,Humbert P,Rimola A,Llach J

更新日期：1988-06-01 00:00:00

abstract：BACKGROUND & AIMS:Acute-on-chronic liver failure (ACLF) develops in patients with chronic liver disease and has high mortality. Mobilization of bone marrow-derived stem cells with granulocyte colony-stimulating factor (G-CSF) could promote hepatic regeneration. METHODS:Consecutive patients with ACLF were randomly assi...

journal_title：Gastroenterology

authors： Garg V,Garg H,Khan A,Trehanpati N,Kumar A,Sharma BC,Sakhuja P,Sarin SK

更新日期：2012-03-01 00:00:00

abstract：:One hundred Chinese patients who received induction cytotoxic therapy for malignant lymphoma were prospectively studied to determine the incidence, morbidity, mortality, and predisposing factors for reactivation of hepatitis B virus replication during cytotoxic therapy. In 18 (67%) hepatitis B surface antigen-positive...

journal_title：Gastroenterology

authors： Lok AS,Liang RH,Chiu EK,Wong KL,Chan TK,Todd D

更新日期：1991-01-01 00:00:00

abstract：:Three analogues of the carboxyl-terminal tricosapeptide of secretin (S5-27), one with glutamine replacing glutamic acid in position 9 (9-Gln-S5-27), a second with asparagine substituted for aspartic acid in position 15 (15-Asn-S5-27), and a third with both replacements (9-Gln-15-Asn-S5-27) were tested for their abilit...

journal_title：Gastroenterology

authors： Gardner JD,Conlon TP,Fink ML,Bodanszky M

更新日期：1976-12-01 00:00:00

abstract：BACKGROUND & AIMS:The US Medicare indications for intestinal transplantation are based on failure of home parenteral nutrition. The American Society of Transplantation also includes patients at high risk of death from their primary disease or with high morbidity intestinal failure. A 3-year prospective study evaluated ...

journal_title：Gastroenterology

authors： Pironi L,Forbes A,Joly F,Colomb V,Lyszkowska M,Van Gossum A,Baxter J,Thul P,Hébuterne X,Gambarara M,Gottrand F,Moreno Villares JM,Messing B,Goulet O,Staun M,Home Artificial Nutrition Working Group of the European Society fo

更新日期：2008-07-01 00:00:00

abstract：:The goal of this study was to identify the structural and compositional features of human gallstones that influence in vitro gallstone dissolution in the cholesterol solvent monooctanoin. Gallstones were obtained from 86 consecutive patients who had at least three morphologically similar stones. One stone from each pa...

journal_title：Gastroenterology

authors： Smith BF

更新日期：1987-07-01 00:00:00

abstract：BACKGROUND & AIMS:There is growing interest in the use of bone marrow cells to treat liver fibrosis, however, little is known about their antifibrotic efficacy or the identity of their effector cell(s). Sphingosine-1-phosphate (S1P) mediates egress of immune cells from the lymphoid organs into the lymphatic vessels; we...

journal_title：Gastroenterology

authors： King A,Houlihan DD,Kavanagh D,Haldar D,Luu N,Owen A,Suresh S,Than NN,Reynolds G,Penny J,Sumption H,Ramachandran P,Henderson NC,Kalia N,Frampton J,Adams DH,Newsome PN

更新日期：2017-07-01 00:00:00

abstract：BACKGROUND & AIMS:Helicobacter pylori attaches to mucin oligosaccharides that are expressed on host gastric epithelium. We used the rhesus macaque model to characterize the effect of H. pylori infection on gastric mucin oligosaccharides during acute and chronic infection. METHODS:Specific pathogen (H. pylori)-free rhe...

journal_title：Gastroenterology

authors： Cooke CL,An HJ,Kim J,Canfield DR,Torres J,Lebrilla CB,Solnick JV

更新日期：2009-09-01 00:00:00

abstract：:We investigated the ability of isolated human colonic epithelial cells to express the common acute lymphoblastic leukemia antigen (CALLA), the transferrin receptor, and the 4F2 antigen in response to different types of stimuli. The expression of these markers was assessed by immunofluorescence using monoclonal antibod...

journal_title：Gastroenterology

authors： Fais S,Pallone F

更新日期：1989-12-01 00:00:00

abstract：BACKGROUND & AIMS:Tumor necrosis factor alpha (TNF-alpha) release plays a pivotal role in the pathogenesis of liver injury induced by lipopolysaccharide (LPS) administration in D-galactosamine (GalN)-sensitized mice. Interleukin (IL) 10 is an anti-inflammatory cytokine that inhibits TNF-alpha synthesis and release both...

journal_title：Gastroenterology

authors： Santucci L,Fiorucci S,Chiorean M,Brunori PM,Di Matteo FM,Sidoni A,Migliorati G,Morelli A

更新日期：1996-09-01 00:00:00

abstract：BACKGROUND & AIMS:Despite many advances in our understanding of Crohn's disease, the course of the disease in any given patient remains unpredictable. There is little agreement as to which factors increase a patient's risk of early postoperative recurrence. We have attempted to identify predictors of early recurrence a...

journal_title：Gastroenterology

authors： Lautenbach E,Berlin JA,Lichtenstein GR

更新日期：1998-08-01 00:00:00

abstract：:Absorptive cells of the small intestine are highly polarized cells with distinct microvillus membrane (MVM) and basolateral plasma membrane domains. We compared membrane structure in the following preparations of rat small intestine commonly used for in vitro study of MVM function: epithelial sheets, isolated epitheli...

journal_title：Gastroenterology

authors： Bjorkman DJ,Allan CH,Hagen SJ,Trier JS

更新日期：1986-12-01 00:00:00

abstract：:Because the esophagus is easily accessible with endoscopy, early diagnosis and curative treatment of esophageal cancer is possible. However, diagnosis is often delayed because symptoms are not specific during early stages of tumor development. The onset of dysphagia is associated with advanced disease, which has a sur...

journal_title：Gastroenterology

authors： di Pietro M,Canto MI,Fitzgerald RC

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND & AIMS:No controlled trial has examined the clinical efficacy of antibiotics in small bowel bacterial overgrowth. METHODS:Ten patients with bacterial overgrowth-related diarrhea underwent the following five 7-day treatment periods: untreated (control period), then placebo, and subsequently, in random order ...

journal_title：Gastroenterology

authors： Attar A,Flourié B,Rambaud JC,Franchisseur C,Ruszniewski P,Bouhnik Y

更新日期：1999-10-01 00:00:00

abstract：:In ilea of spontaneously infested guinea pigs, we examined the interface between the plasma membranes of cryptosporidia and absorptive cells using thin section and freeze fracture techniques. Initially, cryptosporidia invaginate microvilli, and the resulting redundant folds of membrane envelop the protozoan, thereby i...

journal_title：Gastroenterology

authors： Marcial MA,Madara JL

更新日期：1986-03-01 00:00:00

abstract：BACKGROUND & AIMS:Metaplasias often have characteristics of developmentally related tissues. Pancreatic metaplastic ducts are usually associated with pancreatitis and pancreatic ductal adenocarcinoma. The tuft cell is a chemosensory cell that responds to signals in the extracellular environment via effector molecules. ...

journal_title：Gastroenterology

authors： Delgiorno KE,Hall JC,Takeuchi KK,Pan FC,Halbrook CJ,Washington MK,Olive KP,Spence JR,Sipos B,Wright CV,Wells JM,Crawford HC

更新日期：2014-01-01 00:00:00

abstract：:Antral ulcers were produced in unanesthetized rats in 3 hr by simultaneous intravenous administration of acetylsalicylic acid (ASA) and gastric perfusion with 0.15 M HCl. Intravenous infusion of ASA alone or gastric perfusion with HCl alone produced no antral ulcers. Plasma salicylate levels ranged from 250 to 350 mic...

journal_title：Gastroenterology

authors： Kauffman GL Jr,Grossman MI

更新日期：1978-12-01 00:00:00

abstract：BACKGROUND & AIMS:Biliary epithelial cells are the target of numerous immune-mediated liver diseases, yet their role in pathogenesis remains unclear because of difficulties in obtaining pure preparations. The aim of this study was to establish pure clones of immortalized murine intrahepatic biliary epithelial cells. M...

journal_title：Gastroenterology

authors： Paradis K,Le ON,Russo P,St-Cyr M,Fournier H,Bu D

更新日期：1995-10-01 00:00:00

abstract：:Biofeedback has been advocated as first-line therapy for patients whose symptoms of mild to moderate fecal incontinence have not responded to simple dietary advice or medication. Three main modalities have been described: (1) use of an intra-anal electromyographic sensor, a probe to measure intra-anal pressure, or per...

journal_title：Gastroenterology

authors： Norton C

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND & AIMS:Probiotics can reduce symptoms of irritable bowel syndrome (IBS), but little is known about their effects on psychiatric comorbidities. We performed a prospective study to evaluate the effects of Bifidobacterium longum NCC3001 (BL) on anxiety and depression in patients with IBS. METHODS:We performed ...

journal_title：Gastroenterology

authors： Pinto-Sanchez MI,Hall GB,Ghajar K,Nardelli A,Bolino C,Lau JT,Martin FP,Cominetti O,Welsh C,Rieder A,Traynor J,Gregory C,De Palma G,Pigrau M,Ford AC,Macri J,Berger B,Bergonzelli G,Surette MG,Collins SM,Moayyedi P,

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND & AIMS:Upon liver injury in which hepatocyte proliferation is compromised, liver progenitor cells (LPCs), derived from biliary epithelial cells (BECs), differentiate into hepatocytes. Little is known about the mechanisms of LPC differentiation. We used zebrafish and mouse models of liver injury to study the ...

journal_title：Gastroenterology

authors： Ko S,Russell JO,Tian J,Gao C,Kobayashi M,Feng R,Yuan X,Shao C,Ding H,Poddar M,Singh S,Locker J,Weng HL,Monga SP,Shin D

更新日期：2019-01-01 00:00:00

abstract：:Pentane, a volatile hydrocarbon, is cleared from inspired air by the rat. We have studied this clearance to learn whether or not it is a function of the liver. Rats were put individually into airtight chambers which contained CO2 absorbent and were connected to an O2 reservoir. Pentane was injected into each chamber a...

journal_title：Gastroenterology

authors： Burk RJ,Ludden TM,Lane JM

更新日期：1983-01-01 00:00:00

abstract：BACKGROUND/AIMS:The gastric mucosa is covered by a continuous layer of bicarbonate-containing mucus gel; the question arises how acid, formed in the gastric glands, moves into the lumen. METHODS:The pH in the gastric mucus gel and gel thickness were measured in anesthetized rats with pH-sensitive microelectrodes (tip ...

journal_title：Gastroenterology

authors： Schade C,Flemström G,Holm L

更新日期：1994-07-01 00:00:00

abstract：BACKGROUND & AIMS:Helicobacter pylori infection causes inflammation, accumulation of reactive oxygen species, and oxidative DNA damage in the gastric mucosa. Apurinic/apyrimidinic endonuclease-1 (APE-1)/redox factor-1 (Ref-1) repairs damaged DNA and reductively activates transcription factors, including activator prote...

journal_title：Gastroenterology

authors： Ding SZ,O'Hara AM,Denning TL,Dirden-Kramer B,Mifflin RC,Reyes VE,Ryan KA,Elliott SN,Izumi T,Boldogh I,Mitra S,Ernst PB,Crowe SE

更新日期：2004-09-01 00:00:00