Abstract：
:The purpose of these experiments was to determine the contribution of gastrin to the acid secretory response to eating in healthy human subjects. To simulate the gastric and intestinal phases of eating, a meal was homogenized and then infused into the stomach through a nasogastric tube. At the same time, the cephalic phase of acid secretion was activated by sham feeding. With this simulated meal, mean serum gastrin concentration increased from a basal value of 43 +/- 9 pg/ml to an average postprandial gastrin concentration over 2 h of 121 +/- 25 pg/ml. Gastrin release after this simulated meal was similar to gastrin release after a normally eaten meal in the same 12 subjects. Gastric acid secretion in response to the simulated meal, which was measured by in vivo intragastric titration, averaged 24.2 +/- 2.4 mmol/h. To determine how much of this postprandial acid secretion could be attributed to gastrin, gastrin 17 I was infused intravenously in the same subjects on a separate day and acid secretion and serum gastrin concentrations were measured. By relating serum gastrin concentration during gastrin 17 infusion to concomitant acid secretion, we determined that an average postprandial serum gastrin concentration of 121 pg/ml could result in an acid secretion rate of 21.5 mmol/h, 89% of the actual acid secreted after the simulated meal in these subjects. However, in individual subjects, the amount of gastrin released after a meal could produce as little as 51% or as much as 162% of actual postprandial acid secretion. Thus, in individual human subjects the contribution of gastrin to acid secretion after a meal is variable.
journal_name
Gastroenterologyjournal_title
Gastroenterologyauthors
Blair AJ 3rd,Richardson CT,Walsh JH,Feldman Mdoi
10.1016/0016-5085(87)90968-1subject
Has Abstractpub_date
1987-04-01 00:00:00pages
944-9issue
4eissn
0016-5085issn
1528-0012pii
0016-5085(87)90968-1journal_volume
92pub_type
杂志文章相关文献
GASTROENTEROLOGY文献大全abstract：:A bile fistula patient was administered intravenously a constant infusion of [3H]mevalonic acid for 4 hrs, and then after 2 weeks he was given a pulse of [3H]mevalonic acid. Bile and blood were collected at frequent intervals. The specific activity-time course curves did not show a precursor-product relationship betwe...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：
更新日期：1975-12-01 00:00:00
abstract：:Monocytopoietic proliferation activity was determined in 8 patients during severe attacks of Crohn's disease and in 6 patients with ulcerative colitis. Similar results were obtained in both groups of patients. A moderate but significant hyperproliferation of monocytopoiesis was found to be present in about half of the...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：
更新日期：1978-03-01 00:00:00
abstract：:Ethanol (10 or 15% in the drinking water) was found to increase the amount of collagen in the livers of rats receiving a cirrhogenic diet. This effect of ethanol was most striking in the animals receiving 10% ethanol. Ethanol lowered the amount of labeled proline incorporated into hydroxyproline and, therefore, into c...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：
更新日期：1977-03-01 00:00:00
abstract：BACKGROUND & AIMS:Abdominal pain is the main symptom in patients with irritable bowel syndrome (IBS). Glycerol is an irritant of colonic mucosa. The aim of this study was to evaluate the effects of an intraluminal injection of glycerol on colonic motility and tone in patients with IBS and their modulation by drugs. ME...
journal_title：Gastroenterology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1053/gast.1996.v110.pm8566580
更新日期：1996-02-01 00:00:00
abstract：:Fifteen (2.2%) of 693 patients with cystic fibrosis seen over an 18-year period developed clinical hepatic disease. In 13 patients all symptoms were secondary to portal hypertension. Ten had hypersplenism and 6 had variceal bleeding, including 3 who developed both conditions. All 5 patients who survived the initial ep...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：
更新日期：1976-05-01 00:00:00
abstract：BACKGROUND & AIMS:Estimates of complication rates following elective percutaneous liver biopsy vary and might not accurately reflect current practice. We studied mortality and complication rates, by indication, in patients after they underwent liver biopsies. METHODS:We performed a study using hospital episode statist...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/j.gastro.2010.06.015
更新日期：2010-10-01 00:00:00
abstract：BACKGROUND & AIMS:Modulation of the host innate immune response is an attractive means of inhibiting hepatitis C virus (HCV) replication. Having previously determined that expression of the interferon-sensitive gene (ISG)15 protease USP18 is increased in the liver biopsy specimens of patients who do not respond to inte...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/j.gastro.2006.08.043
更新日期：2006-11-01 00:00:00
abstract：:Nonalcoholic fatty liver disease (NAFLD) is one of the main chronic noncommunicable diseases in Westernized societies; its worldwide prevalence has doubled during the last 20 years. NAFLD has serious health implications not only for adults, but also for children. However, pediatric NAFLD is not only an important globa...
journal_title：Gastroenterology
pub_type： 杂志文章,评审
doi：10.1053/j.gastro.2016.03.009
更新日期：2016-06-01 00:00:00
abstract：BACKGROUND & AIMS:Protein kinase C (PKC) has been implicated as a mediator of growth control during colorectal carcinogenesis, but the mechanisms involved are still a matter of dispute. The aim of this study was to analyze PKC patterns and tissue distribution to gain further insight in PKC function during tumor develop...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/gast.1996.v110.pm8964400
更新日期：1996-06-01 00:00:00
abstract：BACKGROUND & AIMS:A Western-style diet, which is high in fat and sugar, can cause significant dyslipidemia and nonalcoholic fatty liver disease; the diet has an especially strong effect in women, regardless of total calorie intake. Dietary supplementation with beneficial microbes might reduce the detrimental effects of...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/j.gastro.2020.03.010
更新日期：2020-08-01 00:00:00
abstract：:Modern manometric and scintigraphic techniques were employed in an effort to determine the relationships between esophageal contractions and esophageal transit and clearance. The effects of direct cholinergic stimulation with bethanechol and blockade with atropine were evaluated in a total of 20 normal subjects and 13...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：
更新日期：1981-11-01 00:00:00
abstract：BACKGROUND & AIMS:In patients with limited life expectancy, the risks of colorectal cancer screening may outweigh the benefits. The aim of this study was to quantify risks and benefits of different screening strategies in elderly patients with varying life expectancies. METHODS:We examined risks and benefits of screen...
journal_title：Gastroenterology
pub_type： 评论,杂志文章
doi：10.1053/j.gastro.2005.07.027
更新日期：2005-10-01 00:00:00
abstract：BACKGROUND & AIMS:We have shown that addition of gum arabic (GA) to a 90 mmol/L sodium-111 mmol/L glucose oral rehydration solution (ORS) enhances its effectiveness for water and electrolyte absorption in normal rats. The present study extends these observations on GA in ORS to two rat models of diarrheal disease. MET...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/gast.1997.v112.pm9178690
更新日期：1997-06-01 00:00:00
abstract：:The effect of secretin5-27 and four substituted analogues (9 Gln-secretin5-27, 15-Asn-secretin5-27, 9-Gln-15-Asn-secretin5-27, and 15-Lys-secretin5-27) on pancreatic secretion in the rat and guinea pig was examined. Secretin5-27 retained significant pancreatic secretory activity in both species. Its efficacy (intrinsi...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：
更新日期：1978-08-01 00:00:00
abstract：:Epithelial renewal of the small intestine was measured in the Syrian hamster utilizing tritiated thymidine by standard autoradiographic and a scintillation counting technique. Scintillation counting of intestinal replicates proved to be as accurate as standard autoradiography. Average mucosal cell turnover was 71 +/- ...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：
更新日期：1978-10-01 00:00:00
abstract：:For decades, interactions between the enteric neuromuscular apparatus and the central nervous system have served as the primary focus of pathophysiological research in the functional gastrointestinal disorders. The accumulation of patient reports, as well as clinical observations, has belatedly led to an interest in t...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/j.gastro.2016.02.028
更新日期：2016-02-18 00:00:00
abstract：:The prospect of a significant increase in global health-related costs associated with high cardiometabolic complications of obesity in Asians has encouraged more attention to be focused on the problem of growing obesity prevalence in these populations. Although these studies have shown that cardiometabolic complicatio...
journal_title：Gastroenterology
pub_type： 杂志文章,评审
doi：10.1053/j.gastro.2017.01.046
更新日期：2017-05-01 00:00:00
abstract：BACKGROUND & AIMS:In colorectal adenoma and carcinoma, glutathione S-transferase-pi (GSTP1-1) is highly expressed. K-ras mutation is also known to occur frequently in colorectal adenoma and carcinoma, as well as in the putative precursor of adenoma, aberrant crypt foci (ACF). Further, forced expression of v-H-ras in ra...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/gast.2001.27982
更新日期：2001-10-01 00:00:00
abstract：:The clinical, endoscopic, histologic, manometric, and esophageal potential difference characteristics of 20 patients with columnar epithelia lining the lower esophagus (Barrett's esophagus) are presented. Endoscopically, two distinct types were identified: a circumferential-type and an island-type Barrett's esophagus....
journal_title：Gastroenterology
pub_type： 杂志文章
doi：
更新日期：1984-03-01 00:00:00
abstract：:The role of lipoxygenase metabolites in ethanol-induced gastric mucosal injury and submucosal microvascular change in the rat was studied by in vivo microscopy. Intragastric ethanol-instillation caused marked submucosal venular constriction, dilatation of small arterioles, and corpus mucosal gross lesion formation. Th...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/0016-5085(89)90065-6
更新日期：1989-08-01 00:00:00
abstract：BACKGROUND & AIMS:Quantitative neurophysiological studies have identified the presence of at least 2 spinal neuronal populations (abrupt and sustained) that are excited by the noxious visceral stimulus colorectal distention. This study examined the effects of the kappa opioid receptor agonists fedotozine and U50488H on...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/gast.1999.0029900388
更新日期：1999-08-01 00:00:00
abstract：BACKGROUND & AIMS:We have reported that contrast echocardiography is a sensitive screening test for the hepatopulmonary syndrome (HPS). However, contrast echocardiography lacks specificity because many cirrhotic patients have positive study results with normal arterial blood gases and therefore do not fulfill criteria ...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/s0016-5085(98)70481-0
更新日期：1998-02-01 00:00:00
abstract：BACKGROUND & AIMS:Galectins are beta-galactoside-binding proteins possibly involved in tumor progression. The aim of this study was to determine the pattern of galectin 3 and galectin 1 expression and involvement in colorectal cancer progression. METHODS:Galectin 3 expression was examined immunohistochemically in 39 s...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/s0016-5085(97)70010-6
更新日期：1997-12-01 00:00:00
abstract：:The effects of pancreatic duct ligation on the digestion and absorption of a randomly 14C-labeled protein meal has been investigated in the rat. Although there was a significant reduction in luminal digestion and absorption of the protein meal in the pancreatic duct-ligated animals compared with controls, 37% of admin...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：
更新日期：1978-06-01 00:00:00
abstract：:Six patients (4 women, 2 men) with malignant gastrinoma developed multiple bone metastases; osteolytic as well as osteoblastic lesions occurred. All lesions involved the central skeleton, most caused symptoms, and, in 2 cases, there was associated hypercalcemia with normal serum parathormone levels. Poor responses wer...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/s0016-5085(86)80014-2
更新日期：1986-11-01 00:00:00
abstract：:In neurogenic fecal incontinence there is denervation of the external anal sphincter and pelvic floor muscles but the role of the internal anal sphincter is incompletely understood. We have evaluated the internal anal sphincter in 6 patients with neurogenic incontinence undergoing postanal repair and in 7 control subj...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/0016-5085(88)90175-8
更新日期：1988-10-01 00:00:00
abstract：:Aminopeptidase M (APM) was localized in the kidney and alimentary tract of guinea pigs and rats by indirect immunohistochemistry. APM was detected in the brush border of the epithelium of the proximal convoluted tubule of the kidney and of the small intestine, and it was localized to cells scattered throughout lymphoi...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/0016-5085(92)90307-k
更新日期：1992-06-01 00:00:00
abstract：:This literature review and the recommendations therein were prepared for the American Gastroenterological Association Clinical Practice and Practice Economics committee. The paper was approved by the committee on May 16, 1999, and by the AGA governing board on July 18, 1999. ...
journal_title：Gastroenterology
pub_type： 杂志文章,评审
doi：10.1016/s0016-5085(00)70430-6
更新日期：2000-01-01 00:00:00
abstract：:Intramural pH of the gastric mucosa was measured using a microelectrode technique in rabbit gastric pouches under different secretory conditions and luminal acidity. Exposure of spontaneously secreting or metiamide-treated fundic pouches to a relatively high concentration of luminal acid. HCl 120 mM, for 60 min, led ...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：
更新日期：1978-10-01 00:00:00
abstract：:Colchicine can induce the malabsorption of vitamin B12 and other nutrients. Previous investigations have suggested but not proved that this malabsorption was due to a lesion in the ileal mucosa. Employing the receptor assay of M. Katz and B. A. Cooper (J Clin Invest 54:733-739, 1974), the authors have observed a dose-...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：
更新日期：1979-02-01 00:00:00
