Kappa opioid receptor agonists differentially inhibit two classes of rat spinal neurons excited by colorectal distention.

abstract：BACKGROUND & AIMS:The effects of trypsin on pancreatic ductal epithelial cells (PDECs) vary among species and depend on the localization of proteinase-activated receptor 2 (PAR-2). We compared PAR-2 localization in human and guinea-pig PDECs, and used isolated guinea pig ducts to study the effects of trypsin and a PAR-...

journal_title：Gastroenterology

authors： Pallagi P,Venglovecz V,Rakonczay Z Jr,Borka K,Korompay A,Ozsvári B,Judák L,Sahin-Tóth M,Geisz A,Schnúr A,Maléth J,Takács T,Gray MA,Argent BE,Mayerle J,Lerch MM,Wittmann T,Hegyi P

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND & AIMS:Colorectal cancer screening with diagnostic imaging can detect polyps. The management of patients whose largest polyp is less than 10 mm is uncertain. The primary aim of this study was to determine rates of advanced histology in patients undergoing colorectal cancer screening whose largest polyp is 9 ...

journal_title：Gastroenterology

authors： Lieberman D,Moravec M,Holub J,Michaels L,Eisen G

更新日期：2008-10-01 00:00:00

abstract：:We have developed an isolated intestinal cell system to study the regulation of cholecystokinin release. Enzymatically dispersed canine jejunal mucosal cells were separated by counterflow elutriation to enrich cholecystokinin content 20-fold. Release of cholecystokinin from freshly isolated cells was determined by rad...

journal_title：Gastroenterology

authors： Barber DL,Walsh JH,Soll AH

更新日期：1986-09-01 00:00:00

abstract：:In this review, we compared the outcome of 25 studies of experimentally induced pancreatitis in animals with 13 studies of human acute pancreatitis in which the same therapeutic agents were used (aprotinin, glucagon, 5-fluorouracil, somatostatin, peritoneal lavage). Whereas 81% of the animal studies had a positive out...

journal_title：Gastroenterology

authors： Steinberg WM,Schlesselman SE

更新日期：1987-12-01 00:00:00

abstract：:We have previously shown that in pregnancy fasting gallbladder volume is increased and emptying after a small volume liquid meal is incomplete. In this study we measured gallbladder volume throughout day and night in healthy women ingesting regular meals. Pregnant women, postpartum women, contraceptive-steroid users, ...

journal_title：Gastroenterology

authors： Everson GT,McKinley C,Lawson M,Johnson M,Kern F Jr

更新日期：1982-04-01 00:00:00

abstract：BACKGROUND & AIMS:The activation of Wnt/beta-catenin signaling causes the development of gastric and colon cancers. Sox17 represses Wnt/beta-catenin signaling and is down-regulated in colon cancer. This study was designed to elucidate the role of Sox17 during the course of gastrointestinal tumorigenesis. METHODS:Sox17...

journal_title：Gastroenterology

authors： Du YC,Oshima H,Oguma K,Kitamura T,Itadani H,Fujimura T,Piao YS,Yoshimoto T,Minamoto T,Kotani H,Taketo MM,Oshima M

更新日期：2009-10-01 00:00:00

abstract：BACKGROUND & AIMS:Fish is a rich source of n-3 polyunsaturated fatty acids (PUFAs), such as eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA), and docosahexaenoic acid (DHA). Although consumption of fish and n-3 PUFA has been reported to protect against the development of some types of cancer, little is known ab...

journal_title：Gastroenterology

authors： Sawada N,Inoue M,Iwasaki M,Sasazuki S,Shimazu T,Yamaji T,Takachi R,Tanaka Y,Mizokami M,Tsugane S,Japan Public Health Center-Based Prospective Study Group.

更新日期：2012-06-01 00:00:00

abstract：BACKGROUND & AIMS:The mechanisms for tissue regeneration and renewal after acute pancreatitis are not well understood but may involve activation of Notch signaling. To study the effect of Notch signaling ablation during acute experimental pancreatitis, we used a chemical and genetic approach to ablate Notch signaling i...

journal_title：Gastroenterology

authors： Siveke JT,Lubeseder-Martellato C,Lee M,Mazur PK,Nakhai H,Radtke F,Schmid RM

更新日期：2008-02-01 00:00:00

abstract：BACKGROUND & AIMS:Gastric emptying plays an important role in regulating food intake. This study was designed to investigate whether intraperitoneally injected urocortin reduces gastric emptying, feeding, and body weight in lean and ob/ob obese mice. METHODS:Food intake and body weight were measured after intraperiton...

journal_title：Gastroenterology

authors： Asakawa A,Inui A,Ueno N,Makino S,Fujino MA,Kasuga M

更新日期：1999-06-01 00:00:00

abstract：BACKGROUND & AIMS:CD8(+) T cells that produce interleukin (IL)-17 (Tc17 cells) promote inflammation and have been identified in tumors. We investigated their role in the pathogenesis of gastric cancer. METHODS:We used flow cytometry analyses to determine levels and phenotype of Tc17 cells in blood and tumor samples fr...

journal_title：Gastroenterology

authors： Zhuang Y,Peng LS,Zhao YL,Shi Y,Mao XH,Chen W,Pang KC,Liu XF,Liu T,Zhang JY,Zeng H,Liu KY,Guo G,Tong WD,Shi Y,Tang B,Li N,Yu S,Luo P,Zhang WJ,Lu DS,Yu PW,Zou QM

更新日期：2012-10-01 00:00:00

abstract：BACKGROUND & AIMS:Therapies for perianal fistulas in patients with Crohn's disease are often ineffective in producing long-term healing. We performed a randomized placebo-controlled trial to determine the long-term efficacy and safety of a single local administration of allogeneic expanded adipose-derived stem cells (C...

journal_title：Gastroenterology

authors： Panés J,García-Olmo D,Van Assche G,Colombel JF,Reinisch W,Baumgart DC,Dignass A,Nachury M,Ferrante M,Kazemi-Shirazi L,Grimaud JC,de la Portilla F,Goldin E,Richard MP,Diez MC,Tagarro I,Leselbaum A,Danese S,ADMIRE CD St

更新日期：2018-04-01 00:00:00

abstract：BACKGROUND & AIMS:Patients with Barrett's esophagus (BE) have a risk of esophageal adenocarcinoma of approximately 0.5% per year. Patients may have difficulty understanding this risk. This study assessed the perceived risk of cancer in patients with BE, and correlated their risk estimates with their health care use beh...

journal_title：Gastroenterology

authors： Shaheen NJ,Green B,Medapalli RK,Mitchell KL,Wei JT,Schmitz SM,West LM,Brown A,Noble M,Sultan S,Provenzale D

更新日期：2005-08-01 00:00:00

abstract：BACKGROUND & AIMS:A Western-style diet, which is high in fat and sugar, can cause significant dyslipidemia and nonalcoholic fatty liver disease; the diet has an especially strong effect in women, regardless of total calorie intake. Dietary supplementation with beneficial microbes might reduce the detrimental effects of...

journal_title：Gastroenterology

authors： Naudin CR,Maner-Smith K,Owens JA,Wynn GM,Robinson BS,Matthews JD,Reedy AR,Luo L,Wolfarth AA,Darby TM,Ortlund EA,Jones RM

更新日期：2020-08-01 00:00:00

abstract：:A patient who developed symptomatic giardiasis after a tour of the Soviet Union is presented. The diagnosis was established by duodenal aspiration. A small intestinal biopsy revealed total villous atrophy in the absence of celiac sprue or a gastrointestinal immunodeficiency syndrome, a finding not previously described...

journal_title：Gastroenterology

authors： Levinson JD,Nastro LJ

更新日期：1978-02-01 00:00:00

abstract：BACKGROUND & AIMS:Host cell lipid rafts form a scaffold required for replication of hepatitis C virus (HCV). Serine palmitoyltransferases (SPTs) produce sphingolipids, which are essential components of the lipid rafts that associate with HCV nonstructural proteins. Prevention of the de novo synthesis of sphingolipids b...

journal_title：Gastroenterology

authors： Katsume A,Tokunaga Y,Hirata Y,Munakata T,Saito M,Hayashi H,Okamoto K,Ohmori Y,Kusanagi I,Fujiwara S,Tsukuda T,Aoki Y,Klumpp K,Tsukiyama-Kohara K,El-Gohary A,Sudoh M,Kohara M

更新日期：2013-10-01 00:00:00

abstract：BACKGROUND & AIMS:Lactase-phlorizin hydrolase (LPH) is an intestinal microvillus membrane glycoprotein that hydrolyzes lactose and phlorizin. These enzymatic activities have been assigned to glutamic acid (E) residues 1271 and 1747 in rabbit LPH. The aim of this study was to determine directly if this assignment was co...

journal_title：Gastroenterology

authors： Neele AM,Einerhand AW,Dekker J,Büller HA,Freund JN,Verhave M,Grand RJ,Montgomery RK

更新日期：1995-10-01 00:00:00

abstract：BACKGROUND & AIMS:Cellular and molecular mechanisms of esophageal ulcer healing remain unexplored. We studied the sequential cellular events and the expression of keratinocyte growth factor (KGF) and its receptor (KGF-R) during the healing of experimental esophageal ulcers. METHODS:Esophageal ulcers were produced in r...

journal_title：Gastroenterology

authors： Baatar D,Kawanaka H,Szabo IL,Pai R,Jones MK,Kitano S,Tarnawski AS

更新日期：2002-02-01 00:00:00

abstract：:We investigated the possibility that monocyte suppressor cells play a role in the peripheral lymphocyte hyporesponsiveness of chronic liver disease by utilizing assays of monocyte-mediated suppressor activity in 46 patients with chronic liver disease and 46 controls. The percent change achieved by the addition of indo...

journal_title：Gastroenterology

authors： Holdstock G,Chastenay BF,Krawitt EL

更新日期：1982-02-01 00:00:00

abstract：:In the TMC435-C101 study, 6 patients infected with hepatitis C virus genotype 1 were treated with the protease inhibitor TMC435 (200 mg once daily) as monotherapy for 5 days. Approximately 1.5 years later, 5 of these patients were re-treated with TMC435 (200 mg once daily) plus pegylated interferon alfa-2a and ribavir...

journal_title：Gastroenterology

authors： Lenz O,de Bruijne J,Vijgen L,Verbinnen T,Weegink C,Van Marck H,Vandenbroucke I,Peeters M,Simmen K,Fanning G,Verloes R,Picchio G,Reesink H

更新日期：2012-11-01 00:00:00

abstract：:The hemodynamic effects of octreotide were studied in 20 patients with hepatitis B-related cirrhosis. In patients receiving a 100-micrograms bolus and a 100-micrograms/h infusion, heart rate, cardiac index, and systemic vascular resistance showed no significant changes, whereas right atrial pressure, pulmonary capilla...

journal_title：Gastroenterology

authors： Lin HC,Tsai YT,Lee FY,Lee SD,Hsia HC,Lin WJ,Lo KJ

更新日期：1992-07-01 00:00:00

abstract：:The pathogenesis of gastroesophageal reflux disease (GERD) is complex and involves changes in reflux exposure, epithelial resistance, and visceral sensitivity. The gastric refluxate is a noxious material that injures the esophagus and elicits symptoms. Esophageal exposure to gastric refluxate is the primary determinan...

journal_title：Gastroenterology

authors： Tack J,Pandolfino JE

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND & AIMS:The morphology of acid damage to esophageal epithelium is characterized by marked cell (swelling) edema. This observation suggests that, in the process of acid damage, an increase in osmotic forces develops within the cell that accounts for the increase in cell water. The aim of this study was to docu...

journal_title：Gastroenterology

authors： Tobey NA,Cragoe EJ Jr,Orlando RC

更新日期：1995-08-01 00:00:00

abstract：BACKGROUND & AIMS:Cell stress signaling pathways result in phosphorylation of the eukaryotic translation initiation factor 2 subunit alpha (EIF2S1 or EIF2A), which affects regulation of protein translation. Translation reprogramming mitigates stress by activating pathways that result in autophagy and cell death, to eli...

journal_title：Gastroenterology

authors： Roy S,Esmaeilniakooshkghazi A,Patnaik S,Wang Y,George SP,Ahrorov A,Hou JK,Herron AJ,Sesaki H,Khurana S

更新日期：2018-04-01 00:00:00

abstract：BACKGROUND & AIMS:The ratio of liver size to body weight (hepatostat) is tightly controlled, but little is known about how the physiologic functions of the liver help determine its size. Livers of mice repopulated with human hepatocytes (humanized livers) grow to larger than normal; the human hepatocytes do not recogni...

journal_title：Gastroenterology

authors： Naugler WE,Tarlow BD,Fedorov LM,Taylor M,Pelz C,Li B,Darnell J,Grompe M

更新日期：2015-09-01 00:00:00

abstract：BACKGROUND & AIMS:The molecular basis underlying visceral hypersensitivity in functional irritable bowel syndrome remains elusive, resulting in poor treatment effectiveness. Because alterations in spinal non-neuronal (astrocytic) glutamate reuptake are suspected to participate in chronic pain, we asked whether such pro...

journal_title：Gastroenterology

authors： Gosselin RD,O'Connor RM,Tramullas M,Julio-Pieper M,Dinan TG,Cryan JF

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND & AIMS:Corticotropin-releasing factor (CRF) signaling pathways play a key role in the stress response through the activation of CRF(1) and CRF(2) receptors. We investigated the CRF receptor subtypes involved in gastric postoperative ileus. METHODS:Adult male mice (C57BL/6, CRF(1)-deficient, and wild-type), ...

journal_title：Gastroenterology

authors： Luckey A,Wang L,Jamieson PM,Basa NR,Million M,Czimmer J,Vale W,Taché Y

更新日期：2003-09-01 00:00:00

abstract：:Our objectives in this study were (a) to determine the role of antroduodenal resistance in the control of fasting duodenogastric bile reflux in the dog and (b) to elucidate the contribution of the pylorus both to resistance and to reflux. Thus, we measured simultaneously throughout the interdigestive motor cycle (a) a...

journal_title：Gastroenterology

authors： Mearin F,Azpiroz F,Malagelada JR,Zinsmeister AR

更新日期：1987-11-01 00:00:00

abstract：BACKGROUND/AIMS:Growth factors and their receptors play a role in healing ulcers of the rat. Somatostatin is a putative growth factor in the gastric mucosa with multiple functions mediated by specific receptors. Therefore, the distribution of somatostatin receptors was evaluated in the gastric mucosa of healing ulcers....

journal_title：Gastroenterology

authors： Reubi JC,Waser B,Schmassmann A,Halter F

更新日期：1994-08-01 00:00:00

abstract：:In this study, quantitation of the epithelial proliferation status of gastric glands and duodenal crypts was performed using endoscopic biopsy specimens from patients with rheumatological conditions requiring long-term anti-inflammatory and analgesic therapy, testing the hypothesis that long-term administration of non...

journal_title：Gastroenterology

authors： Levi S,Goodlad RA,Lee CY,Walport MJ,Wright NA,Hodgson HJ

更新日期：1992-05-01 00:00:00

abstract：BACKGROUND/AIMS:Hepatic glucuronidation is quantitatively the most important conjugation reaction by which an array of endogenous compounds and xenobiotics undergo biotransformation and detoxification. The active site of the uridine diphosphate (UDP) glucuronosyltransferases, which catalyze glucuronidation reactions, h...

journal_title：Gastroenterology

authors： Berg CL,Radominska A,Lester R,Gollan JL

更新日期：1995-01-01 00:00:00