Abstract:
:The pathogenesis of gastroesophageal reflux disease (GERD) is complex and involves changes in reflux exposure, epithelial resistance, and visceral sensitivity. The gastric refluxate is a noxious material that injures the esophagus and elicits symptoms. Esophageal exposure to gastric refluxate is the primary determinant of disease severity. This exposure arises via compromise of the anti-reflux barrier and reduced ability of the esophagus to clear and buffer the refluxate, leading to reflux disease. However, complications and symptoms also occur in the context of normal reflux burden, when there is either poor epithelial resistance or increased visceral sensitivity. Reflux therefore develops via alterations in the balance of aggressive and defensive forces.
journal_name
Gastroenterologyjournal_title
Gastroenterologyauthors
Tack J,Pandolfino JEdoi
10.1053/j.gastro.2017.09.047subject
Has Abstractpub_date
2018-01-01 00:00:00pages
277-288issue
2eissn
0016-5085issn
1528-0012pii
S0016-5085(17)36248-0journal_volume
154pub_type
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