Abstract:
:There are conflicting reports on the influence of cigarette smoking on healing in patients with duodenal ulcer; some studies show an adverse effect on healing rate and others no effect. This study reports the influence of smoking on short-term healing and relapse rate in 135 patients with duodenal ulcer who were treated with cimetidine (90), ranitidine (25), and oxmetidine (20), all powerful H2-receptor antagonists. Ulcer healing and relapse were documented endoscopically and all studies were performed in a double-blind manner. In the short term, 95% of nonsmokers healed compared with 63% smokers (p less than 0.01) and there was a positive correlation between failure to heal and number of cigarettes smoked. During a 12-mo follow-up examination after healing and on no treatment, 53% of nonsmokers and 84% of smokers relapsed (p less than 0.01). These results show that smoking adversely affects healing of duodenal ulcer with H2-receptor antagonists and that continued smoking leads to a higher relapse rate.
journal_name
Gastroenterologyjournal_title
Gastroenterologyauthors
Korman MG,Hansky J,Eaves ER,Schmidt GTsubject
Has Abstractpub_date
1983-10-01 00:00:00pages
871-4issue
4eissn
0016-5085issn
1528-0012pii
S0016508583002371journal_volume
85pub_type
临床试验,杂志文章相关文献
GASTROENTEROLOGY文献大全abstract::The effects of corticosteroid treatment on mucosal mast cells in rat jejunal mucosa were examined. Rats previously infected with Nippostrongylus brasiliensis received a single IP injection of 1 mg dexamethasone. Three hours later, one third of mucosal mast cells demonstrated minor granular changes (fusion or periphera...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(91)90266-n
更新日期:1991-04-01 00:00:00
abstract::In neurogenic fecal incontinence there is denervation of the external anal sphincter and pelvic floor muscles but the role of the internal anal sphincter is incompletely understood. We have evaluated the internal anal sphincter in 6 patients with neurogenic incontinence undergoing postanal repair and in 7 control subj...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(88)90175-8
更新日期:1988-10-01 00:00:00
abstract:BACKGROUND & AIMS:Indomethacin impairs liver microsomal monooxygenase activities mediated by cytochrome P450 (CYP). We investigated the inhibition mechanism and the isoform selectivity in vitro and in vivo. METHODS:In an in vitro study, liver microsomes from male Wistar rats were preincubated with indomethacin and a r...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/gast.2002.31886
更新日期:2002-03-01 00:00:00
abstract::Helicobacter pylori infects the stomach of half of the human population worldwide and causes chronic active gastritis, which can lead to peptic ulcer disease, gastric adenocarcinoma, and mucosa-associated lymphoid tissue lymphoma. The host immune response to the infection is ineffective, because the bacterium persists...
journal_title:Gastroenterology
pub_type: 杂志文章,评审
doi:10.1053/j.gastro.2007.05.008
更新日期:2007-07-01 00:00:00
abstract::Pancreatitis is a common disorder with significant morbidity and mortality, yet little is known about its pathogenesis, and there is no specific or effective treatment. Its development involves dysregulated autophagy and unresolved inflammation, demonstrated by studies in genetic and experimental mouse models. Disease...
journal_title:Gastroenterology
pub_type: 杂志文章,评审
doi:10.1053/j.gastro.2017.08.071
更新日期:2017-11-01 00:00:00
abstract::Acute self-limited liver disease has been associated with tetracycline use. However, severe prolonged cholestatic hepatitis and bile duct paucity have not been previously attributed to tetracyclines. Hepatitis, characterized by prolonged jaundice, severe pruritus, and moderate increased transaminase values, occurred w...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(94)90830-3
更新日期:1994-12-01 00:00:00
abstract:BACKGROUND & AIMS:Hepatitis G virus (HGV) has been recently identified as a new transfusion-transmissible agent. This study was performed to evaluate the role of HGV infection in patients with acute posttransfusion hepatitis in Taiwan. METHODS:Sera from 63 patients with acute posttransfusion hepatitis and 61 patients ...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/s0016-5085(97)70138-0
更新日期:1997-04-01 00:00:00
abstract::Two models of severe acute pancreatitis were chosen and pancreatitis induced by sodium taurocholate and by a choline-deficient ethionine-supplemented diet, to evaluate the effectiveness of FOY-305 (camostate), a new synthetic trypsin inhibitor. Prophylactic administration of FOY-305 had a significantly favorable effec...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(89)90780-4
更新日期:1989-01-01 00:00:00
abstract::Three generations of a kindred comprising 50 individuals are described in which recurrent intrahepatic cholestasis of pregnancy has occurred with high frequency. A uniform expression and complete penetrance of the trait in the women of a limited "affected" portion of the kindred (6 affected of 10 women), along with th...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1983-07-01 00:00:00
abstract:BACKGROUND & AIMS:The signal transducers and activators of transcription (STATs) are cytoplasmic transcription factors mediating acute-phase response (APR) of the human angiotensinogen (hAGT) gene in hepatocytes. The mechanisms of how STAT3 activates target genes are unknown. Here we analyzed the biochemistry of STAT3 ...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2005.07.055
更新日期:2005-11-01 00:00:00
abstract:BACKGROUND & AIMS:Early metastasis is a hallmark of pancreatic ductal adenocarcinoma and responsible for >90% of pancreatic cancer death. Because little is known about the biology and genetics of the metastatic process, we desired to elucidate molecular pathways mediating pancreatic cancer metastasis in vivo by an unbi...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2009.04.004
更新日期:2009-07-01 00:00:00
abstract:BACKGROUND & AIMS:Crohn's disease (CD) is an inflammatory bowel disease characterized by uncontrolled immune responses to bacterial flora, with excessive activation of T lymphocytes. MICA is a stress-induced major histocompatibility complex-related molecule expressed on normal intestinal epithelial cells (IECs) and rec...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2007.03.025
更新日期:2007-06-01 00:00:00
abstract::Phosphatase-mediated hydrolysis is the first step in the intestinal absorption of pyridoxal 5'-phosphate (PLP). Studies presented here evaluated the effects of PLP-protein binding and pH on intestinal hydrolysis in the rat. Models included in vitro PLP decay and in vivo PLP disappearance from perfused jejunal segments...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(86)90567-6
更新日期:1986-08-01 00:00:00
abstract:BACKGROUND & AIMS:Canalicular secretion of bile acids is stimulated by tauroursodesoxycholate (TUDC). This study investigates the underlying mechanisms. METHODS:TUDC effects on mitogen-activated protein (MAP) kinases, taurocholate (TC) excretion, proteolysis, and the localization of the bile salt export pump (Bsep) we...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/gast.2001.26262
更新日期:2001-08-01 00:00:00
abstract::Gallbladder stasis has been implicated in gallstone formation. Gallbladder filling and emptying were quantitated by computer-assisted cholescintigraphy in 41 normal subjects versus 26 patients with gallstones. Gallbladder contraction was induced by low-dose (1.2 U/kg . h) cholecystokinin infusion. Gallstone patients e...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(85)90152-0
更新日期:1985-03-01 00:00:00
abstract::Evidence-based medicine combines clinical expertise and the best available evidence from systematic research to aid decision making in patient care. Levels of evidence can be graded from I to V, with level I, the strongest, coming from large randomized controlled trials (RCTs). When a definitive RCT has not been perfo...
journal_title:Gastroenterology
pub_type: 杂志文章,评审
doi:10.1016/s0016-5085(97)80022-4
更新日期:1997-12-01 00:00:00
abstract::The growth rate of 31 asymptomatic hepatocellular carcinomas (diameter less than or equal to 5 cm) discovered in 28 patients by a prospective screening program was determined by real-time ultrasonography over 36-860 days. Except for one tumor that shrank on follow-up, the doubling time ranged from 29 to 398 days, with...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(85)90324-5
更新日期:1985-08-01 00:00:00
abstract::Upper gut transit and motility among 10 symptomatic and 9 asymptomatic patients with Roux gastrectomy were compared with those among 10 healthy, unoperated controls. Gastric emptying of solids and Roux limb and small intestinal transit of liquids were assessed scintigraphically. Motor patterns in the Roux limb or heal...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(92)91496-q
更新日期:1992-10-01 00:00:00
abstract::Thyrotropin-releasing hormone transiently increased resting tension and spontaneous contraction amplitude more potently in longitudinal muscle than in circular muscle. The frequency of the contraction did not change. Excitation was enhanced by eserine, and blocked by atropine and tetrodotoxin; this excitation was, the...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/s0016-5085(85)80070-6
更新日期:1985-05-01 00:00:00
abstract:BACKGROUND & AIMS:Major histocompatibility complex (MHC) class I-restricted CD8(+) T cells are required for clearance of hepatitis C virus (HCV) infection. MHC class I expression is up-regulated by type I and II interferons (IFNs). However, little is known about the effects of HCV infection on IFN-induced expression of...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2014.01.054
更新日期:2014-05-01 00:00:00
abstract:BACKGROUND & AIMS:The majority of patients with Helicobacter pylori infection have autoantibodies cross-reacting with gastric antigens. In this study, the relation between autoantibody status, histopathology of body mucosa, and antigenic profile of H. pylori was investigated. METHODS:One hundred patients were examined...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/gast.1996.v111.pm8780570
更新日期:1996-09-01 00:00:00
abstract::Disappearance of symptoms, resolution of most biochemical abnormalities, and histologic improvement to mild chronic inflammation were accomplished in 69 of 123 patients (56%) with severe chronic active liver disease treated with corticosteroids for up to 6.5 yr. Remission of at least 6 mo duration was possible in 35 o...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1980-03-01 00:00:00
abstract:BACKGROUND & AIMS:Metaplasias often have characteristics of developmentally related tissues. Pancreatic metaplastic ducts are usually associated with pancreatitis and pancreatic ductal adenocarcinoma. The tuft cell is a chemosensory cell that responds to signals in the extracellular environment via effector molecules. ...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2013.08.053
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND & AIMS:IKBL gene lies telomeric of the tumor necrosis factor cluster in the central major histocompatibility complex and carries a structural polymorphism at position +738. In the Spanish white population, we found the IKBL+738(C) allele in haplotypes carrying either HLA-DRB1(*)1501 or -DRB1(*)0103. Because ...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/gast.2000.20258
更新日期:2000-12-01 00:00:00
abstract::We studied the response of lymphocytes from 43 patients with inflammatory bowel disease to allogeneic stimulation in one-way mixed-lymphocyte cultures. We found that 53% of patients with inflammatory bowel disease, in contrast to 4% of normal and disease controls, had significant depression of mixed-lymphocyte culture...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1980-10-01 00:00:00
abstract:BACKGROUND & AIMS:Proliferating cholangiocytes secrete and respond to neuroendocrine hormones, including secretin. We investigated whether secretin secreted by S cells and cholangiocytes stimulates biliary proliferation in mice. METHODS:Cholestasis was induced in secretin knockout (Sct(-/-)) and wild-type (control) mi...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2014.02.030
更新日期:2014-06-01 00:00:00
abstract:BACKGROUND & AIMS:Interstitial cells of Cajal (ICC) play an important role in the control of gastrointestinal motility. We aimed to determine a potential role for ICC in the pathophysiology of inflammation-induced motor disorders. METHODS:Effects of Trichinella spiralis infection on electrical pacemaker activity, the ...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/gast.2000.20221
更新日期:2000-12-01 00:00:00
abstract:BACKGROUND & AIMS:Pancreatic acinar cells are used to study regulated exocytosis. We investigated the role of interferon regulatory factor-2 (IRF2) in exocytosis in pancreatic acinar cells. METHODS:Pancreas tissues from Irf2⁺/⁺, Irf2⁺/⁻), and Irf2⁻/⁻ mice were examined by microscopy, immunohistochemical, and immunoblo...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2011.05.051
更新日期:2011-09-01 00:00:00
abstract:BACKGROUND & AIMS:Macrophage migration inhibitory factor (MIF) inhibits macrophage migration and has pleiotropic activities on immune and inflammatory responses, cell growth, and glucose metabolism. MIF is produced by T cells, macrophages, and endothelial cells. Because intestinal epithelial cells produce mediators imp...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/gast.2002.31891
更新日期:2002-03-01 00:00:00
abstract::Specific radioimmunoassay were used to measure somatostatin and vasoactive peptide in portal and peripheral plasma from conscious dogs prepared with indwelling portal catheters. In six animals with intact stomachs, a test meal induced a significant rise of portal and peripheral somatostatin, while the significant resp...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1980-11-01 00:00:00