Pancreatic cystic neoplasms: management and unanswered questions.

abstract：BACKGROUND & AIMS:Collagen I deposition contributes to liver fibrosis, yet little is known about other factors that mediate this process. Fibromodulin is a liver proteoglycan that regulates extracellular matrix organization and is induced by fibrogenic stimuli. We propose that fibromodulin contributes to the pathogenes...

journal_title：Gastroenterology

authors： Mormone E,Lu Y,Ge X,Fiel MI,Nieto N

更新日期：2012-03-01 00:00:00

abstract：BACKGROUND & AIMS:The course of hereditary hemochromatosis may depend on the degree of iron overload and the time of therapeutic intervention. This analysis evaluates the impact of early diagnosis and iron removal on survival and complications in hereditary hemochromatosis. METHODS:A Cohort of 251 patients with hemoch...

journal_title：Gastroenterology

authors： Niederau C,Fischer R,Pürschel A,Stremmel W,Häussinger D,Strohmeyer G

更新日期：1996-04-01 00:00:00

abstract：BACKGROUND & AIMS:The ratio of liver size to body weight (hepatostat) is tightly controlled, but little is known about how the physiologic functions of the liver help determine its size. Livers of mice repopulated with human hepatocytes (humanized livers) grow to larger than normal; the human hepatocytes do not recogni...

journal_title：Gastroenterology

authors： Naugler WE,Tarlow BD,Fedorov LM,Taylor M,Pelz C,Li B,Darnell J,Grompe M

更新日期：2015-09-01 00:00:00

abstract：BACKGROUND/AIMS:A double-blind, placebo-controlled trial of ursodeoxycholic acid (UDCA) was conducted in 180 patients with primary biliary cirrhosis (PBC) to define the efficacy and safety of UDCA. Efficacy was assessed by time to treatment failure defined as death; liver transplantation; histological progression; deve...

journal_title：Gastroenterology

authors： Lindor KD,Dickson ER,Baldus WP,Jorgensen RA,Ludwig J,Murtaugh PA,Harrison JM,Wiesner RH,Anderson ML,Lange SM

更新日期：1994-05-01 00:00:00

abstract：BACKGROUND & AIMS:The characteristics of colonic circular smooth muscle slow waves are altered during inflammation. The aim of this study was to examine whether inflammation modulates the open-state probability of Ca2+-activated K+ (KCa) channels in these cells to contribute to these alterations. METHODS:The experimen...

journal_title：Gastroenterology

authors： Lu G,Mazet B,Sun C,Qian X,Johnson CP,Adams MB,Roman RJ,Sarna SK

更新日期：1999-04-01 00:00:00

abstract：:Endosonography was performed preoperatively in 33 patients with common bile duct carcinoma and in 43 patients with carcinoma of the common hepatic duct and its bifurcation. The results were correlated with the histology of resected specimens according to the new (1987) TNM (tumor, node, metastasis) classification. End...

journal_title：Gastroenterology

authors： Tio TL,Cheng J,Wijers OB,Sars PR,Tytgat GN

更新日期：1991-05-01 00:00:00

abstract：:The effects of IV injection of 5-hydroxytryptamine 3 receptor antagonists (BRL 43694 and GR38032F) on gastrointestinal contractile activity were studied in dogs with vagally denervated fundic pouch in the conscious state by means of chronically implanted force transducers in the gastrointestinal tract and the pouch. I...

journal_title：Gastroenterology

authors： Itoh Z,Mizumoto A,Iwanaga Y,Yoshida N,Torii K,Wakabayashi K

更新日期：1991-04-01 00:00:00

abstract：BACKGROUND/AIMS:Gastrointestinal peptides and biogenic monoamines participate in the regulation of gastrointestinal functions. The aim of this study was to examine the influence of the microflora on the distribution of endocrine cells and on the release of gastrointestinal peptides. METHODS:A quantitative morphologica...

journal_title：Gastroenterology

authors： Uribe A,Alam M,Johansson O,Midtvedt T,Theodorsson E

更新日期：1994-11-01 00:00:00

abstract：BACKGROUND & AIMS:There is growing interest in the use of bone marrow cells to treat liver fibrosis, however, little is known about their antifibrotic efficacy or the identity of their effector cell(s). Sphingosine-1-phosphate (S1P) mediates egress of immune cells from the lymphoid organs into the lymphatic vessels; we...

journal_title：Gastroenterology

authors： King A,Houlihan DD,Kavanagh D,Haldar D,Luu N,Owen A,Suresh S,Than NN,Reynolds G,Penny J,Sumption H,Ramachandran P,Henderson NC,Kalia N,Frampton J,Adams DH,Newsome PN

更新日期：2017-07-01 00:00:00

abstract：:A 50-year-old woman with a typical history of chronic idiopathic intestinal pseudo-obstruction was admitted to hospital because of an acute episode of abdominal cramps, nausea, and vomiting. The diagnosis of chronic idiopathic intestinal pseudo-obstruction had been established in this patient who had malnutrition and ...

journal_title：Gastroenterology

authors： Allescher HD,Safrany L,Neuhaus H,Feussner H,Classen M

更新日期：1992-05-01 00:00:00

abstract：BACKGROUND & AIMS:Notch downstream targets are fundamental to intestinal cell lineage commitment and are suggested as therapeutic targets for colon cancer cells. However, the role of endogenous Notch signaling through receptor-ligand interaction, and effects of its longer term down-regulation on intestinal homeostasis,...

journal_title：Gastroenterology

authors： Guilmeau S,Flandez M,Bancroft L,Sellers RS,Tear B,Stanley P,Augenlicht LH

更新日期：2008-09-01 00:00:00

abstract：BACKGROUND & AIMS:Thyroid hormones are implicated in intestinal development. Their effects are mediated by nuclear receptors, which are transcriptional regulators activated upon binding of triiodothyronine. The aim of this study was to define the involvement of the receptor subtypes during intestinal development. METH...

journal_title：Gastroenterology

authors： Plateroti M,Chassande O,Fraichard A,Gauthier K,Freund JN,Samarut J,Kedinger M

更新日期：1999-06-01 00:00:00

abstract：BACKGROUND & AIMS:Current stool DNA tests identify about half of individuals with colorectal cancers and miss most individuals with advanced adenomas. We developed a digital melt curve (DMC) assay to quantify low-abundance mutations in stool samples for detection of colorectal neoplasms and compared this test with othe...

journal_title：Gastroenterology

authors： Zou H,Taylor WR,Harrington JJ,Hussain FT,Cao X,Loprinzi CL,Levine TR,Rex DK,Ahnen D,Knigge KL,Lance P,Jiang X,Smith DI,Ahlquist DA

更新日期：2009-02-01 00:00:00

abstract：BACKGROUND & AIMS:Interactions between genetic and environmental factors are believed to be involved in onset and initiation of inflammatory bowel disease. We analyzed the interaction between gastrointestinal mucosal microbiota and host genes in twin pairs discordant for ulcerative colitis (UC) to study the functional ...

journal_title：Gastroenterology

authors： Lepage P,Häsler R,Spehlmann ME,Rehman A,Zvirbliene A,Begun A,Ott S,Kupcinskas L,Doré J,Raedler A,Schreiber S

更新日期：2011-07-01 00:00:00

abstract：BACKGROUND & AIMS:Mechanisms responsible for crypt architectural distortion in chronic ulcerative colitis (CUC) are not well understood. Data indicate that serine/threonine protein kinase Akt (Akt) signaling cooperates with Wingless (Wnt) to activate beta-catenin in intestinal stem and progenitor cells through phosphor...

journal_title：Gastroenterology

authors： Lee G,Goretsky T,Managlia E,Dirisina R,Singh AP,Brown JB,May R,Yang GY,Ragheb JW,Evers BM,Weber CR,Turner JR,He XC,Katzman RB,Li L,Barrett TA

更新日期：2010-09-01 00:00:00

abstract：:This study was undertaken to try to solve the controversy about the influence of gastrointestinal contents on the genesis of bowel sounds, and to probe the respective importance of the various abdominal viscera. Eleven healthy volunteers were intubated by mouth with a multiple-lumen tube. Bowel sounds were recorded fo...

journal_title：Gastroenterology

authors： Politzer JP,Devroede G,Vasseur C,Gerard J,Thibault R

更新日期：1976-08-01 00:00:00

abstract：BACKGROUND & AIMS:Lactase is the intestinal disaccharidase responsible for digestion of lactose, the predominant carbohydrate in milk. Transcription of the lactase gene is activated during enterocyte differentiation. We have characterized the interaction between the lactase promoter and Cdx2, a homeodomain protein invo...

journal_title：Gastroenterology

authors： Fang R,Santiago NA,Olds LC,Sibley E

更新日期：2000-01-01 00:00:00

abstract：:Rotaviruses cause life-threatening gastroenteritis in children worldwide; the enormous disease burden has focused efforts to develop vaccines and led to the discovery of novel mechanisms of gastrointestinal virus pathogenesis and host responses to infection. Two live-attenuated vaccines for gastroenteritis (Rotateq [M...

journal_title：Gastroenterology

authors： Greenberg HB,Estes MK

更新日期：2009-05-01 00:00:00

abstract：BACKGROUND & AIMS:Adenomatous polyps are by definition dysplastic and pathologically indistinguishable from the dysplasia-associated lesion or mass (DALM) described in 1981. Yet, adenomatous polyps in noncolitic colons are usually removed definitively endoscopically, whereas DALMs are regarded as harbingers of colon ca...

journal_title：Gastroenterology

authors： Rubin PH,Friedman S,Harpaz N,Goldstein E,Weiser J,Schiller J,Waye JD,Present DH

更新日期：1999-12-01 00:00:00

abstract：BACKGROUND & AIMS:A single nucleotide polymorphism (SNP) upstream of the IL28B gene has been associated with response of patients with chronic hepatitis C to therapy with pegylated interferon and ribavirin and also with spontaneous clearance of acute hepatitis C in a heterogeneous population. We analyzed the associatio...

journal_title：Gastroenterology

authors： Tillmann HL,Thompson AJ,Patel K,Wiese M,Tenckhoff H,Nischalke HD,Lokhnygina Y,Kullig U,Göbel U,Capka E,Wiegand J,Schiefke I,Güthoff W,Grüngreiff K,König I,Spengler U,McCarthy J,Shianna KV,Goldstein DB,McHutchison JG

更新日期：2010-11-01 00:00:00

abstract：BACKGROUND/AIMS:Hepatic glucuronidation is quantitatively the most important conjugation reaction by which an array of endogenous compounds and xenobiotics undergo biotransformation and detoxification. The active site of the uridine diphosphate (UDP) glucuronosyltransferases, which catalyze glucuronidation reactions, h...

journal_title：Gastroenterology

authors： Berg CL,Radominska A,Lester R,Gollan JL

更新日期：1995-01-01 00:00:00

abstract：:Osteopenia in the form of osteoporosis is a common clinical problem associated with chronic cholestatic liver disease, and clinical morbidity from atraumatic fractures is increasing as more patients with PBC and PSC undergo successful liver transplantation. In the absence of symptomatic fractures, the clinical diagnos...

journal_title：Gastroenterology

authors： Hay JE

更新日期：1995-01-01 00:00:00

abstract：:The authors' previous observation that many of the monoclonal antibodies against Helicobacter pylori cross-react with the cells of the human gastric mucosa prompted them to investigate the possibility that gastric self-antigens cross-reacting with H. pylori could be involved in the immune response against this organis...

journal_title：Gastroenterology

authors： Negrini R,Lisato L,Zanella I,Cavazzini L,Gullini S,Villanacci V,Poiesi C,Albertini A,Ghielmi S

更新日期：1991-08-01 00:00:00

abstract：:Approximately 5% of the world's human population have an increased risk for developing liver cancer and cirrhosis as a direct consequence of chronic infection with the hepatitis B virus (HBV). Antiviral chemotherapy remains the only option for controlling infection in these individuals, for whom the current licensed h...

journal_title：Gastroenterology

authors： Torresi J,Locarnini S

更新日期：2000-02-01 00:00:00

abstract：BACKGROUND & AIMS:Intestinal myofibroblasts are known to respond to inflammatory signals and may play a role in Crohn's disease-associated fibrosis. However, putative involvement by myofibroblasts in innate immune responses as part of intestinal host defense has not been characterized. We therefore analyzed expression ...

journal_title：Gastroenterology

authors： Otte JM,Rosenberg IM,Podolsky DK

更新日期：2003-06-01 00:00:00

abstract：BACKGROUND & AIMS:Genetic factors are believed to affect risk for irritable bowel syndrome (IBS), but there have been no sufficiently powered and adequately sized studies. To identify DNA variants associated with IBS risk, we performed a genome-wide association study (GWAS) of the large UK Biobank population-based coho...

journal_title：Gastroenterology

authors： Bonfiglio F,Zheng T,Garcia-Etxebarria K,Hadizadeh F,Bujanda L,Bresso F,Agreus L,Andreasson A,Dlugosz A,Lindberg G,Schmidt PT,Karling P,Ohlsson B,Simren M,Walter S,Nardone G,Cuomo R,Usai-Satta P,Galeazzi F,Neri M,P

更新日期：2018-07-01 00:00:00

abstract：BACKGROUND & AIMS:Platelet-activating factor (PAF) is increased during relapse of ulcerative colitis. In animal models of experimental colitis, specific inhibition of PAF has reduced inflammation. The aim of this study was to evaluate the efficacy and safety of the PAF antagonist SR27417A in moderately active UC. METH...

journal_title：Gastroenterology

authors： Stack WA,Jenkins D,Vivet P,Hawkey CJ

更新日期：1998-12-01 00:00:00

abstract：BACKGROUND/AIMS:The gastric mucosa is covered by a continuous layer of bicarbonate-containing mucus gel; the question arises how acid, formed in the gastric glands, moves into the lumen. METHODS:The pH in the gastric mucus gel and gel thickness were measured in anesthetized rats with pH-sensitive microelectrodes (tip ...

journal_title：Gastroenterology

authors： Schade C,Flemström G,Holm L

更新日期：1994-07-01 00:00:00

abstract：BACKGROUND & AIMS:In human and canine colon, both slow (slow waves, 2-8/min) and fast (myenteric potential oscillations [MPOs]; 16-20/min) electrical rhythms in the smooth muscle originate at the submucosal and myenteric borders, respectively. We used Ca(2+) imaging to investigate whether interstitial cells of Cajal (I...

journal_title：Gastroenterology

authors： Lee HT,Hennig GW,Park KJ,Bayguinov PO,Ward SM,Sanders KM,Smith TK

更新日期：2009-06-01 00:00:00

abstract：BACKGROUND & AIMS:Treatment options are limited for patients with hepatitis C (HCV) infection with treatment failure after sofosbuvir plus an NS5A inhibitor. There are some data for the efficacy of glecaprevir/pibrentasvir (G/P) in these patients. We performed a randomized trial of the safety and efficacy of 12 and 16 ...

journal_title：Gastroenterology

authors： Lok AS,Sulkowski MS,Kort JJ,Willner I,Reddy KR,Shiffman ML,Hassan MA,Pearlman BL,Hinestrosa F,Jacobson IM,Morelli G,Peter JA,Vainorius M,Michael LC,Fried MW,Wang GP,Lu W,Larsen L,Nelson DR

更新日期：2019-12-01 00:00:00