Inflammatory bowel disease in a Swedish twin cohort: a long-term follow-up of concordance and clinical characteristics.


BACKGROUND & AIMS:In 1988, we reported the first twin study in inflammatory bowel disease. The aim of the current study was to follow up these twins regarding new cases of inflammatory bowel disease and Crohn's disease characteristics using the Vienna classification. METHODS:The official Swedish population register and the cause of death register were used to search for the twins. All living patients were interviewed. RESULTS:Three monozygotic twins earlier classified as healthy had been diagnosed with inflammatory bowel disease (ulcerative colitis, n = 2; Crohn's disease, n = 1). Retrospectively, all 3 were symptomatic at the original survey. This changed the pair concordance in monozygotic twins from 6.3% to 18.8% in ulcerative colitis and from 44.4% to 50.0% in Crohn's disease. A high degree of concordance regarding age at diagnosis, disease location at diagnosis and during the course, and disease behavior was found in concordant monozygotic twin pairs with Crohn's disease. Seven of 9 pairs were identical in 3 or more of these disease characteristics compared with an expected number of 1.5 (P = 0.000076). CONCLUSIONS:This study confirms that the genetic influence is stronger in Crohn's disease than in ulcerative colitis. A remarkable phenotype similarity within concordant pairs with Crohn's disease was found using the Vienna classification.






Halfvarson J,Bodin L,Tysk C,Lindberg E,Järnerot G





Has Abstract


2003-06-01 00:00:00














  • Inactivation of the transcription factor Elf3 in mice results in dysmorphogenesis and altered differentiation of intestinal epithelium.

    abstract:BACKGROUND & AIMS:The mammalian small intestine is lined by a highly specialized epithelium that functions in the digestion and absorption of nutrients. The molecular mechanisms that direct intestinal epithelial cell morphogenesis and terminal differentiation are poorly understood. We have previously identified Elf3 (E...


    pub_type: 杂志文章


    authors: Ng AY,Waring P,Ristevski S,Wang C,Wilson T,Pritchard M,Hertzog P,Kola I

    更新日期:2002-05-01 00:00:00

  • Probiotic Bifidobacterium longum NCC3001 Reduces Depression Scores and Alters Brain Activity: A Pilot Study in Patients With Irritable Bowel Syndrome.

    abstract:BACKGROUND & AIMS:Probiotics can reduce symptoms of irritable bowel syndrome (IBS), but little is known about their effects on psychiatric comorbidities. We performed a prospective study to evaluate the effects of Bifidobacterium longum NCC3001 (BL) on anxiety and depression in patients with IBS. METHODS:We performed ...


    pub_type: 杂志文章,随机对照试验


    authors: Pinto-Sanchez MI,Hall GB,Ghajar K,Nardelli A,Bolino C,Lau JT,Martin FP,Cominetti O,Welsh C,Rieder A,Traynor J,Gregory C,De Palma G,Pigrau M,Ford AC,Macri J,Berger B,Bergonzelli G,Surette MG,Collins SM,Moayyedi P,

    更新日期:2017-08-01 00:00:00

  • Intracellular study of effects of morphine on electrical activity of myenteric neurons in cat small intestine.

    abstract::Intracellular recording methods were used to study the effects of morphine on electrical behavior of myenteric neurons in cat small intestine. Two general categories of myenteric ganglion cells were found. AH/Type 2 neurons and relatively high resting membrane potentials, low input resistances, spikes only at the onse...


    pub_type: 杂志文章


    authors: Wood JD

    更新日期:1980-12-01 00:00:00

  • Liver transplantation for hepatocellular carcinoma: a model including α-fetoprotein improves the performance of Milan criteria.

    abstract:BACKGROUND & AIMS:The aim of this study was to generate an improved prognostic model for predicting recurrence in liver transplant candidates with hepatocellular carcinoma (HCC). METHODS:Predictors of recurrence were tested by a Cox model analysis in a training cohort of 537 patients transplanted for HCC. A prognostic...


    pub_type: 杂志文章


    authors: Duvoux C,Roudot-Thoraval F,Decaens T,Pessione F,Badran H,Piardi T,Francoz C,Compagnon P,Vanlemmens C,Dumortier J,Dharancy S,Gugenheim J,Bernard PH,Adam R,Radenne S,Muscari F,Conti F,Hardwigsen J,Pageaux GP,Chazouill

    更新日期:2012-10-01 00:00:00

  • Persistence of cccDNA during the natural history of chronic hepatitis B and decline during adefovir dipivoxil therapy.

    abstract:BACKGROUND & AIMS:Hepatitis B virus (HBV) covalently closed circular DNA (cccDNA) is a unique episomal replicative intermediate responsible for persistent infection of hepatocytes. Technical constraints have hampered the direct study of cccDNA maintenance and clearance mechanisms in patients. The aim of this study was ...


    pub_type: 杂志文章


    authors: Werle-Lapostolle B,Bowden S,Locarnini S,Wursthorn K,Petersen J,Lau G,Trepo C,Marcellin P,Goodman Z,Delaney WE 4th,Xiong S,Brosgart CL,Chen SS,Gibbs CS,Zoulim F

    更新日期:2004-06-01 00:00:00

  • Balloon dilatation of upper digestive tract strictures.

    abstract::The results of balloon dilatation of upper digestive tract stricture in 111 patients were evaluated. Eighty-eight patients had esophageal strictures and 23 had gastric or pyloric strictures. Thirty-six patients had strictures associated with previous operations. Twenty-two percent of the patients with esophageal stric...


    pub_type: 杂志文章


    authors: Lindor KD,Ott BJ,Hughes RW Jr

    更新日期:1985-09-01 00:00:00

  • Correlations between clinical, blood leukocyte, and skin test data in the National Cooperative Crohn's Disease Study.

    abstract::Peripheral blood leukocyte counts, percentages of lymphocytes and granulocytes, serum albumin levels, and results of skin tests with five antigens were examined in patients randomized in the National Cooperative Crohn's Disease Study. Inspection for differences from normal and correlations with a variety of variables ...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Beeken WL,Sessions JT Jr,Bozymski EM

    更新日期:1979-10-01 00:00:00

  • Comparison of methionine-enkephalin and morphine in the stimulation of gastric acid secretion in the dog.

    abstract::In dogs with Heidenhain pouches and gastric fistulas, we studied acid secretion in response to systemic or portal infusion of methionine-enkephalin (met-enkephalin), enkephalin-analog, or morphine. All these opiate compounds caused a dose-dependent increase in acid secretion under basal conditions and resulted in a si...


    pub_type: 杂志文章


    authors: Konturek SJ,Tasler J,Cieszkowski M,Mikoś E,Coy DH,Schally AV

    更新日期:1980-02-01 00:00:00

  • Randomized comparison of Nd YAG laser, heater probe, and no endoscopic therapy for bleeding peptic ulcers.

    abstract::Of 550 patients admitted with acute upper gastrointestinal hemorrhage, 143 with peptic ulcers containing stigmata of recent hemorrhage accessible to endoscopic therapy were included in a randomized comparison of neodymium yttrium aluminum garnet laser, heater probe, and no endoscopic therapy. The rebleeding rate in la...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Matthewson K,Swain CP,Bland M,Kirkham JS,Bown SG,Northfield TC

    更新日期:1990-05-01 00:00:00

  • Recurrent familial prolonged intrahepatic cholestasis of pregnancy associated with chronic liver disease.

    abstract::Four Puerto Rican sisters had recurrent prolonged cholestasis of pregnancy without preexisting or intercurrent hepatic disorders. Available information was reviewed on the course, mechanism, and sequelae of prolonged recurrent cholestasis after 14 pregnancies in the 4 sisters. Etiologic, clinical, laboratory, radiolog...


    pub_type: 杂志文章


    authors: Leevy CB,Koneru B,Klein KM

    更新日期:1997-09-01 00:00:00

  • B cells that produce immunoglobulin E mediate colitis in BALB/c mice.

    abstract:BACKGROUND & AIMS:Induction of colitis in mice by administration of oxazolone is mediated by T-helper (Th) 2 cells and has features of human ulcerative colitis. We investigated whether activation of interleukin (IL)-4Rα on T and B cells determines their effector functions and mediates oxazolone-induced colitis. METHOD...


    pub_type: 杂志文章


    authors: Hoving JC,Kirstein F,Nieuwenhuizen NE,Fick LC,Hobeika E,Reth M,Brombacher F

    更新日期:2012-01-01 00:00:00

  • Protease inhibitor-resistant hepatitis C virus mutants with reduced fitness from impaired production of infectious virus.

    abstract:BACKGROUND & AIMS:Several small molecule inhibitors of the hepatitis C virus (HCV) nonstructural protein (NS) 3/4A protease have advanced successfully to clinical trials. However, the selection of drug-resistant mutants is a significant issue with protease inhibitors (PIs). A variety of amino acid substitutions in the ...


    pub_type: 杂志文章


    authors: Shimakami T,Welsch C,Yamane D,McGivern DR,Yi M,Zeuzem S,Lemon SM

    更新日期:2011-02-01 00:00:00

  • Riluzole normalizes early-life stress-induced visceral hypersensitivity in rats: role of spinal glutamate reuptake mechanisms.

    abstract:BACKGROUND & AIMS:The molecular basis underlying visceral hypersensitivity in functional irritable bowel syndrome remains elusive, resulting in poor treatment effectiveness. Because alterations in spinal non-neuronal (astrocytic) glutamate reuptake are suspected to participate in chronic pain, we asked whether such pro...


    pub_type: 杂志文章


    authors: Gosselin RD,O'Connor RM,Tramullas M,Julio-Pieper M,Dinan TG,Cryan JF

    更新日期:2010-06-01 00:00:00

  • Gliadin immune reactivity is associated with overt and latent enteropathy in relatives of celiac patients.

    abstract::Antigliadin antibodies have been widely used in the screening of celiac disease. Using this test, candidates for jejunal biopsy were selected from 328 first-degree relatives of 128 adult celiac patients. All relatives geographically available were willing to participate in the study. Twenty-one turned out to be positi...


    pub_type: 杂志文章


    authors: Corazza G,Valentini RA,Frisoni M,Volta U,Corrao G,Bianchi FB,Gasbarrini G

    更新日期:1992-11-01 00:00:00

  • Advances in Use of Endoscopy, Radiology, and Biomarkers to Monitor Inflammatory Bowel Diseases.

    abstract::Crohn's disease and ulcerative colitis are heterogeneous inflammatory bowel diseases, and therapeutic requirements vary among patients. We have a limited capacity to predict disease progression for individual patients, therefore it is important that they are evaluated for the presence of active disease when symptoms a...


    pub_type: 杂志文章,评审


    authors: Panes J,Jairath V,Levesque BG

    更新日期:2017-02-01 00:00:00

  • Peptidergic and nitrinergic denervation in congenital esophageal stenosis.

    abstract::Congenital esophageal stenosis (CES) is a rare disorder with narrowed esophageal lumen that presents as dysphagia from childhood and that is often associated with tracheobronchial remnants or webs. The pathogenesis of CES is unknown. The aim of this study was to examine the histological and immunohistochemical feature...


    pub_type: 杂志文章


    authors: Singaram C,Sweet MA,Gaumnitz EA,Cameron AJ,Camilleri M

    更新日期:1995-07-01 00:00:00

  • Localization of central prostaglandin E2 antisecretory effects.

    abstract::Intracerebroventricular prostaglandin E2 (PGE2) inhibits stimulated gastric acid secretion; however, the central site of action is unknown. Specific PGE2 binding sites have been localized to the ventromedial hypothalamic nucleus and central amygdala (A). The nuclear accumbens has been shown to play a role in central n...


    pub_type: 杂志文章


    authors: Barocelli E,Impicciatore M,Seaton J,Conter R,Kauffman G

    更新日期:1991-02-01 00:00:00

  • Helicobacter heilmannii-associated primary gastric low-grade MALT lymphoma: complete remission after curing the infection.

    abstract:BACKGROUND & AIMS:Cure of Helicobacter pylori infection may lead to complete remission of associated low-grade mucosa-associated lymphoid tissue (MALT) lymphoma in stage EI. This study investigated whether Helicobacter heilmannii infection-associated primary gastric MALT lymphoma will regress after cure of the infectio...


    pub_type: 临床试验,杂志文章


    authors: Morgner A,Lehn N,Andersen LP,Thiede C,Bennedsen M,Trebesius K,Neubauer B,Neubauer A,Stolte M,Bayerdörffer E

    更新日期:2000-05-01 00:00:00

  • Colorectal cancer after cholecystectomy: absence of risk increase within 11-14 years.

    abstract::The importance of cholecystectomy as a risk factor for colorectal cancer was analyzed in an historical cohort study covering 16,773 cases during 11-14 years completed after operation. The observed number of colorectal cancers (130) was lower than the expected 153.5 [relative risk (RR) = 0.85]. For cancer of the colon,...


    pub_type: 杂志文章


    authors: Adami HO,Meirik O,Gustavsson S,Nyrén O,Krusemo UB

    更新日期:1983-10-01 00:00:00

  • Normalization of plasma vitamin B12 concentration by intranasal hydroxocobalamin in vitamin B12-deficient patients.

    abstract:BACKGROUND & AIMS:Patients with previous stomach and terminal ileum resections are often treated with intramuscular vitamin B12 injections. Disadvantages are, on a worldwide scale, the frequent need for medical personnel to administer injections and the sometimes painful way of application. This study was designed to i...


    pub_type: 临床试验,杂志文章


    authors: Slot WB,Merkus FW,Van Deventer SJ,Tytgat GN

    更新日期:1997-08-01 00:00:00

  • Gastrin induces proliferation in Barrett's metaplasia through activation of the CCK2 receptor.

    abstract:BACKGROUND AND AIMS:Factors associated with the development and malignant progression of Barrett's esophagus are poorly understood. Gastrin is a mitogen capable of inducing growth in normal and malignant gastrointestinal mucosa. It is unknown whether gastrin can influence cellular events in the esophagus in Barrett's. ...


    pub_type: 杂志文章


    authors: Haigh CR,Attwood SE,Thompson DG,Jankowski JA,Kirton CM,Pritchard DM,Varro A,Dimaline R

    更新日期:2003-03-01 00:00:00

  • Blockade of kit signaling induces transdifferentiation of interstitial cells of cajal to a smooth muscle phenotype.

    abstract:BACKGROUND & AIMS:Interstitial cells of Cajal (ICC) serve as pacemaker cells and mediators of neurotransmission from the enteric nervous system to gastrointestinal muscles. ICC develop from mesenchymal cells that express c-Kit, and signaling via Kit receptors is necessary for normal development of ICC. We studied the f...


    pub_type: 杂志文章


    authors: Torihashi S,Nishi K,Tokutomi Y,Nishi T,Ward S,Sanders KM

    更新日期:1999-07-01 00:00:00

  • Effects of omeprazole on intragastric pH and plasma gastrin are dependent on the CYP2C19 polymorphism.

    abstract:BACKGROUND & AIMS:Omeprazole is metabolized by cytochrome P450 (CYP2C19). The activity of this enzyme is polymorphic, with incidences of poor metabolizers (PMs), heterozygous extensive metabolizers (EMs), and homozygous EMs in white populations of 3%, 30%, and 67%, respectively. The importance of the CYP2C19 polymorphi...


    pub_type: 杂志文章


    authors: Sagar M,Tybring G,Dahl ML,Bertilsson L,Seensalu R

    更新日期:2000-09-01 00:00:00

  • STAT3 NH2-terminal acetylation is activated by the hepatic acute-phase response and required for IL-6 induction of angiotensinogen.

    abstract:BACKGROUND & AIMS:The signal transducers and activators of transcription (STATs) are cytoplasmic transcription factors mediating acute-phase response (APR) of the human angiotensinogen (hAGT) gene in hepatocytes. The mechanisms of how STAT3 activates target genes are unknown. Here we analyzed the biochemistry of STAT3 ...


    pub_type: 杂志文章


    authors: Ray S,Boldogh I,Brasier AR

    更新日期:2005-11-01 00:00:00

  • Effect of size and density on canine gastric emptying of nondigestible solids.

    abstract::Previous studies suggested that the food-containing canine stomach retains large, nondigestible spheres until all food has emptied; but it is not known whether there is a threshold size or a gradation of sizes that will empty along with food. Further, nothing is known of the effects of such parameters as density, shap...


    pub_type: 杂志文章


    authors: Meyer JH,Dressman J,Fink A,Amidon G

    更新日期:1985-10-01 00:00:00

  • Prior colorectal neoplasia is associated with increased risk of ileoanal pouch neoplasia in patients with inflammatory bowel disease.

    abstract:BACKGROUND & AIMS:Although restorative proctocolectomy with ileal pouch-anal anastomosis (IPAA) substantially reduces the risk of colorectal cancer in patients with inflammatory bowel disease (IBD), subsequent pouch neoplasia can develop. There are few data on the incidence of and risk factors for neoplasia, so there i...


    pub_type: 杂志文章


    authors: Derikx LA,Kievit W,Drenth JP,de Jong DJ,Ponsioen CY,Oldenburg B,van der Meulen-de Jong AE,Dijkstra G,Grubben MJ,van Laarhoven CJ,Nagtegaal ID,Hoentjen F,Dutch Initiative on Crohn and Colitis.

    更新日期:2014-01-01 00:00:00

  • Colonoscopic polypectomy in chronic colitis: conservative management after endoscopic resection of dysplastic polyps.

    abstract:BACKGROUND & AIMS:Adenomatous polyps are by definition dysplastic and pathologically indistinguishable from the dysplasia-associated lesion or mass (DALM) described in 1981. Yet, adenomatous polyps in noncolitic colons are usually removed definitively endoscopically, whereas DALMs are regarded as harbingers of colon ca...


    pub_type: 杂志文章


    authors: Rubin PH,Friedman S,Harpaz N,Goldstein E,Weiser J,Schiller J,Waye JD,Present DH

    更新日期:1999-12-01 00:00:00

  • CD4(+ )T cells play an important role in acute experimental pancreatitis in mice.

    abstract:BACKGROUND & AIMS:Few data are available on the potential role of T lymphocytes in experimental acute pancreatitis. The aim of this study was to characterize their role in the inflammatory cascade of acute pancreatitis. METHODS:To type this issue, acute pancreatitis was induced by repeated injections of cerulein in nu...


    pub_type: 杂志文章


    authors: Demols A,Le Moine O,Desalle F,Quertinmont E,Van Laethem JL,Devière J

    更新日期:2000-03-01 00:00:00

  • Restricted V(H) gene usage in lamina propria B cells producing anticolon antibody from patients with ulcerative colitis.

    abstract:BACKGROUND AND AIMS:Autoimmune responses against colonic epithelium may play a role in the development of colonic inflammation associated with ulcerative colitis (UC). In this study, we established and characterized B-cell lines and clones that produced anticolon antibody from inflamed colonic mucosa of UC subjects. M...


    pub_type: 杂志文章


    authors: Inoue N,Watanabe M,Sato T,Okazawa A,Yamazaki M,Kanai T,Ogata H,Iwao Y,Ishii H,Hibi T

    更新日期:2001-07-01 00:00:00

  • A possible involvement of Fas-Fas ligand signaling in the pathogenesis of murine autoimmune gastritis.

    abstract:BACKGROUND & AIMS:A Th1 clone, II-6, established from an autoimmune gastritis BALB/c mouse that underwent thymectomy 3 days after birth, recognized a 15 mer peptide constructing the alpha subunit of H+, K(+)-adenosine triphosphatase as antigen and induced gastritis in nu/nu mice by adoptive transfer. The aim of this st...


    pub_type: 杂志文章


    authors: Nishio A,Katakai T,Oshima C,Kasakura S,Sakai M,Yonehara S,Suda T,Nagata S,Masuda T

    更新日期:1996-10-01 00:00:00