Inflammatory bowel disease in a Swedish twin cohort: a long-term follow-up of concordance and clinical characteristics.

abstract：:The role of central (supraspinal and spinal) and peripheral alpha-adrenoceptors in the regulation of gastrointestinal propulsion in the mouse was studied using clonidine, an alpha 2-adrenoceptor agonist. Clonidine produced a dose-dependent inhibition of propulsion when given intracerebroventricularly, intrathecally, o...

journal_title：Gastroenterology

authors： Jiang Q,Sheldon RJ,Porreca F

更新日期：1988-11-01 00:00:00

abstract：BACKGROUND & AIMS:There have been conflicting results on a cell of origin in pancreatic regeneration. These discrepancies predominantly stem from lack of specific markers for the pancreatic precursors/stem cells, as well as differences in the targeted cells and severity of tissue injury in the experimental models so fa...

journal_title：Gastroenterology

authors： Criscimanna A,Speicher JA,Houshmand G,Shiota C,Prasadan K,Ji B,Logsdon CD,Gittes GK,Esni F

更新日期：2011-10-01 00:00:00

abstract：BACKGROUND & AIMS:Black patients with chronic hepatitis C have lower response rates than white patients to interferon monotherapy. The factors responsible for these differences are unknown, as is the impact of combination antiviral therapy on responsiveness among ethnic groups. We evaluated the impact of race on respon...

journal_title：Gastroenterology

authors： McHutchison JG,Poynard T,Pianko S,Gordon SC,Reid AE,Dienstag J,Morgan T,Yao R,Albrecht J

更新日期：2000-11-01 00:00:00

abstract：BACKGROUND & AIMS:Caco-2 cells have been used extensively to elucidate events involved in intestinal cell proliferation and differentiation. Because individual isoforms of protein kinase C (PKC) and p21waf1, a cyclin-dependent kinase inhibitor, may regulate these processes, their role(s) on the growth and differentiati...

journal_title：Gastroenterology

authors： Abraham C,Scaglione-Sewell B,Skarosi SF,Qin W,Bissonnette M,Brasitus TA

更新日期：1998-03-01 00:00:00

abstract：BACKGROUND & AIMS:Ground-glass (GG) inclusions within hepatocytes are an important histopathologic marker of chronic hepatitis B virus (HBV) infection but may also be seen in Lafora's disease (myoclonus epilepsy), cyanamide alcohol aversion therapy, and type IV glycogenosis. We have noted a recent increased incidence o...

journal_title：Gastroenterology

authors： Lefkowitch JH,Lobritto SJ,Brown RS Jr,Emond JC,Schilsky ML,Rosenthal LA,George DM,Cairo MS

更新日期：2006-09-01 00:00:00

abstract：BACKGROUND & AIMS:In experimental animals, the indigenous microbiota modulates mucosal immunity. In humans, such direct evidence is scarce. The aim of this study was to examine the effect of intestinal bacteria on the local immunoglobulin (Ig) response. METHODS:The numbers of IgA-, IgM-, and IgG-producing immunocytes ...

journal_title：Gastroenterology

authors： Kett K,Baklien K,Bakken A,Kral JG,Fausa O,Brandtzaeg P

更新日期：1995-09-01 00:00:00

abstract：:One hundred Chinese patients who received induction cytotoxic therapy for malignant lymphoma were prospectively studied to determine the incidence, morbidity, mortality, and predisposing factors for reactivation of hepatitis B virus replication during cytotoxic therapy. In 18 (67%) hepatitis B surface antigen-positive...

journal_title：Gastroenterology

authors： Lok AS,Liang RH,Chiu EK,Wong KL,Chan TK,Todd D

更新日期：1991-01-01 00:00:00

abstract：:A prospective endoscopic and histologic study of terminal ileum and colorectum in 211 patients with seronegative spondylarthropathy revealed macroscopic inflammatory lesions varying from erythema to superficial erosions in 30% of the patients and microscopic inflammation in 61%. Two types of inflammation were observed...

journal_title：Gastroenterology

authors： De Vos M,Cuvelier C,Mielants H,Veys E,Barbier F,Elewaut A

更新日期：1989-02-01 00:00:00

abstract：BACKGROUND & AIMS:Multiple molecular mechanisms are likely to contribute to the establishment of persistent infection by hepatitis C virus (HCV). The aim of this work was to study the evasion of cell-mediated antiviral immune responses in transgenic mice with liver-targeted expression of the hepatitis C viral genome. T...

journal_title：Gastroenterology

authors： Disson O,Haouzi D,Desagher S,Loesch K,Hahne M,Kremer EJ,Jacquet C,Lemon SM,Hibner U,Lerat H

更新日期：2004-03-01 00:00:00

abstract：BACKGROUND & AIMS:Qualitative endoscopic ultrasound (EUS) elastography is an accurate but subjective tool for the differential diagnosis of solid pancreatic masses. Second-generation EUS elastography allows quantitative analysis of tissue stiffness. We evaluated the accuracy of quantitative, second-generation EUS elast...

journal_title：Gastroenterology

authors： Iglesias-Garcia J,Larino-Noia J,Abdulkader I,Forteza J,Dominguez-Munoz JE

更新日期：2010-10-01 00:00:00

abstract：:A multicenter study was conducted on 173 patients with active, endoscopically proven duodenal ulcers (158 men, 15 women). They were randomly assigned, in a double-blind manner, to two groups: those receiving placebo capsules (91 patients) and those receiving capsules containing 100 microgram of 15(R)-15-methyl prostag...

journal_title：Gastroenterology

authors： Vantrappen G,Janssens J,Popiela T,Kulig J,Tytgat GN,Huibregtse K,Lambert R,Pauchard JP,Robert A

更新日期：1982-08-01 00:00:00

abstract：BACKGROUND & AIMS:We have few population-level data on the performance of endoscopic retrograde cholangiopancreatography (ERCP) in the United States. We investigated the numbers of unplanned hospital encounters (UHEs), patient and facility factors associated with UHEs, and variation in quality and outcomes in the perfo...

journal_title：Gastroenterology

authors： Huang RJ,Barakat MT,Girotra M,Lee JS,Banerjee S

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND & AIMS:High-level coffee consumption has been associated with reduced progression of pre-existing liver diseases and lower risk of hepatocellular carcinoma. However, its relationship with therapy for hepatitis C virus infection has not been evaluated. METHODS:Patients (n=885) from the lead-in phase of the H...

journal_title：Gastroenterology

authors： Freedman ND,Curto TM,Lindsay KL,Wright EC,Sinha R,Everhart JE,HALT-C TRIAL GROUP.

更新日期：2011-06-01 00:00:00

abstract：BACKGROUND & AIMS:Infliximab is effective in closing fistulas in patients with Crohn's disease. We examined the effect of infliximab maintenance treatment on hospitalizations, surgeries, and procedures in patients with fistulizing Crohn's disease enrolled in the ACCENT II study. METHODS:After 5 mg/kg infliximab at wee...

journal_title：Gastroenterology

authors： Lichtenstein GR,Yan S,Bala M,Blank M,Sands BE

更新日期：2005-04-01 00:00:00

abstract：:Microsatellite instability (MSI) caused by mismatch repair deficiency (dMMR) is detected in a small proportion of pancreatic ductal adenocarcinomas (PDACs). dMMR and MSI have been associated with responses of metastatic tumors, including PDACs, to immune checkpoint inhibitor therapy. We performed immunohistochemical a...

journal_title：Gastroenterology

authors： Lupinacci RM,Goloudina A,Buhard O,Bachet JB,Maréchal R,Demetter P,Cros J,Bardier-Dupas A,Collura A,Cervera P,Scriva A,Dumont S,Hammel P,Sauvanet A,Louvet C,Delpéro JR,Paye F,Vaillant JC,André T,Closset J,Emile JF

更新日期：2018-03-01 00:00:00

abstract：BACKGROUND & AIMS:The aim of this study was to evaluate the role of known colorectal adenoma and carcinoma susceptibility genes and to locate a novel susceptibility gene in an Ashkenazi family (SM1311) with dominantly inherited predisposition to colorectal adenomas and carcinomas. METHODS:Clinicopathologic and family ...

journal_title：Gastroenterology

authors： Tomlinson I,Rahman N,Frayling I,Mangion J,Barfoot R,Hamoudi R,Seal S,Northover J,Thomas HJ,Neale K,Hodgson S,Talbot I,Houlston R,Stratton MR

更新日期：1999-04-01 00:00:00

abstract：:The effects of hydroxypropylmethylcellulose on upper gastrointestinal transit, viscosity, and water flux were studied in six dogs fistulated at the proximal duodenum and/or mid-jejunum. Combinations of different grades of hydroxypropylmethylcellulose were prepared as 2% or 3.3% solutions to yield input viscosities of ...

journal_title：Gastroenterology

authors： Reppas C,Meyer JH,Sirois PJ,Dressman JB

更新日期：1991-05-01 00:00:00

abstract：BACKGROUND & AIMS:Trinitrobenzene sulfonic acid (TNBS)-induced colitis is a T-helper 1 (Th1) T cell-mediated inflammation that is rapidly reversed by administration of anti-interleukin (IL) 12. This study sought to define the mechanism of this curative effect. METHODS:Cells and tissue from mice with TNBS colitis recei...

journal_title：Gastroenterology

authors： Fuss IJ,Marth T,Neurath MF,Pearlstein GR,Jain A,Strober W

更新日期：1999-11-01 00:00:00

abstract：:This report defines criteria and reviews the epidemiology, pathophysiology, and management of common anorectal disorders: fecal incontinence (FI), functional anorectal pain and functional defecation disorders. FI is defined as the recurrent uncontrolled passage of fecal material for at least 3 months. The clinical fea...

journal_title：Gastroenterology

authors： Rao SS,Bharucha AE,Chiarioni G,Felt-Bersma R,Knowles C,Malcolm A,Wald A

更新日期：2016-03-25 00:00:00

abstract：BACKGROUND & AIMS:Activated pancreatic stellate cells have recently been implicated in pancreatic fibrogenesis. This study examined the role of pancreatic stellate cells in alcoholic pancreatic fibrosis by determining whether these cells are activated by ethanol itself and, if so, whether such activation is caused by t...

journal_title：Gastroenterology

authors： Apte MV,Phillips PA,Fahmy RG,Darby SJ,Rodgers SC,McCaughan GW,Korsten MA,Pirola RC,Naidoo D,Wilson JS

更新日期：2000-04-01 00:00:00

abstract：BACKGROUND & AIMS:Chronic stress is associated with visceral hyperalgesia in functional gastrointestinal disorders. We investigated whether corticosterone plays a role in chronic psychological stress-induced visceral hyperalgesia. METHODS:Male rats were subjected to 1-hour water avoidance (WA) stress or subcutaneous c...

journal_title：Gastroenterology

authors： Hong S,Zheng G,Wu X,Snider NT,Owyang C,Wiley JW

更新日期：2011-02-01 00:00:00

abstract：:In addition to the previously described molecular forms of gastrin, a new component has been found in high concentrations in the serum of 6 patients with Zollinger-Ellison syndrome. Serum was fractionated by gel filtration, and ion exchange chromatography, and the new component was identified in eluates by radioimmuno...

journal_title：Gastroenterology

authors： Dockray GJ,Walsh JH

更新日期：1975-02-01 00:00:00

abstract：BACKGROUND:Actin is a key contractile protein associated with the normal differentiation and function of gastrointestinal smooth muscle cells. Distinct changes in gastrointestinal smooth muscle cell morphology and function have been reported for the aganglionic rectum and megacolon of the adult lethal spotted mouse. Th...

journal_title：Gastroenterology

authors： Liddell RA,Mooers SU,Siegman MJ,McHugh KM

更新日期：1993-08-01 00:00:00

abstract：BACKGROUND/AIMS:Gastrointestinal peptides and biogenic monoamines participate in the regulation of gastrointestinal functions. The aim of this study was to examine the influence of the microflora on the distribution of endocrine cells and on the release of gastrointestinal peptides. METHODS:A quantitative morphologica...

journal_title：Gastroenterology

authors： Uribe A,Alam M,Johansson O,Midtvedt T,Theodorsson E

更新日期：1994-11-01 00:00:00

abstract：:The efficacy of various adsorbents for endotoxin was tested in vitro and in vivo using a murine experimental model of gut-derived endotoxemia. A quantitative limulus amebocyte lysate microtiter test and the limulus amebocyte lysate tube test were used to determine intestinal and circulating levels of endotoxin. Kaopec...

journal_title：Gastroenterology

authors： Ditter B,Urbaschek R,Urbaschek B

更新日期：1983-06-01 00:00:00

abstract：:We are delighted to introduce a new and simple format in the references section of the articles we publish in Gastroenterology that highlights joint first authors of citations. We believe this is an important step to acknowledging equal contribution to published work as research becomes increasingly team-oriented and ...

journal_title：Gastroenterology

authors： Dubnansky E,Omary MB

更新日期：2012-10-01 00:00:00

abstract：:Exposure of isolated gastric mucosal surface cells to NH4+ results in acidification of cells as determined by a fluorescent dye technique using acridine orange. The resulting intracellular pH gradient is maintained when cells are suspended in either buffered HCO3- -free Ringer's or choline chloride solution. Cells sus...

journal_title：Gastroenterology

authors： Olender EJ,Fromm D,Furukawa T,Kolis M

更新日期：1984-04-01 00:00:00

abstract：:Electromyogram of the submental muscles, esophageal manometry, and pH studies were simultaneously performed in an unselected group of 12 patients with subjective and objective evidence of gastroesophageal reflux (GER) disease to determine the frequency of transient relaxation of the lower esophageal sphincter (LES) an...

journal_title：Gastroenterology

authors： Mittal RK,McCallum RW

更新日期：1988-09-01 00:00:00

abstract：BACKGROUND & AIMS:The basic mechanisms of food allergies are still unknown. The aims of this study were to investigate whether endothelins (ETs) in the intestinal mucosa are involved in the pathogenesis of intestinal anaphylaxis. METHODS:Sprague-Dawley rats were sensitized to chicken egg albumin (EA) by intraperitonea...

journal_title：Gastroenterology

authors： Shigematsu T,Miura S,Hirokawa M,Hokari R,Higuchi H,Tsuzuki Y,Kimura H,Nakatsumi RC,Serizawa H,Saito H,Ishii H

更新日期：1998-08-01 00:00:00

abstract：BACKGROUND & AIMS:Serine proteases are postulated to influence gastrointestinal function by stimulating protease-activated receptors (PARs). This study identified the effects on myenteric neurons of activating PARs and investigated underlying mechanisms of action. METHODS:Intracellular electrophysiologic methods were ...

journal_title：Gastroenterology

authors： Gao C,Liu S,Hu HZ,Gao N,Kim GY,Xia Y,Wood JD

更新日期：2002-11-01 00:00:00