Calcium affinity for biliary lipid aggregates in model biles: complementary importance of bile salts and lecithin.

abstract：:The aim of the present study was to characterize rat mucosal colonic cells harvested from the crypt continuum during differentiation and dimethylhydrazine-induced neoplasia. The collection of colonocytes was performed using a modified nonenzymatic isolation procedure based on Ca2+ chelation and gentle mechanical disso...

journal_title：Gastroenterology

authors： Schwartz B,Avivi C,Lamprecht SA

更新日期：1991-03-01 00:00:00

abstract：BACKGROUND & AIMS:The emergence of oxyntic atrophy and metaplastic cell lineages in response to chronic Helicobacter pylori infection predisposes to gastric neoplasia. We have described a trefoil factor family 2 (TFF2; spasmolytic polypeptide) expressing metaplasia (SPEM) associated with gastric neoplasia in both roden...

journal_title：Gastroenterology

authors： Nomura S,Baxter T,Yamaguchi H,Leys C,Vartapetian AB,Fox JG,Lee JR,Wang TC,Goldenring JR

更新日期：2004-08-01 00:00:00

abstract：:An animal model suitable for in vivo studies of interferon-mediated suppression of hepatic oxidative drug metabolism has been developed. Rats were injected with either recombinant human interferon alpha A, recombinant human interferon gamma, recombinant rat interferon gamma, or vehicle and experiments were performed 2...

journal_title：Gastroenterology

authors： Craig PI,Williams SJ,Cantrill E,Farrell GC

更新日期：1989-10-01 00:00:00

abstract：BACKGROUND & AIMS:We previously demonstrated that the 2 APC mutations in human colorectal tumors are coselected, because tumorigenesis requires an optimal level of Wnt signaling. We and others subsequently showed that the truncated APC proteins in colorectal tumors usually retain a total of 1-2 beta-catenin binding/deg...

journal_title：Gastroenterology

authors： Pollard P,Deheragoda M,Segditsas S,Lewis A,Rowan A,Howarth K,Willis L,Nye E,McCart A,Mandir N,Silver A,Goodlad R,Stamp G,Cockman M,East P,Spencer-Dene B,Poulsom R,Wright N,Tomlinson I

更新日期：2009-06-01 00:00:00

abstract：BACKGROUND & AIMS:Although long-term results of endoscopic sphincterotomy (ES) have been poorly estimated, extended indications of ES have been proposed, especially in young patients. The aim of this study was to assess late biliary complications of ES. METHODS:Between 1981 and 1986, 169 patients younger than age 70 (...

journal_title：Gastroenterology

authors： Prat F,Malak NA,Pelletier G,Buffet C,Fritsch J,Choury AD,Altman C,Liguory C,Etienne JP

更新日期：1996-03-01 00:00:00

abstract：:In dogs with Heidenhain pouches and gastric fistulas, we studied acid secretion in response to systemic or portal infusion of methionine-enkephalin (met-enkephalin), enkephalin-analog, or morphine. All these opiate compounds caused a dose-dependent increase in acid secretion under basal conditions and resulted in a si...

journal_title：Gastroenterology

authors： Konturek SJ,Tasler J,Cieszkowski M,Mikoś E,Coy DH,Schally AV

更新日期：1980-02-01 00:00:00

abstract：BACKGROUND & AIMS:A high-fat diet (HFD) can cause serious health problems, including alteration of gastrointestinal transit, the exact mechanism of which is not clear. Several microRNAs (miRNAs) are involved in energy homeostasis, lipid metabolism, and HFD-induced weight gain. We investigated the role of miRNAs in HFD-...

journal_title：Gastroenterology

authors： Nezami BG,Mwangi SM,Lee JE,Jeppsson S,Anitha M,Yarandi SS,Farris AB 3rd,Srinivasan S

更新日期：2014-02-01 00:00:00

abstract：:Extracellular space and blood volume were measured using 82Br dilution and 51Cr-tagged erythrocytes in 24 tumor-free patients after total gastrectomy. Eleven of the patients suffered from early dumping. Age, blood volume, and extracellular space were significantly smaller in dumpers (P less than 0.05). The dumping sco...

journal_title：Gastroenterology

authors： Miholic J,Reilmann L,Meyer HJ,Körber H,Kotzerke J,Hecker H

更新日期：1990-10-01 00:00:00

abstract：BACKGROUND & AIMS:Corticosteroids have been shown to significantly decrease short-term mortality in patients with severe alcoholic hepatitis. However, independent factors associated with a favorable outcome and long-term survival are unknown. The aim of this study was to examine prognostic factors and long-term surviva...

journal_title：Gastroenterology

authors： Mathurin P,Duchatelle V,Ramond MJ,Degott C,Bedossa P,Erlinger S,Benhamou JP,Chaput JC,Rueff B,Poynard T

更新日期：1996-06-01 00:00:00

abstract：:Evidence showing that interstitial cells of Cajal have important regulatory functions in the gut musculature is accumulating. In the current study, the ultrastructure of the deep muscular plexus and associated interstial cells of Cajal in human small intestine were studied to provide a reference for identification and...

journal_title：Gastroenterology

authors： Rumessen JJ,Mikkelsen HB,Thuneberg L

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND & AIMS:Anemia is associated commonly with acute and chronic inflammation, but the mechanisms of their interaction are not clear. We investigated whether microRNA 122 (MIR122), which is generated in the liver and is secreted into the blood, is involved in the development of anemia associated with inflammation...

journal_title：Gastroenterology

authors： Rivkin M,Simerzin A,Zorde-Khvalevsky E,Chai C,Yuval JB,Rosenberg N,Harari-Steinfeld R,Schneider R,Amir G,Condiotti R,Heikenwalder M,Weber A,Schramm C,Wege H,Kluwe J,Galun E,Giladi H

更新日期：2016-11-01 00:00:00

abstract：BACKGROUND & AIMS:Improving methods for early detection of gastric cancer could reduce mortality. Measurements of serum pepsinogen levels have been used for screening in Japan without satisfactory levels of sensitivity or specificity. Trefoil factor family (TFF) proteins (TFF1, TFF2, and TFF3) are small and stable mole...

journal_title：Gastroenterology

authors： Aikou S,Ohmoto Y,Gunji T,Matsuhashi N,Ohtsu H,Miura H,Kubota K,Yamagata Y,Seto Y,Nakajima A,Goldenring JR,Kaminishi M,Nomura S

更新日期：2011-09-01 00:00:00

abstract：:Decreases in arterial pH markedly increase sodium, chloride, and water absorption in the normal ileum and can reverse ongoing cholera toxin-induced secretion. In the current study we examined whether these effects of pH are evident in other models of ileal secretion, and in a model of increased absorption. Rats were a...

journal_title：Gastroenterology

authors： Charney AN,Ingrassia PM,Thaler SM,Keane MG

更新日期：1989-02-01 00:00:00

abstract：BACKGROUND & AIMS:Treatment options are limited for patients with hepatitis C (HCV) infection with treatment failure after sofosbuvir plus an NS5A inhibitor. There are some data for the efficacy of glecaprevir/pibrentasvir (G/P) in these patients. We performed a randomized trial of the safety and efficacy of 12 and 16 ...

journal_title：Gastroenterology

authors： Lok AS,Sulkowski MS,Kort JJ,Willner I,Reddy KR,Shiffman ML,Hassan MA,Pearlman BL,Hinestrosa F,Jacobson IM,Morelli G,Peter JA,Vainorius M,Michael LC,Fried MW,Wang GP,Lu W,Larsen L,Nelson DR

更新日期：2019-12-01 00:00:00

abstract：:Non-major histocompatibility complex-restricted cytotoxicity triggered by antibodies to the CD3 component of the human T-cell receptor complex is thought to be an indirect measure of in vivo primed cytotoxic T-cell activity. We have used this technique to examine the lytic activity of freshly isolated T cells from non...

journal_title：Gastroenterology

authors： Shanahan F,Deem R,Nayersina R,Leman B,Targan S

更新日期：1988-04-01 00:00:00

abstract：:The interrelationship of the effects of antacids and of rising intragastric pH on serum gastrin levels was examined by comparing the effect of three antacids (Mg(OH)2Al(OH)3, and CaCO3), and their nonbuffering chloride compounds (MgCl2, AlCl3, and CaCl2), on serum gastrin and intragastric pH in duodenal ulcer patients...

journal_title：Gastroenterology

authors： Feurle GE

更新日期：1975-01-01 00:00:00

abstract：BACKGROUND:Fiber and water-holding agents are used for the treatment of constipation. In what may appear to be a paradox, they are sometimes also used for the treatment of diarrhea; it has been proposed that they sequester water from liquid stools and/or increase the ratio of fecal solids to fecal water and thereby imp...

journal_title：Gastroenterology

authors： Eherer AJ,Santa Ana CA,Porter J,Fordtran JS

更新日期：1993-04-01 00:00:00

abstract：:Mucins synthesized in colonic cancer are known to be different from those in the normal colon; however, the biochemical differences between these mucins have not been defined. We have purified mucins from samples of nonneoplastic (normal) human colon and colon cancer and found that the carbohydrate content of the canc...

journal_title：Gastroenterology

authors： Boland CR,Deshmukh GD

更新日期：1990-05-01 00:00:00

abstract：:We studied chronic intake of diets deficient in or supplemented with linoleic acid to determine whether it affects gastric acid secretion, release of prostaglandin E2, and stress-induced lesions. For 8-10 wk rats were fed three dietary regimens supplying 3.5% (control group), 0.3%, and 10% of total calories as linolei...

journal_title：Gastroenterology

authors： Schepp W,Steffen B,Ruoff HJ,Schusdziarra V,Classen M

更新日期：1988-07-01 00:00:00

abstract：BACKGROUND & AIMS:Chronic pancreatitis has been suggested as a causal risk factor for pancreatic cancer in a recent study. The aim of this study was to clarify the relationship between chronic pancreatitis and pancreatic cancer. METHODS:All patients in the Swedish inpatient Register with a discharge diagnosis of pancr...

journal_title：Gastroenterology

authors： Karlson BM,Ekbom A,Josefsson S,McLaughlin JK,Fraumeni JF Jr,Nyrén O

更新日期：1997-08-01 00:00:00

abstract：:The reason why hepatocellular carcinoma occurs less frequently in women than in men is unknown. The possibility that differences in the hepatitis B virus status between men and women with this tumor might be important in this regard was investigated in 75 black women and 75 age- and ethnically-matched men with hepatoc...

journal_title：Gastroenterology

authors： Kew MC,Rossouw E,Paterson A,Hodkinson J,Whitcutt M,Dusheiko G

更新日期：1983-04-01 00:00:00

abstract：:We have examined the possibility that the 33- and 39-amino acid forms of cholecystokinin (CCK) are cleaved to produce CCK-octapeptide (CCK-8) during circulation in humans. When a mixture of the 33- and 39-amino acid forms of porcine CCK was infused at 0.1-2.5 pmol/kg.min into normal subjects, material indistinguishabl...

journal_title：Gastroenterology

authors： Springer CJ,Calam J

更新日期：1988-07-01 00:00:00

abstract：BACKGROUND & AIMS:The adenoma detection rate (ADR) is an important quality indicator of screening colonoscopy; it is inversely associated with risk of interval cancers and colorectal cancer mortality. We assessed trends in the ADR in the first 10 years of the German screening colonoscopy program. METHODS:We calculated...

journal_title：Gastroenterology

authors： Brenner H,Altenhofen L,Kretschmann J,Rösch T,Pox C,Stock C,Hoffmeister M

更新日期：2015-08-01 00:00:00

abstract：BACKGROUND & AIMS:We previously isolated a monoclonal antibody against a Necturus gallbladder epitope that blocks native adenosine 3',5'-cyclic monophosphate (cAMP)-dependent chloride channels in intestine, gallbladder, urinary bladder, and airway epithelia in various animals. METHODS:Using this antibody, we purified ...

journal_title：Gastroenterology

authors： Finn AL,Kuzhikandathil EV,Oxford GS,Itoh-Lindstrom Y

更新日期：2001-01-01 00:00:00

abstract：:The role of capsaicin-sensitive afferent neurons in acid-induced HCO3- secretion was investigated in the duodenum of anesthetized rats. The proximal duodenum was perfused with saline (pH 4.5), the pH of perfusate and the transmucosal potential differences were continuously monitored, and HCO3- output was determined by...

journal_title：Gastroenterology

authors： Takeuchi K,Matsumoto J,Ueshima K,Okabe S

更新日期：1991-10-01 00:00:00

abstract：BACKGROUND & AIMS:Chronic hepatitis C virus infection activates an intrahepatic immune response, leading to increased expression of interferon (IFN)-stimulated genes and activation of natural killer (NK) cells-the most prevalent innate immune cell in the liver. We investigated whether the elimination of hepatitis C vir...

journal_title：Gastroenterology

authors： Serti E,Chepa-Lotrea X,Kim YJ,Keane M,Fryzek N,Liang TJ,Ghany M,Rehermann B

更新日期：2015-07-01 00:00:00

abstract：:Individual l-amino acids were instilled intragastrically to determine possible differences in stimulation of gastric acid secretion and gastrin and pancreatic polypeptide release. Phenylalanine and tryptophan were significantly more potent stimulants of gastric acid secretion and of pancreatic polypeptide and gastrin ...

journal_title：Gastroenterology

authors： Taylor IL,Byrne WJ,Christie DL,Ament ME,Walsh JH

更新日期：1982-07-01 00:00:00

abstract：:Using a radioimmunoassay which detect concentrations of alpha-fetoprotein as low as 5 ng per ml, 38% of 176 patients with viral hepatitis compared with health volunteers and patients with chronic diseases not affecting the liver. When separated into two groups based on histological classification of liver biopsy speci...

journal_title：Gastroenterology

authors： Bloomer JR,Waldmann TA,McIntire R,Klatskin G

更新日期：1975-02-01 00:00:00

abstract：:We report the case of a female patient suffering from Waldenström's macroglobulinemia with three different liver lesions: peliosis hepatis, nodular regenerative hyperplasia, and light-chain deposits within the sinusoidal walls. We hypothesize that both peliosis hepatis and nodular regenerative hyperplasia might be the...

journal_title：Gastroenterology

authors： Voinchet O,Degott C,Scoazec JY,Feldmann G,Benhamou JP

更新日期：1988-08-01 00:00:00

abstract：BACKGROUND & AIMS:Beta-blockers are extensively used to prevent variceal bleeding in patients with large esophageal varices. It is not established if beta-blockers delay the growth of small varices. METHODS:A total of 161 patients with cirrhosis and small esophageal varices (F1 according to the classification of Beppu...

journal_title：Gastroenterology

authors： Merkel C,Marin R,Angeli P,Zanella P,Felder M,Bernardinello E,Cavallarin G,Bolognesi M,Donada C,Bellini B,Torboli P,Gatta A,Gruppo Triveneto per l'Ipertensione Portale.

更新日期：2004-08-01 00:00:00