Biliary symptoms and complications more than 8 years after endoscopic sphincterotomy for choledocholithiasis.


BACKGROUND & AIMS:Although long-term results of endoscopic sphincterotomy (ES) have been poorly estimated, extended indications of ES have been proposed, especially in young patients. The aim of this study was to assess late biliary complications of ES. METHODS:Between 1981 and 1986, 169 patients younger than age 70 (55+/-11.8 years; range, 24-70 years; male-female sex ration, 0.55) underwent ES for choledocholithiasis. One hundred fifteen patients (68%) underwent cholecystectomy. Long-term data were obtained retrospectively from the patients and general practitioners. RESULTS:Information was obtained for 156 patients, 2 of whom died within 1 month (one ES-related death). The mean follow-up for 154 patients was 9.6+/-3.3 years (range 8-13 years); 138 patients had no biliary symptoms. During follow-up, 16 patients experienced biliary symptoms; 2 of these patients underwent elective cholecystectomy, 3 had malignant strictures, 1 had a complicated cirrhosis, and 1 had a benign stricture related to the previous cholecystectomy. Nine patients developed potentially ES-related biliary symptoms. Second endoscopic exploration showed papillary stenosis in 3 patients (with stones in 2 patients) and recurrent bile duct stones in 3 others. Two patients had sine materia cholangitis, and 1 patient developed liver abscesses. CONCLUSIONS:Long-term ES-related complications seem to be rare, ES could reasonably be included in management strategies of choledocholithiasis, even in young patients.






Prat F,Malak NA,Pelletier G,Buffet C,Fritsch J,Choury AD,Altman C,Liguory C,Etienne JP




Has Abstract


1996-03-01 00:00:00














  • Occult radiopaque jaw lesions in familial adenomatous polyposis coli and hereditary nonpolyposis colorectal cancer.

    abstract::The purposes of this study were to determine the association, in 10 pedigrees, between adenomatous polyposis coli, hereditary nonpolyposis colorectal cancer, and occult radiopaque jaw lesions, and to assess whether these radiodensities are predictors for adenomatous polyposis. In seven kindreds with adenomatous polypo...


    pub_type: 杂志文章


    authors: Offerhaus GJ,Levin LS,Giardiello FM,Krush AJ,Welsh SB,Booker SV,Hasler JF,McKusick VA,Yardley JH,Hamilton SR

    更新日期:1987-09-01 00:00:00

  • A serine palmitoyltransferase inhibitor blocks hepatitis C virus replication in human hepatocytes.

    abstract:BACKGROUND & AIMS:Host cell lipid rafts form a scaffold required for replication of hepatitis C virus (HCV). Serine palmitoyltransferases (SPTs) produce sphingolipids, which are essential components of the lipid rafts that associate with HCV nonstructural proteins. Prevention of the de novo synthesis of sphingolipids b...


    pub_type: 杂志文章


    authors: Katsume A,Tokunaga Y,Hirata Y,Munakata T,Saito M,Hayashi H,Okamoto K,Ohmori Y,Kusanagi I,Fujiwara S,Tsukuda T,Aoki Y,Klumpp K,Tsukiyama-Kohara K,El-Gohary A,Sudoh M,Kohara M

    更新日期:2013-10-01 00:00:00

  • Oncogenic KRAS induces progenitor cell expansion and malignant transformation in zebrafish exocrine pancreas.

    abstract:BACKGROUND & AIMS:Although the cell of origin for pancreatic cancer remains unknown, prior studies have suggested that pancreatic neoplasia may be initiated in progenitor-like cells. To examine the effects of oncogene activation within the pancreatic progenitor pool, we devised a system for real-time visualization of b...


    pub_type: 杂志文章


    authors: Park SW,Davison JM,Rhee J,Hruban RH,Maitra A,Leach SD

    更新日期:2008-06-01 00:00:00

  • Colostomy closure promotes cell proliferation and dimethylhydrazine-induced carcinogenesis in rat distal colon.

    abstract::The influence of adaptive cell proliferation on colonic carcinogenesis was studied in male Fischer rats with a defunctioning transverse colostomy that was closed 4 wk later. Control observations were made in other rats after colonic transection, repeated at 4 wk, after laparotomy alone, or after permanent colostomy. T...


    pub_type: 杂志文章


    authors: Terpstra OT,Dahl EP,Williamson RC,Ross JS,Malt RA

    更新日期:1981-09-01 00:00:00

  • Delivery of matrix metalloproteinase-1 attenuates established liver fibrosis in the rat.

    abstract:BACKGROUND & AIMS:During hepatic fibrogenesis, the hepatic extracellular matrix changes to fibrillar collagens types I and III, and cirrhosis is believed to produce an irreversible scar. In this study, we investigated whether gene delivery of human matrix metalloproteinase-1, which degrades collagens types I and type I...


    pub_type: 杂志文章


    authors: Iimuro Y,Nishio T,Morimoto T,Nitta T,Stefanovic B,Choi SK,Brenner DA,Yamaoka Y

    更新日期:2003-02-01 00:00:00

  • Overexpression of glutamine synthetase in human primary liver cancer.

    abstract:BACKGROUND/AIMS:We have identified several clones specifically expressed during malignant cell proliferation by screening a complementary DNA library constructed from a human primary liver cancer with subtractive probes. One clone was identified as the glutamine synthetase (GS) transcript. Its expression is tightly reg...


    pub_type: 杂志文章


    authors: Christa L,Simon MT,Flinois JP,Gebhardt R,Brechot C,Lasserre C

    更新日期:1994-05-01 00:00:00

  • Lipoxygenase metabolites in the rat gastric microvascular response to intragastric ethanol.

    abstract::The role of lipoxygenase metabolites in ethanol-induced gastric mucosal injury and submucosal microvascular change in the rat was studied by in vivo microscopy. Intragastric ethanol-instillation caused marked submucosal venular constriction, dilatation of small arterioles, and corpus mucosal gross lesion formation. Th...


    pub_type: 杂志文章


    authors: Yonei Y,Guth PH

    更新日期:1989-08-01 00:00:00

  • Increased colonic mucosal angiotensin I and II concentrations in Crohn's colitis.

    abstract::To define a potential role for the angiotensin system in Crohn's colitis, the colonic mucosal levels of angiotensin I and II were measured in endoscopic biopsy samples from patients with active Crohn's colitis (n = 20), ulcerative colitis (n = 13), other forms of colitis (n = 3), and normal controls (n = 17). Colonic ...


    pub_type: 杂志文章


    authors: Jaszewski R,Tolia V,Ehrinpreis MN,Bodzin JH,Peleman RR,Korlipara R,Weinstock JV

    更新日期:1990-06-01 00:00:00

  • Alcohollike liver disease in nonalcoholics. A clinical and histologic comparison with alcohol-induced liver injury.

    abstract::Individuals who deny alcohol consumption may develop liver injury that histologically resembles the liver injury found in alcoholic patients. To determine whether any clinical or histologic features distinguish alcoholic and nonalcoholic subjects with "alcohollike" liver injury, the clinical records and liver biopsy s...


    pub_type: 杂志文章


    authors: Diehl AM,Goodman Z,Ishak KG

    更新日期:1988-10-01 00:00:00

  • Cholecystokinin knockout mice are resistant to high-fat diet-induced obesity.

    abstract:BACKGROUND & AIMS:Cholecystokinin (CCK) is a satiation peptide released during meals in response to lipid intake; it regulates pancreatic digestive enzymes that are required for absorption of nutrients. We proposed that mice with a disruption in the CCK gene (CCK knockout [CCK-KO] mice) that were fed a diet of 20% butt...


    pub_type: 杂志文章


    authors: Lo CM,King A,Samuelson LC,Kindel TL,Rider T,Jandacek RJ,Raybould HE,Woods SC,Tso P

    更新日期:2010-05-01 00:00:00

  • Clinical features and prognosis of severe chronic active liver disease (CALD) after corticosteroid-induced remission.

    abstract::Disappearance of symptoms, resolution of most biochemical abnormalities, and histologic improvement to mild chronic inflammation were accomplished in 69 of 123 patients (56%) with severe chronic active liver disease treated with corticosteroids for up to 6.5 yr. Remission of at least 6 mo duration was possible in 35 o...


    pub_type: 杂志文章


    authors: Czaja AJ,Ammon HV,Summerskill WH

    更新日期:1980-03-01 00:00:00

  • Bismuth subsalicylate markedly decreases hydrogen sulfide release in the human colon.

    abstract:BACKGROUND & AIMS:Hydrogen sulfide is one of the main malodorous compounds in human flatus. This toxic gas also has been implicated in the pathogenesis of ulcerative colitis. Therefore, a treatment that reduces colonic H2S levels could be clinically useful in the treatment of flatus odor and of ulcerative colitis. In t...


    pub_type: 杂志文章


    authors: Suarez FL,Furne JK,Springfield J,Levitt MD

    更新日期:1998-05-01 00:00:00

  • Decrease of a hepatic binding protein specific for asialoglycoproteins with accumulation of serum asialoglycoproteins in galactosamine-treated rats.

    abstract::Acute liver injury was induced experimentally in rats by a single injection of a large amount of D-galactosamine. Hepatocellular damage was apparent from decrease of total serum proteins, marked release of transaminases into the circulation, precipitous decrease of total microsomal proteins, and intracellular enzymes ...


    pub_type: 杂志文章


    authors: Sawamura T,Kawasato S,Shiozaki Y,Sameshima Y,Nakada H,Tashiro Y

    更新日期:1981-09-01 00:00:00

  • Corticotropin-releasing factor receptor 1-deficient mice do not develop postoperative gastric ileus.

    abstract:BACKGROUND & AIMS:Corticotropin-releasing factor (CRF) signaling pathways play a key role in the stress response through the activation of CRF(1) and CRF(2) receptors. We investigated the CRF receptor subtypes involved in gastric postoperative ileus. METHODS:Adult male mice (C57BL/6, CRF(1)-deficient, and wild-type), ...


    pub_type: 杂志文章


    authors: Luckey A,Wang L,Jamieson PM,Basa NR,Million M,Czimmer J,Vale W,Taché Y

    更新日期:2003-09-01 00:00:00

  • The association between hepatitis C infection and survival after orthotopic liver transplantation.

    abstract:BACKGROUND & AIMS:The effect of hepatitis C viral (HCV) infection on patient and allograft survival after orthotopic liver transplantation is controversial. Hepatitis C recurrence after transplant is inevitable, but studies to date have not found a survival difference between recipients with and without HCV. METHODS:U...


    pub_type: 杂志文章


    authors: Forman LM,Lewis JD,Berlin JA,Feldman HI,Lucey MR

    更新日期:2002-04-01 00:00:00

  • Increased frequency of transient lower esophageal sphincter relaxation induced by gastric distention in reflux patients with hiatal hernia.

    abstract:BACKGROUND & AIMS:This study aimed to determine if hiatal hernia influences vulnerability to reflux and transient lower esophageal sphincter relaxation (tLESR) during gastric distention in patients with gastroesophageal reflux disease (GERD). METHODS:Eight normal subjects and 15 patients with GERD were studied. A meta...


    pub_type: 杂志文章


    authors: Kahrilas PJ,Shi G,Manka M,Joehl RJ

    更新日期:2000-04-01 00:00:00

  • A polymorphism near IL28B is associated with spontaneous clearance of acute hepatitis C virus and jaundice.

    abstract:BACKGROUND & AIMS:A single nucleotide polymorphism (SNP) upstream of the IL28B gene has been associated with response of patients with chronic hepatitis C to therapy with pegylated interferon and ribavirin and also with spontaneous clearance of acute hepatitis C in a heterogeneous population. We analyzed the associatio...


    pub_type: 杂志文章


    authors: Tillmann HL,Thompson AJ,Patel K,Wiese M,Tenckhoff H,Nischalke HD,Lokhnygina Y,Kullig U,Göbel U,Capka E,Wiegand J,Schiefke I,Güthoff W,Grüngreiff K,König I,Spengler U,McCarthy J,Shianna KV,Goldstein DB,McHutchison JG

    更新日期:2010-11-01 00:00:00

  • Tumor necrosis factor alpha in the pathogenesis of human and murine fulminant hepatic failure.

    abstract:BACKGROUND & AIMS:The tumor necrosis factor (TNF)-alpha/TNF receptor system is critical for liver development because hepatocytes undergo apoptosis if the antiapoptotic cascades resulting in RelA NF-kappaB activation are not effective. Therefore, we studied the role of TNF-alpha in fulminant hepatic failure (FHF) and d...


    pub_type: 杂志文章


    authors: Streetz K,Leifeld L,Grundmann D,Ramakers J,Eckert K,Spengler U,Brenner D,Manns M,Trautwein C

    更新日期:2000-08-01 00:00:00

  • The Wnt antagonist Dkk1 regulates intestinal epithelial homeostasis and wound repair.

    abstract:BACKGROUND & AIMS:Dkk1 is a secreted antagonist of the Wnt/β-catenin signaling pathway. It is induced by inflammatory cytokines during colitis and exacerbates tissue damage by promoting apoptosis of epithelial cells. However, little is known about the physiologic role of Dkk1 in normal intestinal homeostasis and during...


    pub_type: 杂志文章


    authors: Koch S,Nava P,Addis C,Kim W,Denning TL,Li L,Parkos CA,Nusrat A

    更新日期:2011-07-01 00:00:00

  • Pancreatic stenting prevents pancreatitis after biliary sphincterotomy in patients with sphincter of Oddi dysfunction.

    abstract:BACKGROUND & AIMS:Patients with sphincter of Oddi dysfunction are at high risk of developing pancreatitis after endoscopic biliary sphincterotomy. Impaired pancreatic drainage caused by pancreatic sphincter hypertension is the likely explanation for this increased risk. A prospective, randomized controlled trial was co...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Tarnasky PR,Palesch YY,Cunningham JT,Mauldin PD,Cotton PB,Hawes RH

    更新日期:1998-12-01 00:00:00

  • Reactive nitrogen species switch on early extracellular matrix remodeling via induction of MMP1 and TNFalpha.

    abstract:BACKGROUND & AIMS:Liver injury leads to generation of reactive oxygen and nitrogen species, which can react to produce peroxynitrite (ONOO-). We investigated whether ONOO- and its metabolites modulate extracellular matrix remodeling. METHODS:Stellate cells (HSC) were incubated with pure ONOO- or SIN-1 (a ONOO- donor)....


    pub_type: 杂志文章


    authors: Urtasun R,Cubero FJ,Vera M,Nieto N

    更新日期:2009-04-01 00:00:00

  • Prospective study reveals associations between colorectal cancer and type 2 diabetes mellitus or insulin use in men.

    abstract:BACKGROUND & AIMS:Type 2 diabetes mellitus (DM) is associated with an increased risk of colorectal cancer (CRC); it is not clear if this association varies by sex or other factors. Insulin use might also be associated with CRC risk. We investigated associations of type 2 DM and insulin use with CRC risk. METHODS:The C...


    pub_type: 杂志文章


    authors: Campbell PT,Deka A,Jacobs EJ,Newton CC,Hildebrand JS,McCullough ML,Limburg PJ,Gapstur SM

    更新日期:2010-10-01 00:00:00

  • Intestinal Dysbiosis Featuring Abundance of Ruminococcus gnavus Associates With Allergic Diseases in Infants.

    abstract:BACKGROUND & AIMS:Dysbiosis of the intestinal microbiota has been associated with development of allergies in infants. However, it is not clear what microbes might contribute to this process. We investigated what microbe(s) might be involved in analyses of infant twins and mice. METHODS:We studied fecal specimens pros...


    pub_type: 杂志文章


    authors: Chua HH,Chou HC,Tung YL,Chiang BL,Liao CC,Liu HH,Ni YH

    更新日期:2018-01-01 00:00:00

  • Efficacy of re-treatment with TMC435 as combination therapy in hepatitis C virus-infected patients following TMC435 monotherapy.

    abstract::In the TMC435-C101 study, 6 patients infected with hepatitis C virus genotype 1 were treated with the protease inhibitor TMC435 (200 mg once daily) as monotherapy for 5 days. Approximately 1.5 years later, 5 of these patients were re-treated with TMC435 (200 mg once daily) plus pegylated interferon alfa-2a and ribavir...


    pub_type: 临床试验,杂志文章


    authors: Lenz O,de Bruijne J,Vijgen L,Verbinnen T,Weegink C,Van Marck H,Vandenbroucke I,Peeters M,Simmen K,Fanning G,Verloes R,Picchio G,Reesink H

    更新日期:2012-11-01 00:00:00

  • Studies on lymphocyte hyporesponsiveness in cirrhosis: the role of increased monocyte suppressor cell activity.

    abstract::We investigated the possibility that monocyte suppressor cells play a role in the peripheral lymphocyte hyporesponsiveness of chronic liver disease by utilizing assays of monocyte-mediated suppressor activity in 46 patients with chronic liver disease and 46 controls. The percent change achieved by the addition of indo...


    pub_type: 杂志文章


    authors: Holdstock G,Chastenay BF,Krawitt EL

    更新日期:1982-02-01 00:00:00

  • Autophagy, Inflammation, and Immune Dysfunction in the Pathogenesis of Pancreatitis.

    abstract::Pancreatitis is a common disorder with significant morbidity and mortality, yet little is known about its pathogenesis, and there is no specific or effective treatment. Its development involves dysregulated autophagy and unresolved inflammation, demonstrated by studies in genetic and experimental mouse models. Disease...


    pub_type: 杂志文章,评审


    authors: Gukovskaya AS,Gukovsky I,Algül H,Habtezion A

    更新日期:2017-11-01 00:00:00

  • Giardiasis in the mouse: an animal model.

    abstract::An animal model for giardiasis was developed using Giardia muris in Swiss albino mice. Intraesophageal inoculation of G. muris cysts caused a reproducible pattern of infection, with trophozoite and cyst counts reaching a maximum on days 5 to 14 after cyst inoculation and thereafter showing a progressive decline. Spont...


    pub_type: 杂志文章


    authors: Roberts-Thomson IC,Stevens DP,Mahmoud AA,Warren KS

    更新日期:1976-07-01 00:00:00

  • Heterotopic liver transplantation for fulminant Wilson's disease.

    abstract::Wilson's disease may present with severe acute hepatocellular failure. The only effective treatment for fulminant Wilson's disease is liver transplantation, which may lead to reversal of the underlying disease. Some patients with cirrhosis who are too ill to undergo orthotopic liver transplantation have been treated w...


    pub_type: 杂志文章


    authors: Stampfl DA,Muñoz SJ,Moritz MJ,Rubin R,Armenti VT,Jarrell BE,Maddrey WC

    更新日期:1990-12-01 00:00:00

  • Etiological spectrum of post-transfusion hepatitis.

    abstract::Frequent occurrence of post-transfusion hepatitis continues despite screening for Australia antigen in blood before transfusion and elimination of commercial donor sources. The majority of these cases appears unrelated to hepatitis B virus. Preoperative, acute, and convalescent serra were screened for evidence of hepa...


    pub_type: 杂志文章


    authors: Knodell RG,Conrad ME,Dienstag JL,Bell CJ

    更新日期:1975-12-01 00:00:00

  • Characterization of insulinlike growth factor I receptors in human colon cancer.

    abstract::A possible role of insulinlike growth factor I (IGF-I) and IGF-I receptors in the proliferation of human colon cancer has, to the best of the authors' knowledge, not been examined as yet. To determine a role of IGF-I in colon cancer, several human colon cancer cell lines and colon cancers were screened for specific bi...


    pub_type: 杂志文章


    authors: Guo YS,Narayan S,Yallampalli C,Singh P

    更新日期:1992-04-01 00:00:00