Abstract：
BACKGROUND & AIMS:The adenoma detection rate (ADR) is an important quality indicator of screening colonoscopy; it is inversely associated with risk of interval cancers and colorectal cancer mortality. We assessed trends in the ADR in the first 10 years of the German screening colonoscopy program. METHODS:We calculated age-adjusted and age-specific detection rates of nonadvanced adenomas and advanced adenomas for each calendar year based on 4.4 million screening colonoscopies conducted from 2003 through 2012 and reported to the German screening colonoscopy registry. RESULTS:We observed a steady and strong increase in rate of detection of nonadvanced adenomas in both sexes and all age groups. Age-adjusted rates of detection of nonadvanced adenomas increased from 13.3% to 22.3% among men and from 8.4% to 14.9% among women. This increase was mostly due to an increase in detection rates of adenomas <0.5 cm, and it is partly explained by an innovation effect (higher ADRs among incoming colonoscopists than among leaving colonoscopists, and relatively stable ADRs among continuing colonoscopists). Only modest increases were observed in detection rates of advanced adenomas (from 7.4% to 9.0% among men, and from 4.4% to 5.2% among women) and colorectal cancer. In 2012, overall ADR reached 31.3% and 20.1% in men and women, respectively. CONCLUSIONS:We observed a strong increase in ADRs from 2003 through 2012 in Germany. Although we cannot exclude the effects of secular trends in colorectal neoplasm prevalence, the observed increase was mainly the result of a steady increase in detection of nonadvanced adenomas (especially adenomas <0.5 cm). Further research should address potential implications for defining screening and surveillance intervals.
journal_name
Gastroenterologyjournal_title
Gastroenterologyauthors
Brenner H,Altenhofen L,Kretschmann J,Rösch T,Pox C,Stock C,Hoffmeister Mdoi
10.1053/j.gastro.2015.04.012subject
Has Abstractpub_date
2015-08-01 00:00:00pages
356-66.e1issue
2eissn
0016-5085issn
1528-0012pii
S0016-5085(15)00568-5journal_volume
149pub_type
杂志文章相关文献
GASTROENTEROLOGY文献大全abstract：:A patient with a lifelong history of asthma and hay fever was investigated because of symptoms of esophageal spasm. Esophageal biopsies revealed elongated papillae and basal zone hyperplasia of the epithelial layer with eosinophilic infiltration of the lamina propria and muscularis mucosae. There was no evidence of re...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：
更新日期：1977-06-01 00:00:00
abstract：BACKGROUND & AIMS:Numerous studies have linked the proliferation of liver progenitor cells (LPCs) during chronic liver disease to the risk for development of hepatocellular carcinoma. Thus, selective inhibition of LPC growth during preneoplastic injury may prevent or delay the onset of liver cancer. Rats carrying a ger...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/j.gastro.2008.05.077
更新日期：2008-09-01 00:00:00
abstract：BACKGROUND & AIMS:Molecules that regulate T-cell adhesion to hepatic endothelium and thereby recirculation of T cells to the liver are poorly understood. Because the adhesion molecule vascular adhesion protein-1 (VAP-1), which mediates lymphocyte binding to lymph node endothelium, is expressed on hepatic endothelium, i...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/gast.1996.v110.pm8566600
更新日期：1996-02-01 00:00:00
abstract：BACKGROUND & AIMS:Hepatitis G virus (HGV) has been recently identified as a new transfusion-transmissible agent. This study was performed to evaluate the role of HGV infection in patients with acute posttransfusion hepatitis in Taiwan. METHODS:Sera from 63 patients with acute posttransfusion hepatitis and 61 patients ...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/s0016-5085(97)70138-0
更新日期：1997-04-01 00:00:00
abstract：BACKGROUND & AIMS:This study used a low lesion prevalence population reflective of the screening setting to estimate the sensitivity and specificity of computerized tomographic (CT) colonography for detection of colorectal polyps. METHODS:This prospective, blinded study comprised 703 asymptomatic persons at higher-tha...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/s0016-5085(03)00894-1
更新日期：2003-08-01 00:00:00
abstract：:The results of a clinical trial comparing slow-release 5-aminosalicylic acid tablets (Pentasa) and enteric-coated sulfasalazine tablets (Salazopyrin) with regard to the efficacy of maintaining ulcerative colitis patients in remission for 12 mo and with regard to safety of treatment are reported. Seventy-five patients ...
journal_title：Gastroenterology
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1016/s0016-5085(88)80061-1
更新日期：1988-12-01 00:00:00
abstract：BACKGROUND & AIMS:Biglycan (PG-I), a component of the extracellular matrix (ECM), is overexpressed in pancreatic cancer. To determine possible matrix-tumor interactions, we investigated the effects of PG-I on pancreatic cancer. METHODS:PG-I expression in cell lines and tissue samples was examined by Northern blot and ...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/gast.2001.27222
更新日期：2001-09-01 00:00:00
abstract：BACKGROUND AND AIMS:It is not clear what induction dose of mesalamine is optimal for treating patients with mildly and moderately active ulcerative colitis (UC). This study was conducted to determine the efficacy and safety of mesalamine 4.8 g/day compared with 2.4 g/day for the treatment of moderately active UC. METH...
journal_title：Gastroenterology
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1053/j.gastro.2009.08.069
更新日期：2009-12-01 00:00:00
abstract：:We have prospectively evaluated 41 patients who ingested acid for location, extent, severity, and outcome of the injury to the upper gastrointestinal tract. The injury was assessed within 36 h of acid intake by endoscopy or surgery, or at autopsy. Symptoms and signs were unreliable in predicting the extent and severit...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：
更新日期：1989-09-01 00:00:00
abstract：:Regional specific antibodies and gel permeation chromatography were used to analyze the molecular forms of motilin in the human gut and plasma and in the porcine gut. The same antibodies were also used for immunocytochemical localization of the cell of origin of motilin. Two main molecular forms of motilin were identi...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：
更新日期：1981-02-01 00:00:00
abstract：BACKGROUND & AIMS:In one-third of hepatocellular carcinomas (HCCs), cancer cells have mutations that activate β-catenin pathway. These cells have alterations in glutamine, bile, and lipid metabolism. We investigated whether positron emission tomography (PET) imaging allows identification of altered metabolic pathways t...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/j.gastro.2019.05.069
更新日期：2019-09-01 00:00:00
abstract：BACKGROUND & AIMS:Improving methods for early detection of gastric cancer could reduce mortality. Measurements of serum pepsinogen levels have been used for screening in Japan without satisfactory levels of sensitivity or specificity. Trefoil factor family (TFF) proteins (TFF1, TFF2, and TFF3) are small and stable mole...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/j.gastro.2011.05.040
更新日期：2011-09-01 00:00:00
abstract：BACKGROUND & AIMS:Resistance of metastatic human colorectal cancer cells to drugs that block epidermal growth factor (EGF) receptor signaling could be caused by aberrant activity of other receptor tyrosine kinases, activating overlapping signaling pathways. One of these receptor tyrosine kinases could be MET, the recep...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/j.gastro.2017.07.008
更新日期：2017-10-01 00:00:00
abstract：:Somatostatin receptor frequency was evaluated in 12 human exocrine pancreatic carcinomas taken after surgery. The tumors were analyzed by receptor autoradiography on tissue sections and by in vitro binding techniques on tumor homogenates. None of the tested human pancreatic carcinomas was shown to possess specific som...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/s0016-5085(88)80025-8
更新日期：1988-09-01 00:00:00
abstract：:Development of an intraabdominal bile collection (biloma) usually occurs secondary to traumatic or iatrogenic injury including abdominal surgery, percutaneous catheter drainage, and transhepatic cholangiogram. We present a case of hepatic subcapsular biloma following endoscopic retrograde cholangiography and identifie...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：
更新日期：1988-05-01 00:00:00
abstract：BACKGROUND & AIMS:Increased levels of galectin 3 have been associated with nonalcoholic steatohepatitis (NASH) and contribute to toxin-induced liver fibrosis in mice. GR-MD-02 (belapectin) is an inhibitor of galectin 3 that reduces liver fibrosis and portal hypertension in rats and was safe and well tolerated in phase ...
journal_title：Gastroenterology
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1053/j.gastro.2019.11.296
更新日期：2020-04-01 00:00:00
abstract：BACKGROUND & AIMS:There is growing interest in the use of bone marrow cells to treat liver fibrosis, however, little is known about their antifibrotic efficacy or the identity of their effector cell(s). Sphingosine-1-phosphate (S1P) mediates egress of immune cells from the lymphoid organs into the lymphatic vessels; we...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/j.gastro.2017.03.022
更新日期：2017-07-01 00:00:00
abstract：:In vitro studies have shown that some bile salts inhibit the growth of intestinal bacteria. We investigated the possibility that bile salts might have a similar action in vivo in the ileum by performing serial anaerobic cultures and bile salt analyses on postprandial ileal fluid obtained anaerobically via intestinal t...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：
更新日期：1975-08-01 00:00:00
abstract：BACKGROUND/AIMS:We have identified several clones specifically expressed during malignant cell proliferation by screening a complementary DNA library constructed from a human primary liver cancer with subtractive probes. One clone was identified as the glutamine synthetase (GS) transcript. Its expression is tightly reg...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/0016-5085(94)90024-8
更新日期：1994-05-01 00:00:00
abstract：:The relationship between renal tubular acidosis (RTA) and copper metabolism has been investigated in a group of 18 patients with primary biliary cirrhosis. RTA, considered when urinary pH remained above 5.4 after an oral load of ammonium chloride of 0.1 g/kg body wt, was found in 6 patients (33%). Plasma copper concen...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：
更新日期：1981-04-01 00:00:00
abstract：BACKGROUND & AIMS:Idiopathic inflammatory bowel disease (IBD) is associated with bone loss in more than 30% of cases. Nevertheless, the pathogenesis of the bone loss is uncertain. The aim of this study was to investigate the bone loss and underlying mechanisms using an animal model of IBD. METHODS:Severe colitis was i...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/gast.1996.v111.pm8898640
更新日期：1996-11-01 00:00:00
abstract：:Spontaneous bacterial peritonitis in decompensated cirrhotic patients develops when bacteria invade preexising ascites. It is probable that other transudates such as pleural effusions can be afected in a similar manner. This paper describes a cirrhotic patient with long-standing pleural effusion in whom Escherichia co...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：
更新日期：1976-03-01 00:00:00
abstract：BACKGROUND & AIMS:Type 2 diabetes mellitus (DM) is associated with an increased risk of colorectal cancer (CRC); it is not clear if this association varies by sex or other factors. Insulin use might also be associated with CRC risk. We investigated associations of type 2 DM and insulin use with CRC risk. METHODS:The C...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/j.gastro.2010.06.072
更新日期：2010-10-01 00:00:00
abstract：:Fluorescent periodic acid-Schiff reaction (FPR) was used in the study of the normal rabbit ileal epithelium and its changes after injection of living cultures or enterotoxins of enterotoxigenic Escherichia coli. This reaction, with the use of auramine OO-SO2 complex as a Schiff-type reagent, demonstrates gut epitheliu...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：
更新日期：1980-04-01 00:00:00
abstract：BACKGROUND & AIMS:Sigmoidoscopy is an effective screening strategy for colorectal cancer that is not widely used by primary care providers. The aim of this study was to assess the impact of "academic detailing" in the form of an outreach educational seminar combined with implementation of on-site sigmoidoscopy services...
journal_title：Gastroenterology
pub_type： 临床试验,杂志文章
doi：10.1053/gast.1999.0029900304
更新日期：1999-08-01 00:00:00
abstract：:A prospective and randomized study was performed comparing pneumatic forceful dilatation and surgical esophagomyotomy as primary treatment of patients with achalasia of the esophagus. Eighteen dilated and 20 operated patients were studied before and after treatment with 1 patient lost. Clinical, radiologic, and manome...
journal_title：Gastroenterology
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1981-04-01 00:00:00
abstract：BACKGROUND & AIMS:Circulating membrane-shed microparticles (MPs) participate in regulation of vascular tone. We investigated the cellular origins of MPs in plasma from patients with cirrhosis and assessed the contribution of MPs to arterial vasodilation, a mechanism that contributes to portal hypertension. METHODS:We ...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/j.gastro.2012.03.040
更新日期：2012-07-01 00:00:00
abstract：:The range of activity and the location of lipase and pepsin were determined in the stomach and duodenum of infants, children, and adults. The range of lipase activity in biopsy specimens from the gastric body, in 29 subjects aged from 3 months to 26 years, was 1.8-5.3 U/mg protein (1 U is 1 mumol [3H]oleic acid releas...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/0016-5085(91)90467-y
更新日期：1991-07-01 00:00:00
abstract：:Fasting hyperbilirubinemia (FHB) has previously been shown to be rapidly reversed by the ingestion of a mixed diet. This study examines the effect of carbohydrate, fat, amino acids, and noncaloric materials on FHB. After an initial fast of 15 to 39 hr, caloric and noncaloric materials were administered by mouth or vei...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：
更新日期：1975-02-01 00:00:00
abstract：:A human colon cancer cell line, HCT-8, is shown to be an appropriate target cell for study of natural killer (NK) activity in man. In parallel experiments, effector cell characteristics for NK and antibody-dependent cellular cytotoxicity (ADCC) were found to be vested in a single lymphocyte subpopulation, which bore r...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：
更新日期：1980-04-01 00:00:00
