In vivo effect of bile salts and cholestyramine on intestinal anaerobic bacteria.

abstract：:Celiac sprue and Crohn's disease have very rarely been documented in the same patient. We report a case involving an adolescent male with known Crohn's disease who had extreme wasting, growth retardation, intractable diarrhea, and delay in development of secondary sexual characteristics. Peroral jejunal biopsy showed ...

journal_title：Gastroenterology

authors： Euler AR,Ament ME

更新日期：1977-04-01 00:00:00

abstract：BACKGROUND & AIMS:Substance P, a member of the tachykinin family, is a prosecretory neuropeptide distributed widely throughout the enteric nervous system. Implicated in inflammatory states, its role in enterotoxigenic water and electrolyte secretion is unclear. We assessed the effect of substance P antagonists and neur...

journal_title：Gastroenterology

authors： Turvill JL,Connor P,Farthing MJ

更新日期：2000-10-01 00:00:00

abstract：BACKGROUND & AIMS:Genetic and epigenetic alterations contribute to the pathogenesis of colorectal cancer (CRC). There is considerable molecular heterogeneity among colorectal tumors, which appears to arise as polyps progress to cancer. This heterogeneity results in different pathways to tumorigenesis. Although epigenet...

journal_title：Gastroenterology

authors： Luo Y,Wong CJ,Kaz AM,Dzieciatkowski S,Carter KT,Morris SM,Wang J,Willis JE,Makar KW,Ulrich CM,Lutterbaugh JD,Shrubsole MJ,Zheng W,Markowitz SD,Grady WM

更新日期：2014-08-01 00:00:00

abstract：BACKGROUND/AIMS:Recent in vivo studies using proton magnetic resonance (1H-MR) spectroscopy showed low levels of myo-inositol in the brain in hepatic encephalopathy; the pathogenetic relevance of this observation is unclear. METHODS:Myo-inositol and glutamine levels in the brain were studied in vivo by 1H-MR spectrosc...

journal_title：Gastroenterology

authors： Häussinger D,Laubenberger J,vom Dahl S,Ernst T,Bayer S,Langer M,Gerok W,Hennig J

更新日期：1994-11-01 00:00:00

abstract：BACKGROUND & AIMS:Fully covered self-expanding metal stents (FCSEMS) are gaining acceptance for the treatment of benign biliary strictures. We performed a large prospective multinational study to study the ability to remove these stents after extended indwell and the frequency and durability of stricture resolution. M...

journal_title：Gastroenterology

authors： Devière J,Nageshwar Reddy D,Püspök A,Ponchon T,Bruno MJ,Bourke MJ,Neuhaus H,Roy A,González-Huix Lladó F,Barkun AN,Kortan PP,Navarrete C,Peetermans J,Blero D,Lakhtakia S,Dolak W,Lepilliez V,Poley JW,Tringali A,Costam

更新日期：2014-08-01 00:00:00

abstract：BACKGROUND & AIMS:We have shown previously that cure of Helicobacter pylori infection leads to the disappearance of acid-neutralizing substances. Also, patients with ulcer after cure may gain weight. The aim of this study was to investigate whether cure of the infection increases the risk of reflux esophagitis. METHOD...

journal_title：Gastroenterology

authors： Labenz J,Blum AL,Bayerdörffer E,Meining A,Stolte M,Börsch G

更新日期：1997-05-01 00:00:00

abstract：BACKGROUND/AIMS:The survival rate for hepatocellular carcinoma after hepatectomy remains unsatisfactorily low because of the high recurrence rate. The purpose of this study was to elucidate predictive factors for postoperative recurrence of hepatocellular carcinoma. METHODS:Univariate analysis and a multiple regressio...

journal_title：Gastroenterology

authors： Okada S,Shimada K,Yamamoto J,Takayama T,Kosuge T,Yamasaki S,Sakamoto M,Hirohashi S

更新日期：1994-06-01 00:00:00

abstract：:A 61-yr-old woman was found to have multicentric hepatocellular carcinoma associated with clinical hyperthyroidism. Marked elevations in serum thyroid-stimulating hormone, T4, T3, and free T4 were documented. These values increased with tumor progression. It is postulated that this patient's hepatoma produced a substa...

journal_title：Gastroenterology

authors： Helzberg JH,McPhee MS,Zarling EJ,Lukert BP

更新日期：1985-01-01 00:00:00

abstract：BACKGROUND & AIMS:Aberrant activation of β-catenin and Yes-associated protein 1 (Yap1) signaling pathways have been associated with the development of multiple tumor types. Yap functions as a transcriptional coactivator by interacting with TEA domain DNA binding proteins. We investigated the interactions among these pa...

journal_title：Gastroenterology

authors： Tao J,Calvisi DF,Ranganathan S,Cigliano A,Zhou L,Singh S,Jiang L,Fan B,Terracciano L,Armeanu-Ebinger S,Ribback S,Dombrowski F,Evert M,Chen X,Monga SPS

更新日期：2014-09-01 00:00:00

abstract：BACKGROUND & AIMS:Regeneration from cerulein-induced pancreatitis is accompanied by a transient synthesis and deposition of extracellular matrix components in the rat pancreas. The pleiotropic transforming growth factor (TGF)-beta1 has been suggested to regulate extracellular matrix remodeling during regeneration from ...

journal_title：Gastroenterology

authors： Menke A,Yamaguchi H,Gress TM,Adler G

更新日期：1997-07-01 00:00:00

abstract：:A case of spontaneous rupture of a nonparasitic liver cyst, documented by serial computed tomography scans, is reported. The patient was closely followed clinically after the rupture of the cyst and was treated conservatively, without surgical intervention. No peritonitis developed. This unusual complication of nonpar...

journal_title：Gastroenterology

authors： Akriviadis EA,Steindel H,Ralls P,Redeker AG

更新日期：1989-07-01 00:00:00

abstract：:Methylbenzylnitrosamine is an esophageal-specific carcinogen in the rat, and the incidence of methylbenzylnitrosamine-induced esophageal carcinoma is increased by dietary zinc deficiency. Methylbenzylnitrosamine requires activation by cytochrome P-450 to be mutagenic; the present study examined the role of dietary zin...

journal_title：Gastroenterology

authors： Barch DH,Fox CC,Rosche WA,Rundhaugen LM,Wrighton SA

更新日期：1992-09-01 00:00:00

abstract：:Endogenous pancreatic prostaglandin production in control and obstructive jaundice was investigated using isolated and perfused dog pancreas. In both groups, spontaneous production of prostaglandin E2 and prostaglandin I2 was recorded, and the levels did not change in both groups. The production of both prostaglandins...

journal_title：Gastroenterology

authors： Kuroda T,Kajikawa S,Hanazaki K,Horigome N,Sodeyama H,Horiuchi A,Iwatsuki K,Chiba S,Homma T,Iida F

更新日期：1990-05-01 00:00:00

abstract：BACKGROUND & AIMS:Mechanisms of diarrhea in ulcerative colitis (UC) are still unknown. Functional and structural characterization of epithelial barrier and transport properties in ulcerative colitis (UC) was performed. METHODS:Inflamed sigmoid colon epithelium from UC patients was studied by alternating current impeda...

journal_title：Gastroenterology

authors： Schmitz H,Barmeyer C,Fromm M,Runkel N,Foss HD,Bentzel CJ,Riecken EO,Schulzke JD

更新日期：1999-02-01 00:00:00

abstract：BACKGROUND & AIMS:Quantitative neurophysiological studies have identified the presence of at least 2 spinal neuronal populations (abrupt and sustained) that are excited by the noxious visceral stimulus colorectal distention. This study examined the effects of the kappa opioid receptor agonists fedotozine and U50488H on...

journal_title：Gastroenterology

authors： Ness TJ

更新日期：1999-08-01 00:00:00

abstract：:Mucins synthesized in colonic cancer are known to be different from those in the normal colon; however, the biochemical differences between these mucins have not been defined. We have purified mucins from samples of nonneoplastic (normal) human colon and colon cancer and found that the carbohydrate content of the canc...

journal_title：Gastroenterology

authors： Boland CR,Deshmukh GD

更新日期：1990-05-01 00:00:00

abstract：:The pancreatic secretion of 6 normal human volunteers was collected by endoscopic cannulation of the main pancreatic duct. The appearance of newly synthesized proteins was monitored at 1-min intervals after labeling with [75Se]methionine. The minimum transit time of these proteins from their site of synthesis to the a...

journal_title：Gastroenterology

authors： Robberecht P,Cremer M,Christophe J

更新日期：1977-03-01 00:00:00

abstract：BACKGROUND & AIMS:To investigate the peripheral sensory effects of repeated stress in patients with postinfectious irritable bowel syndrome (IBS), we tested whether stress following self-limiting bacterial colitis increases colonic dorsal root ganglia (DRG) nociceptive signaling. METHODS:C57BL/6 mice were infected wit...

journal_title：Gastroenterology

authors： Ibeakanma C,Ochoa-Cortes F,Miranda-Morales M,McDonald T,Spreadbury I,Cenac N,Cattaruzza F,Hurlbut D,Vanner S,Bunnett N,Vergnolle N,Vanner S

更新日期：2011-12-01 00:00:00

abstract：:Sporadic colorectal cancer (CRC) is a somatic genetic disease in which pathogenesis is influenced by the local colonic environment and the patient's genetic background. Consolidating the knowledge of genetic and epigenetic events that occur with initiation, progression, and metastasis of sporadic CRC has identified so...

journal_title：Gastroenterology

authors： Carethers JM,Jung BH

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND & AIMS:The integrin alpha(4)beta(7) mediates homing of effector/memory lymphocytes to the intestine and the mucosa-associated lymphoid tissue. This study examined the ability of alpha(4)beta(7)(hi) CD4(+) T lymphocytes to home to the stomach and their role in immunization-mediated protection against Helicoba...

journal_title：Gastroenterology

authors： Michetti M,Kelly CP,Kraehenbuhl JP,Bouzourene H,Michetti P

更新日期：2000-07-01 00:00:00

abstract：BACKGROUND & AIMS:Although it has been shown that des-acyl ghrelin decreases food intake and gastric emptying, no previous studies have examined the effects of des-acyl ghrelin on physiologic fed and fasted motor activity in the gastrointestinal tract. METHODS:We examined the effects of intraperitoneal (IP) administra...

journal_title：Gastroenterology

authors： Chen CY,Inui A,Asakawa A,Fujino K,Kato I,Chen CC,Ueno N,Fujimiya M

更新日期：2005-07-01 00:00:00

abstract：BACKGROUND & AIMS:Glycolipid "rafts" have been shown to play a role in apical membrane trafficking in the enterocyte. The present study characterized the membrane compartments of the enterocyte involved in transepithelial transport of small intestinal immunoglobulin A (IgA). METHODS:Immunogold electron microscopy and ...

journal_title：Gastroenterology

authors： Hansen GH,Niels-Christiansen LL,Immerdal L,Hunziker W,Kenny AJ,Danielsen EM

更新日期：1999-03-01 00:00:00

abstract：BACKGROUND & AIMS:In searching for effects of acetaminophen (APAP) on hepatocytes downstream of its metabolism that may participate in hepatotoxicity, we examined the role of stress kinases. METHODS:Mouse hepatocytes and C57BL/6 mice were administered a toxic dose of APAP with or without SP600125, a chemical c-jun N-t...

journal_title：Gastroenterology

authors： Gunawan BK,Liu ZX,Han D,Hanawa N,Gaarde WA,Kaplowitz N

更新日期：2006-07-01 00:00:00

abstract：BACKGROUND & AIMS:Administration of secretin improves noninvasive imaging of the pancreatic duct with magnetic resonance cholangiopancreatography (MRCP). We performed a large prospective study to investigate whether synthetic human secretin (RG1068)-stimulated MRCP detects pancreatic duct abnormalities with higher leve...

journal_title：Gastroenterology

authors： Sherman S,Freeman ML,Tarnasky PR,Wilcox CM,Kulkarni A,Aisen AM,Jacoby D,Kozarek RA

更新日期：2014-09-01 00:00:00

abstract：BACKGROUND & AIMS:The effects of leukotriene (LT) D(4) on intestinal epithelial cells govern events that are involved in cell survival and colon cancer, notably increased expression of cyclooxygenase (COX)-2 and enhanced production of prostaglandin E(2). We investigated possible correlations between distribution of the...

journal_title：Gastroenterology

authors： Ohd JF,Nielsen CK,Campbell J,Landberg G,Löfberg H,Sjölander A

更新日期：2003-01-01 00:00:00

abstract：:We studied chronic intake of diets deficient in or supplemented with linoleic acid to determine whether it affects gastric acid secretion, release of prostaglandin E2, and stress-induced lesions. For 8-10 wk rats were fed three dietary regimens supplying 3.5% (control group), 0.3%, and 10% of total calories as linolei...

journal_title：Gastroenterology

authors： Schepp W,Steffen B,Ruoff HJ,Schusdziarra V,Classen M

更新日期：1988-07-01 00:00:00

abstract：BACKGROUND/AIMS:The yeast Saccharomyces boulardii inhibits the secretion induced by cholera toxin (CT) in rat jejunum. The present study was aimed at unraveling the mechanism by which S. boulardii protects intestinal cells against CT. METHODS:CT-induced adenosine 3',5'-cyclic monophosphate (cAMP) levels were measured ...

journal_title：Gastroenterology

authors： Czerucka D,Roux I,Rampal P

更新日期：1994-01-01 00:00:00

abstract：BACKGROUND & AIMS:Changes in the properties of visceral sensory neurons contribute to the development of gastrointestinal pain. However, little is known about the molecules involved in mechanosensation from the gastrointestinal tract. We investigated the phosphorylation of extracellular signal-regulated kinase 1/2 (ERK...

journal_title：Gastroenterology

authors： Sakurai J,Obata K,Ozaki N,Tokunaga A,Kobayashi K,Yamanaka H,Dai Y,Kondo T,Miyoshi K,Sugiura Y,Matsumoto T,Miwa H,Noguchi K

更新日期：2008-04-01 00:00:00

abstract：:It has recently been shown that repeated large-volume paracentesis associated with intravenous albumin infusion is a rapid, effective, and safe therapy of ascites in cirrhosis. To investigate whether intravenous albumin infusion is necessary in the treatment of cirrhotics with large-volume paracentesis, 105 patients w...

journal_title：Gastroenterology

authors： Ginès P,Titó L,Arroyo V,Planas R,Panés J,Viver J,Torres M,Humbert P,Rimola A,Llach J

更新日期：1988-06-01 00:00:00

abstract：:To study the peripheral effect of somatostatin in dogs a tiny Silastic catheter was implanted in an almost terminal branch of the mesenteric artery, providing blood supply to a jejunal segment of 5-10 cm. In 4 dogs one catheter was implanted, perfusing a small bowel segment about 60 cm below the angle of Treitz; in 3 ...

journal_title：Gastroenterology

authors： Hostein J,Janssens J,Vantrappen G,Peeters TL,Vandeweerd M,Leman G

更新日期：1984-11-01 00:00:00