Discharge of newly synthesized proteins in pure juice collected from the human pancreas. Indication of more than one pool of intracellular digestive enzymes.

abstract：BACKGROUND & AIMS:The enteric nervous system (ENS) coordinates essential intestinal functions through the concerted action of diverse enteric neurons (ENs). However, integrated molecular knowledge of EN subtypes is lacking. To compare human and mouse ENs, we transcriptionally profiled healthy ENS from adult humans and ...

journal_title：Gastroenterology

authors： May-Zhang AA,Tycksen E,Southard-Smith AN,Deal KK,Benthal JT,Buehler DP,Adam M,Simmons AJ,Monaghan JR,Matlock BK,Flaherty DK,Potter SS,Lau KS,Southard-Smith EM

更新日期：2020-09-30 00:00:00

abstract：:Uptake of inorganic sulfate into brush-border membrane vesicles isolated by a calcium precipitation method from rat small intestine was investigated using a rapid filtration technique and 35Sulfur acid as tracer. Sulfate uptake by membrane vesicles was osmotically sensitive, suggesting transport into an intravesicular...

journal_title：Gastroenterology

authors： Lücke H,Stange G,Murer H

更新日期：1981-01-01 00:00:00

abstract：BACKGROUND & AIMS:Prediction of relapse of inflammatory bowel disease has important implications for therapeutic strategies. We assessed whether measurement of intestinal permeability and inflammation could predict relapse of inflammatory bowel disease (IBD). METHODS:Forty-three patients with Crohn's disease (CD) and ...

journal_title：Gastroenterology

authors： Tibble JA,Sigthorsson G,Bridger S,Fagerhol MK,Bjarnason I

更新日期：2000-07-01 00:00:00

abstract：BACKGROUND AND AIMS:Tumor necrosis factor (TNF) is a cytokine that promotes inflammation and contributes to pathogenesis of inflammatory bowel diseases. Unlike other cells and tissues, intestinal epithelial cells undergo rapid cell death upon exposure to TNF, by unclear mechanisms. We investigated the roles of inhibito...

journal_title：Gastroenterology

authors： Grabinger T,Bode KJ,Demgenski J,Seitz C,Delgado ME,Kostadinova F,Reinhold C,Etemadi N,Wilhelm S,Schweinlin M,Hänggi K,Knop J,Hauck C,Walles H,Silke J,Wajant H,Nachbur U,W Wei-Lynn W,Brunner T

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND/AIMS:Clinical and experimental studies suggest a link between nutritional status and the recovery of hepatic function after hypoxic and hypothermic insults. This study aimed at determining the metabolic pathways involved in such recovery as a function of nutrition. METHODS:Livers from fed and fasted mice we...

journal_title：Gastroenterology

authors： Dimicoli JL,Patry J,Adam R,Dennison A,Nedelec JF,Bismuth H

更新日期：1994-12-01 00:00:00

abstract：:We studied the appearance of specific secretory immunoglobulin A (IgA) antibody in bile after inoculation of live Giardia lamblia trophozoites into rat intestine. Serial bile specimens collected before and after inoculation of trophozoites were assayed for IgA antibodies by indirect immunofluorescence. Secretory IgA a...

journal_title：Gastroenterology

authors： Loftness TJ,Erlandsen SL,Wilson ID,Meyer EA

更新日期：1984-11-01 00:00:00

abstract：:Increasing resistance to antibiotics worldwide has adverse effects on the effectiveness of standard therapies to eradicate Helicobacter pylori infection. We reviewed guidelines developed by expert groups in Europe, Canada, and the United States for the treatment of H pylori infection. We compared the recommendations o...

journal_title：Gastroenterology

authors： Fallone CA,Moss SF,Malfertheiner P

更新日期：2019-07-01 00:00:00

abstract：:A 14-yr-old girl presented with long-standing symptoms of partial gastric outlet obstruction due to an antral mucosal diaphragm that had a central aperture of 4-5 mm. The literature of this congenital malformation is reviewed with respect to diagnostic criteria and feasibility of endoscopic transection. The procedure ...

journal_title：Gastroenterology

authors： Berr F,Rienmueller R,Sauerbruch T

更新日期：1985-11-01 00:00:00

abstract：:Fever of 10 mo duration in a man of 35 yr was discovered at the time of a second laparatomy to be caused by actinomycotic infection of the liver. Actinomycosis of the liver usually presents as large single or as multiple abscesses. In this patient only nonspecific cellular infiltrates of the liver were found in liver ...

journal_title：Gastroenterology

authors： Meade RH 3rd

更新日期：1980-02-01 00:00:00

abstract：:Strategies for management of inflammatory bowel diseases are shifting from simple control of symptoms toward full control of these diseases (clinical and endoscopic remission), with the final aim of blocking their progression and preventing bowel damage and disability. New goals have been proposed for treatment, such ...

journal_title：Gastroenterology

authors： Colombel JF,Narula N,Peyrin-Biroulet L

更新日期：2017-02-01 00:00:00

abstract：:Increased dietary ratios of ω6/ω3 polyunsaturated fatty acids have been implicated in the pathogenesis of Crohn's disease (CD), but epidemiologic data are limited. We investigated whether variants of genes that control polyunsaturated fatty acid metabolism (CYP4F3, FADS1, and FADS2), along with the dietary ratio of ω6...

journal_title：Gastroenterology

authors： Costea I,Mack DR,Lemaitre RN,Israel D,Marcil V,Ahmad A,Amre DK

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND & AIMS:An association between water sources and the prevalence of Helicobacter pylori infection in Peruvian children was shown previously. The aim of this study was to confirm the presence of H. pylori in drinking water in the same community. METHODS:Forty-eight drinking water samples from different locatio...

journal_title：Gastroenterology

authors： Hulten K,Han SW,Enroth H,Klein PD,Opekun AR,Gilman RH,Evans DG,Engstrand L,Graham DY,El-Zaatari FA

更新日期：1996-04-01 00:00:00

abstract：BACKGROUND & AIMS:We followed patients with ongoing hepatitis C virus (HCV) exposure following control of an initial HCV infection to determine whether primary control conferred protection against future persistent infections. METHODS:Twenty-two active injection drug users (IDU) who had cleared a primary hepatitis C v...

journal_title：Gastroenterology

authors： Osburn WO,Fisher BE,Dowd KA,Urban G,Liu L,Ray SC,Thomas DL,Cox AL

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND & AIMS:We previously demonstrated that the 2 APC mutations in human colorectal tumors are coselected, because tumorigenesis requires an optimal level of Wnt signaling. We and others subsequently showed that the truncated APC proteins in colorectal tumors usually retain a total of 1-2 beta-catenin binding/deg...

journal_title：Gastroenterology

authors： Pollard P,Deheragoda M,Segditsas S,Lewis A,Rowan A,Howarth K,Willis L,Nye E,McCart A,Mandir N,Silver A,Goodlad R,Stamp G,Cockman M,East P,Spencer-Dene B,Poulsom R,Wright N,Tomlinson I

更新日期：2009-06-01 00:00:00

abstract：BACKGROUND & AIMS:Toll-like receptor (TLR)-dependent signaling was proposed as immunotherapeutic targets against invading pathogens and tumorigenesis. Here, we investigated whether TLR5-dependent signaling modulates colonic tumor development in mouse xenograft model of human colon cancer. METHODS:The expression of mye...

journal_title：Gastroenterology

authors： Rhee SH,Im E,Pothoulakis C

更新日期：2008-08-01 00:00:00

abstract：:We report the case of a female patient suffering from Waldenström's macroglobulinemia with three different liver lesions: peliosis hepatis, nodular regenerative hyperplasia, and light-chain deposits within the sinusoidal walls. We hypothesize that both peliosis hepatis and nodular regenerative hyperplasia might be the...

journal_title：Gastroenterology

authors： Voinchet O,Degott C,Scoazec JY,Feldmann G,Benhamou JP

更新日期：1988-08-01 00:00:00

abstract：BACKGROUND & AIMS:Treatment of hepatitis C virus (HCV) infection with boceprevir, peginterferon, and ribavirin can lead to anemia, which has been managed by reducing ribavirin dose and/or erythropoietin therapy. We assessed the effects of these anemia management strategies on rates of sustained virologic response (SVR)...

journal_title：Gastroenterology

authors： Poordad F,Lawitz E,Reddy KR,Afdhal NH,Hézode C,Zeuzem S,Lee SS,Calleja JL,Brown RS Jr,Craxi A,Wedemeyer H,Nyberg L,Nelson DR,Rossaro L,Balart L,Morgan TR,Bacon BR,Flamm SL,Kowdley KV,Deng W,Koury KJ,Pedicone LD

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND & AIMS:We recently showed that dietary supplementation with an analogue of 1alpha,25-dihydroxy-vitamin D3, 1alpha,25-dihydroxy-16-ene-23-yne-26,27 F6-vitamin D3 (RO24-5531), reduced the incidence of colonic tumors in rats treated with azoxymethane (AOM). The aim of this study was to determine whether alterat...

journal_title：Gastroenterology

authors： Wali RK,Bissonnette M,Khare S,Aquino B,Niedziela S,Sitrin M,Brasitus TA

更新日期：1996-07-01 00:00:00

abstract：BACKGROUND & AIMS:Aspirin and nonsteroidal anti-inflammatory drugs (NSAIDs) lower the risk of colorectal cancer (CRC). We investigated whether plasma inflammatory markers were associated with risk of CRC and if use of anti-inflammatory drugs was differentially associated with risk of CRC according to levels of inflamma...

journal_title：Gastroenterology

authors： Chan AT,Ogino S,Giovannucci EL,Fuchs CS

更新日期：2011-03-01 00:00:00

abstract：BACKGROUND & AIMS:Eosinophilic esophagitis (EoE) is a chronic inflammatory disease of the esophagus characterized by dense tissue eosinophilia; it is refractory to proton pump inhibitor therapy. EoE affects all age groups but most frequently individuals between 20 and 50 years of age. Topical corticosteroids are effect...

journal_title：Gastroenterology

authors： Straumann A,Conus S,Degen L,Felder S,Kummer M,Engel H,Bussmann C,Beglinger C,Schoepfer A,Simon HU

更新日期：2010-11-01 00:00:00

abstract：BACKGROUND & AIMS:Previous research has yielded conflicting data as to whether the natural history of inflammatory bowel disease follows a seasonal pattern. The purpose of this study was to determine whether relapse of inflammatory bowel disease follows a seasonal pattern either across a cohort of patients or within in...

journal_title：Gastroenterology

authors： Lewis JD,Aberra FN,Lichtenstein GR,Bilker WB,Brensinger C,Strom BL

更新日期：2004-03-01 00:00:00

abstract：:Detailed porphyrin analysis and additional ultrastructural abnormalities of liver cells are described in a patient with features of Rotor's syndrome. Normal values of porphyrin precursors, delta-aminolevulinic acid and porphobilinogen, and porphyrins were found in plasma, urine, and erythrocytes. However, fecal porphy...

journal_title：Gastroenterology

authors： Evans J,Lefkowitch J,Lim CK,Billing B

更新日期：1981-12-01 00:00:00

abstract：:Urokinase, the plasminogen activator from human urine, produces a dose-dependent increase in blood flow in the canine superior mesenteric artery when injected intraarterially at doses from 10(-1) to 10(3) units kg-1. This vasodilation persists despite blockade of beta-adrenergic and histamine H1 and H2 receptors as we...

journal_title：Gastroenterology

authors： Gurll N,Zinner MJ,Turtinen L,Reynolds DG

更新日期：1978-09-01 00:00:00

abstract：BACKGROUND & AIMS:We have shown that intestinal manipulation leads to a significant inhibition of circular muscle contraction. We hypothesized that the inflammatory mediator inducible nitric oxide (NO) plays a role in surgically induced ileus. METHODS:Rats and inducible NO synthase (iNOS) knockout and wild-type mice u...

journal_title：Gastroenterology

authors： Kalff JC,Schraut WH,Billiar TR,Simmons RL,Bauer AJ

更新日期：2000-02-01 00:00:00

abstract：:Spontaneous remission of gastric acid hypersecretion in the Zollinger-Ellison syndrome occurs rarely. This study shows the development of gastric secretory mucosal atrophy resulting in achlorhydria and loss of pepsin secretion in a 63-year-old woman with the Zollinger-Ellison syndrome. Reduced secretion began soon aft...

journal_title：Gastroenterology

authors： Griffith JL,Cummings OW,Hirschowitz BI

更新日期：1991-07-01 00:00:00

abstract：BACKGROUND & AIMS:It has been proposed that activation of the sympathetic nervous system causes a rightward shift in the renal autoregulatory curve such that renal blood flow is critically dependent on renal perfusion pressure and that this contributes to the development of the hepatorenal syndrome. The aims of the stu...

journal_title：Gastroenterology

authors： Stadlbauer V,Wright GA,Banaji M,Mukhopadhya A,Mookerjee RP,Moore K,Jalan R

更新日期：2008-01-01 00:00:00

abstract：:A 60-year-old white male presenting with a clinical picture of obstructive jaundice was subsequently found to have erythropoietic protoporphyria. The diagnosis was suspected because of a history of life-long photosensitivity and was confirmed by finding high levels of erythrocyte protoporphyrin. Liver biopsy revealed ...

journal_title：Gastroenterology

authors： Singer JA,Plaut AG,Kaplan MM

更新日期：1978-03-01 00:00:00

abstract：BACKGROUND & AIMS:The finding of bone morphogenetic protein (BMP) receptor 1a mutations in juvenile polyposis suggests that BMPs are important in colorectal cancer (CRC). We investigated the BMP pathway in sporadic CRC. METHODS:We investigated BMP receptor (BMPR) expression using immunoblotting and sequenced BMPR2 in ...

journal_title：Gastroenterology

authors： Kodach LL,Wiercinska E,de Miranda NF,Bleuming SA,Musler AR,Peppelenbosch MP,Dekker E,van den Brink GR,van Noesel CJ,Morreau H,Hommes DW,Ten Dijke P,Offerhaus GJ,Hardwick JC

更新日期：2008-05-01 00:00:00

abstract：:We describe a 47-year-old patient who developed cholelithiasis in adolescence, followed by recurrent intrahepatic cholestasis of pregnancy, and finally biliary cirrhosis in adulthood. In our patient, the consecutive presentation of the 3 mentioned disorders raised the suspicion of a defect of MDR3, the canalicular pro...

journal_title：Gastroenterology

authors： Lucena JF,Herrero JI,Quiroga J,Sangro B,Garcia-Foncillas J,Zabalegui N,Sola J,Herraiz M,Medina JF,Prieto J

更新日期：2003-04-01 00:00:00

abstract：:Intracellular microelectrodes were used to evaluate electrical properties of the cell membranes in Necturus antral mucosa during exposure to luminal acid alone (pH 4) or to 5 mmol/L aspirin [acetylsalicylic acid (ASA)] in the presence of luminal acid. When nutrient solutions were buffered by HCO3- (pH 7.3), ASA modera...

journal_title：Gastroenterology

authors： Soybel DI,Davis MB,West AB

更新日期：1992-11-01 00:00:00