Abstract:
BACKGROUND & AIMS:Eosinophilic esophagitis (EoE) is a chronic inflammatory disease of the esophagus characterized by dense tissue eosinophilia; it is refractory to proton pump inhibitor therapy. EoE affects all age groups but most frequently individuals between 20 and 50 years of age. Topical corticosteroids are effective in pediatric patients with EoE, but no controlled studies of corticosteroids have been reported in adult patients. METHODS:We performed a randomized, double-blind, placebo-controlled trial to evaluate the effect of oral budesonide (1 mg twice daily for 15 days) in adolescent and adult patients with active EoE. Pretreatment and posttreatment disease activity was assessed clinically, endoscopically, and histologically. The primary end point was reduced mean numbers of eosinophils in the esophageal epithelium (number per high-power field [hpf] = esophageal eosinophil load). Esophageal biopsy and blood samples were analyzed using immunofluorescence and immunoassays, respectively, for biomarkers of inflammation and treatment response. RESULTS:A 15-day course of therapy significantly decreased the number of eosinophils in the esophageal epithelium in patients given budesonide (from 68.2 to 5.5 eosinophils/hpf; P < .0001) but not in the placebo group (from 62.3 to 56.5 eosinophils/hpf; P = .48). Dysphagia scores significantly improved among patients given budesonide compared with those given placebo (5.61 vs 2.22; P < .0001). White exudates and red furrows were reversed in patients given budesonide, based on endoscopy examination. Budesonide, but not placebo, also reduced apoptosis of epithelial cells and molecular remodeling events in the esophagus; no serious adverse events were observed. CONCLUSIONS:A 15-day course of treatment with budesonide is well tolerated and highly effective in inducing a histologic and clinical remission in adolescent and adult patients with active EoE.
journal_name
Gastroenterologyjournal_title
Gastroenterologyauthors
Straumann A,Conus S,Degen L,Felder S,Kummer M,Engel H,Bussmann C,Beglinger C,Schoepfer A,Simon HUdoi
10.1053/j.gastro.2010.07.048subject
Has Abstractpub_date
2010-11-01 00:00:00pages
1526-37, 1537.e1issue
5eissn
0016-5085issn
1528-0012pii
S0016-5085(10)01143-1journal_volume
139pub_type
杂志文章,随机对照试验相关文献
GASTROENTEROLOGY文献大全abstract:BACKGROUND & AIMS:Linaclotide is a minimally absorbed peptide agonist of the guanylate cyclase-C receptor that stimulates intestinal fluid secretion and transit and reduces pain in animal models. We assessed the safety and efficacy of a range of linaclotide doses in patients with chronic constipation. METHODS:We perfo...
journal_title:Gastroenterology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1053/j.gastro.2009.12.050
更新日期:2010-03-01 00:00:00
abstract::Electronic (video) endoscopes are a significant new development in gastroenterology, offering the potential of enhanced teaching and permanent storage of pictorial data. The primary concern of gastroenterologists is the resolution and color performance of these instruments, as these parameters have important bearings ...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1989-03-01 00:00:00
abstract:BACKGROUND & AIMS:The aim of this study was to determine whether expression of hepatitis C virus proteins alters hepatic morphology or function in the absence of inflammation. METHODS:Transgenic C57BL/6 mice with liver-specific expression of RNA encoding the complete viral polyprotein (FL-N transgene) or viral structu...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/gast.2002.31001
更新日期:2002-02-01 00:00:00
abstract::This study was designed to investigate the location, specificity, and significance of antibody-containing cells in the liver. After intestinal administration of cholera toxin, high numbers of specific antibody-containing cells appeared in the liver during the early priming period and after boosting. In contrast, a sig...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(87)90917-6
更新日期:1987-09-01 00:00:00
abstract:BACKGROUND & AIMS:The morphology of acid damage to esophageal epithelium is characterized by marked cell (swelling) edema. This observation suggests that, in the process of acid damage, an increase in osmotic forces develops within the cell that accounts for the increase in cell water. The aim of this study was to docu...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(95)90328-3
更新日期:1995-08-01 00:00:00
abstract:BACKGROUND:Liver injury in many patients with chronic hepatitis B is sporadic and is often characterized by acute exacerbations alternating with relatively normal liver function. The aim of this study was to perform detailed serological and biochemical analysis during periods of active liver disease to better understan...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(93)90960-k
更新日期:1993-10-01 00:00:00
abstract::The nuclear lamina is a multi-protein lattice composed of A- and B-type lamins and their associated proteins. This protein lattice associates with heterochromatin and integral inner nuclear membrane proteins, providing links among the genome, nucleoskeleton, and cytoskeleton. In the 1990s, mutations in EMD and LMNA we...
journal_title:Gastroenterology
pub_type: 杂志文章,评审
doi:10.1053/j.gastro.2018.03.026
更新日期:2018-05-01 00:00:00
abstract:BACKGROUND & AIMS:We have shown previously that cure of Helicobacter pylori infection leads to the disappearance of acid-neutralizing substances. Also, patients with ulcer after cure may gain weight. The aim of this study was to investigate whether cure of the infection increases the risk of reflux esophagitis. METHOD...
journal_title:Gastroenterology
pub_type: 临床试验,杂志文章
doi:10.1016/s0016-5085(97)70024-6
更新日期:1997-05-01 00:00:00
abstract::Based on in vitro experiments measuring daily secretion rates in the culture media of rat hepatocytes and in vivo experiments using pulse labeling of intracellular precursors, the present study examines the ontogenic expression of the polymeric immunoglobulin receptor and secretory component by hepatocytes during grow...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(92)90181-w
更新日期:1992-03-01 00:00:00
abstract::Pancreatic ductal adenocarcinoma is a devastating disease, and patient outcomes have not improved in decades. Treatments that target tumor cells have largely failed. This could be because research has focused on cancer cells and the influence of the stroma on tumor progression has been largely ignored. The focus of pa...
journal_title:Gastroenterology
pub_type: 杂志文章,评审
doi:10.1053/j.gastro.2012.11.037
更新日期:2013-06-01 00:00:00
abstract:BACKGROUND & AIMS:The complications of diverticulosis cause considerable morbidity in the United States; health care expenditures for this disorder are estimated to be $2.5 billion per year. Many physicians and patients believe that a high-fiber diet and frequent bowel movements prevent the development of diverticulosi...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2011.10.035
更新日期:2012-02-01 00:00:00
abstract::Liver copper concentration was studied in four groups of age-matched patients and in 9 patients with Wilson's disease of comparable age. Neutron activation analysis of hepatic copper concentration revealed markedly elevated hepatic copper levels, comparable with those in Wilson's disease, in 13 of 15 patients (P less ...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1978-11-01 00:00:00
abstract:BACKGROUND & AIMS:HuR is a RNA-binding factor whose expression is commonly upregulated in some human tumor types. We explored the molecular mechanism underlying HuR elevation and its role in gastric cancer tumorigenesis. METHODS:HuR expression and subcellular localization were determined by polymerase chain reaction, ...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2008.08.009
更新日期:2008-12-01 00:00:00
abstract:BACKGROUND & AIMS:Stimulator of Fe Transport (SFT) and transferrin receptor (TfR) are proteins involved in iron transport. This study evaluated iron metabolism protein expression in duodenal biopsy specimens from controls and patients with abnormal iron metabolism. METHODS:Twelve controls, 8 patients with iron deficie...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/gast.2001.23946
更新日期:2001-05-01 00:00:00
abstract:BACKGROUND & AIMS:The NOD2 gene, which is strongly associated with susceptibility to Crohn's disease (CD) of the terminal ileum, interacts with bacterial lipopolysaccharide (LPS), inducing cellular activation. However, the mechanisms by which NOD2 mutations cause terminal ileitis are unknown, and NOD2 is expressed most...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/s0016-5085(03)00661-9
更新日期:2003-07-01 00:00:00
abstract:BACKGROUND & AIMS:De novo hepatitis B virus (HBV)-related hepatitis after chemotherapy results in high morbidity and mortality. We evaluate the clinical course of de novo HBV-related hepatitis after chemotherapy. METHODS:Two hundred forty-four consecutive hepatitis B surface antigen (HBsAg)-negative lymphoma patients ...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2006.04.015
更新日期:2006-07-01 00:00:00
abstract::The fibrinolytic activity of blood draining from the stomachs of patients with gastroduodenal disease has been compared with the fibrinolytic activity of blood in the systemic venous circulation and with the blood draining from normal stomachs. Gastric venous blood from normal and diseased stomachs contains greater am...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1979-03-01 00:00:00
abstract:BACKGROUND & AIMS:Changes in the properties of visceral sensory neurons contribute to the development of gastrointestinal pain. However, little is known about the molecules involved in mechanosensation from the gastrointestinal tract. We investigated the phosphorylation of extracellular signal-regulated kinase 1/2 (ERK...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2008.01.031
更新日期:2008-04-01 00:00:00
abstract::In human cirrhosis, there is evidence that there are considerable alterations in fluid and solute exchange in the hepatic and intestinal microcirculations . Experimental cirrhosis was induced in rats by using oral phenobarbitone and carbon tetrachloride inhalation over an 8-wk period. Portal venous pressure, hepatic a...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1984-07-01 00:00:00
abstract:BACKGROUND & AIMS:Several aspects of the pathogenesis of osteopenia in celiac disease are still unclear. Therefore, bone mass and metabolism were evaluated in adults with celiac disease in a cross-sectional study. METHODS:Bone mineral density (BMD), assessed by total body dual-photon absorptiometry, and serum indices ...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(95)90276-7
更新日期:1995-07-01 00:00:00
abstract::Identification of physiologic factors that predict response to fecal incontinence therapy would be helpful in choosing the optimal treatment and advising patients on the likelihood of a successful outcome. However, few physiologic parameters have been consistently identified as important in predicting response to eith...
journal_title:Gastroenterology
pub_type: 杂志文章,评审
doi:10.1053/j.gastro.2003.10.008
更新日期:2004-01-01 00:00:00
abstract::A prospective and randomized study was performed comparing pneumatic forceful dilatation and surgical esophagomyotomy as primary treatment of patients with achalasia of the esophagus. Eighteen dilated and 20 operated patients were studied before and after treatment with 1 patient lost. Clinical, radiologic, and manome...
journal_title:Gastroenterology
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1981-04-01 00:00:00
abstract:BACKGROUND & AIMS:The physiologic significance of the M(3) muscarinic receptor is unclear due to an absence of specific ligand. In the present study, M(3) receptor knockout (KO) mice were used to elucidate the role of M(3) receptors in gastric acid secretion and gastric mucosal integrity. METHODS:M(3) KO versus wild-t...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2003.09.018
更新日期:2003-12-01 00:00:00
abstract:BACKGROUND & AIMS:Activated recombinant factor VII (rFVIIa) has been shown to be effective in correcting prolonged prothrombin time (PT) in cirrhotic patients. The main objective of this study was to evaluate the effect of 4 (5, 20, 80, and 120 microg/kg) doses of rFVIIa on correction of PT and the time to achieve hemo...
journal_title:Gastroenterology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1053/gast.2002.34164
更新日期:2002-07-01 00:00:00
abstract:BACKGROUND & AIMS:Liver injury leads to generation of reactive oxygen and nitrogen species, which can react to produce peroxynitrite (ONOO-). We investigated whether ONOO- and its metabolites modulate extracellular matrix remodeling. METHODS:Stellate cells (HSC) were incubated with pure ONOO- or SIN-1 (a ONOO- donor)....
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2008.12.065
更新日期:2009-04-01 00:00:00
abstract::Rising trends in the incidence and mortality of early-onset CRC in those who are ages less than 50 years have been well-established. These trends have spurred intense investigation focused on elucidating the epidemiology and characteristics of early-onset CRC, as well on identifying strategies for early detection and ...
journal_title:Gastroenterology
pub_type: 杂志文章,评审
doi:10.1053/j.gastro.2020.12.068
更新日期:2021-01-05 00:00:00
abstract:BACKGROUND & AIMS:Many putative pronucleating proteins have been isolated from the biliary concanavalin A (con A)-binding fraction. The pronase resistance of the overall nucleating-promoting activity was almost never taken into consideration. The aim of this study was to identify the major pronase-resistant con A-bindi...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/gast.1996.v110.pm8964420
更新日期:1996-06-01 00:00:00
abstract:BACKGROUND & AIMS:Regenerating (Reg) gene IV is predominantly expressed in gastrointestinal cells and highly up-regulated in many gastrointestinal malignancies, including colorectal cancer (CRC). Human CRC cells expressing higher levels of Reg IV gene and its protein product (Reg IV) are resistant to conventional thera...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2009.10.050
更新日期:2010-02-01 00:00:00
abstract:BACKGROUND & AIMS:Pancreatic mucinous cystic neoplasm (MCN), a cystic tumor of the pancreas that develops most frequently in women, is a potential precursor to pancreatic ductal adenocarcinoma. MCNs develop primarily in the body and tail of the pancreas and are characterized by the presence of a mucinous epithelium and...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2013.09.044
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:The contribution of the crural diaphragm to the gastroesophageal high pressure zone (HPZ) may be important in prevention of gastroesophageal reflux. The purpose of this study was to investigate the manometric characteristics of the thoracoabdominal junction in patients after surgical removal of the lower eso...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(93)90140-8
更新日期:1993-11-01 00:00:00