Inflammatory markers are associated with risk of colorectal cancer and chemopreventive response to anti-inflammatory drugs.

abstract：BACKGROUND & AIMS:We have few population-level data on the performance of endoscopic retrograde cholangiopancreatography (ERCP) in the United States. We investigated the numbers of unplanned hospital encounters (UHEs), patient and facility factors associated with UHEs, and variation in quality and outcomes in the perfo...

journal_title：Gastroenterology

authors： Huang RJ,Barakat MT,Girotra M,Lee JS,Banerjee S

更新日期：2019-01-01 00:00:00

abstract：:The fibrinolytic activity of blood draining from the stomachs of patients with gastroduodenal disease has been compared with the fibrinolytic activity of blood in the systemic venous circulation and with the blood draining from normal stomachs. Gastric venous blood from normal and diseased stomachs contains greater am...

journal_title：Gastroenterology

authors： O'Brien TE,Hadley H,Irving MH

更新日期：1979-03-01 00:00:00

abstract：BACKGROUND & AIMS:Activating transcription factor 6 (ATF6) regulates endoplasmic reticulum stress. We studied whether ATF6 contributes to the development of colorectal cancer (CRC) using tissue from patients and transgenic mice. METHODS:We analyzed data from 541 patients with CRC in The Cancer Genome Atlas database fo...

journal_title：Gastroenterology

authors： Coleman OI,Lobner EM,Bierwirth S,Sorbie A,Waldschmitt N,Rath E,Berger E,Lagkouvardos I,Clavel T,McCoy KD,Weber A,Heikenwalder M,Janssen KP,Haller D

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND & AIMS:Estimates of complication rates following elective percutaneous liver biopsy vary and might not accurately reflect current practice. We studied mortality and complication rates, by indication, in patients after they underwent liver biopsies. METHODS:We performed a study using hospital episode statist...

journal_title：Gastroenterology

authors： West J,Card TR

更新日期：2010-10-01 00:00:00

abstract：BACKGROUND & AIMS:Standardized instruments are needed to assess the activity of eosinophilic esophagitis (EoE) and to provide end points for clinical trials and observational studies. We aimed to develop and validate a patient-reported outcome (PRO) instrument and score, based on items that could account for variations...

journal_title：Gastroenterology

authors： Schoepfer AM,Straumann A,Panczak R,Coslovsky M,Kuehni CE,Maurer E,Haas NA,Romero Y,Hirano I,Alexander JA,Gonsalves N,Furuta GT,Dellon ES,Leung J,Collins MH,Bussmann C,Netzer P,Gupta SK,Aceves SS,Chehade M,Moawad F

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND & AIMS:The risk for colorectal cancer (CRC) in patients with inflammatory bowel disease (IBD) could have changed over time, with changes in treatment options. We studied CRC risk in a nationwide cohort of 47,374 Danish patients with IBD over a 30-year period. METHODS:We determined relative risk (RR) values ...

journal_title：Gastroenterology

authors： Jess T,Simonsen J,Jørgensen KT,Pedersen BV,Nielsen NM,Frisch M

更新日期：2012-08-01 00:00:00

abstract：BACKGROUND & AIMS:Transplantation of wild-type (H-2k) bone marrow into tg epsilon26 mice (BM-->tg epsilon26) induces colitis, characterized by T-helper cell type 1 activation in the lamina propria. Here we determined whether pathogenic T-cell clones could be derived by serial adoptive transfers into healthy tg epsilon2...

journal_title：Gastroenterology

authors： Abadía-Molina AC,Mizoguchi A,Faubion WA,De Jong YP,Rietdijk ST,Comiskey M,Clarke K,Bhan AK,Terhorst C

更新日期：2005-05-01 00:00:00

abstract：BACKGROUND & AIMS:This study used a low lesion prevalence population reflective of the screening setting to estimate the sensitivity and specificity of computerized tomographic (CT) colonography for detection of colorectal polyps. METHODS:This prospective, blinded study comprised 703 asymptomatic persons at higher-tha...

journal_title：Gastroenterology

authors： Johnson CD,Harmsen WS,Wilson LA,Maccarty RL,Welch TJ,Ilstrup DM,Ahlquist DA

更新日期：2003-08-01 00:00:00

abstract：:The existence of high- and low-affinity cholecystokinin (CCK)-A receptors on rodent pancreatic acini is well established. Until recently, CCK was believed to act directly on pancreatic acini to stimulate pancreatic secretion in both rodents and humans. However, conclusive evidence that human pancreatic acini lack func...

journal_title：Gastroenterology

authors： Owyang C,Logsdon CD

更新日期：2004-09-01 00:00:00

abstract：:Focal nodular hyperplasia (FNH) and hepatocellular adenoma (HCA) are benign hepatocellular tumors that develop most frequently in women without cirrhosis. Genomic approaches have identified signaling pathways related to these benign hepatocyte proliferations. FNH, a polyclonal lesion, is characterized by local vascula...

journal_title：Gastroenterology

authors： Nault JC,Bioulac-Sage P,Zucman-Rossi J

更新日期：2013-05-01 00:00:00

abstract：:To determine whether intravenous nutritional repletion can influence oxidative drug metabolizing capacity, antipyrine metabolism was studied in 6 malnourished patients on the second day of a 2-day baseline period and on the last day of two sequential, 8-day intravenous nutritional repletion periods. During the baselin...

journal_title：Gastroenterology

authors： Pantuck EJ,Pantuck CB,Weissman C,Gil KM,Askanazi J

更新日期：1985-08-01 00:00:00

abstract：:Seven patients with persistent hyponatremia but normal or elevated serum arginine vasopressin levels and refractory ascites undergoing peritoneovenous shunting were studied in a Metabolic Unit on a 20 mEq sodium 1200 ml fluid-restricted diet to elucidate the mechanism of this response. The intravascular volume expansi...

journal_title：Gastroenterology

authors： Reznick RK,Langer B,Taylor BR,Seif S,Blendis LM

更新日期：1983-04-01 00:00:00

abstract：BACKGROUND & AIMS:Prostacyclin and nitric oxide have been involved in the hyperkinetic syndrome in portal hypertension. The aim of this study was to investigate the relative contribution and possible interaction between prostacyclin and NO in this circulatory abnormality. METHODS:Portal vein-ligated and sham-operated ...

journal_title：Gastroenterology

authors： Fernández M,García-Pagán JC,Casadevall M,Mourelle MI,Piqué JM,Bosch J,Rodés J

更新日期：1996-05-01 00:00:00

abstract：:The prevalence of marginal zinc nutriture in several populations of people in this country and the lack of reports on the effect of marginal zinc nutriture in experimental animals prompted us to look at pancreatic acinar cell function and morphology in rats fed a zinc-deficient diet ad libitum: 4 and 50 ppm zinc-suppl...

journal_title：Gastroenterology

authors： Perez-Jimenez F,Bockman DE,Singh M

更新日期：1986-04-01 00:00:00

abstract：:To gain further insight on the mosaic expression of specific functional intestinal markers (such as sucrase-isomaltase) in postconfluent Caco-2 cells, a human colon cancer cell line unique in its property to differentiate in vitro into a mature enterocyte-like cell type, a comparative study was undertaken to examine t...

journal_title：Gastroenterology

authors： Vachon PH,Beaulieu JF

更新日期：1992-08-01 00:00:00

abstract：BACKGROUND & AIMS:Amidated gastrins are acid secretagogues and growth factors. Their precursor, progastrin, is a growth factor but not a secretagogue. Cleavage of progastrin at Arg94/95 determines the expression of these two alternative patterns of biological activity. We examined the hypothesis that cleavage at Arg94/...

journal_title：Gastroenterology

authors： Bishop L,Dimaline R,Blackmore C,Deavall D,Dockray GJ,Varro A

更新日期：1998-11-01 00:00:00

abstract：:The role of lipoxygenase metabolites in ethanol-induced gastric mucosal injury and submucosal microvascular change in the rat was studied by in vivo microscopy. Intragastric ethanol-instillation caused marked submucosal venular constriction, dilatation of small arterioles, and corpus mucosal gross lesion formation. Th...

journal_title：Gastroenterology

authors： Yonei Y,Guth PH

更新日期：1989-08-01 00:00:00

abstract：BACKGROUND & AIMS:No controlled trial has examined the clinical efficacy of antibiotics in small bowel bacterial overgrowth. METHODS:Ten patients with bacterial overgrowth-related diarrhea underwent the following five 7-day treatment periods: untreated (control period), then placebo, and subsequently, in random order ...

journal_title：Gastroenterology

authors： Attar A,Flourié B,Rambaud JC,Franchisseur C,Ruszniewski P,Bouhnik Y

更新日期：1999-10-01 00:00:00

abstract：BACKGROUND AND AIMS:Cholestasis is one of the principal manifestations of liver disease and often results from disorders involving bile duct epithelia rather than hepatocytes. A range of disorders affects biliary epithelia, and no unifying pathophysiologic event in these cells has been identified as the cause of choles...

journal_title：Gastroenterology

authors： Shibao K,Hirata K,Robert ME,Nathanson MH

更新日期：2003-10-01 00:00:00

abstract：:The clinical, endoscopic, histologic, manometric, and esophageal potential difference characteristics of 20 patients with columnar epithelia lining the lower esophagus (Barrett's esophagus) are presented. Endoscopically, two distinct types were identified: a circumferential-type and an island-type Barrett's esophagus....

journal_title：Gastroenterology

authors： Herlihy KJ,Orlando RC,Bryson JC,Bozymski EM,Carney CN,Powell DW

更新日期：1984-03-01 00:00:00

abstract：BACKGROUND AND AIMS:Tumor necrosis factor (TNF) is a cytokine that promotes inflammation and contributes to pathogenesis of inflammatory bowel diseases. Unlike other cells and tissues, intestinal epithelial cells undergo rapid cell death upon exposure to TNF, by unclear mechanisms. We investigated the roles of inhibito...

journal_title：Gastroenterology

authors： Grabinger T,Bode KJ,Demgenski J,Seitz C,Delgado ME,Kostadinova F,Reinhold C,Etemadi N,Wilhelm S,Schweinlin M,Hänggi K,Knop J,Hauck C,Walles H,Silke J,Wajant H,Nachbur U,W Wei-Lynn W,Brunner T

更新日期：2017-03-01 00:00:00

abstract：:The effects of hydroxypropylmethylcellulose on upper gastrointestinal transit, viscosity, and water flux were studied in six dogs fistulated at the proximal duodenum and/or mid-jejunum. Combinations of different grades of hydroxypropylmethylcellulose were prepared as 2% or 3.3% solutions to yield input viscosities of ...

journal_title：Gastroenterology

authors： Reppas C,Meyer JH,Sirois PJ,Dressman JB

更新日期：1991-05-01 00:00:00

abstract：:Hepatic plasma flow was assessed with sorbitol (hepatic extraction = 0.96) at steady state. After infusion of 50 mg/min for 3 h, total and renal sorbitol clearances were calculated, and the extrarenal clearance was obtained by taking the difference between the two. In normal volunteers, the mean (+/- SD) extrarenal so...

journal_title：Gastroenterology

authors： Zeeh J,Lange H,Bosch J,Pohl S,Loesgen H,Eggers R,Navasa M,Chesta J,Bircher J

更新日期：1988-09-01 00:00:00

abstract：BACKGROUND:Over 60 studies have addressed the hypothesis that the risk of colorectal cancer is increased following cholecystectomy; these studies have yielded inconsistent findings. The aim of the present study was to quantitatively summarize the results from the collective studies. METHODS:A meta-analysis of the publ...

journal_title：Gastroenterology

authors： Giovannucci E,Colditz GA,Stampfer MJ

更新日期：1993-07-01 00:00:00

abstract：BACKGROUND & AIMS:Steatosis in patients with nonalcoholic fatty liver disease (NAFLD) is due to an imbalance between intrahepatic triglyceride (IHTG) production and export. The purpose of this study was to evaluate TG metabolism in adipose tissue and liver in NAFLD. METHODS:Fatty acid, VLDL-TG, and VLDL-apolipoprotein...

journal_title：Gastroenterology

authors： Fabbrini E,Mohammed BS,Magkos F,Korenblat KM,Patterson BW,Klein S

更新日期：2008-02-01 00:00:00

abstract：:To clarify the role of fat maldigestion in the pathogenesis of steatorrhea in patients with ileal resection the total and aqueous phase concentrations of bile acid and fatty acid were characterized in 8 such patients (5 patients with small ileal resection, bile acid diarrhea, and steatorrhea less than 20 g per day; 3 ...

journal_title：Gastroenterology

authors： Poley JR,Hofmann AF

更新日期：1976-07-01 00:00:00

abstract：BACKGROUND & AIMS:Intrapancreatic activation of digestive enzymes is a key event in the parenchymal cell injury of pancreatitis. We hypothesized that neutrophils recruited to the pancreas during pancreatitis may contribute to such activation. METHODS:To cause experimental pancreatitis, rats and mice were treated with ...

journal_title：Gastroenterology

authors： Gukovskaya AS,Vaquero E,Zaninovic V,Gorelick FS,Lusis AJ,Brennan ML,Holland S,Pandol SJ

更新日期：2002-04-01 00:00:00

abstract：:We have examined the T-cell functional capabilities of human intestinal mononuclear cells isolated from surgically obtained normal and inflammatory bowel disease intestinal specimens. Intestinal mononuclear cells have T cells present which respond to the mitogenic lectins E-PHA, Con A, and PWM and to foreign cell-surf...

journal_title：Gastroenterology

authors： MacDermott RP,Bragdon MJ,Jenkins KM,Franklin GO,Shedlofsky S,Kodner IJ

更新日期：1981-04-01 00:00:00

abstract：BACKGROUND & AIMS:Epithelial cells of the small intestine migrate to the tip of the villus at which they are shed. It is not understood how the intestinal barrier is maintained during this high cell turnover. The aim of this study was to use high-resolution in vivo light microscopy to investigate the mechanism of epith...

journal_title：Gastroenterology

authors： Watson AJ,Chu S,Sieck L,Gerasimenko O,Bullen T,Campbell F,McKenna M,Rose T,Montrose MH

更新日期：2005-09-01 00:00:00

abstract：BACKGROUND & AIMS:After liver injury, bone marrow-derived liver sinusoidal endothelial cell progenitor cells (BM SPCs) repopulate the sinusoid as liver sinusoidal endothelial cells (LSECs). After partial hepatectomy, BM SPCs provide hepatocyte growth factor, promote hepatocyte proliferation, and are necessary for norma...

journal_title：Gastroenterology

authors： Wang L,Wang X,Wang L,Chiu JD,van de Ven G,Gaarde WA,Deleve LD

更新日期：2012-12-01 00:00:00