Barrett's esophagus: clinical, endoscopic, histologic, manometric, and electrical potential difference characteristics.

abstract：:The type of cirrhosis was blindly evaluated in follow-up liver biopsies performed on 106 alcoholic men with micronodular cirrhosis. The median time interval from entry to follow-up liver biopsy was 31 mo (range, 3-44 mo). Patients were stratified into four groups according to their maximal registered ethanol consumpti...

journal_title：Gastroenterology

authors： Gluud C,Christoffersen P,Eriksen J,Wantzin P,Knudsen BB

更新日期：1987-08-01 00:00:00

abstract：BACKGROUND & AIMS:The aim of this study was to generate an improved prognostic model for predicting recurrence in liver transplant candidates with hepatocellular carcinoma (HCC). METHODS:Predictors of recurrence were tested by a Cox model analysis in a training cohort of 537 patients transplanted for HCC. A prognostic...

journal_title：Gastroenterology

authors： Duvoux C,Roudot-Thoraval F,Decaens T,Pessione F,Badran H,Piardi T,Francoz C,Compagnon P,Vanlemmens C,Dumortier J,Dharancy S,Gugenheim J,Bernard PH,Adam R,Radenne S,Muscari F,Conti F,Hardwigsen J,Pageaux GP,Chazouill

更新日期：2012-10-01 00:00:00

abstract：:Spontaneous remission of gastric acid hypersecretion in the Zollinger-Ellison syndrome occurs rarely. This study shows the development of gastric secretory mucosal atrophy resulting in achlorhydria and loss of pepsin secretion in a 63-year-old woman with the Zollinger-Ellison syndrome. Reduced secretion began soon aft...

journal_title：Gastroenterology

authors： Griffith JL,Cummings OW,Hirschowitz BI

更新日期：1991-07-01 00:00:00

abstract：BACKGROUND & AIMS:Caco-2 cells have been used extensively to elucidate events involved in intestinal cell proliferation and differentiation. Because individual isoforms of protein kinase C (PKC) and p21waf1, a cyclin-dependent kinase inhibitor, may regulate these processes, their role(s) on the growth and differentiati...

journal_title：Gastroenterology

authors： Abraham C,Scaglione-Sewell B,Skarosi SF,Qin W,Bissonnette M,Brasitus TA

更新日期：1998-03-01 00:00:00

abstract：:A human colon cancer cell line, HCT-8, is shown to be an appropriate target cell for study of natural killer (NK) activity in man. In parallel experiments, effector cell characteristics for NK and antibody-dependent cellular cytotoxicity (ADCC) were found to be vested in a single lymphocyte subpopulation, which bore r...

journal_title：Gastroenterology

authors： Helms RA,Bull DM

更新日期：1980-04-01 00:00:00

abstract：BACKGROUND & AIMS:The Ki-RAS oncogene is altered in pancreatic ductal neoplasms. Pancreatic ductal cells (PDCs) were purified from cytokeratin 19 (K19)-Ki-RAS(G12V) transgenic mice and control littermates to identify properties of Ki-Ras activation in a cell-type-specific context. Because Ki-RAS mutation has prognostic...

journal_title：Gastroenterology

authors： Schreiber FS,Deramaudt TB,Brunner TB,Boretti MI,Gooch KJ,Stoffers DA,Bernhard EJ,Rustgi AK

更新日期：2004-07-01 00:00:00

abstract：BACKGROUND & AIMS:It is a challenge to deliver nucleic acids to gastrointestinal (GI) tissues due to their size and need for intracellular delivery. They are also extremely susceptible to degradation by nucleases, which are ubiquitous in the GI tract. We investigated whether ultrasound, which can permeabilize tissue th...

journal_title：Gastroenterology

authors： Schoellhammer CM,Lauwers GY,Goettel JA,Oberli MA,Cleveland C,Park JY,Minahan D,Chen Y,Anderson DG,Jaklenec A,Snapper SB,Langer R,Traverso G

更新日期：2017-04-01 00:00:00

abstract：:To determine the pattern of inheritance of lactase deficiency, we studied 104 American Indian and 2 white subjects in 19 families. Subjects were considered deficient in lactase if breath-hydrogen excretion exceeded 0.20 ml per min above fasting at 2 hr after a lactose load of 2 g per kg of body weight (maximum 50 g). ...

journal_title：Gastroenterology

authors： Newcomer AD,Gordon H,Thomas PJ,McGill DB

更新日期：1977-11-01 00:00:00

abstract：BACKGROUND & AIMS:Despite many advances in our understanding of Crohn's disease, the course of the disease in any given patient remains unpredictable. There is little agreement as to which factors increase a patient's risk of early postoperative recurrence. We have attempted to identify predictors of early recurrence a...

journal_title：Gastroenterology

authors： Lautenbach E,Berlin JA,Lichtenstein GR

更新日期：1998-08-01 00:00:00

abstract：BACKGROUND & AIMS:Lactase is the intestinal disaccharidase responsible for digestion of lactose, the predominant carbohydrate in milk. Transcription of the lactase gene is activated during enterocyte differentiation. We have characterized the interaction between the lactase promoter and Cdx2, a homeodomain protein invo...

journal_title：Gastroenterology

authors： Fang R,Santiago NA,Olds LC,Sibley E

更新日期：2000-01-01 00:00:00

abstract：BACKGROUND & AIMS:Prostacyclin and nitric oxide have been involved in the hyperkinetic syndrome in portal hypertension. The aim of this study was to investigate the relative contribution and possible interaction between prostacyclin and NO in this circulatory abnormality. METHODS:Portal vein-ligated and sham-operated ...

journal_title：Gastroenterology

authors： Fernández M,García-Pagán JC,Casadevall M,Mourelle MI,Piqué JM,Bosch J,Rodés J

更新日期：1996-05-01 00:00:00

abstract：BACKGROUND & AIMS:Recently, the immediate early gene h-sgk was cloned as a hypertonicity-induced gene from human hepatoma cells. The aim of this study was to localize h-sgk messenger RNA (mRNA) expression in normal and inflamed intestinal mucosa and to identify potential transcriptional regulators. METHODS:h-sgk mRNA ...

journal_title：Gastroenterology

authors： Waldegger S,Klingel K,Barth P,Sauter M,Rfer ML,Kandolf R,Lang F

更新日期：1999-05-01 00:00:00

abstract：:The nuclear lamina is a multi-protein lattice composed of A- and B-type lamins and their associated proteins. This protein lattice associates with heterochromatin and integral inner nuclear membrane proteins, providing links among the genome, nucleoskeleton, and cytoskeleton. In the 1990s, mutations in EMD and LMNA we...

journal_title：Gastroenterology

authors： Brady GF,Kwan R,Bragazzi Cunha J,Elenbaas JS,Omary MB

更新日期：2018-05-01 00:00:00

abstract：BACKGROUND:It is generally believed that M cells do not modify the antigens they transport from the intestinal lumen to underlying immunocompetent cells because it has been reported that M cells contain few elements of the lysosomal system. METHODS:We used specific cytochemical and immunocytochemical probes to examine...

journal_title：Gastroenterology

authors： Allan CH,Mendrick DL,Trier JS

更新日期：1993-03-01 00:00:00

abstract：:This study presents normal values of bowel habits, colonic transit times of radioopaque markers, and anorectal pressure obtained from 114 normal subjects. Their stool frequency ranged from 3 to 11 per 7 days, whereas their diet contained an average of 14.4 g of crude fibers. Radioopaque markers progressed regularly al...

journal_title：Gastroenterology

authors： Martelli H,Devroede G,Arhan P,Duguay C,Dornic C,Faverdin C

更新日期：1978-10-01 00:00:00

abstract：BACKGROUND & AIMS:Alcohol abuse causes half of all deaths from cirrhosis in the West, but few tools are available for noninvasive diagnosis of alcoholic liver disease. We evaluated 2 elastography techniques for diagnosis of alcoholic fibrosis and cirrhosis; liver biopsy with Ishak score and collagen-proportionate area ...

journal_title：Gastroenterology

authors： Thiele M,Detlefsen S,Sevelsted Møller L,Madsen BS,Fuglsang Hansen J,Fialla AD,Trebicka J,Krag A

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND & AIMS:Endosonography-guided fine-needle aspiration biopsy (EUS-FNA) permits cytological confirmation of EUS findings. A multicenter prospective evaluation of EUS-FNA for primary diagnosis, staging, and/or follow-up purposes was undertaken. METHODS:EUS-FNA was performed in 457 patients with 554 lesions. Cli...

journal_title：Gastroenterology

authors： Wiersema MJ,Vilmann P,Giovannini M,Chang KJ,Wiersema LM

更新日期：1997-04-01 00:00:00

abstract：:Electromyogram of the submental muscles, esophageal manometry, and pH studies were simultaneously performed in an unselected group of 12 patients with subjective and objective evidence of gastroesophageal reflux (GER) disease to determine the frequency of transient relaxation of the lower esophageal sphincter (LES) an...

journal_title：Gastroenterology

authors： Mittal RK,McCallum RW

更新日期：1988-09-01 00:00:00

abstract：BACKGROUND & AIMS:There are intra- and interobserver variations in endoscopic assessment of ulcerative colitis (UC) and biopsies are often collected for histologic evaluation. We sought to develop a deep neural network system for consistent, objective, and real-time analysis of endoscopic images from patients with UC. ...

journal_title：Gastroenterology

authors： Takenaka K,Ohtsuka K,Fujii T,Negi M,Suzuki K,Shimizu H,Oshima S,Akiyama S,Motobayashi M,Nagahori M,Saito E,Matsuoka K,Watanabe M

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND & AIMS:The physiologic significance of the M(3) muscarinic receptor is unclear due to an absence of specific ligand. In the present study, M(3) receptor knockout (KO) mice were used to elucidate the role of M(3) receptors in gastric acid secretion and gastric mucosal integrity. METHODS:M(3) KO versus wild-t...

journal_title：Gastroenterology

authors： Aihara T,Fujishita T,Kanatani K,Furutani K,Nakamura E,Taketo MM,Matsui M,Chen D,Okabe S

更新日期：2003-12-01 00:00:00

abstract：BACKGROUND/AIMS:Carbonic anhydrase activity plays a role in electrolyte transport in many tissues. This study examined the effect of the carbonic anhydrase inhibitor acetazolamide on human basal and prostaglandin E2- and acid-stimulated duodenal mucosal bicarbonate secretion and transmucosal electrical potential differ...

journal_title：Gastroenterology

authors： Knutson TW,Koss MA,Hogan DL,Isenberg JI,Knutson L

更新日期：1995-01-01 00:00:00

abstract：:Transient relaxation of the lower esophageal sphincter (LES) is observed fairly frequently during prolonged continuous monitoring of the LES. The aim of this study was to test whether the presence of a catheter in the pharynx through the stimulation of mechanoreceptors may induce transient LES relaxation. LES and esop...

journal_title：Gastroenterology

authors： Mittal RK,Stewart WR,Schirmer BD

更新日期：1992-10-01 00:00:00

abstract：:The prevalence of gastroesophageal varices and gastrointestinal hemorrhage was determined in 124 patients with severe chronic active liver disease (CALD) receiving prednisone and followed regularly for up to 10 yr. Varices were demonstrated by contrast radiography in only 19 patients (15%). Ten had varices before ther...

journal_title：Gastroenterology

authors： Czaja AJ,Wolf AM,Summerskill WH

更新日期：1979-10-01 00:00:00

abstract：BACKGROUND/AIMS:We have identified several clones specifically expressed during malignant cell proliferation by screening a complementary DNA library constructed from a human primary liver cancer with subtractive probes. One clone was identified as the glutamine synthetase (GS) transcript. Its expression is tightly reg...

journal_title：Gastroenterology

authors： Christa L,Simon MT,Flinois JP,Gebhardt R,Brechot C,Lasserre C

更新日期：1994-05-01 00:00:00

abstract：:Erythromycin has been shown to act as a motilin agonist by binding to motilin receptors on gastrointestinal smooth muscle and to improve the severely impaired gastric emptying in patients with diabetic gastroparesis. To elucidate the motor pattern that accounts for this accelerated emptying, the effect of 200 mg eryth...

journal_title：Gastroenterology

authors： Annese V,Janssens J,Vantrappen G,Tack J,Peeters TL,Willemse P,Van Cutsem E

更新日期：1992-03-01 00:00:00

abstract：:We investigated whether intrapancreatic coagulation, with deposition of the fibrinogen-γ dimer (Fib-γD) and hypoxia, affect the severity of acute pancreatitis (AP) in mice. Pancreata of mice with AP induced by administration of cerulein or by L-arginine, or from patients with pancreatitis, had increased deposition of ...

journal_title：Gastroenterology

authors： Park MJ,Iyer S,Xue X,Bragazzi Cunha J,Gu S,Moons D,Pipe SW,Williams JA,Simeone DM,Shah YM,Omary MB

更新日期：2018-05-01 00:00:00

abstract：:Acute, acute recurrent, and chronic forms of pancreatitis have been increasingly diagnosed in children in the past 2 decades. Risk factors in the pediatric group are broad and appear to be strikingly different compared with the adult cohort. However, the disease burden and impact on quality of life are surprisingly si...

journal_title：Gastroenterology

authors： Uc A,Husain SZ

更新日期：2019-05-01 00:00:00

abstract：BACKGROUND & AIMS:Neutrophils are generally thought to play an important proinflammatory role in the pathogenesis of inflammatory bowel disease. The objective of this study was to evaluate whether blocking the invasion of neutrophils by anti-L-selectin monoclonal antibodies modulates chemically induced colitis and how ...

journal_title：Gastroenterology

authors： Kühl AA,Kakirman H,Janotta M,Dreher S,Cremer P,Pawlowski NN,Loddenkemper C,Heimesaat MM,Grollich K,Zeitz M,Farkas S,Hoffmann JC

更新日期：2007-12-01 00:00:00

abstract：:The clinical case is presented of a 16-yr-old patient with thoracoabdominal duplication that communicated with the main pancreatic duct and the right pleural cavity and resulted in pancreaticopleural fistula. Although abdominal duplications communicating with the pancreas have been described before, to our knowledge, ...

journal_title：Gastroenterology

authors： Fitzgibbons RJ Jr,Nugent FW,Ellis FH Jr,Braasch JW,Scholz FJ

更新日期：1980-08-01 00:00:00

abstract：:Immunologic injury in the liver involves immigrant T and B lymphocytes and a resident lymphoid population that comprises distinct lymphocytic cells and accessory cells. The forerunner to autoimmunity is breaching of natural self-tolerance and hence the disruption of a fundamental property of the immune system. Such br...

journal_title：Gastroenterology

authors： Kita H,Mackay IR,Van De Water J,Gershwin ME

更新日期：2001-05-01 00:00:00