Abstract：
:To determine the pattern of inheritance of lactase deficiency, we studied 104 American Indian and 2 white subjects in 19 families. Subjects were considered deficient in lactase if breath-hydrogen excretion exceeded 0.20 ml per min above fasting at 2 hr after a lactose load of 2 g per kg of body weight (maximum 50 g). Seventy-one per cent of the males and 75% of the females were lactase deficient. In three families in which both parents were lactase normal, 40% of the children were lactase deficient; and in the three families with one parent lactase normal and the other lactase deficient, 65% of the children were deficient in lactase; and finally, in the seven families with both parents lactase deficient, 93% of the children were lactase deficient. This distribution of lactase deficiency in the families suggests that this trait shows an autosomal-recessive pattern of inheritance.
journal_name
Gastroenterologyjournal_title
Gastroenterologyauthors
Newcomer AD,Gordon H,Thomas PJ,McGill DBsubject
Has Abstractpub_date
1977-11-01 00:00:00pages
985-8issue
5eissn
0016-5085issn
1528-0012pii
S0016508577003242journal_volume
73pub_type
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