Abstract：
BACKGROUND & AIMS:Infliximab is effective in closing fistulas in patients with Crohn's disease. We examined the effect of infliximab maintenance treatment on hospitalizations, surgeries, and procedures in patients with fistulizing Crohn's disease enrolled in the ACCENT II study. METHODS:After 5 mg/kg infliximab at weeks 0, 2, and 6, a total of 282 patients were separately randomized at week 14 as responders (at least a 50% reduction from baseline in the number of draining fistulas at both weeks 10 and 14) or nonresponders to receive placebo or 5 mg/kg infliximab maintenance every 8 weeks. At week 22 and later, patients who lost response could be treated with a maintenance dose 5 mg/kg higher. Data on Crohn's disease-related hospitalizations, surgeries, and procedures were compared between the treatment groups for responders and all randomized patients. RESULTS:A total of 282 patients were randomized at week 14, of whom 195 were randomized as responders. Among patients randomized as responders, those who received infliximab maintenance had significantly fewer mean hospitalization days (0.5 vs. 2.5 days; P < .05), mean numbers (per 100 patients) of hospitalizations (11 vs. 31; P < .05), all surgeries and procedures (65 vs. 126; P < .05), inpatient surgeries and procedures (7 vs. 41; P < .01), and major surgeries (2 vs. 11; P < .05), compared with those who received placebo maintenance. CONCLUSIONS:In patients with fistulizing Crohn's disease, infliximab 5 mg/kg every 8 weeks significantly reduced hospitalizations, surgeries, and procedures compared with placebo.
journal_name
Gastroenterologyjournal_title
Gastroenterologyauthors
Lichtenstein GR,Yan S,Bala M,Blank M,Sands BEdoi
10.1053/j.gastro.2005.01.048keywords:
subject
Has Abstractpub_date
2005-04-01 00:00:00pages
862-9issue
4eissn
0016-5085issn
1528-0012pii
S0016508505001605journal_volume
128pub_type
临床试验,杂志文章,多中心研究,随机对照试验相关文献
GASTROENTEROLOGY文献大全abstract：:A method of measuring gastric secretions and emptying rates after ingestion of an ordinary (solid-liquid) meal has been developed and validated. The technique quantifies movements of volume across the pylorus using constant duodenal perfusion with a nonabsorbable marker, polyethylene glycol (PEG), which, in turn, quan...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：
更新日期：1976-02-01 00:00:00
abstract：BACKGROUND & AIMS:Because current therapies for chronic hepatitis C virus (HCV) infections are suboptimal and associated with severe side effects, novel treatment options are needed. A small animal model has recently been developed to study HCV infections. To examine the usefulness of this human liver-urokinase-type pl...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/j.gastro.2007.07.007
更新日期：2007-10-01 00:00:00
abstract：BACKGROUND & AIMS:This longitudinal study investigated the interactions and roles of hepatitis B virus (HBV) genotypes, pre-S deletions, and core promoter and precore mutations on the progression of liver disease in hepatitis B e antigen (HBeAg)-negative patients. METHODS:A total of 141 HBeAg-negative patients without...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/j.gastro.2007.09.002
更新日期：2007-11-01 00:00:00
abstract：BACKGROUND & AIMS:We have previously shown that patients with irritable bowel syndrome (IBS) have impaired transit of intestinal gas loads. Because abnormal gas retention can be experimentally reproduced in healthy subjects by pharmacological inhibition of gut motility, we hypothesized that impaired gas transit and ret...
journal_title：Gastroenterology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1053/gast.2002.33658
更新日期：2002-06-01 00:00:00
abstract：BACKGROUND & AIMS:Hepatobiliary secretion is generally believed to be an integral step in the pathway of cholesterol excretion from the body. Here we have investigated the validity of this paradigm in mice. METHODS:Cholesterol balance was assessed by measuring intake, excretion, and biliary output in different mouse m...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/j.gastro.2007.06.019
更新日期：2007-09-01 00:00:00
abstract：:To determine if changes in intestinal motility occur during pregnancy, we studied small intestinal myoelectric activity, using monopolar electrodes, in fasted pregnant rats from day 12 to day 18 of the 22-day gestation period. We also studied fasting myoelectric activity in postpartum, nonpregnant, and castrate female...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：
更新日期：1983-02-01 00:00:00
abstract：BACKGROUND & AIMS:This study examined the possible role of endotoxinemia (from increased gut permeability) as an additional trigger factor for overt pancreatic disease and as a promoter of chronic pancreatic injury in alcoholics by using a rat model of chronic alcohol feeding and in vitro experiments with cultured panc...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/j.gastro.2007.06.062
更新日期：2007-10-01 00:00:00
abstract：BACKGROUND & AIMS:AJM300 is an orally active small-molecule antagonist of the α4 integrin subunit. We performed a randomized trial to investigate the efficacy and safety of AJM300 in patients with active ulcerative colitis (UC). METHODS:In a double-blind, placebo-controlled, phase 2a study, 102 patients with moderatel...
journal_title：Gastroenterology
pub_type： 评论,杂志文章
doi：10.1053/j.gastro.2015.08.044
更新日期：2015-12-01 00:00:00
abstract：:The target appearance of grey scale ultrasound is thought to be a characteristic sign of gastrointestinal wall thickening. It consists of a strong echogenic center surrounded by a sonolucent rim. In a prospective controlled study, the sensitivity and specificity of the ultrasonic B-scan for Crohn's disease were invest...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：
更新日期：1982-08-01 00:00:00
abstract：:Chenodeoxycholic acid (CDC) and ursodeoxycholic acid (UDC) have distinct physicochemical and metabolic properties which, being complementary, should favor more rapid removal of cholesterol from gallstones when both bile acids are administered together. To see if the combination is more effective and well tolerated, we...
journal_title：Gastroenterology
pub_type： 临床试验,杂志文章
doi：10.1016/0016-5085(89)90784-1
更新日期：1989-01-01 00:00:00
abstract：BACKGROUND & AIMS:Liver injury leads to generation of reactive oxygen and nitrogen species, which can react to produce peroxynitrite (ONOO-). We investigated whether ONOO- and its metabolites modulate extracellular matrix remodeling. METHODS:Stellate cells (HSC) were incubated with pure ONOO- or SIN-1 (a ONOO- donor)....
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/j.gastro.2008.12.065
更新日期：2009-04-01 00:00:00
abstract：BACKGROUND & AIMS:Predictors of reactivation of hepatitis B following hepatitis B e antigen (HBeAg) seroconversion in chronic hepatitis B have rarely been reported before and deserve further study. METHODS:A total of 133 HBeAg-positive asymptomatic carriers who have undergone HBeAg seroconversion were studied. Reactiv...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/j.gastro.2007.08.039
更新日期：2007-11-01 00:00:00
abstract：BACKGROUND & AIMS:Canalicular secretion of bile acids is stimulated by tauroursodesoxycholate (TUDC). This study investigates the underlying mechanisms. METHODS:TUDC effects on mitogen-activated protein (MAP) kinases, taurocholate (TC) excretion, proteolysis, and the localization of the bile salt export pump (Bsep) we...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/gast.2001.26262
更新日期：2001-08-01 00:00:00
abstract：:Fc receptor-mediated clearance of immunoglobulin G-coated autologous erythrocytes was studied in patients with primary biliary cirrhosis (n = 14), alcoholic liver cirrhosis (n = 5) and healthy reference individuals (n = 14). The mean half-life of the sensitized erythrocytes was significantly prolonged in patients with...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/0016-5085(91)90736-5
更新日期：1991-10-01 00:00:00
abstract：BACKGROUND & AIMS:Due to the phenotypic and molecular diversity of hepatocellular carcinomas (HCC), it is a challenge to determine a patient's prognosis. We aimed to identify new prognostic markers of patients with HCC treated by liver resection. METHODS:We collected 314 HCC samples from patients at Bordeaux (1998-200...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/j.gastro.2013.03.051
更新日期：2013-07-01 00:00:00
abstract：BACKGROUND & AIMS:Although long-term results of endoscopic sphincterotomy (ES) have been poorly estimated, extended indications of ES have been proposed, especially in young patients. The aim of this study was to assess late biliary complications of ES. METHODS:Between 1981 and 1986, 169 patients younger than age 70 (...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/gast.1996.v110.pm8608900
更新日期：1996-03-01 00:00:00
abstract：:Morphologic and physiologic experiments in rodents have demonstrated differences between jejunal and ileal fat absorption. Compared with the rat jejunum, absorbed lipid particles within rat ileal absorptive cells are larger and exit at a slower rate. To evaluate the relevance of these observations to humans, we studie...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/0016-5085(88)90676-2
更新日期：1988-06-01 00:00:00
abstract：BACKGROUND & AIMS:The Pediatric Crohn's Disease Activity Index (PCDAI) is a multi-item measure that, in contrast to the adult-derived CDAI, includes linear growth and places less emphasis on subjectively reported symptoms but more on laboratory parameters of intestinal inflammation. This study compared the feasibility,...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/s0016-5085(99)70173-3
更新日期：1999-03-01 00:00:00
abstract：:Using flowing isotonic NaCl or flowing molar KCl electrodes, the magnitude of liquid junction potentials between the electrode tip and gastric juice was measured directly, and calculated from electrolyte concentrations in gastric juice according to standard formulas. Gastric transepithelial potential difference was ob...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：
更新日期：1979-05-01 00:00:00
abstract：:Twenty patients with antimicrobiol-associated diarrhea had a symptomatic relapse after oral vancomycin therapy. All patients had stool examinations which implicated C. difficile as the causative agent, and 16 had pseudomembranous colitis. Clinical courses were characterized by resolution of symptoms with recurrence of...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：
更新日期：1980-03-01 00:00:00
abstract：:A new experimental model, the isolated perfused antrectomized pig stomach with intact vagal innervation, was shown to produce pepsinogen and gastric acid upon electrical stimulation of the vagus nerves and by intravascular administration of carbachol (from a basal value of 111 +/- 24 units of pepsin per minute and 0.0...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/0016-5085(88)90353-8
更新日期：1988-11-01 00:00:00
abstract：BACKGROUND & AIMS:Colonic crypt elongation occurs during both chronic colitis and in the recovery phase of acute colitis. The impact of these alterations on epithelial cell functions is not fully defined. METHODS:DNA microarray analysis of freshly isolated colonic epithelial cells (CECs) from acute and chronic colitis...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/s0016-5085(03)00665-6
更新日期：2003-07-01 00:00:00
abstract：:An adult patient with chronic idiopathic intestinal pseudo-obstruction maintained on home parenteral nutrition for 6 consecutive years died from cardiomyopathy and ventricular fibrillation. Postmortem examination of the heart revealed widespread myocytolysis and replacement fibrosis similar to that seen in the seleniu...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：
更新日期：1982-09-01 00:00:00
abstract：:Gastric emptying of a solid meal and serum gastrin concentration were studied in 26 patients with duodenal ulcer disease before and after parietal cell vagotomy (PCV), selective gastric vagotomy with drainage (SGV + D), or parietal cell vagotomy with drainage. PCV had no significant effect on gastric emptying rate, wh...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：
更新日期：1977-02-01 00:00:00
abstract：BACKGROUND:It was recently reported that ventromedial hypothalamic (VMH) lesions produced an increase in gastrointestinal DNA content in rats. In the present study, the mechanism of this alteration was examined. METHODS:The DNA content and synthesis after VMH lesioning in rat gastrointestinal tracts were determined. ...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/0016-5085(93)90416-a
更新日期：1993-02-01 00:00:00
abstract：:Colon motility and myoelectric slow wave activity were compared in 10 patients with progressive systemic sclerosis and 18 controls. Recordings were made in the rectosigmoid and rectum, 25-30 cm and 10-15 cm from the anal margin, respectively, during two 4-min baselines and in response to stepwise distention of the col...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/0016-5085(89)91567-9
更新日期：1989-02-01 00:00:00
abstract：BACKGROUND & AIMS:Recent reports suggest that platelet-activating factor (PAF) plays a role in pancreatitis and pancreatitis-associated lung injury. In this study, the effects on these processes of termination of PAF action by recombinant PAF-acetylhydrolase (rPAF-AH) were investigated. METHODS:Rats were given rPAF-AH...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/s0016-5085(98)70096-4
更新日期：1998-11-01 00:00:00
abstract：:The effect of continuous intraduodenal enteral nutrition on gastric pH was compared with the effects of fasting and of parenteral and standard nutrition control regimens containing equal amounts of carbohydrate, protein, and lipid. Eleven healthy volunteers underwent four 24-hour intragastric pH-metry studies; serum g...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/0016-5085(92)91708-c
更新日期：1992-05-01 00:00:00
abstract：BACKGROUND & AIMS:Macrophage migration inhibitory factor (MIF) inhibits macrophage migration and has pleiotropic activities on immune and inflammatory responses, cell growth, and glucose metabolism. MIF is produced by T cells, macrophages, and endothelial cells. Because intestinal epithelial cells produce mediators imp...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/gast.2002.31891
更新日期：2002-03-01 00:00:00
abstract：BACKGROUND & AIMS:One approach to the development of targeted cancer chemotherapy exploits increased uptake of the agent into neoplastic cells. In this scenario, higher concentrations of the agent in cancer cells are responsible for differential killing, whereas the low concentration in normal human cells decreases sid...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/gast.2001.24804
更新日期：2001-06-01 00:00:00
