Liver transplantation for hepatocellular carcinoma: a model including α-fetoprotein improves the performance of Milan criteria.

abstract：BACKGROUND & AIMS:We assessed the influence of genetic variants in the hepatitis B virus (HBV) core, which is a principal immunologic target, on the progression to hepatocellular carcinoma (HCC) in a cohort of 4841 male HBV carriers followed up for 16 years. METHODS:First, baseline sera from 116 HCC cases and 154 cont...

journal_title：Gastroenterology

authors： Sung FY,Jung CM,Wu CF,Lin CL,Liu CJ,Liaw YF,Tsai KS,Yu MW

更新日期：2009-11-01 00:00:00

abstract：:Biofeedback has been advocated as first-line therapy for patients whose symptoms of mild to moderate fecal incontinence have not responded to simple dietary advice or medication. Three main modalities have been described: (1) use of an intra-anal electromyographic sensor, a probe to measure intra-anal pressure, or per...

journal_title：Gastroenterology

authors： Norton C

更新日期：2004-01-01 00:00:00

abstract：:We have recently demonstrated that release of oxygen-derived free radicals by activated hepatic macrophages may be involved in the pathogenesis of a rat model of liver injury induced by Corynebacterium parvum and endotoxin. In the present study we have compared the respiratory burst activity of isolated normal rat Kup...

journal_title：Gastroenterology

authors： Arthur MJ,Kowalski-Saunders P,Wright R

更新日期：1986-07-01 00:00:00

abstract：:Gallbladder stasis has been implicated in gallstone formation. Gallbladder filling and emptying were quantitated by computer-assisted cholescintigraphy in 41 normal subjects versus 26 patients with gallstones. Gallbladder contraction was induced by low-dose (1.2 U/kg . h) cholecystokinin infusion. Gallstone patients e...

journal_title：Gastroenterology

authors： Pomeranz IS,Shaffer EA

更新日期：1985-03-01 00:00:00

abstract：BACKGROUND & AIMS:Knowledge of the placebo outcomes and understanding specific study features that influence these outcomes is important for designing future clinical trials evaluating therapy of ulcerative colitis (UC). The aims of this study were to estimate the placebo rates of remission and response in placebo-cont...

journal_title：Gastroenterology

authors： Su C,Lewis JD,Goldberg B,Brensinger C,Lichtenstein GR

更新日期：2007-02-01 00:00:00

abstract：BACKGROUND & AIMS:Thromboxane levels correlate with severity of liver injury in rats given alcohol. The aim of this study was to evaluate the effect of thromboxane inhibitors on pathological changes in experimental alcoholic liver disease. METHODS:Male Wistar rats were given a liquid diet and ethanol intragastrically ...

journal_title：Gastroenterology

authors： Nanji AA,Khwaja S,Rahemtulla A,Miao L,Zhao S,Tahan SR

更新日期：1997-01-01 00:00:00

abstract：:In the search for novel therapeutic approaches to treat patients with colorectal carcinoma, anticancer vaccination holds promise. A large body of preclinical and clinical evidence has demonstrated that the immune system can be polarized against malignant cells by means of several active specific immunotherapy strategi...

journal_title：Gastroenterology

authors： Mocellin S,Rossi CR,Lise M,Nitti D

更新日期：2004-12-01 00:00:00

abstract：BACKGROUND & AIMS:: At least half of patients with chronic hepatitis C virus (HCV) fail to respond to interferon or interferon/ribavirin therapy. Histological improvement is observed in some nonresponders. We conducted a randomized, controlled trial to determine if maintenance interferon therapy could prevent histologi...

journal_title：Gastroenterology

authors： Shiffman ML,Hofmann CM,Contos MJ,Luketic VA,Sanyal AJ,Sterling RK,Ferreira-Gonzalez A,Mills AS,Garret C

更新日期：1999-11-01 00:00:00

abstract：BACKGROUND/AIMS:The frequency of colorectal adenomas, the precursor lesions for most cases of colorectal carcinoma, has been generally measured as prevalence rates of adenomas at autopsy or colonoscopy. The aim of this study was to estimate the incidence rate of adenomas and compare it with the adenoma recurrence rate....

journal_title：Gastroenterology

authors： Neugut AI,Jacobson JS,Ahsan H,Santos J,Garbowski GC,Forde KA,Treat MR,Waye J

更新日期：1995-02-01 00:00:00

abstract：BACKGROUND:To date, the potential effects of free radicals on the activities of intestinal brush-border membrane enzymes have received little attention. Therefore, we conducted a series of experiments to examine the effects of free radicals on various enzymatic activities of rat small intestinal brush-border membranes....

journal_title：Gastroenterology

authors： Dudeja PK,Brasitus TA

更新日期：1993-08-01 00:00:00

abstract：BACKGROUND & AIMS:Small intestinal carcinomas are rare but occur with increased incidence in Crohn's disease. The aim of this study was to elucidate the genetic alterations. METHODS:Mutations and deletions involved in colorectal carcinoma were studied in sporadic and Crohn's-associated intestinal carcinomas and precur...

journal_title：Gastroenterology

authors： Rashid A,Hamilton SR

更新日期：1997-07-01 00:00:00

abstract：:For decades, interactions between the enteric neuromuscular apparatus and the central nervous system have served as the primary focus of pathophysiological research in the functional gastrointestinal disorders. The accumulation of patient reports, as well as clinical observations, has belatedly led to an interest in t...

journal_title：Gastroenterology

authors： Barbara G,Feinle-Bisset C,Ghoshal UC,Quigley EM,Santos J,Vanner S,Vergnolle N,Zoetendal EG

更新日期：2016-02-18 00:00:00

abstract：:The intestinal epithelium is a repetitive sheet of crypt and villus units with stem cells at the bottom of the crypts. During postnatal development, crypts multiply via fission, generating 2 daughter crypts from 1 parental crypt. In the adult intestine, crypt fission is observed at a low frequency. Using intravital mi...

journal_title：Gastroenterology

authors： Bruens L,Ellenbroek SIJ,van Rheenen J,Snippert HJ

更新日期：2017-09-01 00:00:00

abstract：:Four Puerto Rican sisters had recurrent prolonged cholestasis of pregnancy without preexisting or intercurrent hepatic disorders. Available information was reviewed on the course, mechanism, and sequelae of prolonged recurrent cholestasis after 14 pregnancies in the 4 sisters. Etiologic, clinical, laboratory, radiolog...

journal_title：Gastroenterology

authors： Leevy CB,Koneru B,Klein KM

更新日期：1997-09-01 00:00:00

abstract：:The role of central (supraspinal and spinal) and peripheral alpha-adrenoceptors in the regulation of gastrointestinal propulsion in the mouse was studied using clonidine, an alpha 2-adrenoceptor agonist. Clonidine produced a dose-dependent inhibition of propulsion when given intracerebroventricularly, intrathecally, o...

journal_title：Gastroenterology

authors： Jiang Q,Sheldon RJ,Porreca F

更新日期：1988-11-01 00:00:00

abstract：BACKGROUND & AIMS:Recent studies indicate that kringle 1-5 has a potent and specific antiangiogenic activity. Here, we investigated the antitumor effect of kringle 1-5 gene transfer on hepatocellular carcinoma in mice. METHODS:The inhibitory effect of kringle 1-5 protein on proliferation of bovine capillary endothelia...

journal_title：Gastroenterology

authors： Torimura T,Ueno T,Kin M,Taniguchi E,Nakamura T,Inoue K,Sakata R,Hashimoto O,Sakamoto M,Ohira H,Kumashiro R,Sata M,Yano H,Kojiro M,Veitonmaki N,Cao Y

更新日期：2006-04-01 00:00:00

abstract：:We have prospectively evaluated 41 patients who ingested acid for location, extent, severity, and outcome of the injury to the upper gastrointestinal tract. The injury was assessed within 36 h of acid intake by endoscopy or surgery, or at autopsy. Symptoms and signs were unreliable in predicting the extent and severit...

journal_title：Gastroenterology

authors： Zargar SA,Kochhar R,Nagi B,Mehta S,Mehta SK

更新日期：1989-09-01 00:00:00

abstract：:Cholangiocarcinoma occurs in approximately 10% of patients with primary sclerosing cholangitis. Usually, liver failure, rapidly progressing jaundice, and an increase in alkaline phosphatase levels are suggestive diagnostic features. We report two cases of patients with primary sclerosing cholangitis who developed chol...

journal_title：Gastroenterology

authors： Martins EB,Fleming KA,Garrido MC,Hine KR,Chapman RW

更新日期：1994-08-01 00:00:00

abstract：BACKGROUND & AIMS:New serologic markers of inflammatory bowel disease may be useful for differentiating between Crohn's disease and ulcerative colitis and for disease stratification. We profiled sugar-binding antibodies to identify novel antiglycan antibodies that may be associated with inflammatory bowel disease. MET...

journal_title：Gastroenterology

authors： Dotan I,Fishman S,Dgani Y,Schwartz M,Karban A,Lerner A,Weishauss O,Spector L,Shtevi A,Altstock RT,Dotan N,Halpern Z

更新日期：2006-08-01 00:00:00

abstract：BACKGROUND & AIMS:Host cell lipid rafts form a scaffold required for replication of hepatitis C virus (HCV). Serine palmitoyltransferases (SPTs) produce sphingolipids, which are essential components of the lipid rafts that associate with HCV nonstructural proteins. Prevention of the de novo synthesis of sphingolipids b...

journal_title：Gastroenterology

authors： Katsume A,Tokunaga Y,Hirata Y,Munakata T,Saito M,Hayashi H,Okamoto K,Ohmori Y,Kusanagi I,Fujiwara S,Tsukuda T,Aoki Y,Klumpp K,Tsukiyama-Kohara K,El-Gohary A,Sudoh M,Kohara M

更新日期：2013-10-01 00:00:00

abstract：:The mortality experienced by a cohort of 653 patients with celiac disease in Edinburgh and the Lothian region has been analyzed. Mortality overall was 1.9-fold (95% confidence limits, 1.5-2.2) that of the general population (115 deaths observed, 61.8 expected; p less than 0.0001). The increased mortality was greatest ...

journal_title：Gastroenterology

authors： Logan RF,Rifkind EA,Turner ID,Ferguson A

更新日期：1989-08-01 00:00:00

abstract：BACKGROUND AND AIMS:Interleukin (IL)-15 delivers signals that drive chronic inflammation in several diseases, including celiac disease. Smad3-transforming growth factor-beta (TGF-beta) signaling is instrumental to counteract proinflammatory signals and maintain immune homeostasis. Our goal has been to investigate why t...

journal_title：Gastroenterology

authors： Benahmed M,Meresse B,Arnulf B,Barbe U,Mention JJ,Verkarre V,Allez M,Cellier C,Hermine O,Cerf-Bensussan N

更新日期：2007-03-01 00:00:00

abstract：BACKGROUND & AIMS:Pancreatic mucinous cystic neoplasm (MCN), a cystic tumor of the pancreas that develops most frequently in women, is a potential precursor to pancreatic ductal adenocarcinoma. MCNs develop primarily in the body and tail of the pancreas and are characterized by the presence of a mucinous epithelium and...

journal_title：Gastroenterology

authors： Sano M,Driscoll DR,De Jesus-Monge WE,Klimstra DS,Lewis BC

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND & AIMS:Administration of secretin improves noninvasive imaging of the pancreatic duct with magnetic resonance cholangiopancreatography (MRCP). We performed a large prospective study to investigate whether synthetic human secretin (RG1068)-stimulated MRCP detects pancreatic duct abnormalities with higher leve...

journal_title：Gastroenterology

authors： Sherman S,Freeman ML,Tarnasky PR,Wilcox CM,Kulkarni A,Aisen AM,Jacoby D,Kozarek RA

更新日期：2014-09-01 00:00:00

abstract：BACKGROUND & AIMS:We previously demonstrated that the 2 APC mutations in human colorectal tumors are coselected, because tumorigenesis requires an optimal level of Wnt signaling. We and others subsequently showed that the truncated APC proteins in colorectal tumors usually retain a total of 1-2 beta-catenin binding/deg...

journal_title：Gastroenterology

authors： Pollard P,Deheragoda M,Segditsas S,Lewis A,Rowan A,Howarth K,Willis L,Nye E,McCart A,Mandir N,Silver A,Goodlad R,Stamp G,Cockman M,East P,Spencer-Dene B,Poulsom R,Wright N,Tomlinson I

更新日期：2009-06-01 00:00:00

abstract：BACKGROUND & AIMS:Genetic variation is invoked as a strong component underlying primary biliary cirrhosis (PBC) and other autoimmune disorders. Data suggest that some of this genetic risk is shared, affecting function of the immune mechanisms controlling self-tolerance. Cytotoxic T-lymphocyte antigen 4 (CTLA4) encodes ...

journal_title：Gastroenterology

authors： Juran BD,Atkinson EJ,Schlicht EM,Fridley BL,Lazaridis KN

更新日期：2008-10-01 00:00:00

abstract：:There are apparent similarities in the mechanisms of the intestinal phase of exocrine and pancreatic polypeptide (PP) secretion by the pancreas. To characterize this relationship, we measured incremental responses of protein, bicarbonate, and PP to graded doses of intravenous secretin, caerulein, CCK8, CCK33, bethanec...

journal_title：Gastroenterology

authors： Beglinger C,Taylor IL,Grossman MI,Solomon TE

更新日期：1984-09-01 00:00:00

abstract：BACKGROUND & AIMS:Fully covered self-expanding metal stents (FCSEMS) are gaining acceptance for the treatment of benign biliary strictures. We performed a large prospective multinational study to study the ability to remove these stents after extended indwell and the frequency and durability of stricture resolution. M...

journal_title：Gastroenterology

authors： Devière J,Nageshwar Reddy D,Püspök A,Ponchon T,Bruno MJ,Bourke MJ,Neuhaus H,Roy A,González-Huix Lladó F,Barkun AN,Kortan PP,Navarrete C,Peetermans J,Blero D,Lakhtakia S,Dolak W,Lepilliez V,Poley JW,Tringali A,Costam

更新日期：2014-08-01 00:00:00

abstract：:In this study, quantitation of the epithelial proliferation status of gastric glands and duodenal crypts was performed using endoscopic biopsy specimens from patients with rheumatological conditions requiring long-term anti-inflammatory and analgesic therapy, testing the hypothesis that long-term administration of non...

journal_title：Gastroenterology

authors： Levi S,Goodlad RA,Lee CY,Walport MJ,Wright NA,Hodgson HJ

更新日期：1992-05-01 00:00:00

abstract：BACKGROUND & AIMS:Although a number of epidemiologic studies have found dietary fiber and whole grains to be inversely associated with colorectal cancer incidence, studies of dietary and other risk factors for small intestinal cancer have been sparse and all of a case-control design. We conducted a prospective cohort s...

journal_title：Gastroenterology

authors： Schatzkin A,Park Y,Leitzmann MF,Hollenbeck AR,Cross AJ

更新日期：2008-10-01 00:00:00