Abstract：
:The type of cirrhosis was blindly evaluated in follow-up liver biopsies performed on 106 alcoholic men with micronodular cirrhosis. The median time interval from entry to follow-up liver biopsy was 31 mo (range, 3-44 mo). Patients were stratified into four groups according to their maximal registered ethanol consumption during follow-up. Thirty-six patients (34%) abstained from ethanol, 40 patients (38%) consumed a small amount of ethanol (less than 50 g/day), 19 patients (18%) consumed a moderate amount of ethanol (51-100 g/day), and 11 patients (10%) consumed an excessive amount of ethanol (greater than 100 g/day) during follow-up. Follow-up liver biopsy specimens demonstrated micronodular cirrhosis in 54 patients (51%), micronodular cirrhosis with development of hyperplastic nodules in 47 patients (44%), and nonclassifiable macronodular cirrhosis in 4 patients (4%); 1 patient showed portal fibrosis. The cumulative prevalence of patients developing hyperplastic nodules increased significantly (p = 0.014 for trend) with decreasing ethanol consumption, the prevalence being 57% in abstainers, 58% in those who consumed a small amount of ethanol, 32% in those who consumed a moderate amount, and 18% in those who consumed an excessive amount. In conclusion, alcoholic men with micronodular cirrhosis develop hyperplastic nodules during follow-up, the rate and prevalence of which is significantly related to the amount of ethanol consumed during follow-up. Ethanol consumption may inhibit hepatocellular proliferation in alcoholic men with micronodular cirrhosis.
journal_name
Gastroenterologyjournal_title
Gastroenterologyauthors
Gluud C,Christoffersen P,Eriksen J,Wantzin P,Knudsen BBdoi
10.1016/0016-5085(87)91011-0subject
Has Abstractpub_date
1987-08-01 00:00:00pages
256-60issue
2eissn
0016-5085issn
1528-0012pii
0016-5085(87)91011-0journal_volume
93pub_type
杂志文章相关文献
GASTROENTEROLOGY文献大全abstract：:The hepatic circulation is reviewed with emphasis on the role of hepatic blood vessels in hepatic and homeostatic functions. Contrasts are made with resistance, capacitance, and fluid exchange functions in other better known vascular beds. Hemodynamic changes that produce shifts in fluid exchange in other tissues are ...
journal_title：Gastroenterology
pub_type： 杂志文章,评审
doi：
更新日期：1977-11-01 00:00:00
abstract：:Pentane, a volatile hydrocarbon, is cleared from inspired air by the rat. We have studied this clearance to learn whether or not it is a function of the liver. Rats were put individually into airtight chambers which contained CO2 absorbent and were connected to an O2 reservoir. Pentane was injected into each chamber a...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：
更新日期：1983-01-01 00:00:00
abstract：BACKGROUND & AIMS:Entecavir demonstrated superior benefit to lamivudine at 48 weeks in nucleoside-naive patients with hepatitis B e antigen (HBeAg)-positive chronic hepatitis B (CHB). We evaluated continued entecavir and lamivudine treatment through 96 weeks. METHODS:709 HBeAg-positive CHB patients were randomized to ...
journal_title：Gastroenterology
pub_type： 杂志文章,随机对照试验
doi：10.1053/j.gastro.2007.08.025
更新日期：2007-11-01 00:00:00
abstract：BACKGROUND & AIMS:Growth, progression, and drug resistance of pancreatic ductal adenocarcinomas (PDACs) have been associated with increased levels and activity of glycogen synthase kinase 3 beta (GSK3B) and histone deacetylases (HDACs). We designed and synthesized molecules that simultaneously inhibit the activities of...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/j.gastro.2018.08.028
更新日期：2018-12-01 00:00:00
abstract：:In a series of in vitro studies, both the soluble (plasmatic) coagulation system and the cellular (platelet-mediated) aspect of coagulation were shown to be extremely sensitive to relatively minor increases in hydrogen ion concentration. All studies became abnormal at pH 6.8. At pH 6.4, assays of the intrinsic and ext...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：
更新日期：1978-01-01 00:00:00
abstract：:Studies on the natural history of chronic type B hepatitis have shown that loss of hepatitis B e antigen and seroconversion to antibody to hepatitis B e antigen are usually accompanied by remission of disease activity and improvement in serum aminotransferase levels. Twenty-five symptomatic patients with biopsy-docume...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：
更新日期：1984-02-01 00:00:00
abstract：:A monoclonal antibody to bromodeoxyuridine was used in tissue specimens previously incubated with bromodeoxyuridine to show S-phase cells by immunohistochemical technique. Biopsy specimens of normal mucosa (n = 10), hyperplastic polyps (n = 10), adenomas with low-grade dysplasia (n = 20), adenomas with high-grade dysp...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/0016-5085(88)90545-8
更新日期：1988-04-01 00:00:00
abstract：:Boron may be beneficial for bone growth and maintenance, central nervous system function, and the inflammatory response, and silicon may be beneficial for bone maintenance and wound healing. Fluoride is not an essential element but amounts provided by contamination may be beneficial for bone strength. Fluoride toxicit...
journal_title：Gastroenterology
pub_type： 杂志文章,评审
doi：10.1053/j.gastro.2009.07.072
更新日期：2009-11-01 00:00:00
abstract：:Obstruction of the common bile duct can now be relieved by endoscopic electrosurgery. This report describes our experience with 267 patients. In 192 of 222 patients with choledocholithiasis all calculi were evacuated by endoscopic papillotomy (EP). The remaining patients had EP because of papillary stenosis. Complicat...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：
更新日期：1977-12-01 00:00:00
abstract：:Superficially invasive squamous cell carcinoma of the esophagus, defined as carcinoma with invasion limited to the mucosa or submucosa regardless of the presence of lymph node metastasis, is being increasingly recognized. We found 7 cases (13%) of this entity among 54 cases of esophageal squamous cancer resected betwe...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/0016-5085(86)90201-5
更新日期：1986-12-01 00:00:00
abstract：BACKGROUND & AIMS:Foxl1(+) hepatic progenitor cells (HPCs) differentiate into cholangiocytes and hepatocytes after liver injury. We investigated the requirement for Foxl1(+) HPCs in recovery from liver injury in mice. METHODS:We developed mice in which we could trace and delete Foxl1-expressing HPCs and their descenda...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/j.gastro.2014.09.039
更新日期：2015-01-01 00:00:00
abstract：:We examined whether patients with irritable bowel syndrome have increased airway responsiveness by measuring forced expiratory volumes in 1 second (FEV1) after inhalation of increasing concentrations of methacholine. Responses obtained in 11 IBS patients were compared with those obtained in 11 normal subjects and in 1...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/0016-5085(91)90584-8
更新日期：1991-01-01 00:00:00
abstract：:In the rat, gastric histamine is stored mainly in the enterochromaffinlike cells. Gastrin releases histamine from these cells, and long-term hypergastrinemia results in hyperplasia. The effect of sustained hypergastrinemia on histamine-depleted enterochromaffinlike cells was studied by measuring histidine decarboxylas...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/0016-5085(92)90023-r
更新日期：1992-09-01 00:00:00
abstract：:Fifty consecutive patients with symptomatic endoscopically proven duodenal ulcer were randomized double-blind to Mylanta II or cimetidine treatment schedules. Smoking habits were noted, but patients were not advised to alter these. Healing was determined by reendoscopy at 6 wk. Eighty percent of patients on active cim...
journal_title：Gastroenterology
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1981-06-01 00:00:00
abstract：:The hemodynamic effects of octreotide were studied in 20 patients with hepatitis B-related cirrhosis. In patients receiving a 100-micrograms bolus and a 100-micrograms/h infusion, heart rate, cardiac index, and systemic vascular resistance showed no significant changes, whereas right atrial pressure, pulmonary capilla...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/0016-5085(92)91117-m
更新日期：1992-07-01 00:00:00
abstract：BACKGROUND & AIMS:Crohn's disease (CD) and ulcerative colitis (UC) are associated with chronic tissue damage and continuous tissue repair. A central, but not well-characterized, event during this process is the migration of activated fibroblasts to the wound. METHODS:Human colonic lamina propria fibroblasts (CLPF) wer...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/j.gastro.2003.07.004
更新日期：2003-11-01 00:00:00
abstract：:It is possible to estimate hepatic triglyceride content by calculating the proton density fat fraction (PDFF), using proton magnetic resonance spectroscopy (1H-MRS), instead of collecting and analyzing liver biopsy specimens to detect steatosis. However, the current PDFF cut-off value (5%) used to define steatosis by ...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/j.gastro.2017.03.005
更新日期：2017-07-01 00:00:00
abstract：BACKGROUND & AIMS:Oral bile acid replacement has been shown to be an effective therapy in primary bile acid synthesis defects, but to date there have been no reports of the long-term effects of this therapy. The aim of the study was to evaluate the long-term effectiveness and safety of cholic acid (CA) therapy. METHOD...
journal_title：Gastroenterology
pub_type： 临床试验,杂志文章
doi：10.1053/j.gastro.2009.07.043
更新日期：2009-10-01 00:00:00
abstract：BACKGROUND & AIMS:SMAD4 frequently is lost from colorectal cancers (CRCs), which is associated with the development of metastases and a poor prognosis. SMAD4 loss is believed to alter transforming growth factor β signaling to promote tumor progression. However, SMAD4 is also a central component of the bone morphogeneti...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/j.gastro.2014.03.052
更新日期：2014-07-01 00:00:00
abstract：BACKGROUND & AIMS:Common germline genetic variation in the 3' region of myosin IXB (MYO9B) has been associated recently with susceptibility to celiac disease, with a hypothesis that MYO9B variants might influence intestinal permeability. These findings suggested the current study investigating a possible further role f...
journal_title：Gastroenterology
pub_type： 杂志文章,多中心研究
doi：10.1053/j.gastro.2006.09.011
更新日期：2006-12-01 00:00:00
abstract：:A rapid immunohistochemical method using 5'-bromo-2'-deoxyuridine (BrdU), a thymidine analog, for labeling proliferating epithelial cells was modified and tested for accuracy against standard tritiated thymidine autoradiography (3H-TdR) in rat esophagus, stomach, duodenum, and colon. Either BrdU or 3H-thymidine or bot...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/0016-5085(91)90610-w
更新日期：1991-01-01 00:00:00
abstract：BACKGROUND/AIMS:Hepatic osmoreceptors are sensitive to changes in portal blood osmolality and cause variations in plasma antidiuretic hormone and water diuresis, which prevent major systemic osmotic changes. Insensitivity of hepatic osmoreceptors might contribute to maintaining increased plasma levels of antidiuretic h...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/0016-5085(94)90702-1
更新日期：1994-03-01 00:00:00
abstract：BACKGROUND & AIMS:The signal transducers and activators of transcription (STATs) are cytoplasmic transcription factors mediating acute-phase response (APR) of the human angiotensinogen (hAGT) gene in hepatocytes. The mechanisms of how STAT3 activates target genes are unknown. Here we analyzed the biochemistry of STAT3 ...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/j.gastro.2005.07.055
更新日期：2005-11-01 00:00:00
abstract：BACKGROUND & AIMS:Substance P, a member of the tachykinin family, is a prosecretory neuropeptide distributed widely throughout the enteric nervous system. Implicated in inflammatory states, its role in enterotoxigenic water and electrolyte secretion is unclear. We assessed the effect of substance P antagonists and neur...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/gast.2000.18147
更新日期：2000-10-01 00:00:00
abstract：:The range of activity and the location of lipase and pepsin were determined in the stomach and duodenum of infants, children, and adults. The range of lipase activity in biopsy specimens from the gastric body, in 29 subjects aged from 3 months to 26 years, was 1.8-5.3 U/mg protein (1 U is 1 mumol [3H]oleic acid releas...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/0016-5085(91)90467-y
更新日期：1991-07-01 00:00:00
abstract：BACKGROUND & AIMS:Rabs are monomeric guanosine triphosphatases that regulate membrane trafficking and acid secretion in gastric parietal cells. Using a proteomics approach, we identified a new Rab, Rab27b, in tubulovesicle membranes and determined its role in parietal cell activation. METHODS:We used mass spectrometry...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/j.gastro.2010.09.044
更新日期：2011-03-01 00:00:00
abstract：BACKGROUND & AIMS:Although patients with inflammatory bowel disease (IBD) have reduced bone mass, there is controversy whether there is an increased risk of fracture. This study examines the risk of fracture and its predictors in patients with IBD. METHODS:In a primary care- based nested case-control study, 231,778 fr...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/j.gastro.2003.09.027
更新日期：2003-12-01 00:00:00
abstract：BACKGROUND & AIMS:The secretion and function of antral histamine are not known. The aims of this study were to characterize the mechanisms of histamine release from the gastric antrum of humans, dogs, and rats and to determine whether histamine can influence the secretion of somatostatin and gastrin. METHODS:Somatosta...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/0016-5085(95)90645-2
更新日期：1995-11-01 00:00:00
abstract：:An adult patient with chronic idiopathic intestinal pseudo-obstruction maintained on home parenteral nutrition for 6 consecutive years died from cardiomyopathy and ventricular fibrillation. Postmortem examination of the heart revealed widespread myocytolysis and replacement fibrosis similar to that seen in the seleniu...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：
更新日期：1982-09-01 00:00:00
abstract：BACKGROUND AND AIMS:Earlier studies have suggested that patients with hemochromatosis have poor post-transplantation survival. We aimed to compare patients with hemochromatosis to those with other causes of liver disease with regard to post-transplantation survival. METHODS:We compared the post-transplant survival of ...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/j.gastro.2007.05.054
更新日期：2007-08-01 00:00:00
