Effect of acid and pepsin on blood coagulation and platelet aggregation. A possible contributor prolonged gastroduodenal mucosal hemorrhage.

abstract：BACKGROUND & AIMS:This study examined the possible role of endotoxinemia (from increased gut permeability) as an additional trigger factor for overt pancreatic disease and as a promoter of chronic pancreatic injury in alcoholics by using a rat model of chronic alcohol feeding and in vitro experiments with cultured panc...

journal_title：Gastroenterology

authors： Vonlaufen A,Xu Z,Daniel B,Kumar RK,Pirola R,Wilson J,Apte MV

更新日期：2007-10-01 00:00:00

abstract：:Aminopeptidase M (APM) was localized in the kidney and alimentary tract of guinea pigs and rats by indirect immunohistochemistry. APM was detected in the brush border of the epithelium of the proximal convoluted tubule of the kidney and of the small intestine, and it was localized to cells scattered throughout lymphoi...

journal_title：Gastroenterology

authors： Terashima H,Wong H,Kobayashi R,Bunnett NW

更新日期：1992-06-01 00:00:00

abstract：BACKGROUND & AIMS:Liver graft dysfunction is related to hypothermic preservation and may implicate altered cell volume homeostasis. The aim of this study was to evaluate how cold preservation and rewarming affect hepatocellular volume regulation and concentrative amino acid uptake. METHODS:Rat hepatocytes suspended fo...

journal_title：Gastroenterology

authors： Serrar H,Haddad P

更新日期：1997-04-01 00:00:00

abstract：:This report defines criteria and reviews the epidemiology, pathophysiology, and management of common anorectal disorders: fecal incontinence (FI), functional anorectal pain and functional defecation disorders. FI is defined as the recurrent uncontrolled passage of fecal material for at least 3 months. The clinical fea...

journal_title：Gastroenterology

authors： Rao SS,Bharucha AE,Chiarioni G,Felt-Bersma R,Knowles C,Malcolm A,Wald A

更新日期：2016-03-25 00:00:00

abstract：:Severe cholestasis associated with long-term home parenteral nutrition is rare, and no treatment is known to be effective. This study shows a case of a patient who developed jaundice while receiving long-term home parenteral nutrition. Causes of jaundice, other than the patient's parenteral feedings, were excluded. Th...

journal_title：Gastroenterology

authors： Lindor KD,Burnes J

更新日期：1991-07-01 00:00:00

abstract：BACKGROUND/AIMS:Despite putative roles of calcium in biliary physiology and gallstone formation, quantitative aspects of calcium binding to bile salt (BS) monomers, simple micelles, mixed micelles, and vesicles, which constitute the lipid aggregates in bile, remain unexplored. METHODS:Calcium activity was measured usi...

journal_title：Gastroenterology

authors： Donovan JM,Leonard MR,Batta AK,Carey MC

更新日期：1994-09-01 00:00:00

abstract：:This study presents normal values of bowel habits, colonic transit times of radioopaque markers, and anorectal pressure obtained from 114 normal subjects. Their stool frequency ranged from 3 to 11 per 7 days, whereas their diet contained an average of 14.4 g of crude fibers. Radioopaque markers progressed regularly al...

journal_title：Gastroenterology

authors： Martelli H,Devroede G,Arhan P,Duguay C,Dornic C,Faverdin C

更新日期：1978-10-01 00:00:00

abstract：:The effect of total-body ionizing radiation on the digestive tract is dose-dependent and time-dependent. At low doses (1.5 Gy), one observes only a short prodromal syndrome consisting of nausea, vomiting, and gastric suppression. At doses greater than 6 Gy, the prodromal syndrome is more marked, and it is followed aft...

journal_title：Gastroenterology

authors： Dubois A,Walker RI

更新日期：1988-08-01 00:00:00

abstract：:A randomized, controlled trial was conducted to investigate the ability of indomethacin and chloroquine to reduce intestinal secretion in 29 adult patients with severe cholera. All patients received intravenous infusion to restore fluid balance, but no antibiotics were given. Patients treated with oral indomethacin (t...

journal_title：Gastroenterology

authors： Rabbani GH,Butler T

更新日期：1985-11-01 00:00:00

abstract：:Twenty cirrhotic patients with esophageal varices and an episode of gastrointestinal bleeding within the previous week underwent hemodynamic studies which used an indicator dilution technique based on selective catheterization of the splanchnic arteries and hepatic vein. Portasystemic shunting of splenic arterial flow...

journal_title：Gastroenterology

authors： Lebrec D,Kotelanski B,Cohn JN

更新日期：1976-06-01 00:00:00

abstract：BACKGROUND & AIMS:Monocytes/macrophages infiltrate into injured livers. We tried to clarify their roles in inflammation and subsequent fibrogenesis by inhibiting their infiltration with a mutated form (7ND; 7 amino acids at the N-terminal were deleted) of monocyte chemoattractant protein 1, which may function as a domi...

journal_title：Gastroenterology

authors： Imamura M,Ogawa T,Sasaguri Y,Chayama K,Ueno H

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND & AIMS:Knowledge of the placebo outcomes and understanding specific study features that influence these outcomes is important for designing future clinical trials evaluating therapy of ulcerative colitis (UC). The aims of this study were to estimate the placebo rates of remission and response in placebo-cont...

journal_title：Gastroenterology

authors： Su C,Lewis JD,Goldberg B,Brensinger C,Lichtenstein GR

更新日期：2007-02-01 00:00:00

abstract：BACKGROUND:The mucosal response to intestinal resection has been extensively studied; little is known of the motor response. Our aim was to evaluate motility in the intestinal remnant following distal resection. METHODS:Motor activity, duodenocecal transit, nutrition, and absorption were studied over a 3-month period ...

journal_title：Gastroenterology

authors： Quigley EM,Thompson JS

更新日期：1993-09-01 00:00:00

abstract：BACKGROUND/AIMS:Diarrhea is a significant problem in patients with acquired immunodeficiency syndrome (AIDS). The aim of this study was to determine octreotide effectiveness in refractory AIDS-associated diarrhea. METHODS:In a 3-week protocol, 129 patients with a stool weight of > 500 g/day despite standard antidiarrh...

journal_title：Gastroenterology

authors： Simon DM,Cello JP,Valenzuela J,Levy R,Dickerson G,Goodgame R,Brown M,Lyche K,Fessel WJ,Grendell J

更新日期：1995-06-01 00:00:00

abstract：BACKGROUND & AIMS:Infliximab is effective in closing fistulas in patients with Crohn's disease. We examined the effect of infliximab maintenance treatment on hospitalizations, surgeries, and procedures in patients with fistulizing Crohn's disease enrolled in the ACCENT II study. METHODS:After 5 mg/kg infliximab at wee...

journal_title：Gastroenterology

authors： Lichtenstein GR,Yan S,Bala M,Blank M,Sands BE

更新日期：2005-04-01 00:00:00

abstract：BACKGROUND AND AIMS:Cholestasis is one of the principal manifestations of liver disease and often results from disorders involving bile duct epithelia rather than hepatocytes. A range of disorders affects biliary epithelia, and no unifying pathophysiologic event in these cells has been identified as the cause of choles...

journal_title：Gastroenterology

authors： Shibao K,Hirata K,Robert ME,Nathanson MH

更新日期：2003-10-01 00:00:00

abstract：:Fetal bile salt metabolism was assessed by the intravenous infusion of e114C]cholate into 6 monkey fetuses. The placental transfer, fetal plasma clearance, and fetal hepatic excretion of the administered radiolabeled bile salt were measured. Placental transfer averaged 30% of the injected dose, while biliary excretion...

journal_title：Gastroenterology

authors： Little JM,Smallwood RA,Lester R,Piasecki GJ,Jackson BT

更新日期：1975-12-01 00:00:00

abstract：:Boron may be beneficial for bone growth and maintenance, central nervous system function, and the inflammatory response, and silicon may be beneficial for bone maintenance and wound healing. Fluoride is not an essential element but amounts provided by contamination may be beneficial for bone strength. Fluoride toxicit...

journal_title：Gastroenterology

authors： Nielsen FH

更新日期：2009-11-01 00:00:00

abstract：BACKGROUND & AIMS:The complications of diverticulosis cause considerable morbidity in the United States; health care expenditures for this disorder are estimated to be $2.5 billion per year. Many physicians and patients believe that a high-fiber diet and frequent bowel movements prevent the development of diverticulosi...

journal_title：Gastroenterology

authors： Peery AF,Barrett PR,Park D,Rogers AJ,Galanko JA,Martin CF,Sandler RS

更新日期：2012-02-01 00:00:00

abstract：BACKGROUND & AIMS:The relationship between the sensation of bloating, often ranked as the most bothersome symptom by patients with irritable bowel syndrome (IBS), and actual distention manifest as an increase in abdominal girth is controversial. Investigation of this problem has been hampered by the lack of a reliable ...

journal_title：Gastroenterology

authors： Houghton LA,Lea R,Agrawal A,Reilly B,Whorwell PJ

更新日期：2006-10-01 00:00:00

abstract：BACKGROUND & AIMS:Entecavir is a novel and selective nucleoside analogue with potent activity against hepatitis B virus (HBV). METHODS:In a 24-week, double-blind, randomized, multicenter, phase II clinical trial, the safety and efficacy of entecavir (0.01 mg/day, 0.1 mg/day, or 0.5 mg/day orally) were compared with la...

journal_title：Gastroenterology

authors： Lai CL,Rosmawati M,Lao J,Van Vlierberghe H,Anderson FH,Thomas N,Dehertogh D

更新日期：2002-12-01 00:00:00

abstract：BACKGROUND & AIMS:The mechanisms by which hepatitis C virus (HCV) induces liver fibrosis are unknown. Hepatocytes secrete HCV proteins, which may interact with hepatic stellate cells (HSCs). Our aims were to investigate whether HCV proteins induce fibrogenic effects on HSCs. METHODS & RESULTS:Human-activated HSCs expr...

journal_title：Gastroenterology

authors： Bataller R,Paik YH,Lindquist JN,Lemasters JJ,Brenner DA

更新日期：2004-02-01 00:00:00

abstract：BACKGROUND & AIMS:Lactase is the intestinal disaccharidase responsible for digestion of lactose, the predominant carbohydrate in milk. Transcription of the lactase gene is activated during enterocyte differentiation. We have characterized the interaction between the lactase promoter and Cdx2, a homeodomain protein invo...

journal_title：Gastroenterology

authors： Fang R,Santiago NA,Olds LC,Sibley E

更新日期：2000-01-01 00:00:00

abstract：:Antral ulcers were produced in unanesthetized rats in 3 hr by simultaneous intravenous administration of acetylsalicylic acid (ASA) and gastric perfusion with 0.15 M HCl. Intravenous infusion of ASA alone or gastric perfusion with HCl alone produced no antral ulcers. Plasma salicylate levels ranged from 250 to 350 mic...

journal_title：Gastroenterology

authors： Kauffman GL Jr,Grossman MI

更新日期：1978-12-01 00:00:00

abstract：BACKGROUND & AIMS:Helicobacter pylori-negative idiopathic ulcers are increasingly recognized. The secular trend and long-term outcome of this condition are unknown. METHODS:We prospectively studied consecutive patients with bleeding gastroduodenal ulcers from January to December 2000. The incidence and etiology of ulc...

journal_title：Gastroenterology

authors： Hung LC,Ching JY,Sung JJ,To KF,Hui AJ,Wong VW,Leong RW,Chan HL,Wu JC,Leung WK,Lee YT,Chung SC,Chan FK

更新日期：2005-06-01 00:00:00

abstract：BACKGROUND & AIMS:To define signaling events initiating healing after intestinal epithelial injury, activation of mitogen-activated protein kinase (MAPK) pathways was assessed after wounding using an in vitro model. METHODS:Proteins isolated from wounded monolayers of nontransformed intestinal epithelial cells (IEC-6)...

journal_title：Gastroenterology

authors： Göke M,Kanai M,Lynch-Devaney K,Podolsky DK

更新日期：1998-04-01 00:00:00

abstract：:Adenomatous polyps are the most common neoplastic findings discovered in people who undergo colorectal screening or who have a diagnostic work-up for symptoms. It was common practice in the 1970s for these patients to have annual follow-up surveillance examinations to detect additional new adenomas and missed synchron...

journal_title：Gastroenterology

authors： Winawer SJ,Zauber AG,Fletcher RH,Stillman JS,O'Brien MJ,Levin B,Smith RA,Lieberman DA,Burt RW,Levin TR,Bond JH,Brooks D,Byers T,Hyman N,Kirk L,Thorson A,Simmang C,Johnson D,Rex DK,US Multi-Society Task Force on Colo

更新日期：2006-05-01 00:00:00

abstract：:A possible role of insulinlike growth factor I (IGF-I) and IGF-I receptors in the proliferation of human colon cancer has, to the best of the authors' knowledge, not been examined as yet. To determine a role of IGF-I in colon cancer, several human colon cancer cell lines and colon cancers were screened for specific bi...

journal_title：Gastroenterology

authors： Guo YS,Narayan S,Yallampalli C,Singh P

更新日期：1992-04-01 00:00:00

abstract：BACKGROUND & AIMS:The basic mechanisms of food allergies are still unknown. The aims of this study were to investigate whether endothelins (ETs) in the intestinal mucosa are involved in the pathogenesis of intestinal anaphylaxis. METHODS:Sprague-Dawley rats were sensitized to chicken egg albumin (EA) by intraperitonea...

journal_title：Gastroenterology

authors： Shigematsu T,Miura S,Hirokawa M,Hokari R,Higuchi H,Tsuzuki Y,Kimura H,Nakatsumi RC,Serizawa H,Saito H,Ishii H

更新日期：1998-08-01 00:00:00

abstract：:In fed rats, acid production was estimated to be 7 X 10(8) molecules of HCl per cell per sec or 5 X 10(5) molecules per sec per mu2 of secretory surface. In stimulated frog mucosa the corresponding values were 3 X 10(8) molecules of HCl per cell per sec 2 X 10(5) molecules per sec per mu2 or secretory surface. The gen...

journal_title：Gastroenterology

authors： Helander HF

更新日期：1977-10-01 00:00:00