An attempt to correlate functional and morphological data for the gastric parietal cells.


:In fed rats, acid production was estimated to be 7 X 10(8) molecules of HCl per cell per sec or 5 X 10(5) molecules per sec per mu2 of secretory surface. In stimulated frog mucosa the corresponding values were 3 X 10(8) molecules of HCl per cell per sec 2 X 10(5) molecules per sec per mu2 or secretory surface. The generous assumptions used in making these estimates could have led to large errors.






Helander HF


Has Abstract


1977-10-01 00:00:00




4 Pt 2










  • Incidence, outcomes, and health services burden of very early onset inflammatory bowel disease.

    abstract:BACKGROUND & AIMS:The Paris pediatric modification of the Montreal classification defines very early onset inflammatory bowel disease (VEO-IBD) as a form of IBD distinct from that of older children. We compared the incidence and outcomes of VEO-IBD with those of IBD in older children. METHODS:We performed a population...


    pub_type: 杂志文章


    authors: Benchimol EI,Mack DR,Nguyen GC,Snapper SB,Li W,Mojaverian N,Quach P,Muise AM

    更新日期:2014-10-01 00:00:00

  • An update on anorectal disorders for gastroenterologists.

    abstract::Gastroenterologists frequently encounter pelvic floor disorders, which affect 10% to 15% of the population. The anorectum is a complex organ that collaborates with the pelvic floor muscles to preserve fecal continence and enable defecation. A careful clinical assessment is critical for the diagnosis and management of ...


    pub_type: 杂志文章,评审


    authors: Bharucha AE,Rao SS

    更新日期:2014-01-01 00:00:00

  • Development of the human gastrointestinal tract: twenty years of progress.

    abstract::A combination of approaches has begun to elucidate the mechanisms of gastrointestinal development. This review describes progress over the last 20 years in understanding human gastrointestinal development, including data from both human and experimental animal studies that address molecular mechanisms. Rapid progress ...


    pub_type: 杂志文章,评审


    authors: Montgomery RK,Mulberg AE,Grand RJ

    更新日期:1999-03-01 00:00:00

  • Hepcidin expression inversely correlates with the expression of duodenal iron transporters and iron absorption in rats.

    abstract:BACKGROUND & AIMS:Hepcidin is an antimicrobial peptide thought to be involved in the regulation of intestinal iron absorption. To further investigate its role in this process, we examined hepatic and duodenal gene expression in rats after the switch from a control diet to an iron-deficient diet. METHODS:Adult rats on ...


    pub_type: 杂志文章


    authors: Frazer DM,Wilkins SJ,Becker EM,Vulpe CD,McKie AT,Trinder D,Anderson GJ

    更新日期:2002-09-01 00:00:00

  • Fibroblast Growth Factor Signaling Controls Liver Size in Mice With Humanized Livers.

    abstract:BACKGROUND & AIMS:The ratio of liver size to body weight (hepatostat) is tightly controlled, but little is known about how the physiologic functions of the liver help determine its size. Livers of mice repopulated with human hepatocytes (humanized livers) grow to larger than normal; the human hepatocytes do not recogni...


    pub_type: 杂志文章


    authors: Naugler WE,Tarlow BD,Fedorov LM,Taylor M,Pelz C,Li B,Darnell J,Grompe M

    更新日期:2015-09-01 00:00:00

  • Corynebacterium parvum-elicited hepatic macrophages demonstrate enhanced respiratory burst activity compared with resident Kupffer cells in the rat.

    abstract::We have recently demonstrated that release of oxygen-derived free radicals by activated hepatic macrophages may be involved in the pathogenesis of a rat model of liver injury induced by Corynebacterium parvum and endotoxin. In the present study we have compared the respiratory burst activity of isolated normal rat Kup...


    pub_type: 杂志文章


    authors: Arthur MJ,Kowalski-Saunders P,Wright R

    更新日期:1986-07-01 00:00:00

  • Transcytosis of immunoglobulin A in the mouse enterocyte occurs through glycolipid raft- and rab17-containing compartments.

    abstract:BACKGROUND & AIMS:Glycolipid "rafts" have been shown to play a role in apical membrane trafficking in the enterocyte. The present study characterized the membrane compartments of the enterocyte involved in transepithelial transport of small intestinal immunoglobulin A (IgA). METHODS:Immunogold electron microscopy and ...


    pub_type: 杂志文章


    authors: Hansen GH,Niels-Christiansen LL,Immerdal L,Hunziker W,Kenny AJ,Danielsen EM

    更新日期:1999-03-01 00:00:00

  • Pancreatitis in Children.

    abstract::Acute, acute recurrent, and chronic forms of pancreatitis have been increasingly diagnosed in children in the past 2 decades. Risk factors in the pediatric group are broad and appear to be strikingly different compared with the adult cohort. However, the disease burden and impact on quality of life are surprisingly si...


    pub_type: 杂志文章,评审


    authors: Uc A,Husain SZ

    更新日期:2019-05-01 00:00:00

  • Peroxynitrite-induced apoptosis in human intestinal epithelial cells is attenuated by mesalamine.

    abstract:BACKGROUND & AIMS:Peroxynitrite (PN), a potent oxidant, has been implicated in the pathogenesis of gut inflammation and epithelial cell apoptosis. The aim of this study was to investigate mesalamine, a standard therapy for inflammatory bowel disease, to see if it attenuates PN-induced cytotoxicity in human intestinal e...


    pub_type: 杂志文章


    authors: Sandoval M,Liu X,Mannick EE,Clark DA,Miller MJ

    更新日期:1997-11-01 00:00:00

  • Effects of short-term pancreatic duct obstruction in rats.

    abstract::The short-term effects of rat pancreatic duct obstruction were evaluated and compared with those recently reported to follow obstruction of the rabbit pancreatic duct. In both species pancreatic edema and hyperamylasemia are noted, and the lysosomal hydrolase cathepsin B is redistributed from the lysosome-enriched to ...


    pub_type: 杂志文章


    authors: Ohshio G,Saluja A,Steer ML

    更新日期:1991-01-01 00:00:00

  • Augmentation of ethanol absorption by mono- and disaccharides.

    abstract::Assessment of the influence of nutritional substrates on the disposition of ingested ethanol from the blood requires, first, an understanding of the influence that these may exert upon ethanol absorption from the gastrointestinal tract. In this report, the effects of various carbohydrates on the intestinal absorption ...


    pub_type: 杂志文章


    authors: Broitman SA,Gottlieb LS,Vitale JJ

    更新日期:1976-06-01 00:00:00

  • Restoration of CFTR Activity in Ducts Rescues Acinar Cell Function and Reduces Inflammation in Pancreatic and Salivary Glands of Mice.

    abstract:BACKGROUND & AIMS:Sjögren's syndrome and autoimmune pancreatitis are disorders with decreased function of salivary, lacrimal glands, and the exocrine pancreas. Nonobese diabetic/ShiLTJ mice and mice transduced with the cytokine BMP6 develop Sjögren's syndrome and chronic pancreatitis and MRL/Mp mice are models of autoi...


    pub_type: 杂志文章


    authors: Zeng M,Szymczak M,Ahuja M,Zheng C,Yin H,Swaim W,Chiorini JA,Bridges RJ,Muallem S

    更新日期:2017-10-01 00:00:00

  • Ursodeoxycholic acid and cholesterol induce enterohepatic cycling of bilirubin in rodents.

    abstract:BACKGROUND & AIMS:Oral administration of ursodeoxycholic acid (UDCA) and cholesterol causes bile salt malabsorption; the former by competition for and the latter by down-regulation of ileal bile acid transporters. Because ileectomy in rats induces enterohepatic cycling of bilirubin, the hypothesis that dietary steroids...


    pub_type: 杂志文章


    authors: Méndez-Sánchez N,Brink MA,Paigen B,Carey MC

    更新日期:1998-09-01 00:00:00

  • Autophagy, Inflammation, and Immune Dysfunction in the Pathogenesis of Pancreatitis.

    abstract::Pancreatitis is a common disorder with significant morbidity and mortality, yet little is known about its pathogenesis, and there is no specific or effective treatment. Its development involves dysregulated autophagy and unresolved inflammation, demonstrated by studies in genetic and experimental mouse models. Disease...


    pub_type: 杂志文章,评审


    authors: Gukovskaya AS,Gukovsky I,Algül H,Habtezion A

    更新日期:2017-11-01 00:00:00

  • Platelets circulate in an activated state in inflammatory bowel disease.

    abstract:BACKGROUND/AIMS:Platelets show proinflammatory as well as prothrombotic properties. Patients with inflammatory bowel disease are at increased risk of systemic thromboembolism, and multifocal microvascular infarction has been proposed as a pathogenetic mechanism in Crohn's disease. The aim of this study was to determine...


    pub_type: 杂志文章


    authors: Collins CE,Cahill MR,Newland AC,Rampton DS

    更新日期:1994-04-01 00:00:00

  • STRIDE-II: An Update on the Selecting Therapeutic Targets in Inflammatory Bowel Disease (STRIDE) Initiative of the International Organization for the Study of IBD (IOIBD): Determining Therapeutic Goals for Treat-to-Target strategies in IBD.

    abstract:BACKGROUND:The Selecting Therapeutic Targets in Inflammatory Bowel Disease (STRIDE) initiative of the International Organization for the Study of Inflammatory Bowel Diseases (IOIBD) has proposed treatment-targets in 2015 for adult IBD patients. We aimed to update the original STRIDE statements for incorporating treatme...


    pub_type: 杂志文章


    authors: Turner D,Ricciuto A,Lewis A,D'Amico F,Dhaliwal J,Griffiths AM,Bettenworth D,Sandborn WJ,Sands BE,Reinisch W,Schölmerich J,Bemelman W,Danese S,Mary JY,Rubin D,Colombel JF,Peyrin-Biroulet L,Dotan I,Abreu MT,Dignass A

    更新日期:2020-12-21 00:00:00

  • Folic acid increases global DNA methylation and reduces inflammation to prevent Helicobacter-associated gastric cancer in mice.

    abstract:BACKGROUND & AIMS:Previous studies have suggested that dietary folic acid (FA) can protect against certain types of cancers. However, the findings have varied, and the mechanisms by which FA exerts chemopreventive effects remain to be clarified. We examined the effects of FA supplementation on DNA methylation, gene exp...


    pub_type: 杂志文章


    authors: Gonda TA,Kim YI,Salas MC,Gamble MV,Shibata W,Muthupalani S,Sohn KJ,Abrams JA,Fox JG,Wang TC,Tycko B

    更新日期:2012-04-01 00:00:00

  • Surrogate markers of intestinal inflammation are predictive of relapse in patients with inflammatory bowel disease.

    abstract:BACKGROUND & AIMS:Prediction of relapse of inflammatory bowel disease has important implications for therapeutic strategies. We assessed whether measurement of intestinal permeability and inflammation could predict relapse of inflammatory bowel disease (IBD). METHODS:Forty-three patients with Crohn's disease (CD) and ...


    pub_type: 杂志文章


    authors: Tibble JA,Sigthorsson G,Bridger S,Fagerhol MK,Bjarnason I

    更新日期:2000-07-01 00:00:00

  • Risk of Obesity-Related Cardiometabolic Complications in Special Populations: A Crisis in Asians.

    abstract::The prospect of a significant increase in global health-related costs associated with high cardiometabolic complications of obesity in Asians has encouraged more attention to be focused on the problem of growing obesity prevalence in these populations. Although these studies have shown that cardiometabolic complicatio...


    pub_type: 杂志文章,评审


    authors: Abate N,Chandalia M

    更新日期:2017-05-01 00:00:00

  • A prospective trial comparing small bowel radiographs and video capsule endoscopy for suspected small bowel disease.

    abstract:BACKGROUND & AIMS:This study was undertaken to prospectively compare the clinical outcomes of small bowel radiographs with the wireless capsule endoscopy. METHODS:Twenty-two patients were selected consecutively because of suspected small bowel disease. Two patients were excluded owing to ileal stenosis. Thus, the resu...


    pub_type: 临床试验,杂志文章


    authors: Costamagna G,Shah SK,Riccioni ME,Foschia F,Mutignani M,Perri V,Vecchioli A,Brizi MG,Picciocchi A,Marano P

    更新日期:2002-10-01 00:00:00

  • Severe cholestatic jaundice associated with piroxicam.

    abstract::A 62-year-old man with rheumatoid arthritis developed jaundice while taking piroxicam. A full evaluation including ultrasound, computerized tomography, endoscopic cholangiography, and liver biopsy confirmed the diagnosis of intrahepatic cholestasis. The patient's jaundice and all other liver function abnormalities nor...


    pub_type: 杂志文章,评审


    authors: Hepps KS,Maliha GM,Estrada R,Goodgame RW

    更新日期:1991-12-01 00:00:00

  • Organoid Models of Human Gastrointestinal Development and Disease.

    abstract::We have greatly advanced our ability to grow a diverse range of tissue-derived and pluripotent stem cell-derived gastrointestinal (GI) tissues in vitro. These systems, broadly referred to as organoids, have allowed the field to move away from the often nonphysiological, transformed cell lines that have been used for d...


    pub_type: 杂志文章,评审


    authors: Dedhia PH,Bertaux-Skeirik N,Zavros Y,Spence JR

    更新日期:2016-05-01 00:00:00

  • Impaired gastric secretion and lack of trophic responses to hypergastrinemia in M3 muscarinic receptor knockout mice.

    abstract:BACKGROUND & AIMS:The physiologic significance of the M(3) muscarinic receptor is unclear due to an absence of specific ligand. In the present study, M(3) receptor knockout (KO) mice were used to elucidate the role of M(3) receptors in gastric acid secretion and gastric mucosal integrity. METHODS:M(3) KO versus wild-t...


    pub_type: 杂志文章


    authors: Aihara T,Fujishita T,Kanatani K,Furutani K,Nakamura E,Taketo MM,Matsui M,Chen D,Okabe S

    更新日期:2003-12-01 00:00:00

  • Calretinin and calbindin-D28k immunoreactivity in the human gastrointestinal tract.

    abstract:BACKGROUND:Calretinin and calbindin-D28k are similar Ca(2+)-binding proteins previously described in specific central neurons and other cells. METHODS:The immunocytochemical distribution of these two proteins was studied in the human gastrointestinal tract. RESULTS:In gastric and small intestinal endocrine cells, cal...


    pub_type: 杂志文章


    authors: Walters JR,Bishop AE,Facer P,Lawson EM,Rogers JH,Polak JM

    更新日期:1993-05-01 00:00:00

  • Nonsteroidal anti-inflammatory drugs and statins have chemopreventative effects in patients with Barrett's esophagus.

    abstract:BACKGROUND & AIMS:The incidence of Barrett's esophagus and esophageal adenocarcinoma has increased despite surveillance of patients with Barrett's esophagus. Limited data indicate that nonsteroidal anti-inflammatory drug (NSAID) and statin use reduce the risk for esophageal adenocarcinoma. We investigated whether NSAID...


    pub_type: 杂志文章,多中心研究


    authors: Kastelein F,Spaander MC,Biermann K,Steyerberg EW,Kuipers EJ,Bruno MJ,Probar-study Group.

    更新日期:2011-12-01 00:00:00

  • Development and Validation of a Deep Neural Network for Accurate Evaluation of Endoscopic Images From Patients With Ulcerative Colitis.

    abstract:BACKGROUND & AIMS:There are intra- and interobserver variations in endoscopic assessment of ulcerative colitis (UC) and biopsies are often collected for histologic evaluation. We sought to develop a deep neural network system for consistent, objective, and real-time analysis of endoscopic images from patients with UC. ...


    pub_type: 杂志文章


    authors: Takenaka K,Ohtsuka K,Fujii T,Negi M,Suzuki K,Shimizu H,Oshima S,Akiyama S,Motobayashi M,Nagahori M,Saito E,Matsuoka K,Watanabe M

    更新日期:2020-06-01 00:00:00

  • Incidence, prevalence, and clinical course of hepatitis C following liver transplantation.

    abstract::Hepatitis C virus (HCV) is the agent responsible for posttransfusion hepatitis. The incidence, timing, and clinical course of HCV positive hepatitis in liver transplant recipients are unknown. Three hundred and seventeen donor-recipient liver transplant pairs were grouped on the basis of their pretransplant HCV antibo...


    pub_type: 杂志文章


    authors: Shah G,Demetris AJ,Gavaler JS,Lewis JH,Todo S,Starzl TE,Van Thiel DH

    更新日期:1992-07-01 00:00:00

  • Cardiac structural and functional alterations in infants and children with biliary atresia, listed for liver transplantation.

    abstract:BACKGROUND & AIMS:Cirrhotic liver diseases are associated with abnormalities in cardiac geometry and function in adults (cirrhotic cardiomyopathy) but rarely explored in cirrhotic infants or children. We proposed that features of cirrhotic cardiomyopathy are present in infants with cirrhosis due to biliary atresia (BA)...


    pub_type: 杂志文章


    authors: Desai MS,Zainuer S,Kennedy C,Kearney D,Goss J,Karpen SJ

    更新日期:2011-10-01 00:00:00

  • Disordered gustatory acuity in liver disease.

    abstract::Disordered gustatory acuity was demonstrated in 22 patients with acute viral hepatitis and in 16 patients with chronic liver disease utilizing subjective responses and objective measurements of detection and recognition thresholds and scaling for NaCl, sucrose, HCl, and urea. In patients with early hepatitis and those...


    pub_type: 杂志文章


    authors: Smith FR,Henkin RI,Dell RB

    更新日期:1976-04-01 00:00:00

  • Cerebral electrical potentials evoked by balloon distention of the human esophagus.

    abstract:UNLABELLED:Cerebral evoked potentials provide a technique for evaluation of central nervous processing of information derived from a variety of sensory modalities. Evoked potentials associated with balloon distention of the smooth muscle esophagus were studied in 14 adult volunteers. Stimulation was applied via repeate...


    pub_type: 杂志文章


    authors: Castell DO,Wood JD,Frieling T,Wright FS,Vieth RF

    更新日期:1990-03-01 00:00:00