Indomethacin and chloroquine fail to inhibit fluid loss in cholera.

abstract：BACKGROUND & AIMS:Hepatic steatosis is frequent in chronic hepatitis C. Several mechanisms might be implicated, including metabolic cofactors and direct viral effects on intracellular lipid pathways. In a transgenic mouse model, hepatitis C virus (HCV) was shown to inhibit microsomal triglyceride transfer protein (MTP)...

journal_title：Gastroenterology

authors： Mirandola S,Realdon S,Iqbal J,Gerotto M,Dal Pero F,Bortoletto G,Marcolongo M,Vario A,Datz C,Hussain MM,Alberti A

更新日期：2006-05-01 00:00:00

abstract：:A prospective study of 22 patients with antibiotic-associated pseudomembranous colitis demonstrated that the most distal location of the pseudomembranes was noted from 0 to 25 cm from the anus in 17 patients, from 25 to 60 cm from the anus in 3 patients, and greater than 60 cm from the anus in only 2 patients. These d...

journal_title：Gastroenterology

authors： Tedesco FJ,Corless JK,Brownstein RE

更新日期：1982-12-01 00:00:00

abstract：:This paper describes the clinical management of 204 patients with Crohn's disease involving the colon who have been reviewed regularly for many years. The results have been analyzed to define the morbidity, mortality, and long term prognosis of the disorder. Despite a high morbidity, the long term prognosis is good. A...

journal_title：Gastroenterology

authors： Allan R,Steinberg DM,Williams JA,Cooke WT

更新日期：1977-10-01 00:00:00

abstract：BACKGROUND & AIMS:We investigated the prevalence of germline mutations in APC, ATM, BRCA1, BRCA2, CDKN2A, MLH1, MSH2, MSH6, PALB2, PMS2, PRSS1, STK11, and TP53 in patients with pancreatic cancer. METHODS:The Ontario Pancreas Cancer Study enrolls consenting participants with pancreatic cancer from a province-wide elect...

journal_title：Gastroenterology

authors： Grant RC,Selander I,Connor AA,Selvarajah S,Borgida A,Briollais L,Petersen GM,Lerner-Ellis J,Holter S,Gallinger S

更新日期：2015-03-01 00:00:00

abstract：BACKGROUND & AIMS:Animal studies have shown that more than half of the dietary protein intake is used by the gut and that a large proportion of this utilization is devoted to (glyco-)protein synthesis. Recycling of these secretions may play a critical role in the regulation of overall dietary amino acid bioavailability...

journal_title：Gastroenterology

authors： Van Der Schoor SR,Reeds PJ,Stoll B,Henry JF,Rosenberger JR,Burrin DG,Van Goudoever JB

更新日期：2002-12-01 00:00:00

abstract：BACKGROUND AND AIMS:There has been much speculation about the potential impact on the use of conventional colonoscopy if "virtual" computed tomographic colonography (CTC) became a widely accepted modality for colorectal cancer (CRC) screening. However, no formal analysis of the impact of CTC on colonoscopy demand has b...

journal_title：Gastroenterology

authors： Hur C,Gazelle GS,Zalis ME,Podolsky DK

更新日期：2004-11-01 00:00:00

abstract：:In addition to the previously described molecular forms of gastrin, a new component has been found in high concentrations in the serum of 6 patients with Zollinger-Ellison syndrome. Serum was fractionated by gel filtration, and ion exchange chromatography, and the new component was identified in eluates by radioimmuno...

journal_title：Gastroenterology

authors： Dockray GJ,Walsh JH

更新日期：1975-02-01 00:00:00

abstract：BACKGROUND & AIMS:Barrett's esophagus-associated high-grade dysplasia is commonly treated by endoscopy. However, most guidelines offer no recommendations for endoscopic treatment of mucosal adenocarcinoma of the esophagus (mAC). We investigated the efficacy and safety of endoscopic resection in a large series of patien...

journal_title：Gastroenterology

authors： Pech O,May A,Manner H,Behrens A,Pohl J,Weferling M,Hartmann U,Manner N,Huijsmans J,Gossner L,Rabenstein T,Vieth M,Stolte M,Ell C

更新日期：2014-03-01 00:00:00

abstract：:The noninvasive assessment of intestinal permeability in humans has a 20-year history. Because the tests are increasingly used in clinical practice and research and because there is much controversy, we reviewed the literature and outlined the potential and possible shortcomings of these procedures. Data was obtained ...

journal_title：Gastroenterology

authors： Bjarnason I,MacPherson A,Hollander D

更新日期：1995-05-01 00:00:00

abstract：BACKGROUND & AIMS:Prucalopride is a selective, high-affinity agonist of the 5-hydroxytryptamine (serotonin) receptor 4 that enhances motility in the gastrointestinal tract. We performed a multicenter, randomized, placebo-controlled, double-blind, phase 3 trial to evaluate the efficacy and safety of prucalopride in chil...

journal_title：Gastroenterology

authors： Mugie SM,Korczowski B,Bodi P,Green A,Kerstens R,Ausma J,Ruth M,Levine A,Benninga MA

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND/AIMS:The mechanisms of chemically induced injury are poorly understood. The purpose of this study was to develop a rapid method for isolation of gastric mucosal cells (GMCs) and sensitive tests for investigating cell damage and protection. METHODS:GMCs were prepared from rat glandular stomach with pronase a...

journal_title：Gastroenterology

authors： Nagy L,Szabo S,Morales RE,Plebani M,Jenkins JM

更新日期：1994-10-01 00:00:00

abstract：BACKGROUND & AIMS:Cellular and molecular mechanisms of esophageal ulcer healing remain unexplored. We studied the sequential cellular events and the expression of keratinocyte growth factor (KGF) and its receptor (KGF-R) during the healing of experimental esophageal ulcers. METHODS:Esophageal ulcers were produced in r...

journal_title：Gastroenterology

authors： Baatar D,Kawanaka H,Szabo IL,Pai R,Jones MK,Kitano S,Tarnawski AS

更新日期：2002-02-01 00:00:00

abstract：BACKGROUND & AIMS:Conflicting results have been published concerning the effects of different opioid-receptor agonists against visceral noxious stimulation. The introduction of colorectal distention facilitates research in this field. The aim of this study was to examine intrathecally administered opioid agonists again...

journal_title：Gastroenterology

authors： Borgbjerg FM,Frigast C,Madsen JB,Mikkelsen LF

更新日期：1996-01-01 00:00:00

abstract：BACKGROUND & AIMS:The physiologic function of the efflux transporter Multidrug Resistance Protein 3 (MRP3) remains poorly defined. In vitro, MRP3 transports several glucuronidated compounds, but the compounds transported under physiologic conditions are unknown. Knowledge of the compounds transported by MRP3 in vivo wo...

journal_title：Gastroenterology

authors： van de Wetering K,Feddema W,Helms JB,Brouwers JF,Borst P

更新日期：2009-11-01 00:00:00

abstract：:Female monozygotic triplets all developed Crohn's disease within a period of 11 mo. The monozygosity was demonstrated by analysis of 24 genetic markers of different chromosomal localization. Crohn's disease was diagnosed using clinical, radiologic, and endoscopic findings. Histologic evaluation of bowel tissue was con...

journal_title：Gastroenterology

authors： Purrmann J,Bertrams J,Borchard F,Miller B,Cleveland S,Stolze T,Strohmeyer G

更新日期：1986-12-01 00:00:00

abstract：BACKGROUND & AIMS:Patients with colorectal tumors with microsatellite instability (MSI) have better prognoses than patients with tumors without MSI, but have a poor response to 5-fluorouracil–based chemotherapy. A dominant-negative form of heat shock protein (HSP)110 (HSP110DE9) expressed by cancer cells with MSI, via ...

journal_title：Gastroenterology

authors： Collura A,Lagrange A,Svrcek M,Marisa L,Buhard O,Guilloux A,Wanherdrick K,Dorard C,Taieb A,Saget A,Loh M,Soong R,Zeps N,Platell C,Mews A,Iacopetta B,De Thonel A,Seigneuric R,Marcion G,Chapusot C,Lepage C,Bouvier

更新日期：2014-02-01 00:00:00

abstract：BACKGROUND & AIMS:Cirrhotic liver diseases are associated with abnormalities in cardiac geometry and function in adults (cirrhotic cardiomyopathy) but rarely explored in cirrhotic infants or children. We proposed that features of cirrhotic cardiomyopathy are present in infants with cirrhosis due to biliary atresia (BA)...

journal_title：Gastroenterology

authors： Desai MS,Zainuer S,Kennedy C,Kearney D,Goss J,Karpen SJ

更新日期：2011-10-01 00:00:00

abstract：:Pharmacologic and surgical procedures were used to define the neurohumoral pathways that mediate stress-induced changes in gastrointestinal transit in the rat. Physical restraint (a validated stressor) resulted in significant inhibition of gastric emptying and small bowel transit but in stimulation of large bowel tran...

journal_title：Gastroenterology

authors： Lenz HJ

更新日期：1989-07-01 00:00:00

abstract：:Effects of opiates on intestinal motor activity and transport of water and electrolytes have been studied separately in previous investigations. The aim of these experiments was to evaluate simultaneously the effects of a synthetic opiate, loperamide, on motor activity and transport in the human intestine. Jejunal, il...

journal_title：Gastroenterology

authors： Kachel G,Ruppin H,Hagel J,Barina W,Meinhardt M,Domschke W

更新日期：1986-01-01 00:00:00

abstract：BACKGROUND/AIMS:The gastric mucosa is covered by a continuous layer of bicarbonate-containing mucus gel; the question arises how acid, formed in the gastric glands, moves into the lumen. METHODS:The pH in the gastric mucus gel and gel thickness were measured in anesthetized rats with pH-sensitive microelectrodes (tip ...

journal_title：Gastroenterology

authors： Schade C,Flemström G,Holm L

更新日期：1994-07-01 00:00:00

abstract：BACKGROUND & AIMS:Methylation of specific microRNAs (miRNAs) often occurs in an age-dependent manner, as a field defect in some instances, and may be an early event in colitis-associated carcinogenesis. We aimed to determine whether specific mRNA signature patterns (MIR1, MIR9, MIR124, MIR137, MIR34B/C) could be used t...

journal_title：Gastroenterology

authors： Toiyama Y,Okugawa Y,Tanaka K,Araki T,Uchida K,Hishida A,Uchino M,Ikeuchi H,Hirota S,Kusunoki M,Boland CR,Goel A

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND & AIMS:Chemoembolization is one of several standards of care treatment for hepatocellular carcinoma (HCC). Radioembolization with Yttrium-90 microspheres is a novel, transarterial approach to radiation therapy. We performed a comparative effectiveness analysis of these therapies in patients with HCC. METHOD...

journal_title：Gastroenterology

authors： Salem R,Lewandowski RJ,Kulik L,Wang E,Riaz A,Ryu RK,Sato KT,Gupta R,Nikolaidis P,Miller FH,Yaghmai V,Ibrahim SM,Senthilnathan S,Baker T,Gates VL,Atassi B,Newman S,Memon K,Chen R,Vogelzang RL,Nemcek AA,Resnick SA

更新日期：2011-02-01 00:00:00

abstract：:The subcellular localization of intraduodenally administered 59Fe has been studied in control, pregnant, and nonpregnant rats absorbing iron at different rates. Binding of iron to the particulate fractions of mucosal homogenates produced by centrifugation at 500, 10,000, and 100,000 X g did not vary among groups despi...

journal_title：Gastroenterology

authors： Batey RG,Gallagher ND

更新日期：1977-08-01 00:00:00

abstract：:Helicobacter pylori infects the stomach of half of the human population worldwide and causes chronic active gastritis, which can lead to peptic ulcer disease, gastric adenocarcinoma, and mucosa-associated lymphoid tissue lymphoma. The host immune response to the infection is ineffective, because the bacterium persists...

journal_title：Gastroenterology

authors： Wilson KT,Crabtree JE

更新日期：2007-07-01 00:00:00

abstract：:Esophageal ligation in the pylorus-ligated rat significantly inhibited volume, titratable acidity, and titratable acid output and reduced the incidence of ulcers, perforations, and death of 18-hr pylorus-ligated rats. Draining the saliva outside the body of the rat by esophageal cannulation produced a significant incr...

journal_title：Gastroenterology

authors： Brodie DA,Knapp PG

更新日期：1966-06-01 00:00:00

abstract：:In the rat, gastric histamine is stored mainly in the enterochromaffinlike cells. Gastrin releases histamine from these cells, and long-term hypergastrinemia results in hyperplasia. The effect of sustained hypergastrinemia on histamine-depleted enterochromaffinlike cells was studied by measuring histidine decarboxylas...

journal_title：Gastroenterology

authors： Andersson K,Håkanson R,Mattsson H,Ryberg B,Sundler F

更新日期：1992-09-01 00:00:00

abstract：BACKGROUND & AIMS:Estimates of complication rates following elective percutaneous liver biopsy vary and might not accurately reflect current practice. We studied mortality and complication rates, by indication, in patients after they underwent liver biopsies. METHODS:We performed a study using hospital episode statist...

journal_title：Gastroenterology

authors： West J,Card TR

更新日期：2010-10-01 00:00:00

abstract：:The effect of aging on gastric and duodenal mucosal prostaglandins has not been reported. Gastric and duodenal mucosal prostaglandin concentrations were measured in 46 healthy adults, 35 of whom were relatively young (21-40 years old) and 11 of whom were considerably more elderly (aged 52-72 years). Mucosal biopsy spe...

journal_title：Gastroenterology

authors： Cryer B,Redfern JS,Goldschmiedt M,Lee E,Feldman M

更新日期：1992-04-01 00:00:00

abstract：BACKGROUND & AIMS:We aimed to identify long noncoding RNAs (lncRNAs) that are up-regulated in gastric cancer tissues from patients and study their function in gastric tumor metastasis. METHODS:We collected gastric tumor and nontumor tissues from patients in China and analyzed levels of lncRNAs by microarray analysis, ...

journal_title：Gastroenterology

authors： Zhuo W,Liu Y,Li S,Guo D,Sun Q,Jin J,Rao X,Li M,Sun M,Jiang M,Xu Y,Teng L,Jin Y,Si J,Liu W,Kang Y,Zhou T

更新日期：2019-02-01 00:00:00

abstract：BACKGROUND & AIMS:Interstitial cells of Cajal (ICC) serve as pacemaker cells and mediators of neurotransmission from the enteric nervous system to gastrointestinal muscles. ICC develop from mesenchymal cells that express c-Kit, and signaling via Kit receptors is necessary for normal development of ICC. We studied the f...

journal_title：Gastroenterology

authors： Torihashi S,Nishi K,Tokutomi Y,Nishi T,Ward S,Sanders KM

更新日期：1999-07-01 00:00:00