Abstract:
:Fifty consecutive patients with symptomatic endoscopically proven duodenal ulcer were randomized double-blind to Mylanta II or cimetidine treatment schedules. Smoking habits were noted, but patients were not advised to alter these. Healing was determined by reendoscopy at 6 wk. Eighty percent of patients on active cimetidine and 52% on active Mylanta II had healed at 6 wk (not significantly); 85% of nonsmokers healed compared to 44% of smokers (p less than 0.03). In smokers, cimetidine achieved healing in 50%, Mylanta II in 39% (not significantly); while in nonsmokers, cimetidine achieved healing in 100%, Mylanta II in 67% (not significantly). These results indicate a significant and equally adverse effect of smoking on the healing rate of duodenal ulcer achieved by either cimetidine or Mylanta II.
journal_name
Gastroenterologyjournal_title
Gastroenterologyauthors
Korman MG,Shaw RG,Hansky J,Schmidt GT,Stern AIsubject
Has Abstractpub_date
1981-06-01 00:00:00pages
1451-3issue
6eissn
0016-5085issn
1528-0012pii
S0016508581001352journal_volume
80pub_type
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