Influence of smoking on healing rate of duodenal ulcer in response to cimetidine or high-dose antacid.

Abstract:

:Fifty consecutive patients with symptomatic endoscopically proven duodenal ulcer were randomized double-blind to Mylanta II or cimetidine treatment schedules. Smoking habits were noted, but patients were not advised to alter these. Healing was determined by reendoscopy at 6 wk. Eighty percent of patients on active cimetidine and 52% on active Mylanta II had healed at 6 wk (not significantly); 85% of nonsmokers healed compared to 44% of smokers (p less than 0.03). In smokers, cimetidine achieved healing in 50%, Mylanta II in 39% (not significantly); while in nonsmokers, cimetidine achieved healing in 100%, Mylanta II in 67% (not significantly). These results indicate a significant and equally adverse effect of smoking on the healing rate of duodenal ulcer achieved by either cimetidine or Mylanta II.

journal_name

Gastroenterology

journal_title

Gastroenterology

authors

Korman MG,Shaw RG,Hansky J,Schmidt GT,Stern AI

subject

Has Abstract

pub_date

1981-06-01 00:00:00

pages

1451-3

issue

6

eissn

0016-5085

issn

1528-0012

pii

S0016508581001352

journal_volume

80

pub_type

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