Development and Validation of a Deep Neural Network for Accurate Evaluation of Endoscopic Images From Patients With Ulcerative Colitis.


BACKGROUND & AIMS:There are intra- and interobserver variations in endoscopic assessment of ulcerative colitis (UC) and biopsies are often collected for histologic evaluation. We sought to develop a deep neural network system for consistent, objective, and real-time analysis of endoscopic images from patients with UC. METHODS:We constructed the deep neural network for evaluation of UC (DNUC) algorithm using 40,758 images of colonoscopies and 6885 biopsy results from 2012 patients with UC who underwent colonoscopy from January 2014 through March 2018 at a single center in Japan (the training set). We validated the accuracy of the DNUC algorithm in a prospective study of 875 patients with UC who underwent colonoscopy from April 2018 through April 2019, with 4187 endoscopic images and 4104 biopsy specimens. Endoscopic remission was defined as a UC endoscopic index of severity score of 0; histologic remission was defined as a Geboes score of 3 points or less. RESULTS:In the prospective study, the DNUC identified patients with endoscopic remission with 90.1% accuracy (95% confidence interval [CI] 89.2%-90.9%) and a kappa coefficient of 0.798 (95% CI 0.780-0.814), using findings reported by endoscopists as the reference standard. The intraclass correlation coefficient between the DNUC and the endoscopists for UC endoscopic index of severity scoring was 0.917 (95% CI 0.911-0.921). The DNUC identified patients in histologic remission with 92.9% accuracy (95% CI 92.1%-93.7%); the kappa coefficient between the DNUC and the biopsy result was 0.859 (95% CI 0.841-0.875). CONCLUSIONS:We developed a deep neural network for evaluation of endoscopic images from patients with UC that identified those in endoscopic remission with 90.1% accuracy and histologic remission with 92.9% accuracy. The DNUC can therefore identify patients in remission without the need for mucosal biopsy collection and analysis. Trial number: UMIN000031430.






Takenaka K,Ohtsuka K,Fujii T,Negi M,Suzuki K,Shimizu H,Oshima S,Akiyama S,Motobayashi M,Nagahori M,Saito E,Matsuoka K,Watanabe M




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2020-06-01 00:00:00














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    abstract:BACKGROUND & AIMS:Weight loss in response to sibutramine is highly variable. We assessed the association of specific markers of polymorphisms of candidate alpha2A adrenoreceptor, 5-HT transporter, and GNbeta3 genes and weight loss with sibutramine. METHODS:We conducted a randomized, double-blind, pharmacogenetic study...


    pub_type: 杂志文章,随机对照试验


    authors: Grudell AB,Sweetser S,Camilleri M,Eckert DJ,Vazquez-Roque MI,Carlson PJ,Burton DD,Braddock AE,Clark MM,Graszer KM,Kalsy SA,Zinsmeister AR

    更新日期:2008-10-01 00:00:00

  • Protein kinase C tissue localization in human colonic tumors suggests a role for adenoma growth control.

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    pub_type: 杂志文章


    authors: Kahl-Rainer P,Sedivy R,Marian B

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  • Evidence for the hypersensitivity of lumbar splanchnic afferents in irritable bowel syndrome.

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    pub_type: 杂志文章


    authors: Lembo T,Munakata J,Mertz H,Niazi N,Kodner A,Nikas V,Mayer EA

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  • Pin1 interacts with a specific serine-proline motif of hepatitis B virus X-protein to enhance hepatocarcinogenesis.

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    pub_type: 杂志文章


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    更新日期:2007-03-01 00:00:00

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    abstract::Twenty cirrhotic patients with esophageal varices and an episode of gastrointestinal bleeding within the previous week underwent hemodynamic studies which used an indicator dilution technique based on selective catheterization of the splanchnic arteries and hepatic vein. Portasystemic shunting of splenic arterial flow...


    pub_type: 杂志文章


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  • Retinoids: effects on growth, differentiation, and nuclear receptor expression in human pancreatic carcinoma cell lines.

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    pub_type: 杂志文章


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  • Relationship of serum alpha-fetoprotein to the severity and duration of illness in patients with viral hepatitis.

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    pub_type: 杂志文章


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  • Maintenance therapy with peginterferon alfa-2b does not prevent hepatocellular carcinoma in cirrhotic patients with chronic hepatitis C.

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    pub_type: 杂志文章,多中心研究,随机对照试验


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    更新日期:2011-06-01 00:00:00

  • For what conditions is there evidence-based justification for treatment of Helicobacter pylori infection?

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    pub_type: 临床试验,杂志文章,随机对照试验


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    pub_type: 杂志文章


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    pub_type: 杂志文章


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    pub_type: 杂志文章


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    pub_type: 杂志文章


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