Development and Validation of a Deep Neural Network for Accurate Evaluation of Endoscopic Images From Patients With Ulcerative Colitis.


BACKGROUND & AIMS:There are intra- and interobserver variations in endoscopic assessment of ulcerative colitis (UC) and biopsies are often collected for histologic evaluation. We sought to develop a deep neural network system for consistent, objective, and real-time analysis of endoscopic images from patients with UC. METHODS:We constructed the deep neural network for evaluation of UC (DNUC) algorithm using 40,758 images of colonoscopies and 6885 biopsy results from 2012 patients with UC who underwent colonoscopy from January 2014 through March 2018 at a single center in Japan (the training set). We validated the accuracy of the DNUC algorithm in a prospective study of 875 patients with UC who underwent colonoscopy from April 2018 through April 2019, with 4187 endoscopic images and 4104 biopsy specimens. Endoscopic remission was defined as a UC endoscopic index of severity score of 0; histologic remission was defined as a Geboes score of 3 points or less. RESULTS:In the prospective study, the DNUC identified patients with endoscopic remission with 90.1% accuracy (95% confidence interval [CI] 89.2%-90.9%) and a kappa coefficient of 0.798 (95% CI 0.780-0.814), using findings reported by endoscopists as the reference standard. The intraclass correlation coefficient between the DNUC and the endoscopists for UC endoscopic index of severity scoring was 0.917 (95% CI 0.911-0.921). The DNUC identified patients in histologic remission with 92.9% accuracy (95% CI 92.1%-93.7%); the kappa coefficient between the DNUC and the biopsy result was 0.859 (95% CI 0.841-0.875). CONCLUSIONS:We developed a deep neural network for evaluation of endoscopic images from patients with UC that identified those in endoscopic remission with 90.1% accuracy and histologic remission with 92.9% accuracy. The DNUC can therefore identify patients in remission without the need for mucosal biopsy collection and analysis. Trial number: UMIN000031430.






Takenaka K,Ohtsuka K,Fujii T,Negi M,Suzuki K,Shimizu H,Oshima S,Akiyama S,Motobayashi M,Nagahori M,Saito E,Matsuoka K,Watanabe M




Has Abstract


2020-06-01 00:00:00














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    abstract::To study directly the functions of the cells that line the bile ducts inside the liver, we developed a new technique for isolating intrahepatic bile duct epithelial cells (IBDECs) from normal rat liver. Parenchymal and nonparenchymal cells were separated from whole liver by enzymatic digestion and mechanical disruptio...


    pub_type: 杂志文章


    authors: Ishii M,Vroman B,LaRusso NF

    更新日期:1989-11-01 00:00:00

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    abstract:BACKGROUND & AIMS:Proliferating cholangiocytes secrete and respond to neuroendocrine hormones, including secretin. We investigated whether secretin secreted by S cells and cholangiocytes stimulates biliary proliferation in mice. METHODS:Cholestasis was induced in secretin knockout (Sct(-/-)) and wild-type (control) mi...


    pub_type: 杂志文章


    authors: Glaser S,Meng F,Han Y,Onori P,Chow BK,Francis H,Venter J,McDaniel K,Marzioni M,Invernizzi P,Ueno Y,Lai JM,Huang L,Standeford H,Alvaro D,Gaudio E,Franchitto A,Alpini G

    更新日期:2014-06-01 00:00:00

  • Role of prostaglandins in the formation of aspirin-induced gastric ulcers.

    abstract::Gastric mucosa of the rat generates both PGE2 and PGI2 activity in significantly higher concentrations in the antrum than in the fundus. Aspirin, given intravenously or intragastrically in doses producing gastric mucosal lesions, causes a dose-dependent decrease in the generation of mucosal PGE2 and PGI2, which is fur...


    pub_type: 杂志文章


    authors: Konturek SJ,Piastucki I,Brzozowski T,Radecki T,Dembińska-Kieć A,Zmuda A,Gryglewski R

    更新日期:1981-01-01 00:00:00

  • The lymphoid liver: considerations on pathways to autoimmune injury.

    abstract::Immunologic injury in the liver involves immigrant T and B lymphocytes and a resident lymphoid population that comprises distinct lymphocytic cells and accessory cells. The forerunner to autoimmunity is breaching of natural self-tolerance and hence the disruption of a fundamental property of the immune system. Such br...


    pub_type: 杂志文章,评审


    authors: Kita H,Mackay IR,Van De Water J,Gershwin ME

    更新日期:2001-05-01 00:00:00

  • The many faces of celiac disease: clinical presentation of celiac disease in the adult population.

    abstract::The major modes of presentation of patients with celiac disease are the classic diarrhea-predominant form and silent celiac disease. Those with silent celiac disease lack diarrhea, although they may present with manifestations of celiac disease that include an irritable bowel syndrome, anemia, osteoporosis, neurologic...


    pub_type: 杂志文章


    authors: Green PH

    更新日期:2005-04-01 00:00:00

  • Increased de novo lipogenesis is a distinct characteristic of individuals with nonalcoholic fatty liver disease.

    abstract:BACKGROUND & AIMS:There have been few studies of the role of de novo lipogenesis in the development of nonalcoholic fatty liver disease (NAFLD). We used isotope analyses to compare de novo lipogenesis and fatty acid flux between subjects with NAFLD and those without, matched for metabolic factors (controls). METHODS:W...


    pub_type: 杂志文章


    authors: Lambert JE,Ramos-Roman MA,Browning JD,Parks EJ

    更新日期:2014-03-01 00:00:00

  • erbB-2/neu transformed rat cholangiocytes recapitulate key cellular and molecular features of human bile duct cancer.

    abstract:BACKGROUND & AIMS:Cholangiocarcinomas appear to arise from the malignant transformation of cholangiocytes lining the biliary tract. Because the development of an in vitro model of malignant transformation can provide a powerful new tool for establishing critical events governing the molecular pathogenesis of cholangioc...


    pub_type: 杂志文章


    authors: Lai GH,Zhang Z,Shen XN,Ward DJ,Dewitt JL,Holt SE,Rozich RA,Hixson DC,Sirica AE

    更新日期:2005-12-01 00:00:00

  • Allelic variations of the multidrug resistance gene determine susceptibility and disease behavior in ulcerative colitis.

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    pub_type: 杂志文章


    authors: Ho GT,Nimmo ER,Tenesa A,Fennell J,Drummond H,Mowat C,Arnott ID,Satsangi J

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  • Effects of alcohols on the actions of VIP and secretin on acinar cells from guinea pig pancreas.

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    pub_type: 杂志文章


    authors: Uhlemann ER,Robberecht P,Gardner JD

    更新日期:1979-05-01 00:00:00

  • Liver transplantation for hepatocellular carcinoma: a model including α-fetoprotein improves the performance of Milan criteria.

    abstract:BACKGROUND & AIMS:The aim of this study was to generate an improved prognostic model for predicting recurrence in liver transplant candidates with hepatocellular carcinoma (HCC). METHODS:Predictors of recurrence were tested by a Cox model analysis in a training cohort of 537 patients transplanted for HCC. A prognostic...


    pub_type: 杂志文章


    authors: Duvoux C,Roudot-Thoraval F,Decaens T,Pessione F,Badran H,Piardi T,Francoz C,Compagnon P,Vanlemmens C,Dumortier J,Dharancy S,Gugenheim J,Bernard PH,Adam R,Radenne S,Muscari F,Conti F,Hardwigsen J,Pageaux GP,Chazouill

    更新日期:2012-10-01 00:00:00

  • MUC6 apomucin shows a distinct normal tissue distribution that correlates with Lewis antigen expression in the human stomach.

    abstract:BACKGROUND & AIMS:Among the human mucin complementary DNAs thus far identified, two (MUC5AC and MUC6) were cloned from stomach libraries. This study examines the distribution of MUC6 in normal tissues and compares it with that of MUC5AC as well as with the expression of Lewis blood group antigens. METHODS:Affinity-pur...


    pub_type: 评论,杂志文章


    authors: De Bolós C,Garrido M,Real FX

    更新日期:1995-09-01 00:00:00

  • A Phase 1b Safety Study of SER-287, a Spore-Based Microbiome Therapeutic, for Active Mild to Moderate Ulcerative Colitis.

    abstract:BACKGROUND & AIMS:Firmicutes bacteria produce metabolites that maintain the intestinal barrier and mucosal immunity. Firmicutes are reduced in the intestinal microbiota of patients with ulcerative colitis (UC). In a phase 1b trial of patients with UC, we evaluated the safety and efficacy of SER-287, an oral formulation...


    pub_type: 杂志文章


    authors: Henn MR,O'Brien EJ,Diao L,Feagan BG,Sandborn WJ,Huttenhower C,Wortman JR,McGovern BH,Wang-Weigand S,Lichter DI,Chafee M,Ford CB,Bernardo P,Zhao P,Simmons S,Tomlinson AD,Cook DN,Pomerantz RJ,Misra BK,Auninš JG,Truc

    更新日期:2021-01-01 00:00:00

  • Intracolonic injection of glycerol: a model for abdominal pain in irritable bowel syndrome?

    abstract:BACKGROUND & AIMS:Abdominal pain is the main symptom in patients with irritable bowel syndrome (IBS). Glycerol is an irritant of colonic mucosa. The aim of this study was to evaluate the effects of an intraluminal injection of glycerol on colonic motility and tone in patients with IBS and their modulation by drugs. ME...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Louvel D,Delvaux M,Staumont G,Camman F,Fioramonti J,Bueno L,Frexinos J

    更新日期:1996-02-01 00:00:00

  • Choledochoduodenal flow: effect of the sphincter of Oddi in opossums and cats.

    abstract::The aim of this study was to test in vivo (a) whether the sphincter of Oddi acts as a resistor or also as a pump, (b) the effect of an IV infusion of cholecystokinin (CCK) on choledochoduodenal flow, and (c) the ability of the choledochoduodenal junction to prevent duodenobiliary reflux in two animal species, opossums...


    pub_type: 杂志文章


    authors: Calabuig R,Weems WA,Moody FG

    更新日期:1990-12-01 00:00:00

  • Isolation and characterization of normal and neoplastic colonic epithelial cell populations.

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    authors: Schwartz B,Avivi C,Lamprecht SA

    更新日期:1991-03-01 00:00:00

  • Tachykinin antagonists inhibit nerve-mediated contractions in the circular muscle of the human ileum. Involvement of neurokinin-2 receptors.

    abstract::The effects of some newly developed tachykinin antagonists that are selective for the neurokinin (NK)-1 (L 668,169) or the NK-2 (MEN 10,207, L 659,877 and R 396) tachykinin receptor on the cholinergic and noncholinergic contraction and on the nonadrenergic noncholinergic relaxation produced by electrical field stimula...


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    authors: Maggi CA,Giuliani S,Patacchini R,Santicioli P,Theodorsson E,Barbanti G,Turini D,Giachetti A

    更新日期:1992-01-01 00:00:00

  • K-ras-2 G-C and G-T transversions correlate with DNA aneuploidy in colorectal adenomas.

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    pub_type: 杂志文章


    authors: Giaretti W,Pujic N,Rapallo A,Nigro S,Di Vinci A,Geido E,Risio M

    更新日期:1995-04-01 00:00:00

  • The perception of cancer risk in patients with prevalent Barrett's esophagus enrolled in an endoscopic surveillance program.

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    pub_type: 评论,杂志文章


    authors: Shaheen NJ,Green B,Medapalli RK,Mitchell KL,Wei JT,Schmitz SM,West LM,Brown A,Noble M,Sultan S,Provenzale D

    更新日期:2005-08-01 00:00:00

  • MET Signaling Mediates Intestinal Crypt-Villus Development, Regeneration, and Adenoma Formation and Is Promoted by Stem Cell CD44 Isoforms.

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    pub_type: 杂志文章


    authors: Joosten SPJ,Zeilstra J,van Andel H,Mijnals RC,Zaunbrecher J,Duivenvoorden AAM,van de Wetering M,Clevers H,Spaargaren M,Pals ST

    更新日期:2017-10-01 00:00:00

  • Feasibility and reliability of pancreatic cancer staging using fiberoptic confocal fluorescence microscopy in rats.

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    pub_type: 杂志文章


    authors: Ignat M,Aprahamian M,Lindner V,Altmeyer A,Perretta S,Dallemagne B,Mutter D,Marescaux J

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  • Angiotensin II induces contraction and proliferation of human hepatic stellate cells.

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    pub_type: 杂志文章


    authors: Bataller R,Ginès P,Nicolás JM,Görbig MN,Garcia-Ramallo E,Gasull X,Bosch J,Arroyo V,Rodés J

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  • Solute Carrier Family 39 Member 6 Gene Promotes Aggressiveness of Esophageal Carcinoma Cells by Increasing Intracellular Levels of Zinc, Activating Phosphatidylinositol 3-Kinase Signaling, and Up-regulating Genes That Regulate Metastasis.

    abstract:BACKGROUND & AIMS:A common variant in the solute carrier family 39 member 6 gene (SLC39A6) has been associated with survival times of patients with esophageal squamous cell carcinoma (ESCC). We investigated the function of SLC39A6 and ways in which this variant affects tumor progression by studying ESCC samples and cel...


    pub_type: 杂志文章


    authors: Cheng X,Wei L,Huang X,Zheng J,Shao M,Feng T,Li J,Han Y,Tan W,Tan W,Lin D,Wu C

    更新日期:2017-06-01 00:00:00

  • Hepatitis B virus core variants modify natural course of viral infection and hepatocellular carcinoma progression.

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    pub_type: 杂志文章


    authors: Sung FY,Jung CM,Wu CF,Lin CL,Liu CJ,Liaw YF,Tsai KS,Yu MW

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  • Effects of bile salts on energy metabolism and acid secretion by the isolated toad gastric mucosa.

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    pub_type: 杂志文章


    authors: Núñez D,Chacín J

    更新日期:1989-01-01 00:00:00

  • Plasma levels of gastrin, somatostatin, and cholecystokinin immunoreactivity during pregnancy and lactation in dogs.

    abstract::Plasma levels of gastrinlike, somatostatinlike, and cholecystokininlike immunoreactivity were determined by radioimmunoassay in peripheral blood from 11 beagles during pregnancy and in response to suckling during lactation. Cholecystokinin was determined in pooled and in individual plasma samples after separation of c...


    pub_type: 杂志文章


    authors: Linden A,Eriksson M,Carlquist M,Uvnäs-Moberg K

    更新日期:1987-03-01 00:00:00

  • Oral cholic acid for hereditary defects of primary bile acid synthesis: a safe and effective long-term therapy.

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    pub_type: 临床试验,杂志文章


    authors: Gonzales E,Gerhardt MF,Fabre M,Setchell KD,Davit-Spraul A,Vincent I,Heubi JE,Bernard O,Jacquemin E

    更新日期:2009-10-01 00:00:00

  • Drug- and estrogen-induced cholestasis through inhibition of the hepatocellular bile salt export pump (Bsep) of rat liver.

    abstract:BACKGROUND & AIMS:Drug-induced cholestasis is a frequent form of acquired liver disease. To elucidate the molecular pathogenesis of drug-induced cholestasis, we investigated the effects of prototypic cholestatic drugs on the canalicular bile salt export pump (Bsep) of rat liver. METHODS:Vesicles were isolated from Bse...


    pub_type: 杂志文章


    authors: Stieger B,Fattinger K,Madon J,Kullak-Ublick GA,Meier PJ

    更新日期:2000-02-01 00:00:00

  • Absorption of short chain fatty acids from the human jejunum.

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    pub_type: 杂志文章


    authors: Schmitt MG Jr,Soergel KH,Wood CM

    更新日期:1976-02-01 00:00:00

  • Orthotopic liver transplantation for graft-versus-host disease following bone marrow transplantation.

    abstract::Chronic graft-vs.-host disease occurs in 30%-50% of long-term survivors of allogeneic bone marrow grafts, and may eventuate in cirrhosis. In this study, a young woman, originally diagnosed as having acute myelogenous leukemia, underwent successful bone marrow transplantation but later developed graft-vs.-host disease-...


    pub_type: 杂志文章


    authors: Rhodes DF,Lee WM,Wingard JR,Pavy MD,Santos GW,Shaw BW,Wood RP,Sorrell MF,Markin RS

    更新日期:1990-08-01 00:00:00

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    pub_type: 杂志文章


    authors: Abe Y,Aly HH,Hiraga N,Imamura M,Wakita T,Shimotohno K,Chayama K,Hijikata M

    更新日期:2013-09-01 00:00:00