Successful growth and characterization of mouse pancreatic ductal cells: functional properties of the Ki-RAS(G12V) oncogene.

abstract：:Absorptive cells of the small intestine are highly polarized cells with distinct microvillus membrane (MVM) and basolateral plasma membrane domains. We compared membrane structure in the following preparations of rat small intestine commonly used for in vitro study of MVM function: epithelial sheets, isolated epitheli...

journal_title：Gastroenterology

authors： Bjorkman DJ,Allan CH,Hagen SJ,Trier JS

更新日期：1986-12-01 00:00:00

abstract：:This paper describes an ultrasound method of assessing gastric emptying time based on measurements of the gastric antrum, which is visible in almost all subjects before and after meals. A total of 54 subjects were examined including 18 normal subjects and 36 subjects with idiopathic functional dyspepsia. The emptying ...

journal_title：Gastroenterology

authors： Bolondi L,Bortolotti M,Santi V,Calletti T,Gaiani S,Labò G

更新日期：1985-10-01 00:00:00

abstract：BACKGROUND & AIMS:Altered gut microbiota is implicated in development of colorectal cancer (CRC). Some intestinal bacteria have been reported to potentiate intestinal carcinogenesis by producing genotoxins, altering the immune response and intestinal microenvironment, and activating oncogenic signaling pathways. We inv...

journal_title：Gastroenterology

authors： Wong SH,Zhao L,Zhang X,Nakatsu G,Han J,Xu W,Xiao X,Kwong TNY,Tsoi H,Wu WKK,Zeng B,Chan FKL,Sung JJY,Wei H,Yu J

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND & AIMS:Circulating levels of angiotensin II (ANGII), a powerful vasoconstrictor factor, are frequently increased in chronic liver diseases. In these conditions, hepatic stellate cells (HSCs) proliferate and acquire contractile properties. This study investigated the presence of receptors for ANGII and the ef...

journal_title：Gastroenterology

authors： Bataller R,Ginès P,Nicolás JM,Görbig MN,Garcia-Ramallo E,Gasull X,Bosch J,Arroyo V,Rodés J

更新日期：2000-06-01 00:00:00

abstract：BACKGROUND & AIMS:Approximately half of the families that fulfill Amsterdam criteria for Lynch syndrome or hereditary nonpolyposis colorectal cancer (HNPCC) do not have evidence of the germline mismatch repair gene mutations that define this syndrome and result in microsatellite instability (MSI). The carcinogenic path...

journal_title：Gastroenterology

authors： Goel A,Xicola RM,Nguyen TP,Doyle BJ,Sohn VR,Bandipalliam P,Rozek LS,Reyes J,Cordero C,Balaguer F,Castells A,Jover R,Andreu M,Syngal S,Boland CR,Llor X

更新日期：2010-05-01 00:00:00

abstract：BACKGROUND & AIMS:Pancreatic cancers contain exclusively tumorigenic cancer stem cells (CSCs), which are highly resistant to chemotherapy, resulting in a relative increase in CSC numbers during gemcitabine treatment. Signaling through sonic hedgehog and mammalian target of rapamycin (mTOR), respectively, may be essenti...

journal_title：Gastroenterology

authors： Mueller MT,Hermann PC,Witthauer J,Rubio-Viqueira B,Leicht SF,Huber S,Ellwart JW,Mustafa M,Bartenstein P,D'Haese JG,Schoenberg MH,Berger F,Jauch KW,Hidalgo M,Heeschen C

更新日期：2009-09-01 00:00:00

abstract：BACKGROUND/AIMS:We have identified several clones specifically expressed during malignant cell proliferation by screening a complementary DNA library constructed from a human primary liver cancer with subtractive probes. One clone was identified as the glutamine synthetase (GS) transcript. Its expression is tightly reg...

journal_title：Gastroenterology

authors： Christa L,Simon MT,Flinois JP,Gebhardt R,Brechot C,Lasserre C

更新日期：1994-05-01 00:00:00

abstract：:We studied intestinal function and hepatic microsomal phase I monooxygenase function in healthy, free-living subjects, aged 19-91 yr. In subjects (n = 114) given a diet including 100 g/day of fat, fecal fat in a 72-h collection did not increase with advancing age. D-Xylose excretion (n = 54) following a 25-g oral load...

journal_title：Gastroenterology

authors： Arora S,Kassarjian Z,Krasinski SD,Croffey B,Kaplan MM,Russell RM

更新日期：1989-06-01 00:00:00

abstract：:The growth rate of 31 asymptomatic hepatocellular carcinomas (diameter less than or equal to 5 cm) discovered in 28 patients by a prospective screening program was determined by real-time ultrasonography over 36-860 days. Except for one tumor that shrank on follow-up, the doubling time ranged from 29 to 398 days, with...

journal_title：Gastroenterology

authors： Sheu JC,Sung JL,Chen DS,Yang PM,Lai MY,Lee CS,Hsu HC,Chuang CN,Yang PC,Wang TH

更新日期：1985-08-01 00:00:00

abstract：BACKGROUND & AIMS:Our aim was to investigate the relationship between alcohol consumption and iron overload, iron deficiency, or iron deficiency anemia in the U.S. population. METHODS:Adult participants of the Third National Health and Nutrition Examination Survey who did not consume alcohol (n = 8839) were compared w...

journal_title：Gastroenterology

authors： Ioannou GN,Dominitz JA,Weiss NS,Heagerty PJ,Kowdley KV

更新日期：2004-05-01 00:00:00

abstract：:A bile fistula patient was administered intravenously a constant infusion of [3H]mevalonic acid for 4 hrs, and then after 2 weeks he was given a pulse of [3H]mevalonic acid. Bile and blood were collected at frequent intervals. The specific activity-time course curves did not show a precursor-product relationship betwe...

journal_title：Gastroenterology

authors： Schwartz CC,Vlahcevic ZR,Halloran LG,Gregory DH,Meek JB,Swell L

更新日期：1975-12-01 00:00:00

abstract：:Disappearance of symptoms, resolution of most biochemical abnormalities, and histologic improvement to mild chronic inflammation were accomplished in 69 of 123 patients (56%) with severe chronic active liver disease treated with corticosteroids for up to 6.5 yr. Remission of at least 6 mo duration was possible in 35 o...

journal_title：Gastroenterology

authors： Czaja AJ,Ammon HV,Summerskill WH

更新日期：1980-03-01 00:00:00

abstract：:The kinetics of cholesterol and bile acid was determined from a 10-week analysis of the biliary lipids after a single injection of labeled cholesterol in parallel with a conventional 1-week study of primary bile acid kinetics. Six healthy controls and 6 patients with cholesterol cholelithiasis were studied. Two of the...

journal_title：Gastroenterology

authors： Hepner GW,Quarfordt SH

更新日期：1975-08-01 00:00:00

abstract：BACKGROUND & AIMS:Liver X receptors (LXRs) are transcriptional regulators of cholesterol metabolism, controlling cholesterol flow into cells, catabolism, and efflux. Cholesterol controls cell proliferation; disruptions in cholesterol metabolism have been associated with the development of colon cancer. We investigated ...

journal_title：Gastroenterology

authors： Lo Sasso G,Bovenga F,Murzilli S,Salvatore L,Di Tullio G,Martelli N,D'Orazio A,Rainaldi S,Vacca M,Mangia A,Palasciano G,Moschetta A

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND:Newly synthesized apical membrane proteins in hepatocytes go first to the basolateral membrane, from which they are retrieved and delivered to the apical domain. The goal of the present study was to identify the vesicular carriers of these molecules. METHODS:The common bile duct of rats was ligated for 10-7...

journal_title：Gastroenterology

authors： Barr VA,Hubbard AL

更新日期：1993-08-01 00:00:00

abstract：:To define a potential role for the angiotensin system in Crohn's colitis, the colonic mucosal levels of angiotensin I and II were measured in endoscopic biopsy samples from patients with active Crohn's colitis (n = 20), ulcerative colitis (n = 13), other forms of colitis (n = 3), and normal controls (n = 17). Colonic ...

journal_title：Gastroenterology

authors： Jaszewski R,Tolia V,Ehrinpreis MN,Bodzin JH,Peleman RR,Korlipara R,Weinstock JV

更新日期：1990-06-01 00:00:00

abstract：:In this review, we speculate about future therapeutic approaches for inflammatory bowel diseases (IBDs), focusing on the need for better preclinical and clinical models and approaches beyond small molecules and systemically administered biologics. We offer ideas to change clinical trial programs and to use immunologic...

journal_title：Gastroenterology

authors： Plevy SE,Targan SR

更新日期：2011-05-01 00:00:00

abstract：:Esophageal ligation in the pylorus-ligated rat significantly inhibited volume, titratable acidity, and titratable acid output and reduced the incidence of ulcers, perforations, and death of 18-hr pylorus-ligated rats. Draining the saliva outside the body of the rat by esophageal cannulation produced a significant incr...

journal_title：Gastroenterology

authors： Brodie DA,Knapp PG

更新日期：1966-06-01 00:00:00

abstract：:The prevalence of marginal zinc nutriture in several populations of people in this country and the lack of reports on the effect of marginal zinc nutriture in experimental animals prompted us to look at pancreatic acinar cell function and morphology in rats fed a zinc-deficient diet ad libitum: 4 and 50 ppm zinc-suppl...

journal_title：Gastroenterology

authors： Perez-Jimenez F,Bockman DE,Singh M

更新日期：1986-04-01 00:00:00

abstract：:Fc receptor-mediated clearance of immunoglobulin G-coated autologous erythrocytes was studied in patients with primary biliary cirrhosis (n = 14), alcoholic liver cirrhosis (n = 5) and healthy reference individuals (n = 14). The mean half-life of the sensitized erythrocytes was significantly prolonged in patients with...

journal_title：Gastroenterology

authors： Ekdahl KN,Lööf L,Nyberg A,Nilsson UR,Nilsson B

更新日期：1991-10-01 00:00:00

abstract：BACKGROUND & AIMS:Gastroesophageal reflux is common among patients with postnasal drainage. We investigated whether proton pump inhibitor therapy improved symptoms in patients with postnasal drainage without sinusitis or allergies. METHODS:In a parallel-group, double-blind, multi-specialty trial, we randomly assigned ...

journal_title：Gastroenterology

authors： Vaezi MF,Hagaman DD,Slaughter JC,Tanner SB,Duncavage JA,Allocco CT,Sparkman C,Clement LE,Wasden CM,Wirth D,Goutte M,McCafferty BA,Lanza DC

更新日期：2010-12-01 00:00:00

abstract：BACKGROUND & AIMS:Hypercoagulable states may play an important role in the pathogenesis of colon ischemia. Aim of this study was to assess this hypothesis investigating the role of acquired and hereditary thrombotic risk factors in patients with definite diagnosis of colon ischemia. METHODS:We compared the frequency o...

journal_title：Gastroenterology

authors： Koutroubakis IE,Sfiridaki A,Theodoropoulou A,Kouroumalis EA

更新日期：2001-09-01 00:00:00

abstract：:Using in vivo and in vitro techniques, the mechanism by which intestinal mucosa obtains glutamine from luminal oligopeptides was investigated in humans. The rate of hydrolysis by mucosal brush border membrane was more than threefold greater for alanylglutamine than for glycylglutamine. Despite this difference, rates o...

journal_title：Gastroenterology

authors： Minami H,Morse EL,Adibi SA

更新日期：1992-07-01 00:00:00

abstract：:Recent reports suggest most solid food enters the duodenum as small particles. Our studies showed that small particles of liver were capable of binding hydrogen ions (H+), but there was slow equilibration of H+ between particulate and aqueous phases. We wondered whether titratable acid as H+ bound to meat particles co...

journal_title：Gastroenterology

authors： Meyer JH,Fink AS

更新日期：1984-09-01 00:00:00

abstract：BACKGROUND & AIMS:Cirrhosis and portal hypertension due to chronic common bile duct ligation reproduce the features of human hepatopulmonary syndrome, whereas portal hypertension alone due to partial portal vein ligation does not. Nitric oxide contributes to experimental hepatopulmonary syndrome, but the nitric oxide s...

journal_title：Gastroenterology

authors： Zhang J,Ling Y,Luo B,Tang L,Ryter SW,Stockard CR,Grizzle WE,Fallon MB

更新日期：2003-11-01 00:00:00

abstract：BACKGROUND & AIMS:Visceral hypersensitivity plays a major role in the pathophysiology of inflammatory bowel syndrome (IBS). Opioid kappa receptors on afferent nerves may modulate it and may be the target of new IBS treatments. The aim of this study was to evaluate the effects of fedotozine, a potent and selective kappa...

journal_title：Gastroenterology

authors： Delvaux M,Louvel D,Lagier E,Scherrer B,Abitbol JL,Frexinos J

更新日期：1999-01-01 00:00:00

abstract：BACKGROUND & AIMS:Foxp3-expressing regulatory T cells (Tregs) play a key role in the maintenance of the gut immune homeostasis, and an intact transforming growth factor (TGF)-beta signaling is required for their function. In inflammatory bowel disease (IBD), the TGF-beta signaling is impaired because of high expression...

journal_title：Gastroenterology

authors： Fantini MC,Rizzo A,Fina D,Caruso R,Sarra M,Stolfi C,Becker C,Macdonald TT,Pallone F,Neurath MF,Monteleone G

更新日期：2009-04-01 00:00:00

abstract：:Sepsis following the placement of a transjugular intrahepatic portosystemic shunt (TIPS) has been reported in up to 10% of cases. This report describes an unusual case of polymicrobial gram-negative sepsis after placement of TIPS associated with a cholangiographically documented fistulous connection between the biliar...

journal_title：Gastroenterology

authors： Mallery S,Freeman ML,Peine CJ,Miller RP,Stanchfield WR

更新日期：1996-11-01 00:00:00

abstract：BACKGROUND & AIMS:Hypoxic inflammation (decreased oxygen tension at sites of inflammation) is a feature of inflammatory bowel disease (IBD). The hypoxia response is mediated by the transcription factors hypoxia-inducible factor (HIF) 1α and endothelial PAS domain protein 1 (EPAS1 or HIF2α), which are induced in intesti...

journal_title：Gastroenterology

authors： Xue X,Ramakrishnan S,Anderson E,Taylor M,Zimmermann EM,Spence JR,Huang S,Greenson JK,Shah YM

更新日期：2013-10-01 00:00:00

abstract：BACKGROUND & AIMS:The characteristics of colonic circular smooth muscle slow waves are altered during inflammation. The aim of this study was to examine whether inflammation modulates the open-state probability of Ca2+-activated K+ (KCa) channels in these cells to contribute to these alterations. METHODS:The experimen...

journal_title：Gastroenterology

authors： Lu G,Mazet B,Sun C,Qian X,Johnson CP,Adams MB,Roman RJ,Sarna SK

更新日期：1999-04-01 00:00:00