Aggravation of different types of experimental colitis by depletion or adhesion blockade of neutrophils.

abstract：BACKGROUND & AIMS:Some patients with irritable bowel syndrome with diarrhea (IBS-D) have intestinal hyperpermeability, which contributes to their diarrhea and abdominal pain. MicroRNA 29 (MIR29) regulates intestinal permeability in patients with IBS-D. We investigated and searched for targets of MIR29 and investigated ...

journal_title：Gastroenterology

authors： Zhou Q,Costinean S,Croce CM,Brasier AR,Merwat S,Larson SA,Basra S,Verne GN

更新日期：2015-01-01 00:00:00

abstract：:The pathogenesis of gastroesophageal reflux disease (GERD) is complex and involves changes in reflux exposure, epithelial resistance, and visceral sensitivity. The gastric refluxate is a noxious material that injures the esophagus and elicits symptoms. Esophageal exposure to gastric refluxate is the primary determinan...

journal_title：Gastroenterology

authors： Tack J,Pandolfino JE

更新日期：2018-01-01 00:00:00

abstract：:Weight gain and obesity are major risk factors for conditions and diseases ranging from insulin resistance and type 2 diabetes mellitus to atherosclerosis and the sequelae of nonalcoholic fatty liver disease. A chronic, subacute state of inflammation often accompanies the accumulation of excess lipid in adipose tissue...

journal_title：Gastroenterology

authors： Shoelson SE,Herrero L,Naaz A

更新日期：2007-05-01 00:00:00

abstract：:In humans and most other species, a decline in pH of gallbladder contents occurs during the concentration of bile. Recent in vitro studies in rabbit, guinea pig, and Necturus gallbladders have strongly suggested mucosal H+ secretion during sodium reabsorption, presumably representing a Na+/H+ exchange. The present in ...

journal_title：Gastroenterology

authors： Rege RV,Moore EW

更新日期：1987-02-01 00:00:00

abstract：:Rising trends in the incidence and mortality of early-onset CRC in those who are ages less than 50 years have been well-established. These trends have spurred intense investigation focused on elucidating the epidemiology and characteristics of early-onset CRC, as well on identifying strategies for early detection and ...

journal_title：Gastroenterology

authors： Burnett-Hartman AN,Lee JK,Demb J,Gupta S

更新日期：2021-01-05 00:00:00

abstract：:This report defines criteria and reviews the epidemiology, pathophysiology, and management of common anorectal disorders: fecal incontinence (FI), functional anorectal pain and functional defecation disorders. FI is defined as the recurrent uncontrolled passage of fecal material for at least 3 months. The clinical fea...

journal_title：Gastroenterology

authors： Rao SS,Bharucha AE,Chiarioni G,Felt-Bersma R,Knowles C,Malcolm A,Wald A

更新日期：2016-03-25 00:00:00

abstract：BACKGROUND & AIMS:Defects in the epithelial tight junction (TJ) barrier contribute to development of intestinal inflammation associated with diseases. Interleukin 1 beta (IL1B) increases intestinal permeability in mice. We investigated microRNAs that are regulated by IL1B and their effects on expression of TJ proteins ...

journal_title：Gastroenterology

authors： Rawat M,Nighot M,Al-Sadi R,Gupta Y,Viszwapriya D,Yochum G,Koltun W,Ma TY

更新日期：2020-10-01 00:00:00

abstract：DESCRIPTION:The purpose of this American Gastroenterological Association (AGA) Institute Clinical Practice Update is to review the available evidence and best practice advice statements regarding the use of endoscopic therapies in treating patients with non-variceal upper gastrointestinal bleeding. METHODS:This expert...

journal_title：Gastroenterology

authors： Mullady DK,Wang AY,Waschke KA

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND & AIMS:Although different brands of fecal immunochemical tests (FITs) are used for colorectal cancer (CRC) screening, few studies have compared their accuracy in detecting advanced neoplasia. METHODS:We performed a large prospective cohort study within the Dutch national CRC screening program to evaluate 2 ...

journal_title：Gastroenterology

authors： Wieten E,de Klerk CM,van der Steen A,Ramakers CR,Kuipers EJ,Hansen BE,Lansdorp-Vogelaar I,Bossuyt PM,Dekker E,Spaander MCW

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND/AIMS:Carbonic anhydrase activity plays a role in electrolyte transport in many tissues. This study examined the effect of the carbonic anhydrase inhibitor acetazolamide on human basal and prostaglandin E2- and acid-stimulated duodenal mucosal bicarbonate secretion and transmucosal electrical potential differ...

journal_title：Gastroenterology

authors： Knutson TW,Koss MA,Hogan DL,Isenberg JI,Knutson L

更新日期：1995-01-01 00:00:00

abstract：BACKGROUND & AIMS:Oral bile acid replacement has been shown to be an effective therapy in primary bile acid synthesis defects, but to date there have been no reports of the long-term effects of this therapy. The aim of the study was to evaluate the long-term effectiveness and safety of cholic acid (CA) therapy. METHOD...

journal_title：Gastroenterology

authors： Gonzales E,Gerhardt MF,Fabre M,Setchell KD,Davit-Spraul A,Vincent I,Heubi JE,Bernard O,Jacquemin E

更新日期：2009-10-01 00:00:00

abstract：:We have quantified neurotransmitter changes in the rat jejunum in which the myenteric neurons were ablated by serosal application of benzalkonium chloride. Within 2 days after benzalkonium chloride treatment, there was a 40% reduction in the activity of choline acetyltransferase, a specific marker for cholinergic neur...

journal_title：Gastroenterology

authors： Dahl JL,Bloom DD,Epstein ML,Fox DA,Bass P

更新日期：1987-02-01 00:00:00

abstract：BACKGROUND & AIMS:The adenoma detection rate (ADR) is an important quality indicator of screening colonoscopy; it is inversely associated with risk of interval cancers and colorectal cancer mortality. We assessed trends in the ADR in the first 10 years of the German screening colonoscopy program. METHODS:We calculated...

journal_title：Gastroenterology

authors： Brenner H,Altenhofen L,Kretschmann J,Rösch T,Pox C,Stock C,Hoffmeister M

更新日期：2015-08-01 00:00:00

abstract：BACKGROUND AND AIMS:Autoimmune responses against colonic epithelium may play a role in the development of colonic inflammation associated with ulcerative colitis (UC). In this study, we established and characterized B-cell lines and clones that produced anticolon antibody from inflamed colonic mucosa of UC subjects. M...

journal_title：Gastroenterology

authors： Inoue N,Watanabe M,Sato T,Okazawa A,Yamazaki M,Kanai T,Ogata H,Iwao Y,Ishii H,Hibi T

更新日期：2001-07-01 00:00:00

abstract：:A new experimental model, the isolated perfused antrectomized pig stomach with intact vagal innervation, was shown to produce pepsinogen and gastric acid upon electrical stimulation of the vagus nerves and by intravascular administration of carbachol (from a basal value of 111 +/- 24 units of pepsin per minute and 0.0...

journal_title：Gastroenterology

authors： Skak-Nielsen T,Holst JJ,Nielsen OV

更新日期：1988-11-01 00:00:00

abstract：BACKGROUND & AIMS:Increased levels of galectin 3 have been associated with nonalcoholic steatohepatitis (NASH) and contribute to toxin-induced liver fibrosis in mice. GR-MD-02 (belapectin) is an inhibitor of galectin 3 that reduces liver fibrosis and portal hypertension in rats and was safe and well tolerated in phase ...

journal_title：Gastroenterology

authors： Chalasani N,Abdelmalek MF,Garcia-Tsao G,Vuppalanchi R,Alkhouri N,Rinella M,Noureddin M,Pyko M,Shiffman M,Sanyal A,Allgood A,Shlevin H,Horton R,Zomer E,Irish W,Goodman Z,Harrison SA,Traber PG,Belapectin (GR-MD-02) Stud

更新日期：2020-04-01 00:00:00

abstract：:Helicobacter pylori infects the stomach of half of the human population worldwide and causes chronic active gastritis, which can lead to peptic ulcer disease, gastric adenocarcinoma, and mucosa-associated lymphoid tissue lymphoma. The host immune response to the infection is ineffective, because the bacterium persists...

journal_title：Gastroenterology

authors： Wilson KT,Crabtree JE

更新日期：2007-07-01 00:00:00

abstract：:The prevalence of delta-markers among 71 patients with fulminant B viral hepatitis was found to be 33.8%. The majority of the patients with delta-markers showed serologic evidence of simultaneous acute delta-infection and B viral infection. Only 5 of the 24 patients with serologic markers of acute delta-infection in t...

journal_title：Gastroenterology

authors： Govindarajan S,Chin KP,Redeker AG,Peters RL

更新日期：1984-06-01 00:00:00

abstract：BACKGROUND & AIMS:Although ustekinumab is an effective therapy for moderate to severe Crohn's disease (CD), its effects on the microscopic manifestations of CD are unknown. METHODS:We evaluated the effects of ustekinumab on histologic CD activity in an analysis of data from 251 participants in phase 3 induction and ma...

journal_title：Gastroenterology

authors： Li K,Friedman JR,Chan D,Pollack P,Yang F,Jacobstein D,Brodmerkel C,Gasink C,Feagan BG,Sandborn WJ,Rutgeerts P,De Hertogh G

更新日期：2019-10-01 00:00:00

abstract：:Cholylglycylhistamine, a derivative of cholic acid, has been synthesized and characterized. This derivative has been iodinated using Na125I and chloramine-T and purified free from unlabeled cholylglycylhistamine. Application of this iodinated bile salt derivative to radioimmunoassay of bile salts in human serum is rep...

journal_title：Gastroenterology

authors： Spenney JG,Johnson BJ,Hirschowitz BI,Mihas AA,Gibson R

更新日期：1977-02-01 00:00:00

abstract：:Serum group I pepsinogen (PG I) levels, basal acid output, and peak acid output (PAO) have been determined in 120 patients, 54 with duodenal ulcer, 14 with prepyloric ulcer, 12 with gastric ulcer, and 40 without ulcer. The correlation between serum PG I and PAO was statistically significant (r = 0.736, P less than 0.0...

journal_title：Gastroenterology

authors： Samloff IM,Secrist DM,Passaro E Jr

更新日期：1975-12-01 00:00:00

abstract：:A case is presented of a 76-yr-old woman with primary biliary cirrhosis and adult polycystic liver disease who developed bone marrow toxicity associated with chronic low-dose colchicine therapy. Two months after starting colchicine therapy (0.6 mg b.i.d. p.o.), the patient developed hematologic toxicity as evidenced b...

journal_title：Gastroenterology

authors： Finklestein M,Goldman L,Grace ND,Foley M,Randall N

更新日期：1987-12-01 00:00:00

abstract：BACKGROUND:Nitric oxide acts as a neurotransmitter of nonadrenergic, noncholinergic pathways. The present study examined the role of the L-arginine/NO pathway on sphincter of Oddi motility. METHODS:In anesthetized guinea pigs and rabbits, intracholedochal pressure was recorded by a perfused catheter whose open tip was...

journal_title：Gastroenterology

authors： Mourelle M,Guarner F,Moncada S,Malagelada JR

更新日期：1993-11-01 00:00:00

abstract：:Antimitochondrial antibodies, serological hallmarks of primary biliary cirrhosis, recently were found to be directed against the E2 subunits of mitochondrial dehydrogenase complexes (pyruvate, branched-chain ketoacid, and alpha-ketoglutarate dehydrogenases). The objectives of this study were to extend these findings a...

journal_title：Gastroenterology

authors： Yoshida T,Bonkovsky H,Ansari A,Danner D

更新日期：1990-07-01 00:00:00

abstract：:Three cases of Stevens-Johnson syndrome with intestinal involvement are described. Two patients had esophageal involvement, the severity of which paralleled skin lesions and, in 1 case, probably contributed to death. Dysphagia and bleeding were manifestations. The third patient was unique and had gastric, small and la...

journal_title：Gastroenterology

authors： Zweiban B,Cohen H,Chandrasoma P

更新日期：1986-08-01 00:00:00

abstract：BACKGROUND & AIMS:Krüppel-like factor 5 (KLF5) is a transcription factor that promotes proliferation, is highly expressed in dividing crypt cells of the gastrointestinal epithelium, and is induced by various stress stimuli. We sought to determine the role of KLF5 in colonic inflammation and recovery by studying mice wi...

journal_title：Gastroenterology

authors： McConnell BB,Kim SS,Bialkowska AB,Yu K,Sitaraman SV,Yang VW

更新日期：2011-02-01 00:00:00

abstract：:Spontaneous remission of gastric acid hypersecretion in the Zollinger-Ellison syndrome occurs rarely. This study shows the development of gastric secretory mucosal atrophy resulting in achlorhydria and loss of pepsin secretion in a 63-year-old woman with the Zollinger-Ellison syndrome. Reduced secretion began soon aft...

journal_title：Gastroenterology

authors： Griffith JL,Cummings OW,Hirschowitz BI

更新日期：1991-07-01 00:00:00

abstract：BACKGROUND & AIMS:We previously demonstrated that the 2 APC mutations in human colorectal tumors are coselected, because tumorigenesis requires an optimal level of Wnt signaling. We and others subsequently showed that the truncated APC proteins in colorectal tumors usually retain a total of 1-2 beta-catenin binding/deg...

journal_title：Gastroenterology

authors： Pollard P,Deheragoda M,Segditsas S,Lewis A,Rowan A,Howarth K,Willis L,Nye E,McCart A,Mandir N,Silver A,Goodlad R,Stamp G,Cockman M,East P,Spencer-Dene B,Poulsom R,Wright N,Tomlinson I

更新日期：2009-06-01 00:00:00

abstract：BACKGROUND & AIMS:Trinitrobenzene sulfonic acid (TNBS)-induced colitis is a T-helper 1 (Th1) T cell-mediated inflammation that is rapidly reversed by administration of anti-interleukin (IL) 12. This study sought to define the mechanism of this curative effect. METHODS:Cells and tissue from mice with TNBS colitis recei...

journal_title：Gastroenterology

authors： Fuss IJ,Marth T,Neurath MF,Pearlstein GR,Jain A,Strober W

更新日期：1999-11-01 00:00:00

abstract：BACKGROUND & AIMS:There have been few studies of the role of de novo lipogenesis in the development of nonalcoholic fatty liver disease (NAFLD). We used isotope analyses to compare de novo lipogenesis and fatty acid flux between subjects with NAFLD and those without, matched for metabolic factors (controls). METHODS:W...

journal_title：Gastroenterology

authors： Lambert JE,Ramos-Roman MA,Browning JD,Parks EJ

更新日期：2014-03-01 00:00:00