Acute and chronic cyclooxygenase blockage in portal-hypertensive rats: influence in nitric oxide biosynthesis.


BACKGROUND & AIMS:Prostacyclin and nitric oxide have been involved in the hyperkinetic syndrome in portal hypertension. The aim of this study was to investigate the relative contribution and possible interaction between prostacyclin and NO in this circulatory abnormality. METHODS:Portal vein-ligated and sham-operated rats received indomethacin and vehicle either on a short-term (5 mg/kg subcutaneously) or long-term basis (5, continuous 7-day infusion with an osmotic minipump). Measurements of arterial pressure and superior mesenteric arterial flow (, ultrasonic flow probe) were then performed before and after NG-nitro-L-arginine methyl ester (L-NAME) injection (13 mg/kg intravenously). RESULTS:Short-term or long-term indomethacin treatment had no effect in sham-operated rats but significantly decreased mesenteric arterial flow in portal-hypertensive rats. Mesenteric flow remained higher after long-term than after short-term indomethacin treatment (54.5 +/- 2 vs. 46.1 +/- 2; P = 0.01). This blunted response to long-term indomethacin treatment was associated with an enhanced response to L-NAME, shown by greater increments in arterial pressure (29% +/- 3%) and mesenteric arterial resistance (209 +/- 22%) in indomethacin-treated rats than in rats receiving vehicle (19% +/- 2% and 130% +/- 20%; P < 0.05). CONCLUSIONS:Both prostacyclin and NO contributed to splanchnic hyperemia in portal-hypertensive rats. There was an enhanced release of NO after long-term prostacyclin inhibition, suggesting that both vasodilatory systems interact, promoting splanchnic hyperemia in portal hypertension.






Fernández M,García-Pagán JC,Casadevall M,Mourelle MI,Piqué JM,Bosch J,Rodés J




Has Abstract


1996-05-01 00:00:00














  • Bile acid is a host factor that regulates the composition of the cecal microbiota in rats.

    abstract:BACKGROUND & AIMS:Alterations in the gastrointestinal microbiota have been associated with metabolic diseases. However, little is known about host factors that induce changes in gastrointestinal bacterial populations. We investigated the role of bile acids in this process because of their strong antimicrobial activitie...


    pub_type: 杂志文章


    authors: Islam KB,Fukiya S,Hagio M,Fujii N,Ishizuka S,Ooka T,Ogura Y,Hayashi T,Yokota A

    更新日期:2011-11-01 00:00:00

  • Gastrointestinal health care resource utilization with chronic use of COX-2-specific inhibitors versus traditional NSAIDs.

    abstract:BACKGROUND & AIMS:Cyclooxygenase 2 (COX-2)-specific inhibitors (coxibs) decrease gastrointestinal (GI) events in controlled trials, but results in clinical practice are unknown. We assessed GI-related resource use and costs in patients switching from chronic nonsteroidal anti-inflammatory drug (NSAID) therapy to chroni...


    pub_type: 杂志文章


    authors: Laine L,Wogen J,Yu H

    更新日期:2003-08-01 00:00:00

  • Sites of clonidine action to inhibit gut propulsion in mice: demonstration of a central component.

    abstract::The role of central (supraspinal and spinal) and peripheral alpha-adrenoceptors in the regulation of gastrointestinal propulsion in the mouse was studied using clonidine, an alpha 2-adrenoceptor agonist. Clonidine produced a dose-dependent inhibition of propulsion when given intracerebroventricularly, intrathecally, o...


    pub_type: 杂志文章


    authors: Jiang Q,Sheldon RJ,Porreca F

    更新日期:1988-11-01 00:00:00

  • The arginine/nitric oxide pathway modulates sphincter of Oddi motor activity in guinea pigs and rabbits.

    abstract:BACKGROUND:Nitric oxide acts as a neurotransmitter of nonadrenergic, noncholinergic pathways. The present study examined the role of the L-arginine/NO pathway on sphincter of Oddi motility. METHODS:In anesthetized guinea pigs and rabbits, intracholedochal pressure was recorded by a perfused catheter whose open tip was...


    pub_type: 杂志文章


    authors: Mourelle M,Guarner F,Moncada S,Malagelada JR

    更新日期:1993-11-01 00:00:00

  • Quantitative endoscopic ultrasound elastography: an accurate method for the differentiation of solid pancreatic masses.

    abstract:BACKGROUND & AIMS:Qualitative endoscopic ultrasound (EUS) elastography is an accurate but subjective tool for the differential diagnosis of solid pancreatic masses. Second-generation EUS elastography allows quantitative analysis of tissue stiffness. We evaluated the accuracy of quantitative, second-generation EUS elast...


    pub_type: 杂志文章


    authors: Iglesias-Garcia J,Larino-Noia J,Abdulkader I,Forteza J,Dominguez-Munoz JE

    更新日期:2010-10-01 00:00:00

  • Hepatocellular Carcinomas With Mutational Activation of Beta-Catenin Require Choline and Can Be Detected by Positron Emission Tomography.

    abstract:BACKGROUND & AIMS:In one-third of hepatocellular carcinomas (HCCs), cancer cells have mutations that activate β-catenin pathway. These cells have alterations in glutamine, bile, and lipid metabolism. We investigated whether positron emission tomography (PET) imaging allows identification of altered metabolic pathways t...


    pub_type: 杂志文章


    authors: Gougelet A,Sartor C,Senni N,Calderaro J,Fartoux L,Lequoy M,Wendum D,Talbot JN,Prignon A,Chalaye J,Imbeaud S,Zucman-Rossi J,Tordjmann T,Godard C,Bossard P,Rosmorduc O,Amaddeo G,Colnot S

    更新日期:2019-09-01 00:00:00

  • Chronic mild restraint protects the rat gastric mucosa from injury by ethanol or cold restraint.

    abstract::The effects of chronic mild restraint on the susceptibility of the rat gastric mucosa to ethanol or cold-restraint injury were studied. Gastric mucosas of animals subjected to chronic mild restraint exhibited less damage when bathed with 40% ethanol than those of control animals. This reduced damage was observed with ...


    pub_type: 杂志文章


    authors: Wallace JL,Track NS,Cohen MM

    更新日期:1983-08-01 00:00:00

  • The pregnane X receptor locus is associated with susceptibility to inflammatory bowel disease.

    abstract:BACKGROUND & AIMS:The pregnane X receptor (PXR) regulates an array of genes involved in the response to xenobiotics. Evidence from several studies suggests that xenobiotic metabolism may play a role in inflammatory bowel disease (IBD) and that low levels of PXR may be associated with disease expression. The aim of this...


    pub_type: 杂志文章


    authors: Dring MM,Goulding CA,Trimble VI,Keegan D,Ryan AW,Brophy KM,Smyth CM,Keeling PW,O'Donoghue D,O'Sullivan M,O'Morain C,Mahmud N,Wikström AC,Kelleher D,McManus R

    更新日期:2006-02-01 00:00:00

  • Effects of somatostatin on gallbladder emptying.

    abstract::Because approximately 80% of reported patients with somatostatinomas have gallstones, this study was performed to determine the effects of exogenous somatostatin on gallbladder emptying responses to liquid and solid meals, direct cholinergic stimulation by bethanechol, indirect cholinergic stimulation by sham feeding,...


    pub_type: 杂志文章


    authors: Fisher RS,Rock E,Levin G,Malmud L

    更新日期:1987-04-01 00:00:00

  • Cholelitholysis using methyl tertiary butyl ether.

    abstract::We tested methyl tertiary butyl ether both in vitro and in vivo to evaluate its efficacy as a potential cholesterol gallstone solvent for direct instillation into the human gallbladder or bile duct. Like diethyl ether, methyl tertiary butyl ether is an aliphatic ether with an excellent cholesterol-solubilizing capacit...


    pub_type: 杂志文章


    authors: Allen MJ,Borody TJ,Bugliosi TF,May GR,LaRusso NF,Thistle JL

    更新日期:1985-01-01 00:00:00

  • The forkhead transcription factor FoxO1 regulates proliferation and transdifferentiation of hepatic stellate cells.

    abstract:BACKGROUND & AIMS:The Forkhead box gene, group O (FoxO) family of Forkhead transcription factors is phopsphorylated and inactivated by the phosphatidylinositol 3-kinase (PI3K)/AKT pathway and regulates a variety of cellular functions. Hepatic stellate cells (HSCs) play a crucial role in liver fibrosis. A fibrotic stimu...


    pub_type: 杂志文章


    authors: Adachi M,Osawa Y,Uchinami H,Kitamura T,Accili D,Brenner DA

    更新日期:2007-04-01 00:00:00

  • AGA technical review on the evaluation and management of occult and obscure gastrointestinal bleeding.

    abstract::This literature review and the recommendations therein were prepared for the American Gastroenterological Association Clinical Practice and Practice Economics committee. The paper was approved by the committee on May 16, 1999, and by the AGA governing board on July 18, 1999. ...


    pub_type: 杂志文章,评审


    authors: Zuckerman GR,Prakash C,Askin MP,Lewis BS

    更新日期:2000-01-01 00:00:00

  • Augmentation of ethanol absorption by mono- and disaccharides.

    abstract::Assessment of the influence of nutritional substrates on the disposition of ingested ethanol from the blood requires, first, an understanding of the influence that these may exert upon ethanol absorption from the gastrointestinal tract. In this report, the effects of various carbohydrates on the intestinal absorption ...


    pub_type: 杂志文章


    authors: Broitman SA,Gottlieb LS,Vitale JJ

    更新日期:1976-06-01 00:00:00

  • Defective Fc receptor-mediated clearance in patients with primary biliary cirrhosis.

    abstract::Fc receptor-mediated clearance of immunoglobulin G-coated autologous erythrocytes was studied in patients with primary biliary cirrhosis (n = 14), alcoholic liver cirrhosis (n = 5) and healthy reference individuals (n = 14). The mean half-life of the sensitized erythrocytes was significantly prolonged in patients with...


    pub_type: 杂志文章


    authors: Ekdahl KN,Lööf L,Nyberg A,Nilsson UR,Nilsson B

    更新日期:1991-10-01 00:00:00

  • Effect of endogenous hypergastrinemia on gastrin receptor expressing human colon carcinoma transplanted to athymic rats.

    abstract:BACKGROUND & AIMS:The effect of endogenous hypergastrinemia on growth of human colon carcinoma is not known. Our aim was to study the growth of human colon carcinoma in an animal model with endogenous hypergastrinemia. METHODS:Human colon carcinoma was transplanted to the colon of 40 athymic rats. Of these, 25 underwe...


    pub_type: 杂志文章


    authors: Chu M,Nielsen FC,Franzén L,Rehfeld JF,Holst JJ,Borch K

    更新日期:1995-11-01 00:00:00

  • In vitro characterization of human intestinal intraepithelial lymphocytes.

    abstract::Enriched populations of human intestinal and colonic intraepithelial lymphocytes were isolated separate from lamina propria lymphocytes. These populations, and peripheral blood mononuclear cells, were characterized for membrane features, lymphocyte subsets, and proliferative potential to the nonspecific mitogenic lect...


    pub_type: 杂志文章


    authors: Greenwood JH,Austin LL,Dobbins WO 3rd

    更新日期:1983-11-01 00:00:00

  • Effect of exorphins on gastrointestinal function, hormonal release, and appetite.

    abstract::Peptic digestion of gluten results in the production of substances having opiatelike activity in bio- and receptor assays. These substances have been termed exorphins. In this study, we determined the effect of gluten, hydrolyzed gluten, and hydrolyzed gluten plus the opiate blocker naloxone on a variety of hormonal p...


    pub_type: 杂志文章


    authors: Morley JE,Levine AS,Yamada T,Gebhard RL,Prigge WF,Shafer RB,Goetz FC,Silvis SE

    更新日期:1983-06-01 00:00:00

  • Discordant HLA haplotype segregation in familial Crohn's disease.

    abstract::To look for possible HLA linkage in familial Crohn's disease, HLA haplotype segregation patterns were determined in 70 members of five kindreds, each having 2 or more patients with Crohn's disease (total number: 13 with Crohn's disease, 1 with ulcerative colitis). Concordant segregation of HLA haplotypes and disease w...


    pub_type: 杂志文章


    authors: Eade OE,Moulton C,MacPherson BR,Andre-Ukena SS,Albertini RJ,Beeken WL

    更新日期:1980-08-01 00:00:00

  • Complementary functions of the flippase ATP8B1 and the floppase ABCB4 in maintaining canalicular membrane integrity.

    abstract:BACKGROUND & AIMS:Progressive familial intrahepatic cholestasis can be caused by mutations in ABCB4 or ATP8B1; each encodes a protein that translocates phospholipids, but in opposite directions. ABCB4 flops phosphatidylcholine from the inner to the outer leaflet, where it is extracted by bile salts. ATP8B1, in complex ...


    pub_type: 杂志文章


    authors: Groen A,Romero MR,Kunne C,Hoosdally SJ,Dixon PH,Wooding C,Williamson C,Seppen J,Van den Oever K,Mok KS,Paulusma CC,Linton KJ,Oude Elferink RP

    更新日期:2011-11-01 00:00:00

  • Multiple pathways for amino acid transport in brush border membrane vesicles isolated from the human fetal small intestine.

    abstract::The present study was undertaken to identify the different amino acid transport pathways present in the human small intestine during the early gestational period. The uptake time courses of neutral (L-leucine, L-alanine, L-methionine), acidic (L-glutamic and D-aspartic acids), basic (L-lysine), and imino (L-proline) a...


    pub_type: 杂志文章


    authors: Malo C

    更新日期:1991-06-01 00:00:00

  • The importance of local acid production in the distribution of Helicobacter felis in the mouse stomach.

    abstract:BACKGROUND/AIMS:Helicobacter felis colonizes the gastric mucosa of rodents. Preliminary studies showed differences in the distribution of the organism in different parts of the stomach that seemed related to the secretory capacity of the mucosa. The aim of this study was to determine the localization of H. felis in the...


    pub_type: 杂志文章


    authors: Danon SJ,O'Rourke JL,Moss ND,Lee A

    更新日期:1995-05-01 00:00:00

  • Gallbladder filling and emptying during cholesterol gallstone formation in the prairie dog. A cholescintigraphic study.

    abstract::We studied gallbladder bile flow before, during, and after cholesterol gallstone formation in the prairie dog using infusion cholescintigraphy with 99mTc-diethyl iminodiacetic acid. In 18 fasting animals partitioning of bile between gallbladder and intestine was determined every 15 min for 140 min, and gallbladder res...


    pub_type: 杂志文章


    authors: Pellegrini CA,Ryan T,Broderick W,Way LW

    更新日期:1986-01-01 00:00:00

  • Phosphoinositide 3-kinase signaling mediates beta-catenin activation in intestinal epithelial stem and progenitor cells in colitis.

    abstract:BACKGROUND & AIMS:Mechanisms responsible for crypt architectural distortion in chronic ulcerative colitis (CUC) are not well understood. Data indicate that serine/threonine protein kinase Akt (Akt) signaling cooperates with Wingless (Wnt) to activate beta-catenin in intestinal stem and progenitor cells through phosphor...


    pub_type: 杂志文章


    authors: Lee G,Goretsky T,Managlia E,Dirisina R,Singh AP,Brown JB,May R,Yang GY,Ragheb JW,Evers BM,Weber CR,Turner JR,He XC,Katzman RB,Li L,Barrett TA

    更新日期:2010-09-01 00:00:00

  • Pregnancy-related changes in small intestinal myoelectric activity in the rat.

    abstract::To determine if changes in intestinal motility occur during pregnancy, we studied small intestinal myoelectric activity, using monopolar electrodes, in fasted pregnant rats from day 12 to day 18 of the 22-day gestation period. We also studied fasting myoelectric activity in postpartum, nonpregnant, and castrate female...


    pub_type: 杂志文章


    authors: Scott LD,Lester R,Van Thiel DH,Wald A

    更新日期:1983-02-01 00:00:00

  • Fecal porphyrin abnormalities in a patient with features of Rotor's syndrome.

    abstract::Detailed porphyrin analysis and additional ultrastructural abnormalities of liver cells are described in a patient with features of Rotor's syndrome. Normal values of porphyrin precursors, delta-aminolevulinic acid and porphobilinogen, and porphyrins were found in plasma, urine, and erythrocytes. However, fecal porphy...


    pub_type: 杂志文章


    authors: Evans J,Lefkowitch J,Lim CK,Billing B

    更新日期:1981-12-01 00:00:00

  • Comparison of endogenous and radiolabeled bile acid excretion in patients with idiopathic chronic diarrhea.

    abstract::Fecal recovery of radioactivity after ingestion of a bolus of radiolabeled bile acid is abnormally high in most patients with idiopathic chronic diarrhea. To evaluate the significance of this malabsorption, concurrent fecal excretion of both exogenous radiolabeled bile acid and endogenous (unlabeled) bile acid were me...


    pub_type: 杂志文章


    authors: Schiller LR,Bilhartz LE,Santa Ana CA,Fordtran JS

    更新日期:1990-04-01 00:00:00

  • Adenine arabinoside therapy in HBsAg-positive chronic liver disease: a controlled study.

    abstract::A controlled trial has been undertaken to evaluate adenine arabinoside in the treatment of hepatitis B surface antigen-positive chronic liver disease. Thirteen patients (7 hepatitis B virus DNA polymerase and hepatitis B e antigen-positive, 6 DNA polymerase negative and hepatitis B e antibody-positive) were treated wi...


    pub_type: 临床试验,杂志文章


    authors: Bassendine MF,Chadwick RG,Salmeron J,Shipton U,Thomas HC,Sherlock S

    更新日期:1981-05-01 00:00:00

  • Relationship between patterns of bleeding and Hemoccult sensitivity in patients with colorectal cancers or adenomas.

    abstract::Although Hemoccult (Smith Kline Diagnostics, Inc., Sunnyvale, Calif.) screening for colorectal cancer is based on detection of the peroxidase activity of blood, little is known about the relationship between patterns of bleeding from cancers or adenomas and sensitivity of the test slides. 51Cr-labeled blood loss was m...


    pub_type: 杂志文章


    authors: Macrae FA,St John DJ

    更新日期:1982-05-01 00:00:00

  • Interleukin 1 Up-regulates MicroRNA 135b to Promote Inflammation-Associated Gastric Carcinogenesis in Mice.

    abstract:BACKGROUND & AIMS:Gastritis is associated with development of stomach cancer, but little is known about changes in microRNA expression patterns during gastric inflammation. Specific changes in gene expression in epithelial cells are difficult to monitor because of the heterogeneity of the tissue. We investigated epithe...


    pub_type: 杂志文章


    authors: Han TS,Voon DC,Oshima H,Nakayama M,Echizen K,Sakai E,Yong ZWE,Murakami K,Yu L,Minamoto T,Ock CY,Jenkins BJ,Kim SJ,Yang HK,Oshima M

    更新日期:2019-03-01 00:00:00

  • Guidelines for colonoscopy surveillance after polypectomy: a consensus update by the US Multi-Society Task Force on Colorectal Cancer and the American Cancer Society.

    abstract::Adenomatous polyps are the most common neoplastic findings discovered in people who undergo colorectal screening or who have a diagnostic work-up for symptoms. It was common practice in the 1970s for these patients to have annual follow-up surveillance examinations to detect additional new adenomas and missed synchron...


    pub_type: 杂志文章,实务指引,评审


    authors: Winawer SJ,Zauber AG,Fletcher RH,Stillman JS,O'Brien MJ,Levin B,Smith RA,Lieberman DA,Burt RW,Levin TR,Bond JH,Brooks D,Byers T,Hyman N,Kirk L,Thorson A,Simmang C,Johnson D,Rex DK,US Multi-Society Task Force on Colo

    更新日期:2006-05-01 00:00:00