当前位置： SCI文献检索 > GASTROENTEROLOGY期刊下所有文献 > Antibiotic efficacy in small intestinal bacterial overgrowth-related chronic diarrhea: a crossover, randomized trial.

Antibiotic efficacy in small intestinal bacterial overgrowth-related chronic diarrhea: a crossover, randomized trial.

Abstract：

BACKGROUND & AIMS:No controlled trial has examined the clinical efficacy of antibiotics in small bowel bacterial overgrowth. METHODS:Ten patients with bacterial overgrowth-related diarrhea underwent the following five 7-day treatment periods: untreated (control period), then placebo, and subsequently, in random order and blinded fashion, norfloxacin (800 mg/day), amoxicillin-clavulanic acid (1500 mg/day), and Saccharomyces boulardii (1500 mg/day). A hydrogen breath test was performed on the first and last day of each period. RESULTS:Daily stool frequency was similar during the control and placebo periods (4.2 +/- 0.6 vs. 3.9 +/- 0.6 [mean +/- SEM], respectively). Norfloxacin and amoxicillin-clavulanic acid led to a significant reduction in daily stool frequency (2.3 +/- 0.4 and 3.0 +/- 0.5, respectively; P < 0.01 vs. placebo period) after 2.0 +/- 1.4 and 1.2 +/- 0.4 days, which was maintained for 6.1 +/- 3.7 and 6.0 +/- 9.6 days, respectively. Breath-expired H(2) volume decreased with norfloxacin (37 +/- 8 to 12 +/- 5 mL per 2 hours; P < 0.01) and amoxicillin-clavulanic acid (24 +/- 6 to 8 +/- 4 mL per 2 hours, respectively; P = 0.01), but H(2) breath test result was negative in only 3 and 5 patients. CONCLUSIONS:Norfloxacin and amoxicillin-clavulanic acid are effective in the treatment of bacterial overgrowth-related diarrhea.

journal_name

Gastroenterology

journal_title

Gastroenterology

authors

Attar A,Flourié B,Rambaud JC,Franchisseur C,Ruszniewski P,Bouhnik Y

doi

10.1016/s0016-5085(99)70336-7

keywords:

subject

Has Abstract

pub_date

1999-10-01 00:00:00

pages

794-7

issue

4

eissn

0016-5085

issn

1528-0012

pii

S0016508599003339

journal_volume

117

pub_type

临床试验,杂志文章,随机对照试验

相关文献

GASTROENTEROLOGY文献大全
  • Comparison of endogenous and radiolabeled bile acid excretion in patients with idiopathic chronic diarrhea.

    abstract：:Fecal recovery of radioactivity after ingestion of a bolus of radiolabeled bile acid is abnormally high in most patients with idiopathic chronic diarrhea. To evaluate the significance of this malabsorption, concurrent fecal excretion of both exogenous radiolabeled bile acid and endogenous (unlabeled) bile acid were me...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/0016-5085(90)90031-u

    authors： Schiller LR,Bilhartz LE,Santa Ana CA,Fordtran JS

    更新日期：1990-04-01 00:00:00

  • AGA Technical Review on the Evaluation of Functional Diarrhea and Diarrhea-Predominant Irritable Bowel Syndrome in Adults (IBS-D).

    abstract：BACKGROUND & AIMS:The evaluation of patients with chronic watery diarrhea represents a diagnostic challenge for clinicians because organic causes, including inflammatory bowel disease, microscopic colitis, and chronic infection, must be differentiated from functional diarrhea and diarrhea-predominant irritable bowel sy...

    journal_title：Gastroenterology

    pub_type： 杂志文章,实务指引,评审

    doi：10.1053/j.gastro.2019.06.014

    authors： Carrasco-Labra A,Lytvyn L,Falck-Ytter Y,Surawicz CM,Chey WD

    更新日期：2019-09-01 00:00:00

  • Toll-like receptor 2 controls mucosal inflammation by regulating epithelial barrier function.

    abstract：BACKGROUND & AIMS:Toll-like receptors (TLRs) represent a class of transmembrane pattern recognition receptors essential for microbial recognition and control of innate immune responses. Commensal bacteria play an important role in maintaining tolerance and active stability of the intestinal epithelial barrier by suppre...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2007.02.056

    authors： Cario E,Gerken G,Podolsky DK

    更新日期：2007-04-01 00:00:00

  • Serum bile acid concentrations during pregnancy and their relationship to obstetric cholestasis.

    abstract：:We have prospectively studied changes in serum postprandial cholylglycine (CG) concentration during 297 pregnancies. We found an increase in CG concentration from 0.3 mumol/L at 15 weeks' pregnancy to 0.6 mumol/L at 40 weeks' pregnancy. Although this increase was statistically significant (p less than 0.005), median c...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/0016-5085(86)90682-7

    authors： Lunzer M,Barnes P,Byth K,O'Halloran M

    更新日期：1986-10-01 00:00:00

  • An update on the epidemiology, molecular characterization, diagnosis, and screening strategies for early-onset colorectal cancer.

    abstract：:Rising trends in the incidence and mortality of early-onset CRC in those who are ages less than 50 years have been well-established. These trends have spurred intense investigation focused on elucidating the epidemiology and characteristics of early-onset CRC, as well on identifying strategies for early detection and ...

    journal_title：Gastroenterology

    pub_type： 杂志文章,评审

    doi：10.1053/j.gastro.2020.12.068

    authors： Burnett-Hartman AN,Lee JK,Demb J,Gupta S

    更新日期：2021-01-05 00:00:00

  • Neurokinin 1 and 2 receptors mediate cholera toxin secretion in rat jejunum.

    abstract：BACKGROUND & AIMS:Substance P, a member of the tachykinin family, is a prosecretory neuropeptide distributed widely throughout the enteric nervous system. Implicated in inflammatory states, its role in enterotoxigenic water and electrolyte secretion is unclear. We assessed the effect of substance P antagonists and neur...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/gast.2000.18147

    authors： Turvill JL,Connor P,Farthing MJ

    更新日期：2000-10-01 00:00:00

  • Factors that determine the development and progression of gastroesophageal varices in patients with chronic hepatitis C.

    abstract：BACKGROUND & AIMS:We aimed to identify the incidence and predictors of de novo gastroesophageal variceal formation and progression in a large cohort of patients with chronic hepatitis C and advanced fibrosis. METHODS:All participants in the Hepatitis C Antiviral Long-Term Treatment against Cirrhosis Trial were offered...

    journal_title：Gastroenterology

    pub_type： 杂志文章,随机对照试验

    doi：10.1053/j.gastro.2010.02.058

    authors： Fontana RJ,Sanyal AJ,Ghany MG,Lee WM,Reid AE,Naishadham D,Everson GT,Kahn JA,Di Bisceglie AM,Szabo G,Morgan TR,Everhart JE,HALT-C Trial Group.

    更新日期：2010-06-01 00:00:00

  • The perception of cancer risk in patients with prevalent Barrett's esophagus enrolled in an endoscopic surveillance program.

    abstract：BACKGROUND & AIMS:Patients with Barrett's esophagus (BE) have a risk of esophageal adenocarcinoma of approximately 0.5% per year. Patients may have difficulty understanding this risk. This study assessed the perceived risk of cancer in patients with BE, and correlated their risk estimates with their health care use beh...

    journal_title：Gastroenterology

    pub_type： 评论,杂志文章

    doi：10.1016/j.gastro.2005.05.055

    authors： Shaheen NJ,Green B,Medapalli RK,Mitchell KL,Wei JT,Schmitz SM,West LM,Brown A,Noble M,Sultan S,Provenzale D

    更新日期：2005-08-01 00:00:00

  • Prospective cohort study of transarterial chemoembolization for unresectable hepatocellular carcinoma in 8510 patients.

    abstract：BACKGROUND & AIMS:To elucidate the survival of the patients with unresectable hepatocellular carcinoma (HCC) who underwent transcatheter arterial lipiodol chemoembolization (TACE) and to analyze the factors affecting the survivals. METHODS:During the last 8 years, a nationwide prospective cohort study was performed in...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2006.05.021

    authors： Takayasu K,Arii S,Ikai I,Omata M,Okita K,Ichida T,Matsuyama Y,Nakanuma Y,Kojiro M,Makuuchi M,Yamaoka Y,Liver Cancer Study Group of Japan.

    更新日期：2006-08-01 00:00:00

  • Correlation Between Concentrations of Fecal Calprotectin and Outcomes of Patients With Ulcerative Colitis in a Phase 2 Trial.

    abstract：BACKGROUND & AIMS:Accurate biomarkers of disease activity and therapeutic response can be valuable for clinical trials. We performed a post hoc analysis of data from a phase 2 trial to assess the relationship between the concentration of fecal calprotectin (FCP) and clinical and endoscopic outcomes of patients with mod...

    journal_title：Gastroenterology

    pub_type： 杂志文章,随机对照试验

    doi：10.1053/j.gastro.2015.09.001

    authors： Sandborn WJ,Panés J,Zhang H,Yu D,Niezychowski W,Su C

    更新日期：2016-01-01 00:00:00

  • Aging is associated with decreased pancreatic acinar cell regeneration and phosphatidylinositol 3-kinase/Akt activation.

    abstract：BACKGROUND & AIMS:The effects of aging on pancreatic acinar cell proliferation have not been clearly defined. Phosphatidylinositol 3-kinase (PI3K)-mediated phosphorylation of Akt is a critical step for proliferation of various cell types and insulin secretion from pancreatic endocrine cells; however, its role in acinar...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2005.03.016

    authors： Watanabe H,Saito H,Rychahou PG,Uchida T,Evers BM

    更新日期：2005-05-01 00:00:00

  • Altered isoactin gene expression in the affected bowel segments of the lethal spotted mouse.

    abstract：BACKGROUND:Actin is a key contractile protein associated with the normal differentiation and function of gastrointestinal smooth muscle cells. Distinct changes in gastrointestinal smooth muscle cell morphology and function have been reported for the aganglionic rectum and megacolon of the adult lethal spotted mouse. Th...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/0016-5085(93)90718-r

    authors： Liddell RA,Mooers SU,Siegman MJ,McHugh KM

    更新日期：1993-08-01 00:00:00

  • Surrogate markers of intestinal inflammation are predictive of relapse in patients with inflammatory bowel disease.

    abstract：BACKGROUND & AIMS:Prediction of relapse of inflammatory bowel disease has important implications for therapeutic strategies. We assessed whether measurement of intestinal permeability and inflammation could predict relapse of inflammatory bowel disease (IBD). METHODS:Forty-three patients with Crohn's disease (CD) and ...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/gast.2000.8523

    authors： Tibble JA,Sigthorsson G,Bridger S,Fagerhol MK,Bjarnason I

    更新日期：2000-07-01 00:00:00

  • The SH3 binding motif of HCV [corrected] NS5A protein interacts with Bin1 and is important for apoptosis and infectivity.

    abstract：BACKGROUND & AIMS:HCV nonstructural protein 5A (NS5A) has been implicated in regulating cell growth and interferon response. The NS5A protein contains proline-rich regions that are highly conserved among HCV genotypes and match Src homology 3 (SH3)-binding motifs (PxxP) found in various cellular signaling molecules. M...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2005.12.030

    authors： Nanda SK,Herion D,Liang TJ

    更新日期：2006-03-01 00:00:00

  • Overt hepatic encephalopathy precipitated by zinc deficiency.

    abstract：:Encephalopathy in liver disease may be unresponsive to protein restriction, lactulose, and neomycin. Zinc supplements have been reported to improve psychometric performance in liver cirrhosis, but the importance of zinc deficiency in overt hepatic encephalopathy has not yet been clearly established. A patient with sev...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/0016-5085(91)90290-2

    authors： Van der Rijt CC,Schalm SW,Schat H,Foeken K,De Jong G

    更新日期：1991-04-01 00:00:00

  • Consumption of n-3 fatty acids and fish reduces risk of hepatocellular carcinoma.

    abstract：BACKGROUND & AIMS:Fish is a rich source of n-3 polyunsaturated fatty acids (PUFAs), such as eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA), and docosahexaenoic acid (DHA). Although consumption of fish and n-3 PUFA has been reported to protect against the development of some types of cancer, little is known ab...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2012.02.018

    authors： Sawada N,Inoue M,Iwasaki M,Sasazuki S,Shimazu T,Yamaji T,Takachi R,Tanaka Y,Mizokami M,Tsugane S,Japan Public Health Center-Based Prospective Study Group.

    更新日期：2012-06-01 00:00:00

  • Hepatic bilirubin UDP-glucuronyltransferase in patients with sickle cell anemia.

    abstract：:In sickle cell anemia the shortened survival of red blood cells presents the liver with an augmented load of bilirubin for hepatic clearance. To determine the effects of this excessive bilirubin load on the microsomal conjugating enzyme, hepatic bilirubin UDP-glucuronyltransferase, levels of this enzyme were measured ...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：

    authors： Maddrey WC,Cukier JO,Maglalang AC,Boitnott JK,Odell GB

    更新日期：1978-02-01 00:00:00

  • Wnt-β-catenin signaling protects against hepatic ischemia and reperfusion injury in mice.

    abstract：BACKGROUND & AIMS:Ischemia and reperfusion injury are common causes of oxidative tissue damage associated with many liver diseases and hepatic surgery. The Wnt-β-catenin signaling pathway is an important regulator of hepatic development, regeneration, and carcinogenesis. However, the role of Wnt signaling in the hepato...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2011.04.051

    authors： Lehwald N,Tao GZ,Jang KY,Sorkin M,Knoefel WT,Sylvester KG

    更新日期：2011-08-01 00:00:00

  • APC I1307K increases risk of transition from polyp to colorectal carcinoma in Ashkenazi Jews.

    abstract：BACKGROUND & AIMS:The I1307K allele of the APC gene has been shown to confer a modestly elevated risk of colorectal cancer in the Ashkenazi Jewish population (relative risk, 1.5-1.7). However, it is unclear whether the alteration predisposes to adenomas and whether the genetic information can be used in clinical practi...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/gast.2001.21170

    authors： Stern HS,Viertelhausen S,Hunter AG,O'Rourke K,Cappelli M,Perras H,Serfas K,Blumenthall A,Dewar D,Baumann E,Lagarde AE

    更新日期：2001-02-01 00:00:00

  • The mechanism of the inhibition of gastric secretion produced by esophageal ligation in the pylorus-ligated rat.

    abstract：:Esophageal ligation in the pylorus-ligated rat significantly inhibited volume, titratable acidity, and titratable acid output and reduced the incidence of ulcers, perforations, and death of 18-hr pylorus-ligated rats. Draining the saliva outside the body of the rat by esophageal cannulation produced a significant incr...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：

    authors： Brodie DA,Knapp PG

    更新日期：1966-06-01 00:00:00

  • Preparation of subcellular membranes from rat intestinal scrapings or isolated cells. Different Ca2+ binding, nonesterified fatty acid levels, and lipolytic activity.

    abstract：:Basolateral, brush-border, and Golgi-enriched subcellular membrane fractions, prepared from homogenates of rat small intestinal mucosa obtained by scraping, had unusually high concentrations of nonesterified fatty acids. These fatty acids appear to be responsible for the large amount of calcium binding, an effect that...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/0016-5085(86)90435-x

    authors： Walters JR,Horvath PJ,Weiser MM

    更新日期：1986-07-01 00:00:00

  • Loss of SMAD4 alters BMP signaling to promote colorectal cancer cell metastasis via activation of Rho and ROCK.

    abstract：BACKGROUND & AIMS:SMAD4 frequently is lost from colorectal cancers (CRCs), which is associated with the development of metastases and a poor prognosis. SMAD4 loss is believed to alter transforming growth factor β signaling to promote tumor progression. However, SMAD4 is also a central component of the bone morphogeneti...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2014.03.052

    authors： Voorneveld PW,Kodach LL,Jacobs RJ,Liv N,Zonnevylle AC,Hoogenboom JP,Biemond I,Verspaget HW,Hommes DW,de Rooij K,van Noesel CJ,Morreau H,van Wezel T,Offerhaus GJ,van den Brink GR,Peppelenbosch MP,Ten Dijke P,Hardwick JC

    更新日期：2014-07-01 00:00:00

  • Altered adrenergic responsiveness of endothelium-denuded hepatic arteries and portal veins in patients with cirrhosis.

    abstract：BACKGROUND & AIMS:Patients with cirrhosis are characterized by a reduced splanchnic vascular resistance and a hyporeactivity to adrenergic vasoconstrictors. So far, their adrenergic splanchnic vascular responsiveness has not been evaluated in vitro. We compared responses to alpha1- and beta2-adrenoceptor stimulation of...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/s0016-5085(99)70136-8

    authors： Heller J,Schepke M,Gehnen N,Molderings GJ,Müller A,Erhard J,Spengler U,Sauerbruch T

    更新日期：1999-02-01 00:00:00

  • A comparative analysis by SAGE of gene expression profiles of Barrett's esophagus, normal squamous esophagus, and gastric cardia.

    abstract：BACKGROUND & AIMS:The metaplastic process in which the normal squamous epithelium of the distal esophagus is replaced by columnar-lined epithelium, known as Barrett's esophagus (BE), is poorly understood. The aim of this study was to define, analyze, and compare transcription profiles of BE, normal cardia epithelium, a...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2005.07.026

    authors： van Baal JW,Milano F,Rygiel AM,Bergman JJ,Rosmolen WD,van Deventer SJ,Wang KK,Peppelenbosch MP,Krishnadath KK

    更新日期：2005-10-01 00:00:00

  • Direct intestinal cholesterol secretion contributes significantly to total fecal neutral sterol excretion in mice.

    abstract：BACKGROUND & AIMS:Hepatobiliary secretion is generally believed to be an integral step in the pathway of cholesterol excretion from the body. Here we have investigated the validity of this paradigm in mice. METHODS:Cholesterol balance was assessed by measuring intake, excretion, and biliary output in different mouse m...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2007.06.019

    authors： van der Velde AE,Vrins CL,van den Oever K,Kunne C,Oude Elferink RP,Kuipers F,Groen AK

    更新日期：2007-09-01 00:00:00

  • Effect of dopamine and bromocriptine on rat ileal and colonic transport. Stimulation of absorption and reversal of cholera toxin-induced secretion.

    abstract：:Water and electrolyte transport were determined in rat ileum and colon using the single-pass perfusion technique. Intraperitoneal dopamine caused prompt stimulation of both ileal and colonic water absorption. The dopamine effect was mediated by both specific dopamine and alpha 2-adrenergic receptors. Haloperidol, a sp...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：

    authors： Donowitz M,Elta G,Battisti L,Fogel R,Label-Schwartz E

    更新日期：1983-03-01 00:00:00

  • Retinoids: effects on growth, differentiation, and nuclear receptor expression in human pancreatic carcinoma cell lines.

    abstract：BACKGROUND & AIMS:Advanced pancreatic carcinoma has a dismal prognosis despite extensive chemotherapeutic trials. The aim of this study was to evaluate the role of retinoids as an experimental therapeutic approach for pancreatic cancer. METHODS:Four ductal and one acinar pancreatic tumor cell lines were investigated. ...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/0016-5085(95)90655-x

    authors： Rosewicz S,Stier U,Brembeck F,Kaiser A,Papadimitriou CA,Berdel WE,Wiedenmann B,Riecken EO

    更新日期：1995-11-01 00:00:00

  • Evidence for H+ secretion by the in vivo canine gallbladder.

    abstract：:In humans and most other species, a decline in pH of gallbladder contents occurs during the concentration of bile. Recent in vitro studies in rabbit, guinea pig, and Necturus gallbladders have strongly suggested mucosal H+ secretion during sodium reabsorption, presumably representing a Na+/H+ exchange. The present in ...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/0016-5085(87)90118-1

    authors： Rege RV,Moore EW

    更新日期：1987-02-01 00:00:00

  • Endoscopic papillotomy.

    abstract：:Obstruction of the common bile duct can now be relieved by endoscopic electrosurgery. This report describes our experience with 267 patients. In 192 of 222 patients with choledocholithiasis all calculi were evacuated by endoscopic papillotomy (EP). The remaining patients had EP because of papillary stenosis. Complicat...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：

    authors： Koch H,Rösch W,Schaffner O,Demling L

    更新日期：1977-12-01 00:00:00

  • Genome-wide analysis of hepatic fibrosis in inbred mice identifies the susceptibility locus Hfib1 on chromosome 15.

    abstract：BACKGROUND & AIMS:Host genetic factors are likely to contribute to the variable course of hepatic fibrosis in response to chronic liver injury. Similarly, the fibrotic response differs among inbred mouse strains after challenge with CCl(4). Our aim was to identify unknown susceptibility loci for hepatic fibrosis in a c...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/gast.2002.37069

    authors： Hillebrandt S,Goos C,Matern S,Lammert F

    更新日期：2002-12-01 00:00:00