Aging is associated with decreased pancreatic acinar cell regeneration and phosphatidylinositol 3-kinase/Akt activation.

abstract：BACKGROUND & AIMS:Incidence of and mortality from pancreatic ductal adenocarcinoma (PDAC), the most common form of pancreatic cancer, are almost equivalent, so better treatments are needed. We studied gene expression profiles of PDACs and the functions of genes with altered expression to identify new therapeutic target...

journal_title：Gastroenterology

authors： Jandaghi P,Najafabadi HS,Bauer AS,Papadakis AI,Fassan M,Hall A,Monast A,von Knebel Doeberitz M,Neoptolemos JP,Costello E,Greenhalf W,Scarpa A,Sipos B,Auld D,Lathrop M,Park M,Büchler MW,Strobel O,Hackert T,Giese NA,

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND & AIMS:Screening colonoscopy is an effective method to reduce the incidence of and mortality from colorectal cancer (CRC). There is little empirical evidence available about the optimal interval for screening, making this a subject of debate. We associated the prevalence of advanced colorectal neoplasms with...

journal_title：Gastroenterology

authors： Brenner H,Haug U,Arndt V,Stegmaier C,Altenhofen L,Hoffmeister M

更新日期：2010-03-01 00:00:00

abstract：BACKGROUND/AIMS:Both hemorrhagic and cardiogenic shock are associated with hepatic shock gene expression at resuscitation. This study investigated the potential role of intravascular superoxide anion as a proximal trigger of heat shock protein gene expression. METHODS:Preanesthetized pigs were subjected to 120 m of to...

journal_title：Gastroenterology

authors： Schoeniger LO,Andreoni KA,Ott GR,Risby TH,Bulkley GB,Udelsman R,Burdick JF,Buchman TG

更新日期：1994-01-01 00:00:00

abstract：BACKGROUND & AIMS:Crohn's disease has a bimodal age distribution of disease onset diagnosis. The peaks (20 and 50 years) may represent different phenotypes or different genetic and/or environmental influences between younger- and older-onset individuals. The aim of this study was to examine the influences of age at dia...

journal_title：Gastroenterology

authors： Polito JM 2nd,Childs B,Mellits ED,Tokayer AZ,Harris ML,Bayless TM

更新日期：1996-09-01 00:00:00

abstract：:A patient with a lifelong history of asthma and hay fever was investigated because of symptoms of esophageal spasm. Esophageal biopsies revealed elongated papillae and basal zone hyperplasia of the epithelial layer with eosinophilic infiltration of the lamina propria and muscularis mucosae. There was no evidence of re...

journal_title：Gastroenterology

authors： Dobbins JW,Sheahan DG,Behar J

更新日期：1977-06-01 00:00:00

abstract：:Although Hemoccult (Smith Kline Diagnostics, Inc., Sunnyvale, Calif.) screening for colorectal cancer is based on detection of the peroxidase activity of blood, little is known about the relationship between patterns of bleeding from cancers or adenomas and sensitivity of the test slides. 51Cr-labeled blood loss was m...

journal_title：Gastroenterology

authors： Macrae FA,St John DJ

更新日期：1982-05-01 00:00:00

abstract：BACKGROUND & AIMS:The role of the gallbladder in gallstone pathogenesis is still unclear. We examined the effects of gallbladder mucosal lipid absorption on lipid composition and cholesterol crystallization in bile. METHODS:The in vitro-isolated, intra-arterially perfused gallbladder model was used (1) to compare the ...

journal_title：Gastroenterology

authors： Corradini SG,Elisei W,Giovannelli L,Ripani C,Della Guardia P,Corsi A,Cantafora A,Capocaccia L,Ziparo V,Stipa V,Chirletti P,Caronna R,Lomanto D,Attili AF

更新日期：2000-05-01 00:00:00

abstract：:This study was performed to ascertain whether testosterone metabolism is altered in male rats with portal bypass, and whether such changes could contribute to the reduction in serum testosterone concentration and raised serum estrogen levels that are observed in this situation. The metabolic clearance rate of testoste...

journal_title：Gastroenterology

authors： Farrell G,Koltai A

更新日期：1988-08-01 00:00:00

abstract：:Gastrointestinal loss of plasma is usually measured with radiolabeled macromolecules. These methods are expensive and cumbersome. The use of alpha 1-antitrypsin as an endogenous marker and the determination of alpha 1-antitrypsin fecal clearance enable the diagnosis of protein-losing enteropathy. alpha 1-Antitrypsin i...

journal_title：Gastroenterology

authors： Florent C,L'Hirondel C,Desmazures C,Aymes C,Bernier JJ

更新日期：1981-10-01 00:00:00

abstract：:Effects of opiates on intestinal motor activity and transport of water and electrolytes have been studied separately in previous investigations. The aim of these experiments was to evaluate simultaneously the effects of a synthetic opiate, loperamide, on motor activity and transport in the human intestine. Jejunal, il...

journal_title：Gastroenterology

authors： Kachel G,Ruppin H,Hagel J,Barina W,Meinhardt M,Domschke W

更新日期：1986-01-01 00:00:00

abstract：BACKGROUND & AIMS:Circulating membrane-shed microparticles (MPs) participate in regulation of vascular tone. We investigated the cellular origins of MPs in plasma from patients with cirrhosis and assessed the contribution of MPs to arterial vasodilation, a mechanism that contributes to portal hypertension. METHODS:We ...

journal_title：Gastroenterology

authors： Rautou PE,Bresson J,Sainte-Marie Y,Vion AC,Paradis V,Renard JM,Devue C,Heymes C,Letteron P,Elkrief L,Lebrec D,Valla D,Tedgui A,Moreau R,Boulanger CM

更新日期：2012-07-01 00:00:00

abstract：BACKGROUND & AIMS:Advanced pancreatic carcinoma has a dismal prognosis despite extensive chemotherapeutic trials. The aim of this study was to evaluate the role of retinoids as an experimental therapeutic approach for pancreatic cancer. METHODS:Four ductal and one acinar pancreatic tumor cell lines were investigated. ...

journal_title：Gastroenterology

authors： Rosewicz S,Stier U,Brembeck F,Kaiser A,Papadimitriou CA,Berdel WE,Wiedenmann B,Riecken EO

更新日期：1995-11-01 00:00:00

abstract：BACKGROUND & AIMS:The rate of 12alpha-hydroxylation of bile acid intermediates is believed to determine the ratio of cholic acid (CA) to chenodeoxycholic acid (CDCA) biosynthesis and the overall hydrophobicity of the bile acid pool. The aim of this study was to determine the effects of the level of expression of sterol...

journal_title：Gastroenterology

authors： Pandak WM,Bohdan P,Franklund C,Mallonee DH,Eggertsen G,Björkhem I,Gil G,Vlahcevic ZR,Hylemon PB

更新日期：2001-06-01 00:00:00

abstract：BACKGROUND & AIMS:Point mutations of the Ki-ras gene at codon 12 have been frequently identified in pure pancreatic juice of patients with pancreatic cancer in studies examining pancreatic cancer tissues. The aim of this study was to examine mutations of the Ki-ras codon 12 in the duodenal juice collected from patients...

journal_title：Gastroenterology

authors： Iguchi H,Sugano K,Fukayama N,Ohkura H,Sadamoto K,Ohkoshi K,Seo Y,Tomoda H,Funakoshi A,Wakasugi H

更新日期：1996-01-01 00:00:00

abstract：:A reliable method for studying lead absorption and excretion in rats is described. Lead absorption occurs primarily in theduodenum where lead enters the epithelial mucosal cells. There is a relative mucosal block for lead with increasing intraluminal doses. Certain substances which bind lead and increase its solubilit...

journal_title：Gastroenterology

authors： Conrad ME,Barton JC

更新日期：1978-04-01 00:00:00

abstract：:This literature review and the recommendations therein were prepared for the American Gastroenterological Association Clinical Practice and Practice Economics committee. The paper was approved by the committee on May 16, 1999, and by the AGA governing board on July 18, 1999. ...

journal_title：Gastroenterology

authors： Zuckerman GR,Prakash C,Askin MP,Lewis BS

更新日期：2000-01-01 00:00:00

abstract：:The normal surface anatomy of rat hepatocytes, sinusoids, and bile canaliculi was examined by scanning electron microscopy following finger fracture of tissues that were perfused via the portal vein and fixed with 2.5% glutaraldehyde. These normal findings were contrasted with several models of cholestasis, including ...

journal_title：Gastroenterology

authors： Layden TJ,Schwarz,Boyer JL

更新日期：1975-09-01 00:00:00

abstract：:Spontaneous bacterial peritonitis in decompensated cirrhotic patients develops when bacteria invade preexising ascites. It is probable that other transudates such as pleural effusions can be afected in a similar manner. This paper describes a cirrhotic patient with long-standing pleural effusion in whom Escherichia co...

journal_title：Gastroenterology

authors： Flaum MA

更新日期：1976-03-01 00:00:00

abstract：BACKGROUND AND AIMS:Earlier studies have suggested that patients with hemochromatosis have poor post-transplantation survival. We aimed to compare patients with hemochromatosis to those with other causes of liver disease with regard to post-transplantation survival. METHODS:We compared the post-transplant survival of ...

journal_title：Gastroenterology

authors： Yu L,Ioannou GN

更新日期：2007-08-01 00:00:00

abstract：BACKGROUND & AIMS:Surgical management of pancreatic cancer depends on tumor resectability and staging. This study evaluated a new in vivo technique, fiberoptic confocal fluorescence microscopy (FCFM), for detection and staging of pancreatic tumors in rats. METHODS:FCFM was used with a protease-activated fluorescent ma...

journal_title：Gastroenterology

authors： Ignat M,Aprahamian M,Lindner V,Altmeyer A,Perretta S,Dallemagne B,Mutter D,Marescaux J

更新日期：2009-11-01 00:00:00

abstract：BACKGROUND & AIMS:Immune-nonimmune cell interactions modulate mucosal immunity. We investigated the expression of adhesion molecules by intestinal fibroblasts, the effect of immune cell-derived factor on fibroblast binding of T cells, and the consequences of interfering with adhesion molecule expression on fibroblast-T...

journal_title：Gastroenterology

authors： Musso A,Condon TP,West GA,De La Motte C,Strong SA,Levine AD,Bennett CF,Fiocchi C

更新日期：1999-09-01 00:00:00

abstract：:Specimens of the sigmoid colon were obtained from male and female patients (n = 11) with carcinoma of the colon or rectum and studied immunohistochemically for vasoactive intestinal polypeptide-, somatostatin-, substance P-, neuropeptide Y-, calcitonin gene-related peptide-, met- and leu-enkephalin-, 5-hydroxytryptami...

journal_title：Gastroenterology

authors： Crowe R,Kamm MA,Burnstock G,Lennard-Jones JE

更新日期：1992-02-01 00:00:00

abstract：:Previously, we reported that two glycoproteins, carcinoembryonic antigen and secretory component, are preferentially expressed on the apical or laterobasal surfaces, respectively, of normal human colonic epithelial cells, whereas these antigens may be expressed over the entire cell surface of colonic cancer cells. The...

journal_title：Gastroenterology

authors： Sugiyama T,Brown WR,Ahnen DJ

更新日期：1988-02-01 00:00:00

abstract：:The study of cholesterol gallstone disease would be facilitated if the nucleation time of cholesterol crystals could be measured in duodenal bile and was correlated with nucleation occurring in vivo. Therefore, our aims were to determine (a) if nucleation time could be measured in duodenal bile, (b) the effect of bact...

journal_title：Gastroenterology

authors： Marks JW,Broomfield P,Bonorris GG,Schoenfield LJ

更新日期：1991-07-01 00:00:00

abstract：BACKGROUND & AIMS:Endosonography-guided fine-needle aspiration biopsy (EUS-FNA) permits cytological confirmation of EUS findings. A multicenter prospective evaluation of EUS-FNA for primary diagnosis, staging, and/or follow-up purposes was undertaken. METHODS:EUS-FNA was performed in 457 patients with 554 lesions. Cli...

journal_title：Gastroenterology

authors： Wiersema MJ,Vilmann P,Giovannini M,Chang KJ,Wiersema LM

更新日期：1997-04-01 00:00:00

abstract：:Basal lower esophageal sphincter (LES) pressure was measured in 6 patients with the Zollinger-Ellison syndrome (ZES) and hypergastrinemia, and in 6 patients with duodenal ulcer and normogastrinemia. Basal LES pressure in ZES patients, 17.0 +/- 3.7 (mean +/- SE) mm Hg was similar to basal LES pressure in duodenal ulcer...

journal_title：Gastroenterology

authors： Snyder N,Hughes W

更新日期：1977-06-01 00:00:00

abstract：BACKGROUND/AIMS:K-ras-2 mutations and DNA content heterogeneity represent early events of human colorectal tumor progression. The aim of the study was to investigate if specific K-ras-2 mutations in 58 human sporadic adenomas were correlated with DNA aneuploidization and cell proliferation. METHODS:Multiparameter flow...

journal_title：Gastroenterology

authors： Giaretti W,Pujic N,Rapallo A,Nigro S,Di Vinci A,Geido E,Risio M

更新日期：1995-04-01 00:00:00

abstract：:Eosinophilic esophagitis (EoE) was historically distinguished from gastroesophageal reflux disease on the basis of histology and lack of responsiveness to acid suppressive therapy, but it is now appreciated that esophageal eosinophilia can respond to proton pump inhibitors. Genetic and environmental factors contribute...

journal_title：Gastroenterology

authors： Rothenberg ME

更新日期：2015-05-01 00:00:00

abstract：BACKGROUND & AIMS:Feeding intolerance because of functional gastrointestinal dysmotility and parenteral nutrition-associated cholestasis (PNAC) are common problems in preterm, very-low-birth-weight (VLBW) infants. This double-blind, randomized, placebo-controlled study aimed to assess the effectiveness of "high-dose" o...

journal_title：Gastroenterology

authors： Ng PC,Lee CH,Wong SP,Lam HS,Liu FY,So KW,Lee CY,Fok TF

更新日期：2007-05-01 00:00:00

abstract：BACKGROUND:Active transport of conjugated bile acids by ileal enterocytes is a key mechanism for conservation of the bile acid pool. Experiments were performed to determine whether such transport is regulated by substrate load. METHODS:Using anesthetized biliary fistula guinea pigs or rats, the ileum was perfused with...

journal_title：Gastroenterology

authors： Lillienau J,Crombie DL,Munoz J,Longmire-Cook SJ,Hagey LR,Hofmann AF

更新日期：1993-01-01 00:00:00