Feasibility and reliability of pancreatic cancer staging using fiberoptic confocal fluorescence microscopy in rats.

abstract：BACKGROUND & AIMS:Nitric oxide is a major inhibitory neurotransmitter in the enteric nervous system. Loss or dysfunction of nitrinergic neurons is associated with serious disruptions of motility, intractable symptoms, and long-term suffering. The aim of this study was to evaluate the effect of intrapyloric transplantat...

journal_title：Gastroenterology

authors： Micci MA,Kahrig KM,Simmons RS,Sarna SK,Espejo-Navarro MR,Pasricha PJ

更新日期：2005-12-01 00:00:00

abstract：:The appropriate treatment of patients with fistulas in the setting of Crohn's disease requires a knowledge of the specific medical and surgical literature of fistulizing Crohn's. The patient with symptomatic fistulizing Crohn's disease may respond differently to specific medical therapy than a patient with symptomatic...

journal_title：Gastroenterology

authors： Lichtenstein GR

更新日期：2000-10-01 00:00:00

abstract：BACKGROUND & AIMS:Patients with colorectal tumors with microsatellite instability (MSI) have better prognoses than patients with tumors without MSI, but have a poor response to 5-fluorouracil–based chemotherapy. A dominant-negative form of heat shock protein (HSP)110 (HSP110DE9) expressed by cancer cells with MSI, via ...

journal_title：Gastroenterology

authors： Collura A,Lagrange A,Svrcek M,Marisa L,Buhard O,Guilloux A,Wanherdrick K,Dorard C,Taieb A,Saget A,Loh M,Soong R,Zeps N,Platell C,Mews A,Iacopetta B,De Thonel A,Seigneuric R,Marcion G,Chapusot C,Lepage C,Bouvier

更新日期：2014-02-01 00:00:00

abstract：:The origin and neoplastic potential of gastric epithelial polyps remains an area of great interest, and treatment choices are a topic of controversy. This report describes a patient diagnosed with three concurrent hyperplastic gastric polyps that were studied for genetic alterations. The polyps were investigated for a...

journal_title：Gastroenterology

authors： Dijkhuizen SM,Entius MM,Clement MJ,Polak MM,Van den Berg FM,Craanen ME,Slebos RJ,Offerhaus GJ

更新日期：1997-02-01 00:00:00

abstract：:Two patients developed local gangrene after subcutaneous infiltration of vasopressin (Pitressin, Parke, Davis & Company, Detroit, Mich.) utilized for the control of bleeding from esophageal varices. In the 1st patient, ischemic gangrene resulted in transmetatarsal amputation and also necessitated skin grafts on the fo...

journal_title：Gastroenterology

authors： Greenwald RA,Rheingold OJ,Chiprut RO,Rogers AI

更新日期：1978-04-01 00:00:00

abstract：:Altered gallbladder motility could predispose to, or result from, gallstone formation and could also explain the alleged relief of biliary colic seen during bile acid therapy. Therefore, in 14 controls, 25 patients with radiolucent gallstones, and 14 patients with radiopaque gallstones, we used two techniques to measu...

journal_title：Gastroenterology

authors： Forgacs IC,Maisey MN,Murphy GM,Dowling RH

更新日期：1984-08-01 00:00:00

abstract：BACKGROUND & AIMS:High-level coffee consumption has been associated with reduced progression of pre-existing liver diseases and lower risk of hepatocellular carcinoma. However, its relationship with therapy for hepatitis C virus infection has not been evaluated. METHODS:Patients (n=885) from the lead-in phase of the H...

journal_title：Gastroenterology

authors： Freedman ND,Curto TM,Lindsay KL,Wright EC,Sinha R,Everhart JE,HALT-C TRIAL GROUP.

更新日期：2011-06-01 00:00:00

abstract：BACKGROUND & AIMS:Numerous studies have linked the proliferation of liver progenitor cells (LPCs) during chronic liver disease to the risk for development of hepatocellular carcinoma. Thus, selective inhibition of LPC growth during preneoplastic injury may prevent or delay the onset of liver cancer. Rats carrying a ger...

journal_title：Gastroenterology

authors： Knight B,Tirnitz-Parker JE,Olynyk JK

更新日期：2008-09-01 00:00:00

abstract：BACKGROUND & AIMS:Oral bile acid replacement has been shown to be an effective therapy in primary bile acid synthesis defects, but to date there have been no reports of the long-term effects of this therapy. The aim of the study was to evaluate the long-term effectiveness and safety of cholic acid (CA) therapy. METHOD...

journal_title：Gastroenterology

authors： Gonzales E,Gerhardt MF,Fabre M,Setchell KD,Davit-Spraul A,Vincent I,Heubi JE,Bernard O,Jacquemin E

更新日期：2009-10-01 00:00:00

abstract：:Bile acids cause diarrhea by inducing colonic secretion, probably mediated through the cyclic AMP system. The aim was to determine the effects of an adenylate cyclase inhibitor, propranolol, on deoxycholic acid (DCA) stimulation of net secretion and the cyclic AMP system in the colon. In each of 30 New Zealand white r...

journal_title：Gastroenterology

authors： Conley D,Coyne M,Chung A,Bonorris G,Schoenfield L

更新日期：1976-07-01 00:00:00

abstract：BACKGROUND & AIMS:Improving methods for early detection of gastric cancer could reduce mortality. Measurements of serum pepsinogen levels have been used for screening in Japan without satisfactory levels of sensitivity or specificity. Trefoil factor family (TFF) proteins (TFF1, TFF2, and TFF3) are small and stable mole...

journal_title：Gastroenterology

authors： Aikou S,Ohmoto Y,Gunji T,Matsuhashi N,Ohtsu H,Miura H,Kubota K,Yamagata Y,Seto Y,Nakajima A,Goldenring JR,Kaminishi M,Nomura S

更新日期：2011-09-01 00:00:00

abstract：:We have quantified neurotransmitter changes in the rat jejunum in which the myenteric neurons were ablated by serosal application of benzalkonium chloride. Within 2 days after benzalkonium chloride treatment, there was a 40% reduction in the activity of choline acetyltransferase, a specific marker for cholinergic neur...

journal_title：Gastroenterology

authors： Dahl JL,Bloom DD,Epstein ML,Fox DA,Bass P

更新日期：1987-02-01 00:00:00

abstract：BACKGROUND & AIMS:Hepatic iron toxicity may be mediated by free radical species and lipid peroxidation of biological membranes. The antioxidant property of silybin, a main constituent of natural flavonoids, was investigated in vivo during experimental iron overload. METHODS:Rats were fed a 2.5% carbonyl-iron diet and ...

journal_title：Gastroenterology

authors： Pietrangelo A,Borella F,Casalgrandi G,Montosi G,Ceccarelli D,Gallesi D,Giovannini F,Gasparetto A,Masini A

更新日期：1995-12-01 00:00:00

abstract：BACKGROUND & AIMS:Alterations of hepatic cholesterol metabolism in patients with cholesterol gallstones are still controversial. This study investigated whether hepatic cholesterol metabolism is altered in Japanese patients with cholesterol gallstones. METHODS:In this systematic study of 24 middle-aged nonobese and no...

journal_title：Gastroenterology

authors： Ito T,Kawata S,Imai Y,Kakimoto H,Trzaskos JM,Matsuzawa Y

更新日期：1996-05-01 00:00:00

abstract：BACKGROUND & AIMS:Quantitative neurophysiological studies have identified the presence of at least 2 spinal neuronal populations (abrupt and sustained) that are excited by the noxious visceral stimulus colorectal distention. This study examined the effects of the kappa opioid receptor agonists fedotozine and U50488H on...

journal_title：Gastroenterology

authors： Ness TJ

更新日期：1999-08-01 00:00:00

abstract：:By correlating morphological observations with quantitative measurements of net water transport, we determined whether bile salts altered colonic absorptive cells. Epithelial alteration was equivocal and water absorption was uninhibited during infusions of 1 mM deoxycholate or of concentrations of taurocholate less th...

journal_title：Gastroenterology

authors： Saunders DR,Hedges JR,Sillery J,Esther L,Matsumura K,Rubin CE

更新日期：1975-05-01 00:00:00

abstract：:A case of spontaneous rupture of a nonparasitic liver cyst, documented by serial computed tomography scans, is reported. The patient was closely followed clinically after the rupture of the cyst and was treated conservatively, without surgical intervention. No peritonitis developed. This unusual complication of nonpar...

journal_title：Gastroenterology

authors： Akriviadis EA,Steindel H,Ralls P,Redeker AG

更新日期：1989-07-01 00:00:00

abstract：:It is possible to estimate hepatic triglyceride content by calculating the proton density fat fraction (PDFF), using proton magnetic resonance spectroscopy (1H-MRS), instead of collecting and analyzing liver biopsy specimens to detect steatosis. However, the current PDFF cut-off value (5%) used to define steatosis by ...

journal_title：Gastroenterology

authors： Nasr P,Forsgren MF,Ignatova S,Dahlström N,Cedersund G,Leinhard OD,Norén B,Ekstedt M,Lundberg P,Kechagias S

更新日期：2017-07-01 00:00:00

abstract：:Increasing evidence has emerged that supports an important intersection between 3 fundamental cell biologic pathways in the pathogenesis of inflammatory bowel disease. These include the intersection between autophagy, as revealed by the original identification of ATG16L1 and IRGM as major genetic risk factors for Croh...

journal_title：Gastroenterology

authors： Kaser A,Blumberg RS

更新日期：2011-05-01 00:00:00

abstract：DESCRIPTION:This expert review was commissioned and approved by the AGA Institute Clinical Practice Updates Committee and the AGA Governing Board to provide timely guidance on a topic of high clinical importance to the AGA membership. The intent is to evaluate the current data on mechanism of altered coagulation in pat...

journal_title：Gastroenterology

authors： O'Leary JG,Greenberg CS,Patton HM,Caldwell SH

更新日期：2019-07-01 00:00:00

abstract：:The conventional method of ascitic fluid culture detects bacteria in only 42%-65% of patients who have neutrocytic ascites and suspected spontaneous bacterial peritonitis. In this study ascitic fluid was cultured by the conventional method as well as by a new method consisting of bedside inoculation of blood culture b...

journal_title：Gastroenterology

authors： Runyon BA,Canawati HN,Akriviadis EA

更新日期：1988-11-01 00:00:00

abstract：BACKGROUND & AIMS:This study used a low lesion prevalence population reflective of the screening setting to estimate the sensitivity and specificity of computerized tomographic (CT) colonography for detection of colorectal polyps. METHODS:This prospective, blinded study comprised 703 asymptomatic persons at higher-tha...

journal_title：Gastroenterology

authors： Johnson CD,Harmsen WS,Wilson LA,Maccarty RL,Welch TJ,Ilstrup DM,Ahlquist DA

更新日期：2003-08-01 00:00:00

abstract：:Based on in vitro experiments measuring daily secretion rates in the culture media of rat hepatocytes and in vivo experiments using pulse labeling of intracellular precursors, the present study examines the ontogenic expression of the polymeric immunoglobulin receptor and secretory component by hepatocytes during grow...

journal_title：Gastroenterology

authors： Buts JP,Vaerman JP,Lescoat G

更新日期：1992-03-01 00:00:00

abstract：BACKGROUND & AIMS:The US Medicare indications for intestinal transplantation are based on failure of home parenteral nutrition. The American Society of Transplantation also includes patients at high risk of death from their primary disease or with high morbidity intestinal failure. A 3-year prospective study evaluated ...

journal_title：Gastroenterology

authors： Pironi L,Forbes A,Joly F,Colomb V,Lyszkowska M,Van Gossum A,Baxter J,Thul P,Hébuterne X,Gambarara M,Gottrand F,Moreno Villares JM,Messing B,Goulet O,Staun M,Home Artificial Nutrition Working Group of the European Society fo

更新日期：2008-07-01 00:00:00

abstract：:In the rat, gastric histamine is stored mainly in the enterochromaffinlike cells. Gastrin releases histamine from these cells, and long-term hypergastrinemia results in hyperplasia. The effect of sustained hypergastrinemia on histamine-depleted enterochromaffinlike cells was studied by measuring histidine decarboxylas...

journal_title：Gastroenterology

authors： Andersson K,Håkanson R,Mattsson H,Ryberg B,Sundler F

更新日期：1992-09-01 00:00:00

abstract：BACKGROUND & AIMS:Electroneutral NaCl absorption across small intestine contributes importantly to systemic fluid balance. Disturbances in this process occur in both obstructive and diarrheal diseases, eg, cystic fibrosis, secretory diarrhea. NaCl absorption involves coupling of Cl(-)/HCO(3)(-) exchanger(s) primarily w...

journal_title：Gastroenterology

authors： Walker NM,Simpson JE,Yen PF,Gill RK,Rigsby EV,Brazill JM,Dudeja PK,Schweinfest CW,Clarke LL

更新日期：2008-11-01 00:00:00

abstract：BACKGROUND & AIMS:There have been few studies of the role of de novo lipogenesis in the development of nonalcoholic fatty liver disease (NAFLD). We used isotope analyses to compare de novo lipogenesis and fatty acid flux between subjects with NAFLD and those without, matched for metabolic factors (controls). METHODS:W...

journal_title：Gastroenterology

authors： Lambert JE,Ramos-Roman MA,Browning JD,Parks EJ

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND & AIMS:The host immune response during the chronic phase of hepatitis C virus infection varies among individuals; some patients have a no interferon (IFN) response in the liver, whereas others have full activation of IFN-stimulated genes (ISGs). Preactivation of this endogenous IFN system is associated with ...

journal_title：Gastroenterology

authors： Dill MT,Duong FH,Vogt JE,Bibert S,Bochud PY,Terracciano L,Papassotiropoulos A,Roth V,Heim MH

更新日期：2011-03-01 00:00:00

abstract：:We describe a 47-year-old patient who developed cholelithiasis in adolescence, followed by recurrent intrahepatic cholestasis of pregnancy, and finally biliary cirrhosis in adulthood. In our patient, the consecutive presentation of the 3 mentioned disorders raised the suspicion of a defect of MDR3, the canalicular pro...

journal_title：Gastroenterology

authors： Lucena JF,Herrero JI,Quiroga J,Sangro B,Garcia-Foncillas J,Zabalegui N,Sola J,Herraiz M,Medina JF,Prieto J

更新日期：2003-04-01 00:00:00

abstract：:The effects of corticosteroid treatment on mucosal mast cells in rat jejunal mucosa were examined. Rats previously infected with Nippostrongylus brasiliensis received a single IP injection of 1 mg dexamethasone. Three hours later, one third of mucosal mast cells demonstrated minor granular changes (fusion or periphera...

journal_title：Gastroenterology

authors： Soda K,Kawabori S,Perdue MH,Bienenstock J

更新日期：1991-04-01 00:00:00