Abstract:
:Increasing evidence has emerged that supports an important intersection between 3 fundamental cell biologic pathways in the pathogenesis of inflammatory bowel disease. These include the intersection between autophagy, as revealed by the original identification of ATG16L1 and IRGM as major genetic risk factors for Crohn's disease, and intracellular bacterial sensing, as shown by the importance of NOD2 in autophagy induction upon bacterial entry into the cell. A pathway closely linked to autophagy and innate immunity is the unfolded protein response, initiated by endoplasmic reticulum stress due to the accumulation of misfolded proteins, which is genetically related to ulcerative colitis and Crohn's disease (XBP1 and ORMDL3). Hypomorphic ATG16L1, NOD2, and X box binding protein-1 possess the common attribute of profoundly affecting Paneth cells, specialized epithelial cells at the bottom of intestinal crypts involved in antimicrobial function. Together with their functional juxtaposition in the environmentally exposed intestinal epithelial cell, their remarkable functional convergence on Paneth cells and their behavior in response to environmental factors, including microbes, these 3 pathways are of increasing importance to understanding the pathogenesis of inflammatory bowel disease. Moreover, in conjunction with studies that model deficient nuclear factor-κB function, these studies suggest a central role for altered intestinal epithelial cell function as one of the earliest events in the development of inflammatory bowel disease.
journal_name
Gastroenterologyjournal_title
Gastroenterologyauthors
Kaser A,Blumberg RSdoi
10.1053/j.gastro.2011.02.048subject
Has Abstractpub_date
2011-05-01 00:00:00pages
1738-47issue
6eissn
0016-5085issn
1528-0012pii
S0016-5085(11)00202-2journal_volume
140pub_type
杂志文章,评审相关文献
GASTROENTEROLOGY文献大全abstract::A 22-yr-old woman with a 7-yr history of systemic lupus erythematosus presented with anasarca and a serum albumin of 0.8 g/dl. Renal and hepatic function were near normal; the major route of protein loss appeared to be the intestine. A full-thickness section of jejunum obtained at laparotomy demonstrated a severe, dif...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1981-09-01 00:00:00
abstract::The transport of folic acid was investigated in organ-cultured endoscopic biopsy specimens of intestinal mucosa from normal subjects. In the proximal small intestine at pH 5.5 and 6.5, [3H]folic acid accumulated to concentrations 2.64- and 2.17-fold higher than those of the medium, respectively, but at pH 7.5 the conc...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(90)90614-7
更新日期:1990-10-01 00:00:00
abstract::The effects of vasopressin on blood flow in the superior mesenteric artery and on mean arterial pressure and portal venous pressure were measured in 7 rhesus monkeys. Vasopressin was injected, as either a bolus, or infused both intravenously and intraarterially to assess the influence of the route of administration up...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1978-05-01 00:00:00
abstract::Somatostatin-14 and somatostatin-28 are biologically active peptides derived from the posttranslational cleavage of prosomatostatin. Because both peptides are found in variable concentrations in the gastrointestinal (GI) tract and pancreas, it has been contended that somatostatin-28 is either an intermediate in the pr...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(90)91151-u
更新日期:1990-11-01 00:00:00
abstract:BACKGROUND & AIMS:In the intestines, Toll-like receptor 2 (TLR2) mediates immune responses to pathogens and regulates epithelial barrier function; polymorphisms in TLR2 have been associated with inflammatory bowel disease phenotype. We assessed the effects of TLR2 signaling on the enteric nervous system (ENS) in mice. ...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2013.08.047
更新日期:2013-12-01 00:00:00
abstract::Experiments were designed to test the hypothesis that alterations of intestinal motility accompany enteric helminth infections. Motility was measured in rats during the intestinal phase of infection with the nematode Trichinella spiralis by following the transit of radioactive chromium through the gut. Intraduodenal c...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1976-10-01 00:00:00
abstract:BACKGROUND & AIMS:Cholecystokinin (CCK) is a satiation peptide released during meals in response to lipid intake; it regulates pancreatic digestive enzymes that are required for absorption of nutrients. We proposed that mice with a disruption in the CCK gene (CCK knockout [CCK-KO] mice) that were fed a diet of 20% butt...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2010.01.044
更新日期:2010-05-01 00:00:00
abstract:BACKGROUND & AIMS:MicroRNAs (miRNAs) can promote or inhibit tumor growth and are therefore being developed as targets for cancer therapies. They are diverse not only in the messenger RNAs (mRNA) they target, but in their production; the same hairpin RNA structure can generate mature products from each strand, termed 5p...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2011.12.047
更新日期:2012-04-01 00:00:00
abstract::Incidence of intrahepatic arteriovenous fistula after needle biopsy of the liver, percutaneous transhepatic cholangiography, and transhepatic catheterization of an intrahepatic bile duct or portal vein, was determined by studying the hepatic arteriograms obtained within 1 month of the transhepatic procedure. An arteri...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1978-06-01 00:00:00
abstract:BACKGROUND/AIMS:The gastric mucosa is covered by a continuous layer of bicarbonate-containing mucus gel; the question arises how acid, formed in the gastric glands, moves into the lumen. METHODS:The pH in the gastric mucus gel and gel thickness were measured in anesthetized rats with pH-sensitive microelectrodes (tip ...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(94)90075-2
更新日期:1994-07-01 00:00:00
abstract::Esophageal ligation in the pylorus-ligated rat significantly inhibited volume, titratable acidity, and titratable acid output and reduced the incidence of ulcers, perforations, and death of 18-hr pylorus-ligated rats. Draining the saliva outside the body of the rat by esophageal cannulation produced a significant incr...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1966-06-01 00:00:00
abstract:BACKGROUND & AIMS:Transplantation of wild-type (H-2k) bone marrow into tg epsilon26 mice (BM-->tg epsilon26) induces colitis, characterized by T-helper cell type 1 activation in the lamina propria. Here we determined whether pathogenic T-cell clones could be derived by serial adoptive transfers into healthy tg epsilon2...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2005.01.060
更新日期:2005-05-01 00:00:00
abstract::Several experimental studies have demonstrated that activated intestinal T cells can induce villous atrophy. This observation led us to examine the possible role of activated T cells in the pathogenesis of intestinal lesions in a group of 13 children with intractable diarrhea and villous atrophy of unknown origin. Imm...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(90)90624-a
更新日期:1990-10-01 00:00:00
abstract:BACKGROUND & AIMS:Regenerating (Reg) gene IV is predominantly expressed in gastrointestinal cells and highly up-regulated in many gastrointestinal malignancies, including colorectal cancer (CRC). Human CRC cells expressing higher levels of Reg IV gene and its protein product (Reg IV) are resistant to conventional thera...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2009.10.050
更新日期:2010-02-01 00:00:00
abstract::Increased type III collagen deposition in all layers of the intestinal tract, including the lamina propria, is a common feature of strictures in Crohn's disease. In the present study, it was found that in comparison with fibroblasts from normal or nonstrictured but inflamed intestinal lamina propria, the fibroblasts i...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(92)90314-o
更新日期:1992-06-01 00:00:00
abstract::To study the peripheral effect of somatostatin in dogs a tiny Silastic catheter was implanted in an almost terminal branch of the mesenteric artery, providing blood supply to a jejunal segment of 5-10 cm. In 4 dogs one catheter was implanted, perfusing a small bowel segment about 60 cm below the angle of Treitz; in 3 ...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1984-11-01 00:00:00
abstract:BACKGROUND & AIMS:Individuals with human immunodeficiency virus (HIV) infection frequently also are infected with hepatitis C virus (HCV) (co-infection), but little is known about its effects on the progression of HIV-associated disease. We aimed to determine the effects of co-infection on mortality from HIV and/or acq...
journal_title:Gastroenterology
pub_type: 杂志文章,多中心研究
doi:10.1053/j.gastro.2012.12.026
更新日期:2013-04-01 00:00:00
abstract:BACKGROUND/AIMS:The pathways underlying rectal hypersensitivity to balloon distention in patients with irritable bowel syndrome (IBS) are not known. The aim of this study was to characterize the involvement of sacral and thoracolumbar afferents in the perception of rectal distention. METHODS:Rectal balloon distention ...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(94)90809-5
更新日期:1994-12-01 00:00:00
abstract::The influence of ethinyl estradiol (EE) on the effects of dietary cholesterol on the biliary saturation index and on the rate-limiting hepatic enzymes of cholesterol synthesis, hydroxymethylglutaryl-CoA-reductase, and bile acid synthesis, 7 alpha-hydroxylase, were determined. Four groups of 12 male hamsters were treat...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1978-07-01 00:00:00
abstract:BACKGROUND & AIMS:A previous 4-week trial of telbivudine in patients with chronic hepatitis B indicated marked antiviral effects with good tolerability, leading to the present 1-year phase 2b trial. METHODS:This randomized, double-blind, multicenter trial evaluated the efficacy and safety of telbivudine 400 or 600 mg/...
journal_title:Gastroenterology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1016/j.gastro.2005.05.053
更新日期:2005-08-01 00:00:00
abstract:BACKGROUND:The epidemiology of anorectal melanoma has not been well studied despite its potential relevance to the cutaneous melanoma epidemic, and prognostic studies have generally been based on referred cases. METHODS:Data reported to nine population-based registries in the United States during 1973 through 1987 wer...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(93)90849-8
更新日期:1993-01-01 00:00:00
abstract::Biofeedback has been advocated as first-line therapy for patients whose symptoms of mild to moderate fecal incontinence have not responded to simple dietary advice or medication. Three main modalities have been described: (1) use of an intra-anal electromyographic sensor, a probe to measure intra-anal pressure, or per...
journal_title:Gastroenterology
pub_type: 杂志文章,评审
doi:10.1053/j.gastro.2003.10.058
更新日期:2004-01-01 00:00:00
abstract::In human cirrhosis, there is evidence that there are considerable alterations in fluid and solute exchange in the hepatic and intestinal microcirculations . Experimental cirrhosis was induced in rats by using oral phenobarbitone and carbon tetrachloride inhalation over an 8-wk period. Portal venous pressure, hepatic a...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1984-07-01 00:00:00
abstract:BACKGROUND & AIMS:The accurate identification of inactive (serum HBV-DNA persistently journal_title:Gastroenterology pub_type: 杂志文章 doi:10.1053/j.gastro.2010.04.052 更新日期:2010-08-01 00:00:00
abstract::Rising trends in the incidence and mortality of early-onset CRC in those who are ages less than 50 years have been well-established. These trends have spurred intense investigation focused on elucidating the epidemiology and characteristics of early-onset CRC, as well on identifying strategies for early detection and ...
journal_title:Gastroenterology
pub_type: 杂志文章,评审
doi:10.1053/j.gastro.2020.12.068
更新日期:2021-01-05 00:00:00
abstract:BACKGROUND & AIMS:Nuclear factor kappaB (NF-kappaB) is the master regulator of tumor necrosis factor (TNF) susceptibility. Although mitochondrial glutathione (mGSH) depletion was shown to sensitize hepatocytes to TNF despite NF-kappaB activation, the mechanisms involved, particularly the role of Bax oligomerization and...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2008.01.073
更新日期:2008-05-01 00:00:00
abstract:BACKGROUND & AIMS:Integrity of the intestinal epithelium is required for nutrition absorption and defense against pathogens. Claudins are cell adhesion molecules that localize at tight junctions (TJs); many are expressed in the intestinal tract, but little is known about their functions. Claudin-7 is unique in that it ...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2011.10.025
更新日期:2012-02-01 00:00:00
abstract:BACKGROUND & AIMS:Prostacyclin and nitric oxide have been involved in the hyperkinetic syndrome in portal hypertension. The aim of this study was to investigate the relative contribution and possible interaction between prostacyclin and NO in this circulatory abnormality. METHODS:Portal vein-ligated and sham-operated ...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/gast.1996.v110.pm8613060
更新日期:1996-05-01 00:00:00
abstract::Eleven infants born to mothers with acute hepatitis B during the third trimester of pregnancy who were hepatitis B surface antigen-positive at delivery were treated with hepatitis B immune globulin within 24-48 h of birth. Five infants received one dose of hepatitis B immune globulin and 6 infants received a second do...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(85)90757-7
更新日期:1985-07-01 00:00:00
abstract:BACKGROUND & AIMS:Infection with Helicobacter pylori is associated with reduced risk of esophageal adenocarcinoma (EAC), but it is not clear whether this reduction is modified by genotype, other host characteristics, or environmental factors. Furthermore, little is known about the association between H pylori and adeno...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2010.04.009
更新日期:2010-07-01 00:00:00