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Cholecystokinin knockout mice are resistant to high-fat diet-induced obesity.

Abstract：

BACKGROUND & AIMS:Cholecystokinin (CCK) is a satiation peptide released during meals in response to lipid intake; it regulates pancreatic digestive enzymes that are required for absorption of nutrients. We proposed that mice with a disruption in the CCK gene (CCK knockout [CCK-KO] mice) that were fed a diet of 20% butter fat would have altered fat metabolism. METHODS:We used quantitative magnetic resonance imaging to determine body composition and monitored food intake of CCK-KO mice using an automated measurement system. Intestinal fat absorption and energy expenditure were determined using a noninvasive assessment of intestinal fat absorption and an open circuit calorimeter, respectively. RESULTS:After consuming a high-fat diet for 10 weeks, CCK-KO mice had reduced body weight gain and body fat mass and enlarged adipocytes, despite the same level of food intake as wild-type mice. CCK-KO mice also had defects in fat absorption, especially of long-chain saturated fatty acids, but pancreatic triglyceride lipase did not appear to have a role in the fat malabsorption. Energy expenditure was higher in CCK-KO than wild-type mice, and CCK-KO mice had greater oxidation of carbohydrates while on the high-fat diet. Plasma leptin levels in the CCK-KO mice fed the high-fat diet were markedly lower than in wild-type mice, although levels of insulin, gastric-inhibitory polypeptide, and glucagon-like peptide-1 were normal. CONCLUSIONS:CCK is involved in regulating the metabolic rate and is important for lipid absorption and control of body weight in mice placed on a high-fat diet.

journal_name

Gastroenterology

journal_title

Gastroenterology

authors

Lo CM,King A,Samuelson LC,Kindel TL,Rider T,Jandacek RJ,Raybould HE,Woods SC,Tso P

doi

10.1053/j.gastro.2010.01.044

subject

Has Abstract

pub_date

2010-05-01 00:00:00

pages

1997-2005

issue

5

eissn

0016-5085

issn

1528-0012

pii

S0016-5085(10)00150-2

journal_volume

138

pub_type

杂志文章

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